Nitric oxide activation of guanylate cyclase pushes the α1 signaling helix and the β1 heme-binding domain closer to the substrate-binding site.

scientific article published on 12 November 2013

Nitric oxide activation of guanylate cyclase pushes the α1 signaling helix and the β1 heme-binding domain closer to the substrate-binding site. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.504472
P932PMC publication ID3879570
P698PubMed publication ID24220034

P50authorSönke BehrendsQ48479757
P2093author name stringInga Neidhardt
Mareike Busker
P2860cites workNO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanismQ27641107
PAS-mediated Dimerization of Soluble Guanylyl Cyclase Revealed by Signal Transduction Histidine Kinase Domain Crystal StructureQ27649070
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclaseQ27652454
Probing the Function of Heme Distortion in the H-NOX FamilyQ27652988
Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclaseQ27659219
Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclaseQ27661554
Crystal structure of the Alpha subunit PAS domain from soluble guanylyl cyclaseQ27679506
Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulinQ28247685
Cloning and functional expression of the rat alpha(2) subunit of soluble guanylyl cyclaseQ28579016
The amino-terminus of nitric oxide sensitive guanylyl cyclase α₁ does not affect dimerization but influences subcellular localizationQ28744371
Imaging protein molecules using FRET and FLIM microscopyQ30435991
Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase.Q30539237
The signaling helix: a common functional theme in diverse signaling proteinsQ33256438
Fluorescent fusion proteins of soluble guanylyl cyclase indicate proximity of the heme nitric oxide domain and catalytic domainQ33640041
Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclaseQ34990290
Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclaseQ35124292
Structural insights into the regulation and the activation mechanism of mammalian guanylyl cyclasesQ35935091
Molecular model of a soluble guanylyl cyclase fragment determined by small-angle X-ray scattering and chemical cross-linkingQ36713981
Structure and regulation of soluble guanylate cyclaseQ37992160
Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domainQ39369792
Direct fusion of subunits of heterodimeric nitric oxide sensitive guanylyl cyclase leads to functional enzymes with preserved biochemical properties: evidence for isoform specific activation by ciguates.Q39843769
Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotidesQ40205848
NO activation of guanylyl cyclaseQ40327686
Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.Q40586309
2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors.Q40672995
A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding.Q40673658
Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transductionQ41166663
A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclaseQ42469883
Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphateQ45182671
Broad specificity of mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitorsQ83967632
Picosecond to second dynamics reveals a structural transition in Clostridium botulinum NO-sensor triggered by the activator BAY-41-2272Q87373473
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)476-484
P577publication date2013-11-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleNitric oxide activation of guanylate cyclase pushes the α1 signaling helix and the β1 heme-binding domain closer to the substrate-binding site
P478volume289

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cites work (P2860)
Q27682500Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity
Q35855381Mapping Soluble Guanylyl Cyclase and Protein Disulfide Isomerase Regions of Interaction
Q37727207Nitric oxide-induced conformational changes in soluble guanylate cyclase
Q37660997Probing the Molecular Mechanism of Human Soluble Guanylate Cyclase Activation by NO in vitro and in vivo
Q37697630Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.
Q37612777Single-particle EM reveals the higher-order domain architecture of soluble guanylate cyclase
Q38894826Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor
Q55436230Structure/function of the soluble guanylyl cyclase catalytic domain.
Q38772751The Role of Reactive Oxygen and Nitrogen Species in the Expression and Splicing of Nitric Oxide Receptor

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