Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.

scientific article published on 04 April 2014

Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPHYS.2014.00134
P932PMC publication ID3983488
P698PubMed publication ID24772092
P5875ResearchGate publication ID261923339

P50authorDavid D RobertsQ42408238
P2093author name stringJeffrey S Isenberg
Natasha M Rogers
Elsa D Garcin
Franziska Seeger
P2860cites workRate of deactivation of nitric oxide-stimulated soluble guanylate cyclase: influence of nitric oxide scavengers and calciumQ73399151
Cyclic nucleotide-gated channels mediate membrane depolarization following activation of store-operated calcium entry in endothelial cellsQ73675926
CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1Q74165103
Thrombospondin-1 antagonizes nitric oxide-stimulated vascular smooth muscle cell responsesQ79837874
Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microgliaQ83853842
[Soluble guanylate cyclase in the molecular mechanism underlying the therapeutic action of drugs]Q84237651
Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failureQ84553919
The anti-thrombotic effect of hydrogen sulfide is partly mediated by an upregulation of nitric oxide synthasesQ87203045
Isolation and characterization of a high molecular weight glycoprotein from human blood plateletsQ22009134
Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptakeQ24302047
The L-arginine-nitric oxide pathwayQ24304874
Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent mannerQ24321591
Crystal structures of the catalytic domain of human soluble guanylate cyclaseQ24336722
A thrombin-sensitive protein of human platelet membranesQ24609538
Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factorsQ24633525
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potentialQ24656131
Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activityQ24674570
A peptide against soluble guanylyl cyclase α1: a new approach to treating prostate cancerQ27319501
NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanismQ27641107
PAS-mediated Dimerization of Soluble Guanylyl Cyclase Revealed by Signal Transduction Histidine Kinase Domain Crystal StructureQ27649070
Crystal structure of the guanylyl cyclase Cya2Q27652450
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclaseQ27652454
Probing the Function of Heme Distortion in the H-NOX FamilyQ27652988
A structural basis for H-NOX signaling in Shewanella oneidensis by trapping a histidine kinase inhibitory conformationQ27658207
Determinants of Ligand Affinity and Heme Reactivity in H-NOX DomainsQ27658678
Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclaseQ27659219
Structural insights into the molecular mechanism of H-NOX activationQ27659887
Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclaseQ27661554
Controlling Conformational Flexibility of an O 2 -Binding H-NOX DomainQ27670635
Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domainQ27675023
Insights into BAY 60-2770 Activation and S -Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain ComplexesQ27677544
Crystal structure of the Alpha subunit PAS domain from soluble guanylyl cyclaseQ27679506
Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activityQ27682500
Role of CD47 as a marker of self on red blood cellsQ28138449
Molecular model of a soluble guanylyl cyclase fragment determined by small-angle X-ray scattering and chemical cross-linkingQ36713981
Gene silencing of CD47 and antibody ligation of thrombospondin-1 enhance ischemic tissue survival in a porcine model: implications for human diseaseQ36725128
Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic ratesQ36748594
Desensitization of guanylate cyclase in nitrate tolerance does not impair endothelium-dependent responsesQ69932605
Recombinant truncated thrombospondin-1 monomer modulates endothelial cell plasminogen activator inhibitor 1 accumulation and proliferation in vitroQ70687871
Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxideQ70930193
Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclaseQ71239563
Activation of soluble guanylate cyclase through phosphorylation by protein kinase C in intact PC12 cellsQ72224272
Reversible inactivation of guanylate cyclase by mixed disulfide formationQ72457078
Evidence for phosphorylation of rat brain guanylate cyclase by cyclic AMP-dependent protein kinaseQ72508228
Effect of GTP analogues on purified soluble guanylate cyclaseQ72519691
Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclaseQ72566480
Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin-binding domain and synthetic peptides from the type I repeats of thrombospondinQ72572414
Nitric oxide-sensitive guanylyl cyclase activity inhibition through cyclic GMP-dependent dephosphorylationQ73081040
A molecular basis for nitric oxide sensing by soluble guanylate cyclaseQ36774286
Recruitment of Nox4 to a plasma membrane scaffold is required for localized reactive oxygen species generation and sustained Src activation in response to insulin-like growth factor-I.Q36890594
H₂S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthaseQ36895184
Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling.Q36955405
Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activationQ36997217
Pathobiology of pulmonary hypertensionQ37014730
Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.Q37036482
The nitrate-nitrite-nitric oxide pathway in physiology and therapeuticsQ37048314
Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stressQ37144638
Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1Q37162361
Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability?Q37293823
Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapiesQ37385797
Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexesQ37395595
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activationQ37400455
Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondinQ37409425
A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclaseQ37467778
