The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling

scientific journal article

The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.385658
P932PMC publication ID3408186
P698PubMed publication ID22654112

P50authorBernhard SchermerQ28321515
Thomas BenzingQ2422379
Max Christoph LiebauQ47159237
Matthias HammerschmidtQ71370036
P2093author name stringClaudia Dafinger
Sandra Habbig
Julia Hatzold
Lori Borgal
Ilinca Sacarea
P2860cites workThe Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathwayQ24296279
Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signalingQ24301800
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathwaysQ24302034
The Hippo pathway regulates Wnt/beta-catenin signalingQ24307606
Identification of c-MYC as a target of the APC pathwayQ24310637
Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasiaQ24315070
Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2Q24555759
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTPQ24621121
Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHLQ24634352
Scrutinizing ciliopathies by unraveling ciliary interaction networksQ27025614
Wnt/beta-catenin signaling in development and diseaseQ27860784
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesisQ28000044
Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6Q28116478
Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomesQ28119088
Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor proteinQ28246139
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transductionQ28286117
Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathyQ28506100
Proteomic analysis of mammalian primary ciliaQ28512191
Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1Q28513907
Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-cateninQ28586720
Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epitheliumQ28588368
A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into ciliaQ29026303
When cilia go bad: cilia defects and ciliopathiesQ29547198
Effective targeted gene 'knockdown' in zebrafishQ29547445
The vertebrate primary cilium in development, homeostasis, and diseaseQ29614609
Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanismsQ29614613
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathwaysQ29614619
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt responseQ29617051
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activationQ29618700
The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growthQ30480543
Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathwayQ30489319
Nephronophthisis: disease mechanisms of a ciliopathyQ33594278
The cell biology of polycystic kidney diseaseQ34149966
Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to ciliaQ34324921
Kidney development and disease in the zebrafishQ34383970
Nephronophthisis.Q34793373
Subcellular spatial regulation of canonical Wnt signalling at the primary ciliumQ35022258
NPHP4, a cilia-associated protein, negatively regulates the Hippo pathwayQ35196050
Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout miceQ36119534
Urinary concentration defects and mechanisms underlying nephronophthisisQ37156216
The ubiquitin conjugation system is involved in the disassembly of cilia and flagellaQ37323142
The canonical Wnt/beta-catenin signalling pathwayQ37355851
Ciliary function and Wnt signal modulationQ37369338
Cystic kidney disease: the role of Wnt signalingQ37767526
Zebrafish Kidney DevelopmentQ37812722
Inversin, Wnt signaling and primary ciliaQ37972186
Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signalingQ38289224
Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephrosQ39557728
Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monociliaQ39584826
pVHL and GSK3beta are components of a primary cilium-maintenance signalling networkQ40142798
Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafishQ47073512
Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathwaysQ47073543
A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidneyQ47074132
Kinase cogs go forward and reverse in the Wnt signaling machineQ47354687
Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function.Q52182505
Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin geneQ74604719
Linking cilia to WntsQ81695265
A homozygous mutation in INVS causing juvenile nephronophthisis with abnormal reactivity of the Wnt/beta-catenin pathwayQ84960994
P433issue30
P407language of work or nameEnglishQ1860
P921main subjectnegative regulation of canonical Wnt signaling pathwayQ14860027
Jade family PHD finger 1Q21113948
Nephrocystin 4Q21118162
Jade family PHD finger 1Q29834377
P304page(s)25370–25380
P577publication date2012-07-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling
P478volume287

Reverse relations

cites work (P2860)
Q35195922Bioinformatic analysis of ciliary transition zone proteins reveals insights into the evolution of ciliopathy networks.
Q39178607CILIA: before and after
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Q91410919Cellular signalling by primary cilia in development, organ function and disease
Q38171918Cilia and coordination of signaling networks during heart development
Q34207085Ciliopathies: the trafficking connection
Q55417331Control of Hedgehog Signalling by the Cilia-Regulated Proteasome.
Q37668895DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study
Q47919079Expression profiles of NPHP1 in the germ cells in the semen of men with male factor infertility
Q92293141FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation
Q36596124HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.
Q36956926Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression
Q39339465Nuclear roles for cilia-associated proteins
Q37618918Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition.
Q39819105Primary cilia modulate balance of canonical and non-canonical Wnt signaling responses in the injured kidney
Q94463957Silencing of microRNA-135b inhibits invasion, migration, and stemness of CD24+CD44+ pancreatic cancer stem cells through JADE-1-dependent AKT/mTOR pathway
Q38828242Structure, function and regulation of jade family PHD finger 1 (JADE1).
Q55616467Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.
Q30540974The Meckel syndrome protein meckelin (TMEM67) is a key regulator of cilia function but is not required for tissue planar polarity.
Q64092333The Role of Primary Cilia in the Crosstalk between the Ubiquitin⁻Proteasome System and Autophagy
Q90740314The ciliary protein Rpgrip1l in development and disease
Q45354108The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.
Q34483855The novel function of JADE1S in cytokinesis of epithelial cells
Q35826045The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium
Q55689509Zebrafish as a Model for Drug Screening in Genetic Kidney Diseases.
Q35124210β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma

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