Adenosine A₂a receptors and O₂ sensing in development

scientific article

Adenosine A₂a receptors and O₂ sensing in development is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1152/AJPREGU.00664.2010
P932PMC publication ID3174752
P698PubMed publication ID21677265
P5875ResearchGate publication ID51223021

P2093author name stringBrian J Koos
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Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature ratsQ28270571
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Assessment of fetal compromise by Doppler ultrasound investigation of the fetal circulation. Arterial, intracardiac, and venous blood flow velocity studiesQ28304543
Modulation of pulmonary vasomotor tone in the fetus and neonateQ28362889
On the specificity and type of receptor involved in carotid body chemoreceptor activation by adenosine in the catQ28366298
Characterization of purine receptors in fetal lamb pulmonary circulationQ28378454
An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cellsQ28565265
Aspects of the general biology of adenosine A2A signaling.Q36931193
Hypoxia-induced signaling in the cardiovascular systemQ36938391
Long-term effects of the perinatal environment on respiratory controlQ37054696
Control of coronary blood flow during hypoxemiaQ37082632
Heme oxygenase is necessary for the excitatory response of cultured neonatal rat rostral ventrolateral medulla neurons to hypoxiaQ37086406
Reactive oxygen species and respiratory plasticity following intermittent hypoxia.Q37097685
Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeineQ37101201
Embryonic caffeine exposure induces adverse effects in adulthoodQ37139819
Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheepQ37151035
Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxiaQ37151044
Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeineQ37162515
Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor.Q37172666
Fetal cerebrovascular circulation: a review of prenatal ultrasound assessmentQ37209294
NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia.Q37217629
Neonatal intermittent hypoxia leads to long-lasting facilitation of acute hypoxia-evoked catecholamine secretion from rat chromaffin cellsQ37221793
Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.Q37228613
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Intrauterine growth restriction: implications for placental metabolism and transport. A review.Q37368571
NADPH oxidase activity is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.Q37399757
The impact of adenosine and an A2A adenosine receptor agonist on the ACh-induced increase in intracellular calcium of the glomus cells of the cat carotid bodyQ37440789
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.Q37443475
Mitochondrial-derived hydrogen peroxide inhibits relaxation of bovine coronary arterial smooth muscle to hypoxia through stimulation of ERK MAP kinaseQ37474842
Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia.Q37486977
Carotid body potentiation induced by intermittent hypoxia: implications for cardiorespiratory changes induced by sleep apnoeaQ37497460
Adenosine in peripheral chemoreception: new insights into a historically overlooked molecule--invited article.Q37523357
Developmental maturation of chemosensitivity to hypoxia of peripheral arterial chemoreceptors--invited article.Q37523370
Oxygen sensing in the brain--invited article.Q37523382
Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.Q37597938
The influence of the intrauterine environment on human placental development.Q37598153
Enzyme-linked oxygen sensing by potassium channelsQ37618851
Oxygen sensing in the carotid bodyQ37618854
Regulation of oxygen sensitivity in adrenal chromaffin cellsQ37618857
The neuronal control of hypoxic ventilation: erythropoietin and sexual dimorphismQ37618859
Regulation of fetoplacental vascular bed by hypoxiaQ37687355
Rat carotid body chemosensory discharge and glomus cell HIF-1 alpha expression in vitro: regulation by a common oxygen sensorQ28569806
Adenosine stimulates depolarization and rise in cytoplasmic [Ca2+] in type I cells of rat carotid bodiesQ28572447
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensingQ29615506
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energyQ29618101
Myocardial adenosine formation during hypoxia: Effects of ecto-5′-nucleotidase inhibitionQ30438511
