Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation

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Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.251165
P932PMC publication ID3199487
P698PubMed publication ID21880741
P5875ResearchGate publication ID51608443

P50authorNaihe JingQ64620873
P2093author name stringMeng Li
Lin Li
Tao Huang
Jiyong Wang
Zhihui Xie
P2860cites workThe kinase TNIK is an essential activator of Wnt target genesQ24323107
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.Q24534260
Integration of calcium and cyclic AMP signaling pathways by 14-3-3Q24554335
Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signalingQ24795999
SnapShot: Noncanonical Wnt Signaling PathwaysQ80411299
A similar DNA-binding motif in NFAT family proteins and the Rel homology regionQ95777567
Wnt/beta-catenin signaling in development and diseaseQ27860784
The Wnt signaling pathway in development and diseaseQ27861019
NF-AT components define a family of transcription factors targeted in T-cell activationQ28114991
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathwayQ28118992
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activityQ28140993
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axonsQ28176698
NFAT signaling: choreographing the social lives of cellsQ28216151
Transcription factors of the NFAT family: regulation and functionQ28237645
NFAT proteins: key regulators of T-cell development and functionQ28253919
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and JunQ28263918
NFATc2-mediated repression of cyclin-dependent kinase 4 expressionQ28505899
The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shapeQ28613516
A series of normal stages in the development of the chick embryo. 1951Q29618726
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activationQ29620223
Transcriptional regulation by calcium, calcineurin, and NFATQ29620410
Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylaseQ30486988
G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathwayQ33771080
Requirement for transcription factor NFAT in interleukin-2 expressionQ33957551
Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.Q33996893
Transcriptional mechanisms underlying lymphocyte tolerance.Q34135663
Wnt signaling in disease and in developmentQ34390198
Wnt and calcium signaling: beta-catenin-independent pathwaysQ36228742
Colocalization and redistribution of dishevelled and actin during Wnt-induced mesenchymal morphogenesisQ36328302
Mechanisms of transactivation by nuclear factor of activated T cells-1.Q36367061
Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interactionQ36534593
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis.Q37443849
How diverse--CD4 effector T cells and their functionsQ37502276
Mediator requirement for both recruitment and postrecruitment steps in transcription initiationQ38329746
TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signalingQ39733618
Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1.Q40561279
Alternative splicing of the APC gene and its association with terminal differentiation.Q41131666
Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cellsQ42823306
The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryosQ43996883
Stat3 signaling is present and active during development of the central nervous system and eye of vertebratesQ45057942
WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristicsQ46051855
Sympathetic neuroblasts undergo a developmental switch in trophic dependenceQ46092272
Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cordQ58185802
A mitogen gradient of dorsal midline Wnts organizes growth in the CNSQ77960718
P433issue43
P407language of work or nameEnglishQ1860
P921main subjecttranscription factor 4Q7669683
beta-catenin bindingQ14872998
Dishevelled segment polarity protein 3Q21113750
Dishevelled segment polarity protein 3Q21981226
Dishevelled segment polarity protein 1Q21981314
Dishevelled segment polarity protein 2Q21981319
Nuclear factor of activated T-cells, cytoplasmic 1Q21987757
Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4Q21987767
P304page(s)37399–37405
P577publication date2011-10-28
P1433published inJournal of Biological ChemistryQ867727
P1476titleNuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation
P478volume286

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cites work (P2860)
Q55425485A comprehensive analysis of Wnt/β-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer.
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Q28551183Dynamic Trk and G Protein Signalings Regulate Dopaminergic Neurodifferentiation in Human Trophoblast Stem Cells
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Q34141145Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5.
Q36673354Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.
Q28509892Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules
Q41455846NFAT transcription factors regulate survival, proliferation, migration, and differentiation of neural precursor cells.
Q36985073NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation.
Q90390285NFATC4 promotes quiescence and chemotherapy resistance in ovarian cancer
Q90446391Neuroglobin Regulates Wnt/β-Catenin and NFκB Signaling Pathway through Dvl1
Q35821670Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche
Q38940107Noncanonical Wnt5a-Ca(2+) -NFAT signaling axis in pesticide induced bone marrow aplasia mouse model: A study to explore the novel mechanism of pesticide toxicity
Q28387039Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells
Q34166917Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway
Q64099227R-spondin signaling as a pivotal regulator of tissue development and homeostasis
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Q38629707Transcriptional hallmarks of cancer cell lines reveal an emerging role of branched chain amino acid catabolism.
Q38263093WNT signaling: an emerging mediator of cancer cell metabolism?
Q35788801Wnt pathway in atypical teratoid rhabdoid tumors
Q27022507Wnt your brain be inflamed? Yes, it Wnt!

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