NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

scientific article

NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1031336684
P356DOI10.1038/NRD2038
P3181OpenCitations bibliographic resource ID1534233
P932PMC publication ID2225477
P698PubMed publication ID16955067
P5875ResearchGate publication ID6835258

P50authorPeter SchmidtQ57631064
Johannes-Peter StaschQ66360867
P2093author name stringGyörgy Haskó
Harald H H W Schmidt
Oleg V Evgenov
Pál Pacher
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Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambsQ45091740
Femtomolar sensitivity of a NO sensor from Clostridium botulinum.Q45096466
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Effects of BAY 41-2272, a soluble guanylate cyclase activator, on pulmonary vascular reactivity in the ovine fetus.Q45193709
Efficacy and optimal dose of sildenafil in primary pulmonary hypertensionQ45274674
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Membrane association of nitric oxide-sensitive guanylyl cyclase in cardiomyocytes.Q46544029
Pulmonary vascular effects of nitric oxide-cGMP augmentation in a model of chronic pulmonary hypertension in fetal and neonatal sheep.Q46554951
Enhancing cGMP in experimental progressive renal fibrosis: soluble guanylate cyclase stimulation vs. phosphodiesterase inhibitionQ46622392
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9.Q46720467
Disturbances in nitric oxide/cyclic guanosine monophosphate system in SHR/NDmcr-cp rats, a model of metabolic syndromeQ46723925
Human soluble guanylate cyclase: functional expression and revised isoenzyme familyQ24314629
Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteinsQ24798253
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaSQ27748762
Coronary-artery stentsQ28295059
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclaseQ28379365
Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzymeQ28379416
Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranesQ28565964
Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampusQ28573791
Inflammation, atherosclerosis, and coronary artery diseaseQ29547232
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoformsQ29619683
NO/redox disequilibrium in the failing heart and cardiovascular systemQ30475784
Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclaseQ31805259
NO-independent regulatory site on soluble guanylate cyclaseQ32165040
Downregulation of soluble guanylyl cyclase in young and aging spontaneously hypertensive ratsQ33178899
Stimulation of soluble guanylyl cyclase inhibits mesangial cell proliferation and matrix accumulation in experimental glomerulonephritisQ33209298
Increased nitrovasodilator sensitivity in endothelial nitric oxide synthase knockout mice: role of soluble guanylyl cyclase.Q33887169
Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTPQ33948069
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent componentsQ33948966
Identification of the enzymatic mechanism of nitroglycerin bioactivationQ34032459
Pharmacology of penile erectionQ34090426
Revisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: the simple NO-binding model is incorrectQ34155309
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.Q34312771
Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.Q34401845
Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxideQ40975817
Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic NeurotransmissionQ41082098
Acute blood pressure effects of YC-1-induced activation of soluble guanylyl cyclase in normotensive and hypertensive ratsQ41903134
A-350619: a novel activator of soluble guanylyl cyclaseQ42049434
Inhibition of soluble guanylate cyclase by ODQ.Q42055822
Homodimerization of soluble guanylyl cyclase subunits. Dimerization analysis using a glutathione s-transferase affinity tag.Q42058515
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activityQ42099241
YC-1, a novel activator of platelet guanylate cyclaseQ42275468
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-oneQ42275867
Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilatorsQ42435281
Expression and activity of soluble guanylate cyclase in injury and repair of anti-thy1 glomerulonephritisQ42471113
Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosisQ42479831
Soluble guanylate cyclase: an old therapeutic target re-visited.Q43263737
Soluble guanylate cyclase alpha(1) and beta(1) gene transfer increases NO responsiveness and reduces neointima formation after balloon injury in rats via antiproliferative and antimigratory effectsQ43515684
NO-independent stimulators of soluble guanylate cyclaseQ43558550
Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivoQ43610465
Upregulation of vascular NAD(P)H oxidase subunit gp91phox and impairment of the nitric oxide signal transduction pathway in hypertensionQ43691461
Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agentsQ43770043
cGMP signalling beyond nitric oxideQ43791947
Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxideQ43911622
Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclaseQ43950505
Nitric oxide independent activation of guanylate cyclase by YC-1 causes erectile responses in the rat.Q43961522