Adenosine A(2A) receptors mediate cardiovascular responses to hypoxia in fetal sheepQ31722139
Purinergic contribution to circulatory, metabolic, and adrenergic responses to acute hypoxemia in fetal sheep.Q31920130
Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxiaQ32064876
Plasma adenosine levels and P-selectin expression on platelets in preeclampsiaQ32141013
Adenosine mediates decreased cerebral metabolic rate and increased cerebral blood flow during acute moderate hypoxia in the near-term fetal sheep.Q33193076
Fetal hypertension and abnormal Doppler velocimetry in an ovine model of intrauterine growth restrictionQ33211221
Role of prostanoids in the regulation of cerebral blood flow during normoxia and hypoxia in the fetal sheep.Q33258223
Maternal caffeine administration and cerebral oxygenation in near-term fetal sheepQ33303835
Noninvasive methods of detecting fetal anaemia: a systematic review and meta-analysisQ33493537
Maternal hypoxia increases the activity of MMPs and decreases the expression of TIMPs in the brain of neonatal ratsQ33642536
Neural development in metatherian and eutherian mammals: variation and constraintQ33691347
Dynamics of fetal circulatory responses to hypoxia and asphyxiaQ33700762
Absence of the Adenosine A<sub>2A</sub> Receptor Confers Pulmonary Arterial Hypertension and Increased Pulmonary Vascular Remodeling in MiceQ33715343
Task2 potassium channels set central respiratory CO2 and O2 sensitivity.Q33719818
Review: The placenta is a programming agent for cardiovascular diseaseQ33755531
Coronary flow regulation in the fetal sheepQ33774787
High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitudeQ33821845
Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy.Q33894600
H2S mediates O2 sensing in the carotid bodyQ33935043
Developmental aspects of oxygen sensing by the carotid bodyQ33939188
Mechanisms regulating hypoxic respiratory depression during fetal and postnatal lifeQ33940191
Uneven Distribution of Maternal and Fetal Placental Blood Flow, as Demonstrated Using Macroaggregates, and Its Response to Hypoxia*Q34089475
Glutamate receptors, neurotoxicity and neurodegenerationQ34103957
Chronic hyperoxia alters the early and late phases of the hypoxic ventilatory response in neonatal ratsQ34151255
Carotid body chemoreceptors: from natural stimuli to sensory dischargesQ34324365
The role of redox changes in oxygen sensingQ34349433
Influences of adenosine on the fetus and newborn.Q34396178
Doppler velocimetry in the evaluation of fetal hypoxiaQ34449157
Pharmacology of adenosine receptors in the vasculatureQ34453222
The A(2B)-D(2) receptor interaction that controls carotid body catecholamines release locates between the last two steps of hypoxic transduction cascade.Q42455610
Presynaptic action of adenosine on a 4-aminopyridine-sensitive current in the rat carotid bodyQ42468469
Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors.Q42497501
Carotid body chemosensory activity and ventilatory chemoreflexes in cats persist after combined cholinergic-purinergic blockQ42500984
Effects of combined cholinergic-purinergic block upon cat carotid body chemoreceptors in vitroQ42501047
Interstitial adenosine and cellular metabolism during beta-adrenergic stimulation of the in situ rabbit heartQ42521816
The non-neurogenic catecholamine response of the fetal adrenal to hypoxia is dependent on activation of voltage sensitive Ca2+ channelsQ42524267
Myocardial oxygen consumption modulates adenosine formation by canine right ventricle in absence of hypoxiaQ42622322
AMP-activated protein kinase and adipogenesis in sheep fetal skeletal muscle and 3T3-L1 cellsQ42815568
The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesiaQ42845569
Hypoxia and preeclampsia: increased expression of urocortin 2 and urocortin 3.Q42975696
Functional evidence for oxygen-sensitive voltage-gated potassium channels in human placental vasculature.Q43069761
cAMP: fuel for extracellular adenosine formation?Q43088095
Brain injury caused by chronic fetal hypoxemia is mediated by inflammatory cascade activationQ43111592
Reactive oxygen species and the control of vascular functionQ43157291
Adenosine A(1) receptor mediated suppression of adrenal activity in near-term fetal sheep.Q43195203
Obstructive sleep apnea as a risk factor for stroke and deathQ34466726
