Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin

scientific article published on 13 December 2011

Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin is …
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scholarly articleQ13442814

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P356DOI10.1155/2012/486053
P932PMC publication ID3238375
P698PubMed publication ID22195275
P5875ResearchGate publication ID51921390

P2093author name stringEric M George
Ana C Palei
Joey P Granger
Drew Colson
Jeremy Dixon
P2860cites workRole of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant ratsQ28571017
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaQ29615916
A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use.Q30433214
Pathogenesis and genetics of pre-eclampsiaQ33934445
Pre-eclampsiaQ34079933
Summary of the NHLBI Working Group on Research on Hypertension During PregnancyQ34182166
Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explantsQ34429164
Carbon monoxide: endogenous production, physiological functions, and pharmacological applicationsQ34480319
Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertensionQ34904184
Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsiaQ35764966
Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxideQ35767918
Glomerular endothelial cell differentiation.Q36102370
Adult hypertension and kidney disease: the role of fetal programming.Q36369445
Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunctionQ37022723
Physiological significance of heme oxygenase in hypertensionQ37332818
Role of reactive oxygen species in hypertension produced by reduced uterine perfusion in pregnant ratsQ37449704
Defective deep placentationQ37812517
Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsiaQ40530224
Preeclampsia: an endothelial cell disorderQ41281924
Cardioprotective actions by a water-soluble carbon monoxide-releasing moleculeQ42169432
Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation.Q42286040
Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive ratsQ43710003
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.Q44044678
Heme oxygenase-1 gene expression modulates angiotensin II-induced increase in blood pressureQ44912886
Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1.Q46339760
Increase in heme oxygenase-1 levels ameliorates renovascular hypertensionQ46826547
Circulating angiogenic factors and the risk of preeclampsiaQ47217679
Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsiaQ47915288
Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1.Q51037240
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.Q53600812
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaQ56619493
Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1Q57105968
Bilirubin attenuates radical-mediated damage to serum albuminQ61663181
Endothelial Heme Oxygenase-1 Induction by HypoxiaQ61837706
The role of the spiral arteries in the pathogenesis of preeclampsiaQ69446253
Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblastsQ73376805
Expression of heme oxygenase-1 in the lung in chronic hypoxiaQ73630754
Endoglin regulates trophoblast differentiation along the invasive pathway in human placental villous explantsQ73827019
Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsiaQ74603115
Determination of copy number of c-Myc protein per cell by quantitative Western blottingQ74644736
Evidence for peroxynitrite formation in the vasculature of women with preeclampsiaQ77945531
Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidaseQ80363039
Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expressionQ81411178
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)486053
P577publication date2011-12-13
P1433published inInternational Journal of HypertensionQ24031588
P1476titleHeme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin
P478volume2012

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cites work (P2860)
Q36115311A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model
Q38764650Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells
Q28083815Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia
Q38804071Carbon Monoxide Releasing Molecules Blunt Placental Ischemia-Induced Hypertension
Q34155902Carbon monoxide prevents hypertension and proteinuria in an adenovirus sFlt-1 preeclampsia-like mouse model
Q46481713Chronic carbon monoxide inhalation during pregnancy augments uterine artery blood flow and uteroplacental vascular growth in mice
Q58604380Circulating Heme Oxygenase-1: Not a Predictor of Preeclampsia but Highly Expressed in Pregnant Women Who Subsequently Develop Severe Preeclampsia
Q37229246Endothelial dysfunction. An important mediator in the pathophysiology of hypertension during pre-eclampsia
Q37312044Heme oxygenase in pregnancy and preeclampsia
Q35960186Heme oxygenase induction attenuates TNF-α-induced hypertension in pregnant rodents
Q37065405Heme oxygenase inhibition increases blood pressure in pregnant rats
Q34954230Heme oxygenase-1 in pregnancy and cancer: similarities in cellular invasion, cytoprotection, angiogenesis, and immunomodulation
Q48578792Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells
Q33568810Heme oxygenase-1 promotes migration and β-epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas
Q36422496Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms
Q35850254Induction of heme oxygenase-1 shifts the balance from proinjury to prosurvival in the placentas of pregnant rats with reduced uterine perfusion pressure
Q26865332Pathophysiology of hypertension in pre-eclampsia: a lesson in integrative physiology
Q34391174Sildenafil Inhibits Advanced Glycation End Products-induced sFlt-1 Release Through Upregulation of Heme Oxygenase-1.
Q40871961The Effects of Heme Oxygenase By-Products on the Proliferation and Invasion of HUVECs, HTR-8/SVneo Cells, 3A(tPA 30-1) Cells, and HESCs Under Varying Oxygen Concentrations
Q38283155The balancing act - PPAR-γ's roles at the maternal-fetal interface.
Q34295822The heme oxygenases: important regulators of pregnancy and preeclampsia
Q34581899Vitamin C treatment attenuates hemorrhagic shock related multi-organ injuries through the induction of heme oxygenase-1

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