A novel soluble guanylate cyclase activator with reduced risk of hypotension by short-acting vasodilation

scientific article published on 04 March 2019

A novel soluble guanylate cyclase activator with reduced risk of hypotension by short-acting vasodilation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PRP2.463
P932PMC publication ID6399102
P698PubMed publication ID30873284

P50authorToshihiro SawabeQ92376565
P2093author name stringKazuyuki Aihara
Akiyuki Takaya
Akihiro Kobayashi
Kosuke Nagasaka
Toshiki Chiba
P2860cites workNO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potentialQ24656131
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Venous congestion and endothelial cell activation in acute decompensated heart failureQ37418264
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Clinical and pharmacokinetic results with a new ultrashort-acting calcium antagonist, clevidipine, following gradually increasing intravenous doses to healthy volunteersQ41592382
Inhibition of soluble guanylate cyclase by ODQ.Q42055822
Population pharmacokinetics and pharmacodynamics of cinaciguat, a soluble guanylate cyclase activator, in patients with acute decompensated heart failureQ42645453
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Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromesQ57628743
The renin-angiotensin-aldosterone system, antidiuretic hormone and sympathetic nerve activity in an experimental model of congestive heart failure in the dogQ70334836
Endothelial dysfunction in heart failure: mechanisms and therapeutic approachesQ80472740
Blood pressure-independent effect of long-term treatment with the soluble heme-independent guanylyl cyclase activator HMR1766 on progression in a model of noninflammatory chronic renal damageQ80492373
Effects of tolvaptan on systemic and renal hemodynamic function in dogs with congestive heart failureQ82693298
Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failureQ84553919
Why do drugs for acute heart failure fail?Q84596045
Soluble guanylyl cyclase activation improves progressive cardiac remodeling and failure after myocardial infarction. Cardioprotection over ACE inhibitionQ88036789
Nitrates as a Treatment of Acute Heart FailureQ88711663
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)e00463
P577publication date2019-03-04
P1433published inPharmacology Research & PerspectivesQ27725410
P1476titleA novel soluble guanylate cyclase activator with reduced risk of hypotension by short-acting vasodilation
P478volume7

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