Thrombospondin-1/CD47 blockade following ischemia-reperfusion injury is tissue protective.Q37477176
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclasesQ37511692
Hydrogen sulfide regulates Ca(2+) homeostasis mediated by concomitantly produced nitric oxide via a novel synergistic pathway in exocrine pancreasQ37543214
YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit.Q37557818
A second thrombospondin gene in the mouse is similar in organization to thrombospondin 1 but does not respond to serumQ37600090
Single-particle EM reveals the higher-order domain architecture of soluble guanylate cyclaseQ37612777
Protein disulfide-isomerase interacts with soluble guanylyl cyclase via a redox-based mechanism and modulates its activityQ37712434
Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activationQ37761752
Electronic structure of heme-nitrosyls and its significance for nitric oxide reactivity, sensing, transport, and toxicity in biological systemsQ37776256
Soluble guanylate cyclase modulators in heart failureQ37826122
Riociguat for the treatment of pulmonary hypertension.Q37851516
Adhesion-modulating/matricellular ECM protein families: a structural, functional and evolutionary appraisal.Q37977744
Structure and regulation of soluble guanylate cyclaseQ37992160
Evolving concepts of oxidative stress and reactive oxygen species in cardiovascular disease.Q38041505
Novel aspects of dietary nitrate and human healthQ38103950
Soluble guanylate cyclase stimulators in pulmonary hypertensionQ38149032
Riociguat for pulmonary hypertensionQ38192059
Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobinQ38807815
Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domainQ39369792
Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeatsQ28145149
Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthaseQ28188797
Integrin-associated protein (CD47) and its ligandsQ28212839
Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cellsQ28237012
CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1Q28251463
Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domainsQ28278085
AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclaseQ28283420
Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic propertiesQ28300388
Amyloid-β inhibits No-cGMP signaling in a CD36- and CD47-dependent mannerQ28476620
Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activityQ28477878
Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranesQ28565964
The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cellsQ28582206
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stressQ29615436
Kinetics of nitric oxide dissociation from five- and six-coordinate nitrosyl hemes and heme proteins, including soluble guanylate cyclaseQ30427519
Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparationsQ30449094
Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentrationQ30503997
Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase.Q30539237
Riociguat for the treatment of pulmonary arterial hypertensionQ33163083
Characterization of a novel type of endogenous activator of soluble guanylyl cyclaseQ33208407
Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin graftsQ33312205
Treatment of liver ischemia-reperfusion injury by limiting thrombospondin-1/CD47 signalingQ33392798
Molecular regulation of tumor angiogenesis and perfusion via redox signalingQ33572306
Fluorescent fusion proteins of soluble guanylyl cyclase indicate proximity of the heme nitric oxide domain and catalytic domainQ33640041
Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injuryQ33660552
A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondinQ33763790
Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclaseQ33772904
Guanylyl cyclases and signaling by cyclic GMP.Q33917038
Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTPQ33948069
How do heme-protein sensors exclude oxygen? Lessons learned from cytochrome c', Nostoc puntiforme heme nitric oxide/oxygen-binding domain, and soluble guanylyl cyclaseQ34166721
Nitric oxide insufficiency, platelet activation, and arterial thrombosisQ34234301
Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxationQ34275612
Cyanide toxicity from sodium nitroprusside: risks and managementQ34344067
Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.Q34385843
Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sitesQ34449038
The beta2 subunit inhibits stimulation of the alpha1/beta1 form of soluble guanylyl cyclase by nitric oxide. Potential relevance to regulation of blood pressureQ39790834
Superoxide fluxes limit nitric oxide-induced signalingQ40257194
NO activation of guanylyl cyclaseQ40327686
Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.Q40448208
Intracellular cyclic GMP receptor proteins.Q40485121
Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.Q40586309
Major occurrence of the new alpha2beta1 isoform of NO-sensitive guanylyl cyclase in brainQ40617757
Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organizationQ40630407
A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.Q40657503
Regulation of nitric oxide-responsive recombinant soluble guanylyl cyclase by calcium.Q40951409
Thrombospondin mediates calcium mobilization in fibroblasts via its Arg-Gly-Asp and carboxyl-terminal domainsQ41283869
Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathwayQ41329824
Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitriteQ41531752
Nitric oxide activation of guanylate cyclase pushes the α1 signaling helix and the β1 heme-binding domain closer to the substrate-binding site.Q41848414
Glyceryl trinitrate-induced desensitization of guanylate cyclase in cultured rat lung fibroblasts.Q41891843
Inhibition of soluble guanylate cyclase by ODQ.Q42055822
Homodimerization of soluble guanylyl cyclase subunits. Dimerization analysis using a glutathione s-transferase affinity tag.Q42058515
Regeneration of the ferrous heme of soluble guanylate cyclase from the nitric oxide complex: acceleration by thiols and oxyhemoglobinQ42059639
