Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia

scientific journal article

Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1036604532
P356DOI10.1038/CDD.2009.167
P698PubMed publication ID19942931
P5875ResearchGate publication ID40036085

P50authorIsabella CaniggiaQ37377934
P2093author name stringJ. Garcia
J. E. Ray
A. Jurisicova
P2860cites workBax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondriaQ22011013
Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3Q24301304
IFPA Trophoblast Research Award Lecture: the dynamic role of Bcl-2 family members in trophoblast cell fateQ24309226
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channelQ24523479
Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family membersQ24648909
Movement of Bax from the cytosol to mitochondria during apoptosisQ24677881
Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosisQ28118864
Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigenQ28138082
Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeastQ28272102
Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XLQ28504590
Mitochondria and apoptosisQ29547905
The Ki-67 protein: fascinating forms and an unknown functionQ33334637
Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisitedQ33732595
To be, or not to be, that is the question. Apoptosis in human trophoblastQ33848686
Tissue-specific Bcl-2 protein partners in apoptosis: An ovarian paradigmQ33881268
Pathogenesis and genetics of pre-eclampsiaQ33934445
Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)Q33939664
A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsiaQ34404307
Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and Sensitizes to Stress-induced ApoptosisQ34537816
Control of proliferation by Bcl-2 family membersQ35680518
Hypoxic switch in mitochondrial myeloid cell leukemia factor-1/Mtd apoptotic rheostat contributes to human trophoblast cell death in preeclampsiaQ35916004
Bax alpha perturbs T cell development and affects cell cycle entry of T cellsQ35917304
Living with or without cyclins and cyclin-dependent kinasesQ35951291
BCL2 family in DNA damage and cell cycle controlQ36501194
Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapyQ36736714
Placental pathology: a systematic approach with clinical correlationsQ36976570
Live and let die - regulation of villous trophoblast apoptosis in normal and abnormal pregnancies.Q37244917
A proteolytic fragment of Mcl-1 exhibits nuclear localization and regulates cell growth by interaction with Cdk1.Q40489962
ACOG technology assessment. Genetics and molecular diagnostic testing. Number 1, July 2002. American College of Obstetrics and GynecologyQ40616036
Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.Q40980272
Maternal circulation in the first-trimester human placenta--myth or reality?Q41392140
Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cellsQ43514949
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.Q44044678
Regulation of human placental development by oxygen tensionQ46733260
Molecular evidence of placental hypoxia in preeclampsia.Q51975690
Alteration of the Bcl-2:Bax ratio in the placenta as pregnancy proceeds.Q52123506
E-cadherin in the assessment of aberrant placental cytotrophoblast turnover in pregnancies complicated by pre-eclampsia.Q53658474
Apoptosis is a rare event in first-trimester placental tissueQ59367243
Placental apoptosis in normal human pregnancyQ59367743
Very Low Birthweight Placenta: Clustering of Morphologic CharacteristicsQ59663021
ACOG Practice Bulletin, clinical management guidelines for obstetrician-gynecologists number 98, October 2008 (replaces Practice Bulletin number 58, December 2004). Ultrasonography in pregnancyQ82126982
P433issue5
P921main subjectapoptotic processQ14599311
pre-eclampsiaQ61335
Cyclin E1Q21100448
BCL2 family apoptosis regulator BOKQ21106726
regulation of chorionic trophoblast cell proliferationQ21115940
P304page(s)846–859
P577publication date2010-05-01
P1433published inCell Death & DifferentiationQ2943974
P1476titleMtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia
P478volume17

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cites work (P2860)
Q37616724Altered expression of G1/S phase cell cycle regulators in placental mesenchymal stromal cells derived from preeclamptic pregnancies with fetal-placental compromise.
Q35049491Attenuation of VEGFR-2 expression by sFlt-1 and low oxygen in human placenta
Q34249957BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.
Q38661004BOK displays cell death-independent tumor suppressor activity in non-small-cell lung carcinoma.
Q47304516BOK promotes chemical-induced hepatocarcinogenesis in mice
Q37807748Bcl-2 proteins and mitochondria—Specificity in membrane targeting for death
Q49789815Ceramide-induced BOK promotes mitochondrial fission in preeclampsia
Q35597630Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia
Q34804762Effect of Immortalization-Upregulated Protein-2 (IMUP-2) on Cell Death of Trophoblast
Q36274998Effects of Notch2 and Notch3 on Cell Proliferation and Apoptosis of Trophoblast Cell Lines
Q64880433Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsia.
Q37383229Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis
Q28586794Intracellular localization of the BCL-2 family member BOK and functional implications
Q47107310Kidney-Replenishing Herb Induces SOCS-3 Expression via ERK/MAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells.
Q61807538Placental Expression of NEMO Protein in Normal Pregnancy and Preeclampsia
Q28117624Placental autophagy regulation by the BOK-MCL1 rheostat
Q37699280TREM-1 expression is increased in human placentas from severe early-onset preeclamptic pregnancies where it may be involved in syncytialization
Q48158280The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer
Q48374835The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID.

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