Function-specific intracellular signaling pathways downstream of heparin-binding EGF-like growth factor utilized by human trophoblasts

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Function-specific intracellular signaling pathways downstream of heparin-binding EGF-like growth factor utilized by human trophoblasts is …
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scholarly articleQ13442814

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P356DOI10.1095/BIOLREPROD.109.082305
P932PMC publication ID2857634
P698PubMed publication ID20130271
P5875ResearchGate publication ID41405209

P50authorD. Randall ArmantQ42657516
Roberto RomeroQ42734915
P2093author name stringPhilip Jessmon
Richard E Leach
Brian A Kilburn
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Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.Q34317276
Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation.Q34329881
Factors regulating trophoblast migration and invasiveness: possible derangements contributing to pre-eclampsia and fetal injuryQ35163753
Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factorQ35191560
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Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentationQ61845621
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Epidermal growth factor inhibits cytokine-induced apoptosis of primary human trophoblastsQ71037717
Immunohistochemical localization of transforming growth factor-alpha in human endometrium, decidua, and trophoblastQ72072242
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C-myc and tumour suppressor gene product expression in developing and term human trophoblastQ72746451
Acceleration of trophoblast differentiation by heparin-binding EGF-like growth factor is dependent on the stage-specific activation of calcium influx by ErbB receptors in developing mouse blastocystsQ73400619
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Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblastsQ77966092
The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblastsQ79842633
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Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidantQ35757165
Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wallQ35787199
Placental oxidative stress: from miscarriage to preeclampsiaQ35879133
Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cellsQ35946174
Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cellsQ36016357
Heparin-binding epidermal growth factor (HB-EGF) may improve embryonic development and implantation by increasing vitronectin receptor (integrin alphanubeta3) expression in peri-implantation mouse embryosQ36268776
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Expression of heparin-binding EGF-like growth factor in term chorionic villous explants and its role in trophoblast survivalQ36957136
Live and let die - regulation of villous trophoblast apoptosis in normal and abnormal pregnancies.Q37244917
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Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsiaQ37350668
Pre-eclampsia and expression of heparin-binding EGF-like growth factor.Q38454644
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Does altered oxygenation or reactive oxygen species alter cell turnover of BeWo choriocarcinoma cells?Q39894990
Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cells.Q39899021
Use of hyperosmolar stress to measure stress-activated protein kinase activation and function in human HTR cells and mouse trophoblast stem cellsQ40062637
Ultraviolet radiation (UVR) activates p38 MAP kinase and induces post-transcriptional stabilization of the C/EBPdelta mRNA in G0 growth arrested mammary epithelial cellsQ40074868
EGF upregulates Na+/H+ exchanger NHE1 by post-translational regulation that is important for cervical cancer cell invasivenessQ40076437
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Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptorsQ40316127
Tumor necrosis factor and vascular endothelial growth factor induce endothelial integrin repertories, regulating endovascular differentiation and apoptosis in a human extravillous trophoblast cell line.Q40442948
EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways.Q40521545
Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migrationQ40538973
Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype.Q40596618
Noncatalytic domain of uPA stimulates human extravillous trophoblast migration by using phospholipase C, phosphatidylinositol 3-kinase and mitogen-activated protein kinaseQ40650320
Endothelin-1 promotes migration and induces elevation of [Ca2+]i and phosphorylation of MAP kinase of a human extravillous trophoblast cell line.Q40653534
TNFalpha-induced apoptosis and integrin switching in human extravillous trophoblast cell lineQ40668024
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Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signaling through alpha 5 beta 1 integrin via mitogen-activated protein Kinase pathwayQ40800243
Extracellular matrix composition and hypoxia regulate the expression of HLA-G and integrins in a human trophoblast cell line.Q40898779
Specificity within the EGF family/ErbB receptor family signaling networkQ41721612
p38alpha stabilizes interleukin-6 mRNA via multiple AU-rich elementsQ42049265
Rapid 3D radiofrequency field mapping using catalyzed double-angle methodQ42738944
Establishment and Characterization of First Trimester Human Trophoblast Cells with Extended LifespanQ42804803
Growth factor rescue of cytokine mediated trophoblast apoptosis.Q43968561
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.Q44044678
Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophagesQ46084106
Gabor Than Award Lecture 2008: pre-eclampsia - from placental oxidative stress to maternal endothelial dysfunctionQ46334762
Immunohistochemical localization of epidermal growth factor in human endometrium, decidua, and placentaQ46533926
Multiple anti-apoptotic pathways stimulated by EGF in cytotrophoblasts.Q46579982
Regulation of human placental development by oxygen tensionQ46733260
Heparin-binding epidermal growth factor significantly improves human blastocyst development and hatching in serum-free mediumQ47750544
P433issue5
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)921-929
P577publication date2010-02-03
P1433published inBiology of ReproductionQ4915061
P1476titleFunction-specific intracellular signaling pathways downstream of heparin-binding EGF-like growth factor utilized by human trophoblasts
P478volume82

Reverse relations

cites work (P2860)
Q51173078A regional meeting continues to grow: the 2nd annual Michigan alliance for Reproductive Technologies and Science Conference.
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Q39663346HER1 Signaling Mediates Extravillous Trophoblast Differentiation in Humans1
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