scholarly article | Q13442814 |
P50 | author | Braxton D. Mitchell | Q30348346 |
Laura Almasy | Q57094822 | ||
P2093 | author name string | M. P. Stern | |
J. E. Hixson | |||
A. G. Comuzzie | |||
J. Blangero | |||
J. W. MacCluer | |||
M. C. Mahaney | |||
T. D. Dyer | |||
P2860 | cites work | Positional cloning of the mouse obese gene and its human homologue | Q22251285 |
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results | Q29547377 | ||
Serum immunoreactive-leptin concentrations in normal-weight and obese humans | Q29617230 | ||
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects | Q29617231 | ||
Weight-reducing effects of the plasma protein encoded by the obese gene | Q29617934 | ||
Effects of the obese gene product on body weight regulation in ob/ob mice | Q29617935 | ||
Overexpression of the obese (ob) gene in adipose tissue of human obese subjects | Q34297440 | ||
Increased obese mRNA expression in omental fat cells from massively obese humans | Q34297446 | ||
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks | Q34301257 | ||
Dexamethasone regulates obese expression in isolated rat adipocytes | Q38291253 | ||
Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake | Q38293519 | ||
Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue | Q38293741 | ||
Extreme obesity may be linked to markers flanking the human OB gene | Q38358626 | ||
Indication for linkage of the human OB gene region with extreme obesity | Q38358630 | ||
Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis | Q39800620 | ||
Major gene with sex-specific effects influences fat mass in Mexican Americans. | Q41002488 | ||
Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization. | Q41314089 | ||
Plasma HDL cholesterol, triglycerides, and adiposity. A quantitative genetic test of the conjoint trait hypothesis in the San Antonio Family Heart Study | Q41671973 | ||
Obesity in Mexican American subgroups: findings from the San Antonio Heart Study | Q43913937 | ||
DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy Indians in Singapore. | Q44510863 | ||
Genetic analysis of the IRS. Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures. | Q51583036 | ||
Altered adrenocorticotropin and cortisol secretion in abdominal obesity: implications for the insulin resistance syndrome. | Q51598493 | ||
Programs for pedigree analysis: Mendel, Fisher, and dGene | Q59760870 | ||
Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels, and increased risk of coronary heart disease | Q69928029 | ||
Adipose tissue leptin production and plasma leptin kinetics in humans | Q71150204 | ||
Extensions to multivariate normal models for pedigree analysis | Q72063764 | ||
ApoB-100 gene EcoRI polymorphism. Relations to plasma lipoprotein changes associated with abdominal visceral obesity | Q72673618 | ||
P433 | issue | 3 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | quantitative trait locus | Q853421 |
P304 | page(s) | 273–276 | |
P577 | publication date | 1997-03-01 | |
P1433 | published in | Nature Genetics | Q976454 |
P1476 | title | A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2 | |
P478 | volume | 15 |
Q35764466 | A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program |
Q31049222 | A genome-wide linkage scan for body mass index on Framingham Heart Study families |
Q50645302 | A genome-wide scan for body mass index among Nigerian families. |
Q77525901 | A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10 |
Q46453534 | A genome-wide scan for quantitative trait loci linked to obesity phenotypes among West Africans |
Q37289203 | A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS. |
Q35764160 | A genomewide linkage scan for quantitative-trait loci for obesity phenotypes |
Q30498786 | A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans |
Q28361785 | A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans |
Q37217251 | A major predisposition locus for severe obesity, at 4p15-p14 |
Q41878873 | A novel method, the Variant Impact On Linkage Effect Test (VIOLET), leads to improved identification of causal variants in linkage regions |
Q80628559 | A novel obesity locus on chromosome 4q: the Strong Heart Family Study |
Q37377862 | A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans |
Q44053867 | A quantitative trait locus on chromosome 22 for serum leptin levels adjusted for serum testosterone |
Q44391093 | A search for candidate genes for lipodystrophy, obesity and diabetes via gene expression analysis of A-ZIP/F-1 mice |
Q37219579 | A whole-genome scan for obstructive sleep apnea and obesity |
Q40663100 | ACTH and alpha-MSH inhibit leptin expression and secretion in 3T3-L1 adipocytes: model for a central-peripheral melanocortin-leptin pathway |
Q35821145 | Adiposity signals, genetic and body weight regulation in humans |
Q33835637 | Admixture mapping of obesity-related traits in African Americans: the Atherosclerosis Risk in Communities (ARIC) Study |
Q33680509 | Adrenoceptor genes in human obesity |
Q33665882 | Advances in the molecular genetics of obesity |
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Q21266690 | An integrated approach of comparative genomics and heritability analysis of pig and human on obesity trait: evidence for candidate genes on human chromosome 2 |
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Q37227782 | Genome-wide linkage and regional association study of obesity-related phenotypes: the GenSalt study |
Q51741041 | Genome-wide scan of plasma cholecystokinin in baboons shows linkage to human chromosome 17. |
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Q34144320 | Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. |
Q60696766 | Genotype by smoking interaction for leptin levels in the San Antonio family heart study |
Q60696762 | Genotype-by-smoking interaction for leptin levels in the Metabolic Risk Complications of Obesity Genes project |
Q51379348 | Glucokinase regulatory protein (GCKR) gene rs4425043 polymorphism is associated with overweight and obesity in Chinese women. |
Q74157673 | Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees |
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Q28365983 | High-resolution physical and transcript map of human chromosome 2p21 containing the sitosterolaemia locus. |
Q34143823 | How obesity develops: insights from the new biology |
Q37230950 | Human QTL linkage mapping |
Q24561366 | Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function |
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Q57244364 | Leptin |
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Q34389390 | Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans |
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Q33794462 | Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium |
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Q33864624 | Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci |
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