A1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia

scientific article published on 28 January 2014

A1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...986353W
P356DOI10.1371/JOURNAL.PONE.0086353
P932PMC publication ID3904882
P698PubMed publication ID24489717
P5875ResearchGate publication ID260063182

P2093author name stringBo Akerström
Stefan R Hansson
David Ley
Matthias Mörgelin
Martin E Johansson
Bengt Rippe
Magnus Gram
Karel Marsal
Sigurbjörg Rutardottir
Anneli Edström-Hägerwall
Josefin Axelsson
Vera Casslén
Iréne Larsson
Lena Wester-Rosenlöf
Behnaz Shohani
Madlene Holmqvist
P2860cites workProcessing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation propertiesQ24292393
The pregnant sheep as a model for human pregnancyQ24657385
Up-regulation of A1M/α1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damageQ28477940
Redox properties of the lipocalin alpha1-microglobulin: reduction of cytochrome c, hemoglobin, and free ironQ31145047
Up-regulation of alpha1-microglobulin by hemoglobin and reactive oxygen species in hepatoma and blood cell linesQ33275367
The pathogenetic role of heme in pregnancy-induced hypertension-like disease in ewes.Q51571837
The lipocalin alpha1-microglobulin has radical scavenging activity.Q52683063
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.Q53600812
Production of recombinant human alpha1-microglobulin and mutant forms involved in chromophore formation.Q54450337
Fetal hemoglobin and α1-microglobulin as first- and early second-trimester predictive biomarkers for preeclampsiaQ61848157
Immunological analysis of alpha 1-microglobulin in different mammalian and chicken serum. alpha 1-Microglobulin is 5-8 kilodaltons larger in primatesQ69382677
Is oxidative stress the link in the two-stage model of pre-eclampsia?Q78258200
Acute renal failure in a patient with paroxysmal nocturnal hemoglobinuria and autoimmune hemolytic anemiaQ81342772
Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by α1-microglobulinQ83487574
Collagen VI is a subepithelial adhesive target for human respiratory tract pathogensQ84019923
Rapid, dynamic changes in glomerular permeability to macromolecules during systemic angiotensin II (ANG II) infusion in ratsQ84425205
Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changesQ33312878
Differential gene expression analysis of placentas with increased vascular resistance and pre-eclampsia using whole-genome microarraysQ33872123
Pathogenesis and genetics of pre-eclampsiaQ33934445
Immunocalins: a lipocalin subfamily that modulates immune and inflammatory responses.Q34073697
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell diseaseQ34158521
A current concept of eclampsiaQ35156657
The placenta in preeclampsiaQ36053252
Comparative placentation: some interesting modifications for histotrophic nutrition -- a review.Q36365576
Hemoglobin and heme scavenging.Q36411315
Heme, heme oxygenase, and ferritin: how the vascular endothelium survives (and dies) in an iron-rich environmentQ36927608
Endotoxin limits in formulations for preclinical researchQ36936944
The two stage model of preeclampsia: variations on the themeQ37187589
Evolutionary aspects of hemoglobin scavengers.Q37570502
Toxicological consequences of extracellular hemoglobin: biochemical and physiological perspectivesQ37573785
Pathological conditions involving extracellular hemoglobin: molecular mechanisms, clinical significance, and novel therapeutic opportunities for α(1)-microglobulinQ37983081
Bystander cell death and stress response is inhibited by the radical scavenger α(1)-microglobulin in irradiated cell culturesQ39642906
The lipocalin alpha1-microglobulin protects erythroid K562 cells against oxidative damage induced by heme and reactive oxygen speciesQ39949399
Distribution of iodine 125-labeled alpha1-microglobulin in rats after intravenous injection.Q42500896
Pregnancy-induced hypertension: development of a model in the pregnant sheepQ43410452
Prevention of pre-eclampsiaQ43625987
Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewesQ43768781
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.Q44044678
In vivo rat model of preeclampsiaQ44271036
Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeabilityQ45746271
Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutionsQ46075954
Increased levels of cell-free hemoglobin, oxidation markers, and the antioxidative heme scavenger alpha(1)-microglobulin in preeclampsiaQ46332725
Characterisation of monoclonal antibodies to ovine interleukin-6 and the development of a sensitive capture ELISA.Q46538950
Rat alpha 1-microglobulin. Purification from urine and synthesis by hepatocyte monolayersQ46903264
Alpha1-microglobulin is found both in blood and in most tissuesQ47813923
Endothelial dysfunction in preeclampsiaQ47879591
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpre-eclampsiaQ61335
P304page(s)e86353
P577publication date2014-01-28
P1433published inPLOS OneQ564954
P1476titleA1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia
P478volume9

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cites work (P2860)
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