| scholarly article | Q13442814 |
| P356 | DOI | 10.1161/01.RES.0000024411.22110.AA |
| P698 | PubMed publication ID | 12089065 |
| P50 | author | Steve Charnock-Jone | Q57177791 |
| P2093 | author name string | Graham J Burton | |
| Jeremy N Skepper | |||
| Tai-Ho Hung | |||
| P433 | issue | 12 | |
| P921 | main subject | pre-eclampsia | Q61335 |
| hypoxia | Q105688 | ||
| apoptotic process | Q14599311 | ||
| P304 | page(s) | 1274-1281 | |
| P577 | publication date | 2002-06-01 | |
| P1433 | published in | Circulation Research | Q2599020 |
| P1476 | title | Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia | |
| P478 | volume | 90 |
| Q92591248 | 25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity |
| Q59052362 | A Comparative Pathophysiological Study of Normal and Growth Retarded Human Placental Tissue |
| Q36752126 | A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice |
| Q43157300 | A longitudinal study of oxidative stress and antioxidant status in women with uncomplicated pregnancies throughout gestation |
| Q34404307 | A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia |
| Q37525221 | A1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia |
| Q33725645 | Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies |
| Q36317153 | Acute pyelonephritis during pregnancy changes the balance of angiogenic and anti-angiogenic factors in maternal plasma |
| Q35217420 | Adenosine A₂a receptors and O₂ sensing in development |
| Q51944536 | Altered expression of regulators of caspase activity within trophoblast of normal pregnancies and pregnancies complicated by preeclampsia. |
| Q59136468 | Antioxidants and Oxidative Stress: Focus in Obese Pregnancies |
| Q51112292 | Aquaporins in Fetal Development. |
| Q46302960 | Association of a reduction of G‑protein coupled receptor 30 expression and the pathogenesis of preeclampsia |
| Q39909759 | Autophagy-related proteins, LC3 and Beclin-1, in placentas from pregnancies complicated by preeclampsia |
| Q36752130 | Beyond the threshold: an etiological bridge between hypoxia and immunity in preeclampsia |
| Q35756049 | Biochemical markers for prediction of preclampsia: review of the literature. |
| Q33247983 | Cancer during pregnancy alters the activity of rat placenta and enhances the expression of cleaved PARP, cytochrome-c and caspase 3 |
| Q35222103 | Carbon monoxide inhibits hypoxia/reoxygenation-induced apoptosis and secondary necrosis in syncytiotrophoblast |
| Q36780996 | Caspase-mediated apoptosis of trophoblasts in term human placental villi is restricted to cytotrophoblasts and absent from the multinucleated syncytiotrophoblast |
| Q90265122 | Causes and Consequences of the Dysregulated Maternal Renin-Angiotensin System in Preeclampsia |
| Q38124028 | Cell death mechanisms and potentially cytotoxic natural immune cells in human pregnancies complicated by preeclampsia |
| Q35390255 | Cellular fetal microchimerism in preeclampsia |
| Q54464427 | Change of genes in calcium transport channels caused by hypoxic stress in the placenta, duodenum, and kidney of pregnant rats. |
| Q54507094 | Changes of placental Kiss-1 mRNA expression and maternal/cord kisspeptin levels at preterm delivery. |
| Q36026745 | Chronic hypoxia in vivo reduces placental oxidative stress |
| Q90538941 | Clinical Presentation of Preeclampsia and the Diagnostic Value of Proteins and Their Methylation Products as Biomarkers in Pregnant Women with Preeclampsia and Their Newborns |
| Q34721353 | Comparative proteomics analysis suggests that placental mitochondria are involved in the development of pre-eclampsia |
| Q34280644 | Critical growth factors and signalling pathways controlling human trophoblast invasion |
| Q50488770 | Decreased activation of placental mTOR family members is associated with the induction of intrauterine growth restriction by secondhand smoke in the mouse. |
| Q36983243 | Decreased placental X-linked inhibitor of apoptosis protein in an ovine model of intrauterine growth restriction |
| Q102328555 | Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas |
| Q45271789 | Developmental indices of nutritionally induced placental growth restriction in the adolescent sheep. |
| Q33680974 | Differential Effects of Concomitant Use of Vitamins C and E on Trophoblast Apoptosis and Autophagy between Normoxia and Hypoxia-Reoxygenation |
| Q46029401 | Differential expression of HSP90α and heme oxygenase in cord blood RBC during preeclampsia. |
| Q36666688 | Diminished survival of human cytotrophoblast cells exposed to hypoxia/reoxygenation injury and associated reduction of heparin-binding epidermal growth factor-like growth factor. |
| Q54342986 | Distinct roles for S100a8 in early embryo development and in the maternal deciduum. |
| Q37462447 | Diverse functions of HBEGF during pregnancy. |