Inhibition of deactivation of NO-sensitive guanylyl cyclase accounts for the sensitizing effect of YC-1.Q43972677
Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxideQ44000686
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in ratsQ44260144
A stimulatory role for cGMP-dependent protein kinase in platelet activationQ44277303
BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.Q44289016
Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failureQ44310085
BAY 41-2272: a stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivoQ44322931
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclaseQ44445674
NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritisQ44503836
Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272.Q44587860
Relaxing effects induced by the soluble guanylyl cyclase stimulator BAY 41-2272 in human and rabbit corpus cavernosumQ44602629
Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgeryQ44609195
Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclaseQ44626758
The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclaseQ46834469
Biochemistry and pharmacology of novel anthranilic acid derivatives activating heme-oxidized soluble guanylyl cyclaseQ46839590
Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodelingQ46877903
Vasorelaxing effect of BAY 41-2272 in rat basilar artery: involvement of cGMP-dependent and independent mechanismsQ46877927
Alterations of the vascular and the myocardial guanylate cyclase/cGMP-system induced by long-term hypertension in ratsQ47672866
Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxideQ47910766
Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclasesQ47954577
The burden of adult hypertension in the United States 1999 to 2000: a rising tide.Q50143429
Modulation of nitric oxide-dependent relaxation of pig tracheal smooth muscle by inhibitors of guanylyl cyclase and calcium activated potassium channels.Q50766515
Novel actions of methylene blue.Q50778865
Drug discovery technology Europe 2006 - IBC's Tenth Annual Conference and Exhibition.Q50779782
Nitric oxide and pulmonary arterial pressures in pulmonary hypertension.Q51189384
Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension.Q51398065
YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets.Q52981674
A functional heme-binding site of soluble guanylyl cyclase requires intact N-termini of alpha 1 and beta 1 subunits.Q53005214
The use of nitric oxide donors in pharmacological studies.Q53947007
Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension.Q54240963
Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.Q55663138
BAY 41-2272, a Direct Activator of Soluble Guanylate Cyclase, Reduces Right Ventricular Hypertrophy and Prevents Pulmonary Vascular Remodeling during Chronic Hypoxia in Neonatal RatsQ58351224
Pulmonary Arterial HypertensionQ58485998
Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme formsQ69878955
FK409, a new nitric-oxide donor, suppresses smooth muscle proliferation in the rat model of balloon angioplastyQ70860220
Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclaseQ71239563
Defective L-arginine-nitric oxide pathway in offspring of essential hypertensive patientsQ71571212
Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging StudyQ72641848
Functions of conserved cysteines of soluble guanylyl cyclaseQ73139586
A point-mutated guanylyl cyclase with features of the YC-1-stimulated enzyme: implications for the YC-1 binding site?Q73187839
YC-1, a benzyl indazole derivative, stimulates vascular cGMP and inhibits neointima formationQ73300111
Aging and chronic hypertension decrease expression of rat aortic soluble guanylyl cyclaseQ73371570
Interaction of soluble guanylate cyclase with YC-1: kinetic and resonance Raman studiesQ73626067
Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth StudyQ74532201
Formation of reactive oxygen species by pentaerithrityltetranitrate and glyceryl trinitrate in vitro and development of nitrate toleranceQ77053822
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivationQ78038211
Protective effects of BAY 41-2272 (sGC stimulator) on hypertension, heart, and cardiomyocyte hypertrophy induced by chronic L-NAME treatment in ratsQ83190387
Functional characterization of two nucleotide-binding sites in soluble guanylate cyclaseQ83929538
Taming platelets with cyclic nucleotidesQ34436565
Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase geneQ34693858
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vesselsQ35009484
Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig tracheaQ35028147
Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studiesQ35044037
Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studiesQ35044042
NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principleQ35044464
The Rho-kinase inhibitor Y-27632 and the soluble guanylyl cyclase activator BAY41-2272 relax rabbit vaginal wall and clitoral corpus cavernosumQ35044932
Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclaseQ35124292
Soluble guanylyl cyclase: physiological role as an NO receptor and the potential molecular target for therapeutic applicationQ35206512
Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxideQ35767797
Recent advances in natriuretic peptides in congestive heart failureQ35790792
Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potentialQ35822606
Salutary properties of YC-1 in the cardiovascular and hematological systemsQ35867325
YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclaseQ35872795
Specificity of different organic nitrates to elicit NO formation in rabbit vascular tissues and organs in vivoQ35873058
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.Q36018283
A heretical view on the role of NO and cGMP in vascular proliferative diseasesQ36032424
Nitrosative stress and pharmacological modulation of heart failureQ36145124
ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 GQ36259700
Explaining the phenomenon of nitrate toleranceQ36272905
Activation of purified soluble guanylate cyclase by protoporphyrin IX.Q36293899
Function of cGMP-dependent protein kinases as revealed by gene deletion.Q36350063
Antifibrotic agents for liver diseaseQ36376477
Pharmacological management of renal fibrotic diseaseQ36407348
A molecular basis for nitric oxide sensing by soluble guanylate cyclaseQ36774286
A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cellsQ37089466
Human recombinant soluble guanylyl cyclase: expression, purification, and regulationQ37259340
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclasesQ37511692
Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosisQ37692538
Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferationQ37926154
NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomyQ38758203
Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domainQ39369792
NO activation of guanylyl cyclaseQ40327686
Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation.Q40354874
A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway.Q40446987
Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272.Q40569818
Physiology of penile erectionQ40576740
NO at workQ40630836
Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1.Q40735472
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)755-68
P577publication date2006-09-01
P1433published inNature Reviews Drug DiscoveryQ45998
P1476titleNO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
P478volume5

Reverse relations

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Q27021422New insights into the role of soluble guanylate cyclase in blood pressure regulation
Q38594785New medical therapies for heart failure
Q37724192New therapies for pulmonary arterial hypertension: an update on current bench to bedside translation
Q38412804Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms
Q35884072Nitric Oxide Resistance Reduces Arteriovenous Fistula Maturation in Chronic Kidney Disease in Rats
Q52738823Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease.
Q24645400Nitric oxide and peroxynitrite in health and disease
Q52710382Nitric oxide stimulates human neural progenitor cell migration via cGMP-mediated signal transduction.
Q42467382Nitric oxide targets oligodendrocytes and promotes their morphological differentiation
Q37669139Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension
Q35596709Nitric oxide-cyclic GMP signaling in stem cell differentiation
Q37887771Nitric oxide: a guardian for vascular grafts?
Q37927098Nitric oxide: orchestrator of endothelium-dependent responses
Q34233761Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation
Q96609757Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease
Q38856565Non-nitric oxide based metallovasodilators: synthesis, reactivity and biological studies
Q39024203Novel sGC Stimulators and sGC Activators for the Treatment of Heart Failure
Q37179695Novel therapies for cyclic GMP control of vascular smooth muscle growth
Q38072635Novel vasodilators in heart failure
Q37342409Nucleotide regulation of soluble guanylate cyclase substrate specificity
Q46868100Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes.
Q28247831Oxidative stress associated with middle aging leads to sympathetic hyperactivity and downregulation of soluble guanylyl cyclase in corpus cavernosum
Q28262626PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells
Q36532454Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling
Q45928887Pharmacokinetic analysis of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in individuals with renal impairment compared to healthy controls.
Q40386143Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator Riociguat in Healthy Young Chinese Male Non-Smokers and Smokers: Results of a Randomized, Double-Blind, Placebo-Controlled Study
Q34823612Pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in healthy male volunteers
Q58603529Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery
Q47133234Pharmacological preconditioning with gemfibrozil preserves cardiac function after heart transplantation
Q26785525Pharmacology and Clinical Drug Candidates in Redox Medicine
Q34341399Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages
Q42555438Platelet hyperaggregability in high-fat fed rats: a role for intraplatelet reactive-oxygen species production.