Ductus venosus shunting in the fetal venous circulation: regulatory mechanisms, diagnostic methods and medical importanceQ34565984
Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROSQ34591799
Oxygen sensors in contextQ34717961
The placenta in pre-eclampsia and intrauterine growth restrictionQ34798287
Regulation of gene expression by hypoxia.Q34800091
O2-sensitive K+ currents in carotid body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransductionQ34861221
Neurodevelopmental outcome in 2-year-old infants who were small-for-gestational age term fetuses with cerebral blood flow redistributionQ34889190
Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.Q34890985
The oxygen sensing signal cascade under the influence of reactive oxygen speciesQ35038220
Fetal growth restriction and maternal oxygen transport during high altitude pregnancyQ35175381
Hemodynamic foundation of umbilical arterial Doppler waveform analysisQ35461989
Control of vascular resistance in the human placentaQ35531114
Oxygen-sensing neurons in the central nervous system.Q35602028
A1 adenosine receptors play an essential role in protecting the embryo against hypoxiaQ35834361
Placental metabolic reprogramming: do changes in the mix of energy-generating substrates modulate fetal growth?Q35835710
Cellular oxygen sensing need in CNS function: physiological and pathological implicationsQ35858000
Fetal responses to placental insufficiency: an updateQ35895020
Animal models for the study of adenosine receptor function.Q35897185
Postnatal development of ventilatory and arousal responses to hypoxia in human infantsQ36117708
Postnatal development of carotid body glomus cell O2 sensitivityQ36123116
Postnatal growth of the carotid bodyQ36137809
Neurotransmitters in carotid body development.Q36141006
The role of free radicals in cerebral hypoxia and ischemia.Q36144611
Growth regulation of the vascular system: an emerging role for adenosineQ36193019
Oxygen sensing in the bodyQ36246924
On the peripheral and central chemoreception and control of breathing: an emerging role of ATP.Q36248625
O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?Q36292583
Vascular actions of purines in the foetal circulation of the human placentaQ36330252
The role of placental oxidative stress and lipid peroxidation in preeclampsiaQ36344309
Hypoxic regulation of the fetal cerebral circulation.Q36371873
Placental adaptive responses and fetal programmingQ36392502
Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A.Q36461897
A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing systemQ36474045
Spinal adenosine A2(A) receptor inhibition enhances phrenic long term facilitation following acute intermittent hypoxiaQ43245412
Caffeine in the neonatal period induces long-lasting changes in sleep and breathing in adult ratsQ43273423
Circulatory responses to maternal hyperoxaemia and hypoxaemia assessed non-invasively in fetal sheep at 0.3-0.5 gestation in acute experiments.Q43577192
Adenosine A(1) and A(2A) receptors modulate sleep state and breathing in fetal sheepQ43641760
Fetal cerebral and peripheral circulatory responses to hypoxia after nitric oxide synthase inhibitionQ43670760
Fetal adrenal medulla catecholamine response to hypoxia-direct and neural componentsQ43811516
Fetal breathing, sleep state, and cardiovascular responses to graded anemia in sheepQ43857425
Adenosine A(2A) receptors mediate hypoxic inhibition of fetal breathing in sheepQ43967800
Relation between adenosine and T-helper 1/T-helper 2 imbalance in women with preeclampsiaQ44011592
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.Q44044678
Relationship between plasma malondialdehyde levels and adenosine deaminase activities in preeclampsiaQ44053536
Relation between adenosine deaminase activities and cytokine-producing T cells in women with preeclampsiaQ44075431
Developmental regulation of O(2) sensing in neonatal adrenal chromaffin cells from wild-type and NADPH-oxidase-deficient mice.Q44075793
Autonomic and arginine vasopressin modulation of the hypoxia-induced atrial natriuretic factor release in immature and mature ovine fetusesQ44186004
Maternal plasma adenosine and endothelin-1 levels in twin gestation complicated by preeclampsiaQ44221417
Increased plasma adenosine concentrations and the severity of preeclampsiaQ44240085
Plasma 5'-nucleotidase activities and uric acid levels in women with pre-eclampsiaQ44305117