| Q39894990 | Does altered oxygenation or reactive oxygen species alter cell turnover of BeWo choriocarcinoma cells? |
| Q37379791 | Downregulated Krüppel-like factor 8 is involved in decreased trophoblast invasion under hypoxia-reoxygenation conditions |
| Q28184159 | Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells |
| Q37651294 | Effect of prenatal hypoxia in transgenic mouse models of preeclampsia and fetal growth restriction. |
| Q33744933 | Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial. |
| Q42108623 | Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells |
| Q35655232 | Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia |
| Q33918999 | Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles |
| Q38707996 | Enhancement of trophoblast differentiation and survival by low molecular weight heparin requires heparin-binding EGF-like growth factor |
| Q56517024 | Evidence of oxidative stress-induced senescence in mature, post-mature and pathological human placentas |
| Q38918330 | Expression of DAB2IP in human trophoblast and its role in trophoblast invasion |
| Q35007417 | FOXO1 expression in villous trophoblast of preeclampsia and fetal growth restriction placentas |
| Q33802298 | Function-specific intracellular signaling pathways downstream of heparin-binding EGF-like growth factor utilized by human trophoblasts |
| Q33674855 | G-protein-coupled receptor 30 mediates the effects of estrogen on endothelial cell tube formation in vitro |
| Q35781335 | Glyceryl trinitrate inhibits hypoxia/reoxygenation-induced apoptosis in the syncytiotrophoblast of the human placenta: therapeutic implications for preeclampsia |
| Q54335812 | Haplotypes of heparin-binding epidermal-growth-factor-like growth factor gene are associated with pre-eclampsia. |
| Q35615008 | Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin |
| Q36813648 | High-altitude hypoxia and preeclampsia. |
| Q51474538 | Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption. |
| Q37172666 | Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor. |
| Q35191560 | Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor |
| Q42975696 | Hypoxia and preeclampsia: increased expression of urocortin 2 and urocortin 3. |
| Q36686796 | Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia |
| Q24306183 | Hypoxia up-regulated angiogenin and down-regulated vascular cell adhesion molecule-1 expression and secretion in human placental trophoblasts |
| Q35916004 | Hypoxic switch in mitochondrial myeloid cell leukemia factor-1/Mtd apoptotic rheostat contributes to human trophoblast cell death in preeclampsia |
| Q51716702 | Hypoxic treatment of human dual placental perfusion induces a preeclampsia-like inflammatory response. |
| Q89964444 | Immune and Apoptosis Mechanisms Regulating Placental Development and Vascularization in Preeclampsia |
| Q37786350 | Immunologic characteristics of preeclampsia, a comprehensive review |
| Q57105968 | Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1 |
| Q34164014 | Increased placental XIAP and caspase 3 is associated with increased placental apoptosis in a baboon model of maternal nutrient reduction |
| Q36422496 | Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms |
| Q42515782 | Inhibition of the receptor for advanced glycation end-products (RAGE) protects from secondhand smoke (SHS)-induced intrauterine growth restriction IUGR in mice. |
| Q35604726 | Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia |
| Q37487239 | Intrauterine growth restriction, human placental development and trophoblast cell death |
| Q38674096 | Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities |
| Q38284366 | Involvement of the heme oxygenase system in the development of preeclampsia and as a possible therapeutic target |
| Q91610979 | Knowledge of preeclampsia and its associated factors among pregnant women: a possible link to reduce related adverse outcomes |
| Q36494058 | Maternal hypoxia activates endovascular trophoblast cell invasion |
| Q36577103 | Mechanisms of disease: Pre-eclampsia |
| Q64066947 | MicroRNA-184 promotes apoptosis of trophoblast cells via targeting WIG1 and induces early spontaneous abortion |
| Q51975690 | Molecular evidence of placental hypoxia in preeclampsia. |
| Q36840280 | Morphological changes of placental syncytium and their implications for the pathogenesis of preeclampsia |
| Q28119158 | Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia |
| Q92796871 | Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia |
| Q37465594 | Novel approaches for mechanistic understanding and predicting preeclampsia |
| Q35757165 | Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant |
| Q37809490 | Obesity and oxidative stress: a direct link to preeclampsia? |