Q42645453Population pharmacokinetics and pharmacodynamics of cinaciguat, a soluble guanylate cyclase activator, in patients with acute decompensated heart failure
Q37476512Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice
Q36178862Pretreatment with β-Boswellic Acid Improves Blood Stasis Induced Endothelial Dysfunction: Role of eNOS Activation.
Q37660997Probing the Molecular Mechanism of Human Soluble Guanylate Cyclase Activation by NO in vitro and in vivo
Q35107626Probing the local electronic and geometric properties of the heme iron center in a H-NOX domain
Q39504233Probing the presence of the ligand-binding haem in cellular nitric oxide receptors
Q36693586Protoporphyrin IX/Cobyrinate Derived Hybrids - Novel Activators of Soluble Guanylyl Cyclase
Q87520772Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia
Q34212268Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase stimulator, BAY 41-8543, are modulated by nitric oxide
Q38283873Pulmonary hypertension 2015: current definitions, terminology, and novel treatment options
Q27024762Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications
Q37376997Reactive oxygen and nitrogen species in pulmonary hypertension
Q41983620Real-time monitoring the spatiotemporal dynamics of intracellular cGMP in vascular smooth muscle cells
Q47812722Reduction of obstruction related bladder overactivity by the guanylyl cyclase modulators BAY 41-2272 and BAY 60-2770 alone or in combination with a phosphodiesterase type 5 inhibitor
Q37697630Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.
Q42361109Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide
Q58127035Renal Soluble Guanylate Cyclase Is Downregulated in Sunitinib-Induced Hypertension
Q38112048Right ventricle in pulmonary hypertension.
Q41166010Riociguat (BAY 63-2521) and aspirin: a randomized, pharmacodynamic, and pharmacokinetic interaction study
Q33447738Riociguat (BAY 63–2521) and Warfarin: A Pharmacodynamic and Pharmacokinetic Interaction Study
Q46211817Riociguat and cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats
Q37709398Riociguat for pulmonary hypertension
Q38192059Riociguat for pulmonary hypertension
Q37851516Riociguat for the treatment of pulmonary hypertension.
Q26748684Riociguat: Mode of action and clinical development in pulmonary hypertension
Q41980644Riociguat: PATENT-1 Study
Q38502798Riociguat: a novel new drug for treatment of pulmonary hypertension
Q37537154Role of guanylate cyclase modulators in decompensated heart failure
Q46486715Role of nitric oxide in the control of the pulmonary circulation: physiological, pathophysiological, and therapeutic implications
Q36999849Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells.
Q36426742Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors
Q48270850Role of soluble guanylate cyclase in renal hemodynamics and autoregulation in the rat.
Q46562534Single-dose pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase stimulator BAY 63-2521: an ascending-dose study in healthy male volunteers
Q87418632Small alterations in cobinamide structure considerably influence sGC activation
Q36887547Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface
Q53760527Soluble Guanylate Cyclase Modulators, BAY 41-2272 and BAY 60-2770, Inhibit Human and Rabbit Prostate Contractility.
Q38818645Soluble Guanylate Cyclase Stimulators and Activators: Novel Therapies for Pulmonary Vascular Disease or a Different Method of Increasing cGMP?
Q36902247Soluble guanylate cyclase activation during ischemic injury in mice protects against postischemic inflammation at the mitochondrial level
Q34122462Soluble guanylate cyclase agonists inhibit expression and procoagulant activity of tissue factor
Q34618219Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury.
Q36865999Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma
Q35010064Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease
Q37399819Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons
Q37826122Soluble guanylate cyclase modulators in heart failure
Q37303013Soluble guanylate cyclase redox state under oxidative stress conditions in isolated monkey coronary arteries
Q28742463Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats
Q47664739Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease.