The role of peripheral chemoreceptors in the rapid response of the pulmonary vasculature of the late gestation sheep fetus to changes in PaO2.Q44541598
Plasma adenosine during investigation of hypoxic ventilatory responseQ44803083
Hypoxia induces adenosine release from the rat carotid body.Q44899064
Hemodynamics and organ blood flow in fetal sheep subjected to chronic anemiaQ44949883
Adenosine A2A receptors interact with GABAergic pathways to modulate respiration in neonatal pigletsQ44968162
Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid bodyQ45019738
Apnea is associated with neurodevelopmental impairment in very low birth weight infantsQ45030703
The impact of adenosine on the release of acetylcholine, dopamine, and norepinephrine from the cat carotid bodyQ45036492
Control of ventilation in adult rats hypoxic in the neonatal periodQ45055589
Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor controlQ45101357
Maternal and fetal plasma adenosine deaminase, xanthine oxidase and malondialdehyde levels in pre-eclampsiaQ45130707
Adenosine A2A-receptor blockade abolishes the roll-off respiratory response to hypoxia in awake lambsQ45200753
A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascadeQ45214796
Altered expression of adenosine A1 and A2A receptors in the carotid body and nucleus tractus solitarius of adult male and female rats following neonatal caffeine treatment.Q45947771
Fetal breathing, sleep state, and cardiovascular responses to adenosine in sheep.Q45954413
Venous responses to hypoxemia in the fetal lamb.Q45960024
Effects of hypoxaemia and hypercapnia on breathing movements and sleep state in sinoaortic-denervated fetal sheep.Q45976243
Hypoxia-induced cytosolic calcium decrease is mediated primarily by the forward mode of Na(+)/Ca(2+) exchanger in smooth muscle cells of fetal ductus arteriosus.Q45983323
The contribution of voltage-gated Ca2+ currents to K+ channel activation during ovine adrenal chromaffin cell development.Q46001846
Carotid, not aortic, chemoreceptors mediate the fetal cardiovascular response to acute hypoxemia in lambs.Q46026400
Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+ channel in rat carotid body glomus cells.Q46031621
Adenosine stimulates breathing in fetal sheep with brain stem section.Q46035797
Changes in the pulmonary circulation during birth-related events.Q46036540
Adenosine mediates hypoxic release of arginine vasopressin in fetal sheepQ46049544
Developmental change of T-type Ca2+ channel expression and its role in rat chromaffin cell responsiveness to acute hypoxiaQ46094270
Electrical stimulation of the posteromedial thalamus modulates breathing in unanesthetized fetal sheepQ46157553
Hypoxic inhibition of breathing in fetal sheep: relationship to brain adenosine concentrationsQ46167997
Perinatal alcohol exposure in rat induces long-term depression of respiration after episodic hypoxia.Q46184594
The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep.Q46185799
Thalamic locus mediates hypoxic inhibition of breathing in fetal sheepQ46237346
Fetal cardiovascular and breathing responses to an adenosine A2a receptor agonist in sheep.Q46379328
Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsiaQ46429560
Pulmonary hypertension and right ventricular dysfunction in growth-restricted, extremely low birth weight neonates.Q46437385
Umbilical and hepatic venous responses to circulating vasoconstrictive hormones in fetal lambQ46442058
Carotid body O2 chemoreception and mitochondrial oxidative phosphorylationQ70874833
Adenosine mediates metabolic and cardiovascular responses to hypoxia in fetal sheepQ70939212
The value of fetal arterial, cardiac and venous flows in predicting pH and blood gases measured in umbilical blood at cordocentesis in growth retarded fetusesQ71127683
Distribution and recirculation of umbilical and systemic venous blood flow in fetal lambs during hypoxiaQ71402772
The response to hypoxia of arterial chemoreceptors in fetal sheep and new-born lambsQ71434355
Circulatory and metabolic effects of alpha-adrenergic blockade in the hyperinsulinemic ovine fetusQ71511482
Adenosine receptors mediate both contractile and relaxant effects of adenosine in main pulmonary artery of guinea pigsQ71704199
Adenosine modulates hypoxia-induced atrial natriuretic peptide release in fetal sheepQ71949710
