Assessment of the effects of hepatic impairment and smoking on the pharmacokinetics of a single oral dose of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)

scientific article published on March 2016

Assessment of the effects of hepatic impairment and smoking on the pharmacokinetics of a single oral dose of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521) is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1086/685015
P932PMC publication ID4860536
P698PubMed publication ID27162628
P5875ResearchGate publication ID297893148

P2093author name stringAnja Schmidt
Georg Wensing
Reiner Frey
Sigrun Unger
Wolfgang Mück
Corina Becker
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Riociguat (BAY 63–2521) and Warfarin: A Pharmacodynamic and Pharmacokinetic Interaction StudyQ33447738
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Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.Q34786286
First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertensionQ34917310
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Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ cultureQ41007634
Effects of omeprazole and aluminum hydroxide/magnesium hydroxide on riociguat absorptionQ41165804
Riociguat (BAY 63-2521) and aspirin: a randomized, pharmacodynamic, and pharmacokinetic interaction studyQ41166010
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Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study.Q42663215
Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR.Q44457201
Tobacco smoke-dependent changes in cytochrome P450 1A1, 1A2, and 2E1 protein expressions in fetuses, newborns, pregnant rats, and human placentaQ45078610
No pharmacodynamic (PD) and pharmacokinetic (PK) interaction of riociguat (BAY 63-2521) and aspirin.Q45928610
Single-dose pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase stimulator BAY 63-2521: an ascending-dose study in healthy male volunteersQ46562534
Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with hepatic impairmentQ47132669
Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.Q50139180
Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.Q52240442
Survival in patients with primary pulmonary hypertension. Results from a national prospective registry.Q52422731
Pulmonary Arterial HypertensionQ56388760
P433issueSuppl 1
P407language of work or nameEnglishQ1860
P921main subjectriociguatQ2154494
pharmacokineticsQ323936
P304page(s)S5-S14
P577publication date2016-03-01
P1433published inPulmonary circulationQ26842412
P1476titleAssessment of the effects of hepatic impairment and smoking on the pharmacokinetics of a single oral dose of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)
P478volume6

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cites work (P2860)
Q48023226Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
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Q92785757Practical management of riociguat in patients with pulmonary arterial hypertension
Q53835859Riociguat treatment for portopulmonary hypertension: a subgroup analysis from the PATENT-1/-2 studies.
Q33596457Riociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension
Q90660734Treatment Barriers in Portopulmonary Hypertension

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