Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity

Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1039/C2MD20134H

P2093author name stringTakao Yamori
Shinichi Sato
Hiroyuki Nakamura
Shinae Kizaka-Kondoh
Ayano Takeuchi
Hyun Seung Ban
Takahiro Kuchimaru
Makihito Hori
P2860cites workThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisQ22009936
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potentialQ24656131
Targeting HIF-1 for cancer therapyQ27860504
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationQ27860876
Signal transduction to hypoxia-inducible factor 1Q28221115
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1Q28282227
Hypoxia--a key regulatory factor in tumour growthQ29547318
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor proteinQ29615931
Development of HIF-1 inhibitors for cancer therapyQ33703381
In vivo imaging of HIF-active tumors by an oxygen-dependent degradation protein probe with an interchangeable labeling systemQ33784382
HIF-1 as a target for drug developmentQ35550217
Versatile pharmacological actions of YC-1: anti-platelet to anticancerQ35764741
Hypoxia-inducible factors: central regulators of the tumor phenotypeQ36701590
Targeting hypoxia cell signaling for cancer therapyQ36784388
Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010).Q37826426
1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1alpha inhibitorsQ39852702
Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancerQ39856479
A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.Q39906110
Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the danceQ39946802
Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226.Q40078441
Suppression of hypoxia inducible factor-1alpha (HIF-1alpha) by YC-1 is dependent on murine double minute 2 (Mdm2).Q40241945
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell linesQ41679901
NO-independent stimulators of soluble guanylate cyclaseQ43558550
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.Q43564835
Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agentsQ43770043
YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.Q44387498
Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.Q46465986
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9.Q46720467
The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclaseQ46834469
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.Q52526450
Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitorsQ58615288
Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α InhibitorQ58615302
P433issue11
P921main subjecthypoxiaQ105688
P304page(s)1455
P577publication date2012-01-01
P1433published inMedChemCommQ3303881
P1476titleSynthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity
P478volume3

Reverse relations

cites work (P2860)
Q58615154Diaryl-substituted carboranes as inhibitors of hypoxia inducible factor-1 transcriptional activity
Q42708217Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors.
Q47254418Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): A "structure-activity relationship" perspective.
Q38866132The design, synthesis, and biological evaluation of novel YC-1 derivatives as potent anti-hepatic fibrosis agents

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