Q27331498Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma
Q35075847Soluble guanylate cyclase: a new therapeutic target for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
Q38012596Soluble guanylate cyclase: a potential therapeutic target for heart failure
Q46403664Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress
Q37018298Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice
Q48023073Soluble guanylyl cyclase is a critical regulator of migraine-associated pain
Q36167665Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme
Q58075704Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Q46455331Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema
Q54375096Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling.
Q47603923Stimulators and activators of soluble guanylate cyclase for urogenital disorders
Q38000562Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.
Q38093420Stimulators of soluble guanylyl cyclase: future clinical indications
Q51682930Stimulators of the soluble guanylyl cyclase: promising functional insights from rare coding atherosclerosis-related GUCY1A3 variants.
Q38894826Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor
Q27661554Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase
Q38646890Surface plasmon resonance using the catalytic domain of soluble guanylate cyclase allows the detection of enzyme activators
Q58615248Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity
Q35873815Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα
Q61136944Systemic control of immune cell development by integrated carbon dioxide and hypoxia chemosensation in Drosophila
Q38836199Targeting vascular (endothelial) dysfunction.
Q27308898The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]
Q38772751The Role of Reactive Oxygen and Nitrogen Species in the Expression and Splicing of Nitric Oxide Receptor
Q36031657The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning
Q34389020The anti-aggregating effect of BAY 41-2272, a stimulator of soluble guanylyl cyclase, requires the presence of nitric oxide
Q27024279The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction
Q38130465The chemistry and biology of soluble guanylate cyclase stimulators and activators
Q37703984The current and future management of acute heart failure syndromes
Q38896087The role of cGMP and its signaling pathways in kidney disease
Q34902456The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells.
Q48033453The role of soluble guanylyl cyclase in chronic obstructive pulmonary disease
Q36923923The sGC activator BAY 60-2770 has potent erectile activity in the rat.
Q43119916The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood
Q34981386The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems
Q45925609The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice.
Q55340936The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats.
Q87445917The soluble guanylyl cyclase activator BAY 60-2770 potently relaxes the pulmonary artery on congenital diaphragmatic hernia rabbit model
Q26767305The treatment of erectile dysfunction in patients with neurogenic disease
Q51587859Therapeutic potential of soluble guanylate cyclase modulators in neonatal chronic lung disease.
Q30503997Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration
Q33772904Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase
Q37615958Translating the oxidative stress hypothesis into the clinic: NOX versus NOS.
Q26830290Treatment of pulmonary arterial hypertension (PAH): updated Recommendations of the Cologne Consensus Conference 2011
Q37902509Treatment of pulmonary arterial hypertension with targeted therapies
Q37100702Update in pulmonary arterial hypertension 2007.
Q43073192Vascular biology and pathobiology of the liver: Report of a single-topic symposium
Q37725077Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention
Q54185546Vascular dysfunctions in the isolated aorta of double-transgenic hypertensive mice developing aortic aneurysm.
Q34432730Vascular smooth muscle phenotypic diversity and function
Q35086394Vasculopathy and pulmonary hypertension in sickle cell disease
Q37557818YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit.
Q41983813YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells
Q87460685[Cor pulmonale and pulmonary hypertension. Update after the world conference in Nice]
Q84164467[Interstitial lung diseases and pulmonary hypertension]
Q61799295as a Genetic Model for Hematopoiesis
Q58796764cGMP Imaging in Brain Slices Reveals Brain Region-Specific Activity of NO-Sensitive Guanylyl Cyclases (NO-GCs) and NO-GC Stimulators
Q52578398cGMP Signaling and Vascular Smooth Muscle Cell Plasticity.
Q55004774cGMP Signaling in the Cardiovascular System-The Role of Compartmentation and Its Live Cell Imaging.
Q54978990cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway.
Q37002324cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell lines.
Q91996105sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH

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