Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme

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Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1089/ARS.2005.7.1568
P932PMC publication ID2228261
P698PubMed publication ID16356120
P5875ResearchGate publication ID7414318

P50authorPal PacherQ30347235
Csaba SzabóQ106704479
P2860cites workRole of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategiesQ24656109
Biochemistry and molecular cell biology of diabetic complicationsQ28131781
Prevention of the complications of diabetesQ28195480
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stressQ29615436
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damageQ29616101
Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetesQ30769310
Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemiaQ30813656
Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymeraseQ67990314
Nicotinamide and 3-aminobenzamide inhibit recombinant human interferon-gamma-induced HLA-DR antigen expression, but not HLA-A, B, C antigen expression, on cultured human thyroid cellsQ68054486
Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balanceQ68255326
Differential effects of hyperoxia and hydrogen peroxide on DNA damage, polyadenosine diphosphate-ribose polymerase activity, and nicotinamide adenine dinucleotide and adenosine triphosphate contents in cultured endothelial cells and fibroblastsQ69208927
Mechanisms of endothelial cell ATP depletion after oxidant injuryQ69294343
Homocysteine mediated endothelial cell toxicity and its ameliorationQ71434899
Inhibition of the induction of collagenase by interleukin-1 beta in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose)-polymerase inhibitor 3-aminobenzamideQ71602350
Menadione-induced oxidative stress in bovine heart microvascular endothelial cellsQ71626019
Acute pneumocyte injury, poly(ADP-ribose) polymerase activity, and pyridine nucleotide levels after in vitro exposure of murine lung slices to cyclophosphamideQ72857176
Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchangesQ72885731
Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factorsQ73783792
Assessment of DNA strand breakage by comet assay in diabetic patients and the role of antioxidant supplementationQ73849830
[Vascular endothelium: a target organ for diabetes mellitus]Q74201668
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusionQ77089411
Hydrogen peroxide decreases pHi in human aortic endothelial cells by inhibiting Na+/H+ exchangeQ77315019
Role of peroxynitrite and poly (ADP-ribosyl) synthetase activation in cardiovascular derangement induced by zymosan in the ratQ77332053
The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetesQ77550010
Endothelial dysfunction in diabetes mellitusQ77778745
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseasesQ30824712
Diabetes and endothelial dysfunction: a clinical perspectiveQ31835799
Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient miceQ33891214
Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damageQ33897296
Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell deathQ33948501
Endothelial dysfunction in diabetes.Q33959485
Endothelial dysfunction in hypercholesterolemia: mechanisms, pathophysiological importance, and therapeutic interventionsQ34113182
Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaquesQ34145177
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism.Q34312540
Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation.Q34340925
Role of poly(ADP-ribose) formation in DNA repairQ34359946
Oxidative stress and diabetic vascular complicationsQ34391178
Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activationQ34521265
Tetrahydrobiopterin biosynthesis, utilization and pharmacological effects.Q34633011
The therapeutic potential of poly(ADP-ribose) polymerase inhibitorsQ34838585
Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activationQ35044253
Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailabilityQ35044339
Poly(ADP-ribose) polymerase inhibitorsQ35060963
Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetesQ35065308
Etiology and treatment of erectile failure in diabetes mellitusQ35087516
Preventing microvascular diabetic complications in children and adolescents: looking beyond glycaemic controlQ35095210
New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant TherapyQ35115544
Heart failure: the frequent, forgotten, and often fatal complication of diabetesQ35185828
Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymeraseQ35271750
Treatment of diabetic nephropathy with angiotensin II receptor antagonistQ35571967
Update on the pathogenesis of diabetic neuropathyQ35581275
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscleQ35960752
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cellsQ36001244
Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose?Q36001352
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthaseQ36011589
Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalystQ36087920
Nitrosative stress and pharmacological modulation of heart failureQ36145124
Superoxide generation by endothelial nitric oxide synthase: the influence of cofactorsQ36253833
Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structureQ36297600
Glucose and diabetic vascular disease.Q36379991
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cellsQ36654891
Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitriteQ37370840
Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complicationsQ37373683
Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymeraseQ37429030
DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitriteQ37700756
Endothelial dysfunction and peroxynitrite formation are early events in angiotensin-induced cardiovascular disorders.Q39527979
Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathyQ39691668
Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalystQ39703468
Structure and function of poly(ADP-ribose) polymeraseQ40616439
Molecular and biochemical features of poly (ADP-ribose) metabolismQ40776253
Increased single strand breaks in DNA of lymphocytes from diabetic subjectsQ40921015
Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways.Q41105787
Protective effect of nicotinamide against nephropathy in diabetic ratsQ41352682
Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymeraseQ41735913
Effects of angiotensin II on vascular endothelial cells: formation of receptor-mediated reactive nitrogen speciesQ42438952
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activationQ42497877
Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusionQ43173946
Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymeraseQ43764637
Effects of insulin and antioxidant on plasma 8-hydroxyguanine and tissue 8-hydroxydeoxyguanosine in streptozotocin-induced diabetic ratsQ43808969
Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantationQ43851360
Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humansQ43851364
Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failureQ43893501
Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthaseQ43952389
Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient miceQ43960156
Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agentsQ43990309
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging.Q43994462
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.Q44044678
Poly(ADP-ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H(2)O(2) injuryQ44046046
Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failureQ44133546
Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivityQ44220798
Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodentsQ44225537
Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheepQ44355165
ACE inhibition salvages the visual loss caused by diabetesQ44398243
DNA damage and antioxidant defense in peripheral leukocytes of patients with Type I diabetes mellitusQ44466283
Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activationQ44489912
Sensory neurons with activated caspase-3 survive long-term experimental diabetesQ44564049
Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activationQ44631833
Role of poly(ADP-ribose) polymerase activation in diabetic neuropathyQ44779266
Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.Q44940264
Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymeraseQ45013469
Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.Q45124417
Inhibitors of poly(ADP-ribose) polymerase enhance DNA strand breaks, excision repair, and sister chromatid exchanges induced by alkylating agentsQ45129882
Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injuryQ47817404
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemiaQ48616927
Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.Q52534304
ATP for the DNA ligation step in base excision repair is generated from poly(ADP-ribose).Q52970520
Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging.Q53850917
Proteasome activation by poly-ADP-ribose-polymerase in human myelomonocytic cells after oxidative stress.Q54029457
Vitamin E supplementation and oxidative damage to DNA and plasma LDL in type 1 diabetes.Q54074919
Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.Q55663138
An examination of DNA strand breakage in the comet assay and antioxidant capacity in diabetic patientsQ63439778
Trans-dominant inhibition of poly(ADP-ribosyl)ation leads to decreased recovery from ionizing radiation-induced cell killingQ64389116
P433issue11-12
P921main subjectendotheliumQ111140
pathogenesisQ372016
P304page(s)1568-1580
P577publication date2005-11-01
P1433published inAntioxidants & Redox SignalingQ4775078
P1476titleRole of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme
P478volume7

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