Sildenafil Prevents Apoptosis of Human First-Trimester Trophoblast Cells Exposed to Oxidative Stress: Possible Role for Nitric Oxide Activation of 3',5'-cyclic Guanosine Monophosphate Signaling

scientific article published on 26 November 2014

Sildenafil Prevents Apoptosis of Human First-Trimester Trophoblast Cells Exposed to Oxidative Stress: Possible Role for Nitric Oxide Activation of 3',5'-cyclic Guanosine Monophosphate Signaling is …
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scholarly articleQ13442814

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P356DOI10.1177/1933719114557894
P932PMC publication ID4502801
P698PubMed publication ID25431453
P5875ResearchGate publication ID268876772

P50authorMichael P. DiamondQ38804515
D. Randall ArmantQ42657516
P2093author name stringJing Dai
Alan D Bolnick
Brian A Kilburn
Michael Hertz
Jay M Bolnick
Manvinder Singh
P2860cites workIn vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnanciesQ28350804
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Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsiaQ36686796
Effects and mechanisms of action of sildenafil citrate in human chorionic arteries.Q37187656
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Sildenafil-mediated neovascularization and protection against myocardial ischaemia reperfusion injury in rats: role of VEGF/angiopoietin-1Q37310691
Sildenafil attenuates placental ischemia-induced hypertensionQ37323529
Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsiaQ37350668
Defective deep placentationQ37812517
Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5).Q38336160
Evidence of synergistic/additive effects of sildenafil and erythropoietin in enhancing survival and migration of hypoxic endothelial cells.Q39234023
Extracellular matrix composition and hypoxia regulate the expression of HLA-G and integrins in a human trophoblast cell line.Q40898779
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Sildenafil decreased cardiac cell apoptosis in diabetic mice: reduction of oxidative stress as a possible mechanism.Q43273844
Sildenafil citrate therapy for severe early-onset intrauterine growth restriction.Q43639662
Expression of vascular endothelial growth factor (VEGF) and its receptors in human endometrium throughout the menstrual cycle and in early pregnancyQ43907829
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.Q44044678
Endothelial dysfunction in the human umbilical artery due to preeclampsia can be prevented by sildenafilQ44308542
Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertensionQ44471394
Effects of a phosphodiesterase-5 (PDE5) inhibitor on endothelium-dependent relaxation of myometrial small arteriesQ44914088
Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosisQ46058843
Sildenafil citrate decreases sFlt-1 and sEng in pregnant l-NAME treated Sprague-Dawley ratsQ46298778
Expression of phosphodiesterase 5 in maternal and fetal sheepQ46698469
Pathophysiologic features of "thin" endometriumQ46712309
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteriesQ46782881
Circulating angiogenic factors and the risk of preeclampsiaQ47217679
Effects of sildenafil and tadalafil on ischemia/reperfusion injury in fetal rat brainQ48169431
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.Q53600812
Placental stress and pre-eclampsia: a revised view.Q54774592
Pre-eclampsiaQ56019568
Loss of endothelium-dependent relaxation in myometrial resistance arteries in pre-eclampsiaQ59367714
Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infantsQ69685000
Endometrial thickness: a predictor of implantation in ovum recipients?Q72050998
Abnormal endothelial cell function of resistance arteries from women with preeclampsiaQ72077460
Expression of vascular endothelial growth factor and its receptors in the human corpus luteum during the menstrual cycle and in early pregnancyQ73148530
Summary of the NHLBI Working Group on Research on Hypertension During PregnancyQ73788745
Systemic administration of phosphodiesterase V inhibitor, sildenafil citrate, for attenuation of cerebral vasospasm after experimental subarachnoid hemorrhageQ79401494
Nitric oxide formation is inversely related to serum levels of antiangiogenic factors soluble fms-like tyrosine kinase-1 and soluble endogline in preeclampsiaQ81508545
Sildenafil citrate protects skeletal muscle of ischemia-reperfusion injury: immunohistochemical study in rat modelQ86561108
P433issue6
P1104number of pages7
P304page(s)718-724
P577publication date2014-11-26
P1433published inReproductive SciencesQ7314305
P1476titleSildenafil Prevents Apoptosis of Human First-Trimester Trophoblast Cells Exposed to Oxidative Stress: Possible Role for Nitric Oxide Activation of 3',5'-cyclic Guanosine Monophosphate Signaling
P478volume22

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Q58803671Rosiglitazone augments antioxidant response in the human trophoblast and prevents apoptosis†cites workP2860

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