Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors

scientific article

Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1111/J.1527-3466.2007.00018.X
P932PMC publication ID2225457
P698PubMed publication ID17919258
P5875ResearchGate publication ID5926340

P50authorCsaba SzabóQ106704479
Pal PacherQ30347235
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Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failureQ44133546
Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivityQ44220798
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Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphomaQ44653322
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Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factorQ44822122
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Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.Q44940264
Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymeraseQ44953535
The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: role of the lectin-like oxidized low-density lipoprotein receptor-1.Q44954128
3-Aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, improves hemodynamics and prolongs survival in a porcine model of hemorrhagic shockQ45051387
Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitisQ45156881
Poly(ADP-ribose) polymerase inhibition attenuates biventricular reperfusion injury after orthotopic heart transplantationQ45251195
Poly(ADP-ribose) polymerase-1 hyperactivation and impairment of mitochondrial respiratory chain complex I function in reperfused mouse heartsQ46216917
Inhibition of poly(ADP-ribose) polymerase prevents vascular hyporesponsiveness induced by lipopolysaccharide in isolated rat aortaQ46436975
Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinoneQ46633259
Poly (ADP) ribose polymerase inhibition improves rat cardiac allograft survivalQ46669171
Potential role of poly(adenosine 5'-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shockQ46950042
Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell deaQ47292498
Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injuryQ47817404
Inducible nitric oxide synthase expression in smooth muscle cells and macrophages of human transplant coronary artery disease.Q47930127
PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.Q48528802
Role of nitrosative stress and activation of poly(ADP-ribose) polymerase-1 in cardiovascular failure associated with septic and hemorrhagic shock.Q51218199
Stent-induced neutrophil activation is associated with an oxidative burst in the inflammatory process, leading to neointimal thickening.Q51245961
Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury.Q52537722
Compressing drug development timelines in oncology using phase '0' trials.Q53208031
Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging.Q53850917
Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.Q55663138
A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturationQ61268478
Poly(ADP-Ribose) Polymerase Promotes Cardiac Remodeling, Contractile Failure, and Translocation of Apoptosis-Inducing Factor in a Murine Experimental Model of Aortic Banding and Heart FailureQ61456114
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetaseQ61456117
Contribution of ATP to oxidative stress-induced changes in action potential of isolated cardiac myocytesQ73316795
Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitriteQ73425760
BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymeraseQ73487675
Apoptosis and increased expression of inducible nitric oxide synthase in human allograft rejectionQ74432629
Protection against hypoxia-reoxygenation in the absence of poly (ADP-ribose) synthetase in isolated working heartsQ74596199
Potential role of the peroxynitrate-poly(ADP-ribose) synthetase pathway in a rat model of severe hemorrhagic shockQ74624318
The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetesQ77550010
Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pigQ77614308
Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activityQ77826914
Possible role of poly(ADP-ribose) polymerase in pathological and physiological cardiac hypertrophyQ79603264
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Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologiesQ80387792
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Oxidative-nitrosative stress in hypertensionQ80387798
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Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient miceQ33891214
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Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in gliaQ34017468
Oxidative stress as a signaling mechanism of the vascular response to injury: the redox hypothesis of restenosisQ34017474
Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaquesQ34145177
Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injuryQ34520738
Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activationQ34521265
The therapeutic potential of poly(ADP-ribose) polymerase inhibitorsQ34838585
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Intracellular distribution of peroxynitrite during doxorubicin cardiomyopathy: evidence for selective impairment of myofibrillar creatine kinaseQ35044069
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Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioningQ35044978
Poly(ADP-ribose) polymerase inhibitorsQ35060963
Multiple pathways of peroxynitrite cytotoxicityQ35099313
Peroxynitrite-induced cytotoxicity: mechanism and opportunities for interventionQ35099318
Activation of the poly(ADP-ribose) polymerase pathway in human heart failure.Q35113704
Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleusQ35120057
An inhibitor of poly (ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heartQ35566493
Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytesQ35586887
Poly(ADP-ribose)polymerase inhibition decreases angiogenesisQ35676514
Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesisQ35676519
Poly(ADP-ribose) (PAR) polymer is a death signalQ35722332
Deadly conversations: nuclear-mitochondrial cross-talkQ35891836
Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruptionQ35943974
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscleQ35960752
The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathwaysQ36002884
Nitric oxide, peroxynitrite and lipoxygenase in atherogenesis: mechanistic insightsQ36030007
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitorsQ36111918
Chemopotentiation by PARP inhibitors in cancer therapy.Q36136079
Cardioprotective effects of poly(ADP-ribose) polymerase inhibitionQ36136085
Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complicationsQ36136094
Nitrosative stress and pharmacological modulation of heart failureQ36145124
Poly(ADP-ribose) polymerase activation by reactive nitrogen species--relevance for the pathogenesis of inflammationQ36235834
Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapyQ36254318
Poly(ADP-ribose)polymerase inhibition - where now?Q36266298
Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying themeQ36342643
Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetesQ36398989
Novel modulators of poly(ADP-ribose) polymeraseQ36431798
Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivoQ36431848
Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.Q36464461
Inhibition of poly(ADP-ribose) polymerase in cancerQ36497225
Intracellular targets of matrix metalloproteinase-2 in cardiac disease: rationale and therapeutic approachesQ36665320
Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncologyQ36749057
Poly (ADP-ribose) polymerase activation and circulatory shock.Q36767909
PARP inhibitors and heart failure--translational medicine caught in the act.Q36773354
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A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced agingQ36857395
Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunctionQ37198120
Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitriteQ37370840
Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failureQ37373692
Poly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failureQ37373704
Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymeraseQ37429030
Modulation of leukocyte-mediated myocardial reperfusion injuryQ37918910
Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.Q38346928
Novel NAD(P)H oxidase inhibitor suppresses angioplasty-induced superoxide and neointimal hyperplasia of rat carotid arteryQ39643032
Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brainQ40104867
INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicinQ40107480
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor modelsQ40138516
Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.Q40158513
Protective effects of the PARP-1 inhibitor PJ34 in hypoxic-reoxygenated cardiomyoblastsQ40203725
Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activationQ40323235
Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stressQ40954699
Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts In vitroQ41090734
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activationQ42497877
Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity.Q42612100
Inhibitors of the activity of poly (ADP-ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblastsQ43185132
Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system.Q43608484
Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathyQ43696104
Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice.Q43698886
Peroxynitrite formation from human myocardium after ischemia-reperfusion during open heart operationQ43714815
Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymeraseQ43764637
5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct sizeQ43791925
Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantationQ43851360
Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitorQ43886869
Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failureQ43893501
Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient miceQ43960156
Poly(ADP-ribose) polymerase activation and cell injury in the course of rat heart heterotopic transplantation.Q43985830
Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agentsQ43990309
P433issue3
P921main subjectcardiovascular diseaseQ389735
P304page(s)235-260
P577publication date2007-01-01
P1433published inCardiovascular Drug ReviewsQ13455172
P1476titleRole of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors
P478volume25

Reverse relations

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