| Q46334825 | Obstructive sleep apnoea syndrome (OSAS) in women: a specific entity? |
| Q38641180 | Oxidative Stress: Placenta Function and Dysfunction |
| Q83128591 | Oxidative stress and antioxidant defenses in pregnant women |
| Q35849259 | Oxidative stress and the induction of cyclooxygenase enzymes and apoptosis in the murine placenta. |
| Q36007397 | Oxidative stress, gene expression, and protein changes induced in the human placenta during labor |
| Q38752852 | Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes |
| Q51548450 | Placental bed apoptosis is increased in pregnant women with pre-eclampsia versus normotensive pregnant women. |
| Q37198421 | Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia |
| Q37278804 | Potential markers of preeclampsia--a review |
| Q46320384 | Preeclampsia and cardiovascular disease: interconnected paths that enable detection of the subclinical stages of obstetric and cardiovascular diseases. |
| Q53344481 | Preeclampsia is associated with an elevation of plasma sMet concentrations in the second trimester. |
| Q42498948 | Preeclampsia with and without intrauterine growth restriction-Two pathogenetically different entities? |
| Q36376515 | Preeclampsia: the death of Goliath |
| Q37512886 | Preeclampsia: the role of angiogenic factors in its pathogenesis |
| Q39620056 | Proapoptotic effect of metalloproteinase 9 secreted by trophoblasts on endothelial cells |
| Q34404445 | Recent insights into the pathophysiology of preeclampsia |
| Q44916177 | Reduced antioxidant capacity in second-trimester pregnancies with pathological uterine perfusion |
| Q34988844 | Regulation of pregnancy-associated plasma protein A2 (PAPPA2) in a human placental trophoblast cell line (BeWo). |
| Q38719444 | Relaxin confers cytotrophoblast protection from hypoxia-reoxygenation injury through the phosphatidylinositol 3-kinase-Akt/protein kinase B cell survival pathway |
| Q24645245 | Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy |
| Q33716927 | Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice |
| Q36875755 | Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia |
| Q36342643 | Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme |
| Q58783160 | Role of the Macrophage Migration Inhibitory Factor (MIF) in the survival of first trimester human placenta under induced stress conditions |
| Q37394622 | Role of the syncytium in placenta-mediated complications of preeclampsia |
| Q35096089 | Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia. |
| Q34254466 | Sera from preeclampsia patients elicit symptoms of human disease in mice and provide a basis for an in vitro predictive assay |
| Q48326430 | Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies |
| Q35853161 | Sildenafil Prevents Apoptosis of Human First-Trimester Trophoblast Cells Exposed to Oxidative Stress: Possible Role for Nitric Oxide Activation of 3',5'-cyclic Guanosine Monophosphate Signaling |
| Q37433278 | Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta |
| Q53091333 | The effect of pregnancy-induced hypertensive disorders on placental growth along short and long axes and neonatal outcomes. |
| Q26798193 | The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia |
| Q44901201 | The influence of oxygen and tumor necrosis factor-alpha on the cellular kinetics of term placental villous explants in culture. |
| Q36165860 | The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity |
| Q33331154 | The placental syncytium and the pathophysiology of preeclampsia and intrauterine growth restriction: a novel assay to assess syncytial protein expression |
| Q34317238 | The role of autophagy in the placenta as a regulator of cell death |
| Q33668328 | The therapeutic potential of antioxidants, ER chaperones, NO and H2S donors, and statins for treatment of preeclampsia |
| Q28206002 | Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons |
| Q34987180 | Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model |
| Q34481622 | Trophoblast expression of the minor histocompatibility antigen HA-1 is regulated by oxygen and is increased in placentas from preeclamptic women |
| Q35221979 | Trophoblastic oxidative stress and the release of cell-free feto-placental DNA. |
| Q38116097 | Tumor necrosis factor-alpha, interleukin-6, and interleukin-10 levels are altered in preeclampsia: a systematic review and meta-analysis. |
| Q37298028 | Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayers |
| Q34492106 | Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions. |
| Q37187628 | Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia |
| Q50650235 | XIAP protein is induced by placenta growth factor (PLGF) and decreased during preeclampsia in trophoblast cells. |
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