Matricellular proteins: an overviewQ42096914
Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13.Q42194066
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-oneQ42275867
Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity.Q42439086
Expression of soluble guanylate cyclase activity requires both enzyme subunitsQ42464263
Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate toleranceQ42544768
Inhibition of nitric oxide-activated guanylyl cyclase by calmodulin antagonists.Q42951381
A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells.Q43491083
Calcium ion downregulates soluble guanylyl cyclase activity: evidence for a two-metal ion catalytic mechanismQ43614080
c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1.Q43652228
Role of cyclic-GMP in relaxations of vascular smooth muscleQ43860562
Nitric oxide activation of soluble guanylyl cyclase reveals high and low affinity sites that mediate allosteric inhibition by calcium.Q43904218
Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxideQ43911622
Inhibition of deactivation of NO-sensitive guanylyl cyclase accounts for the sensitizing effect of YC-1.Q43972677
Recognition of the N-terminal modules of thrombospondin-1 and thrombospondin-2 by alpha6beta1 integrin.Q44543826
An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifsQ44553283
Modulation of soluble guanylate cyclase activity by phosphorylationQ44904313
Inhibitory phosphorylation of soluble guanylyl cyclase by muscarinic m2 receptors via Gbetagamma-dependent activation of c-Src kinaseQ44935032
Femtomolar sensitivity of a NO sensor from Clostridium botulinum.Q45096466
Nitric oxide-dependent allosteric inhibitory role of a second nucleotide binding site in soluble guanylyl cyclaseQ45223552
Activation of CD47 receptors causes histamine secretion from mast cellsQ46127263
Inactivation of soluble guanylate cyclase by stoichiometric S-nitrosationQ46180158
Dynamic association of nitric oxide downstream signaling molecules with endothelial caveolin-1 in rat aortaQ46390975
Membrane association of nitric oxide-sensitive guanylyl cyclase in cardiomyocytes.Q46544029
Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive guanylyl cyclaseQ46633532
Control of coronary vascular tone by nitric oxide.Q46687645
Thiol oxidation inhibits nitric oxide-mediated pulmonary artery relaxation and guanylate cyclase stimulationQ46792295
Vasodilator dysfunction in aged spontaneously hypertensive rats: changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion productionQ47863878
Purifieation of a Soluble, Sodium-Nitroprusside-Stimulated Guanylate Cyclase from Bovine LungQ50939098
Hydrogen sulfide promotes nitric oxide production in corpus cavernosum by enhancing expression of endothelial nitric oxide synthase.Q54282706
Activation of CD36 inhibits and induces regression of inflammatory corneal neovascularization.Q54579268
Blocking Thrombospondin-1/CD47 Signaling Alleviates Deleterious Effects of Aging on Tissue Responses to IschemiaQ58315878
Increasing Survival of Ischemic Tissue by Targeting CD47Q58315881
Critical overexpression of thrombospondin 1 in chronic leg ischaemiaQ62996442
Reversible activation of soluble guanylate cyclase by oxidizing agentsQ67514923
Thrombospondin-1 inhibition of vascular smooth muscle cell responses occurs via modulation of both cAMP and cGMP.Q34516854
Age-associated induction of cell membrane CD47 limits basal and temperature-induced changes in cutaneous blood flowQ34527600
Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarctionQ34600570
Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulationQ34686759
Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertensionQ34957241
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vesselsQ35009484
Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary diseaseQ35010064
Membrane-association and the sensitivity of guanylyl cyclase-coupled receptors to nitric oxideQ35047042
Oxidation and loss of heme in soluble guanylyl cyclase from Manduca sextaQ35083181
Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responsesQ35084643
Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism.Q35121057
Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclaseQ35124292
The thrombospondins.Q35230013
Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1.Q35379312
Thioredoxin reductase inhibition reduces relaxation by increasing oxidative stress and s-nitrosylation in mouse aorta.Q35529294
Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertensionQ35543584
Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2Q35558854
Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase [corrected].Q35575494
Dynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitizationQ35604613
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxationQ35642769
Hydrogen sulfide is an endogenous potentiator of T cell activationQ35763228
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.Q35792731
Nitric oxide insufficiency and atherothrombosisQ35874972
Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2.Q35902676
Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylationQ35925811
Regulation of the expression of soluble guanylyl cyclase by reactive oxygen speciesQ36052610
Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzymeQ36167665
Activation of parenchymal CD47 promotes renal ischemia-reperfusion injuryQ36200946
Nitric oxide in wound-healing.Q36207435
Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.Q36223338
Explaining the phenomenon of nitrate toleranceQ36272905
CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cellsQ36276395
Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signalingQ36384766
Targeting reactive oxygen species in hypertensionQ36398049
Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells.Q36496361
P304page(s)134
P577publication date2014-04-04
P1433published inFrontiers in PhysiologyQ2434141
P1476titleRegulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow
P478volume5

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