The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

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The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...872155V
P356DOI10.1371/JOURNAL.PONE.0072155
P932PMC publication ID3756074
P698PubMed publication ID24015214
P5875ResearchGate publication ID256470609

P50authorBenjamin VandendriesscheQ49092829
Johannes-Peter StaschQ66360867
Peter VandenabeeleQ30112482
P2093author name stringPeter Brouckaert
Vera Goossens
Anje Cauwels
Elke Rogge
P2860cites workDuration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shockQ83177700
Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradationQ39845753
Uncoupling of biological oscillators: a complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndromeQ41010995
Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitorQ42048652
Smooth muscle-specific deletion of nitric oxide-sensitive guanylyl cyclase is sufficient to induce hypertension in miceQ43197344
The expression of soluble guanylate cyclase in the vasculature of rat skeletal muscleQ43222467
Infusion of Escherichia coli lipopolysaccharide toxin in rats produces an early and severe impairment of baroreflex function in absence of blood pressure changes.Q43797224
Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2.Q44372580
A role for interleukin 1 in the in vivo actions of tumor necrosis factorQ44714244
Fractal rigidity by enhanced sympatho-vagal antagonism in heartbeat interval dynamics elicited by central application of corticotropin-releasing factor in mice.Q48744796
Drotrecogin alfa (activated) in adults with septic shock.Q55056165
Autonomic cardiovascular control in conscious miceQ73194342
Mediator modulation therapy of severe sepsis and septic shock: does it work?Q75225181
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potentialQ24656131
PhysioBank, PhysioToolkit, and PhysioNet : Components of a New Research Resource for Complex Physiologic SignalsQ28020278
Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular systemQ28513504
The epidemiology of sepsis in the United States from 1979 through 2000Q29547760
NO-independent regulatory site on soluble guanylate cyclaseQ32165040
Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent mannerQ33590497
Cyclic GMP phosphodiesterase-5: target of sildenafilQ33630333
Guanylyl cyclases and signaling by cyclic GMP.Q33917038
Multiple organ dysfunction syndrome: exploring the paradigm of complex nonlinear systemsQ33988265
Reactive oxygen species and small-conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shockQ34063569
Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time seriesQ34089528
Myocardial dysfunction in septic shock: Part I. Clinical manifestation of cardiovascular dysfunctionQ34293378
Autonomic dysfunction in the ICU patientQ34503014
Pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in healthy male volunteersQ34823612
NO-independent, haem-dependent soluble guanylate cyclase stimulatorsQ34906036
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vesselsQ35009484
NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principleQ35044464
Novel strategies for the treatment of sepsisQ35118750
Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase [corrected].Q35575494
Interpretation of normalized spectral heart rate variability indices in sleep research: a critical reviewQ35995533
Severe sepsis and septic shock: review of the literature and emergency department management guidelines.Q36510126
Survival of TNF toxicity: dependence on caspases and NO.Q36744895
sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models.Q37298332
NO- and haem-independent soluble guanylate cyclase activatorsQ37352787
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectendotoxic shockQ11291420
P304page(s)e72155
P577publication date2013-08-28
P1433published inPLOS OneQ564954
P1476titleThe soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems
P478volume8

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cites work (P2860)
Q36424922Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice
Q34538482Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.
Q27021649Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS
Q51687813Guanylyl cyclase activation reverses resistive breathing-induced lung injury and inflammation.
Q49047822Influence of cinaciguat on gastrointestinal motility in apo-sGC mice.
Q42380504Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domain
Q27021987Nitrate/Nitrite as Critical Mediators to Limit Oxidative Injury and Inflammation
Q36430759Progesterone receptor membrane component-1 regulates hepcidin biosynthesis

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