Attenuation of hypoxia-induced increases in ventilation by adenosine antagonists in rhesus monkeysQ71965071
Long-lasting effect of prolonged hypoxemia after birth on the immediate ventilatory response to changes in arterial partial pressure of oxygen in young lambsQ72242113
Plasma adenosine concentration in appropriate- and small-for-gestational-age fetusesQ72264047
Role of endogenous adenosine in hypoxic ventilatory response in humans: a study with dipyridamoleQ72403093
Adenosine and ATP cause nitric oxide-dependent pulmonary vasodilation in fetal lambsQ73109675
Fetal plasma lipid peroxide levels in pregnancies complicated by preeclampsiaQ73287803
cAMP production in rabbit carotid body: role of adenosineQ73394423
Stimulation of alpha 1-adrenoceptors and protein kinase C-mediated activation of ecto-5'-nucleotidase in rat hearts in vivoQ73677474
Prenatal hypoxia impairs the postnatal development of neural and functional chemoafferent pathway in ratQ73680807
Cardiac output and central distribution of blood flow in the human fetusQ73684396
Differential expression of a(2a), A(1)-adenosine and D(2)-dopamine receptor genes in rat peripheral arterial chemoreceptors during postnatal developmentQ74105904
Mice lacking in gp91 phox subunit of NAD(P)H oxidase showed glomus cell [Ca(2+)](i) and respiratory responses to hypoxiaQ74105968
Gene expression and function of adenosine A(2A) receptor in the rat carotid bodyQ74113015
Evidence that cytosolic and ecto 5'-nucleotidases contribute equally to increased interstitial adenosine concentration during porcine myocardial ischemiaQ78052928
Respiratory and metabolic responses to early postnatal chronic intermittent hypoxia and sustained hypoxia in the developing ratQ79301835
An analysis of the primary cardiovascular reflex effects of stimulation of the carotid body chemoreceptors in the dogQ79374745
Catecholamine secretion from rat foetal adrenal chromaffin cells and hypoxia sensitivityQ79429327
Adequate stimuli of the carotid body: more than an oxygen sensor?Q79755022
Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lungQ79827805
Oxidative stress and antioxidant status in fetal circulation in preeclampsiaQ80305596
Low cardiac output to the placenta: an early hemodynamic adaptive mechanism in intrauterine growth restrictionQ81712590
The ventilatory response to hypoxia in the newborn lamb after carotid body denervationQ93561459
Energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiersQ93776956
Chronic intermittent hypoxia reduces ventilatory long-term facilitation and enhances apnea frequency in newborn rats.Q51963779
Molecular evidence of placental hypoxia in preeclampsia.Q51975690
Development and mechanisms of fetal hypoxia in severe fetal growth restriction.Q52007238
The effect of development on the pattern of A1 and A2a-adenosine receptor gene and protein expression in rat peripheral arterial chemoreceptors.Q52018362
Fetal origins of adult disease: strength of effects and biological basis.Q52109997
Chronic hypoxia abolished the postnatal increase in carotid body type I cell sensitivity to hypoxia.Q52174550
Attenuation of the hypoxic ventilatory response in adult rats following one month of perinatal hyperoxia.Q52200054
Role of adenosine in the hypoxic ventilatory response of the newborn piglet.Q52220037
A2a adenosine receptor gene expression in developing rat brain.Q52221509
Distribution of maternal and fetal blood flow within cotyledons of the sheep placenta.Q52733951
Cardiac output and blood flow volume redistribution during acute maternal hypoxia in fetal sheep.Q54062506
Doppler ultrasound evaluation of ductus venosus blood flow during acute hypoxemia in fetal lambs.Q54130846
Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep.Q54249117
Hypoxic acidemia, hyperviscosity, and maternal hypertension do not affect the umbilical arterial velocity waveform in fetal sheep.Q54314614
Acute hypoxemia does not affect the umbilical artery flow velocity waveform in fetal sheep.Q54326891
Effect of placental embolization on the umbilical arterial velocity waveform in fetal sheep.Q54343618
Chronic hypoxia increases fetoplacental vascular resistance and vasoconstrictor reactivity in the ratQ55877026
The role of oxygen in prenatal growth: studies in the chick embryoQ57104391
Ventilation in newborn rats after gestation at simulated high altitudeQ57121696
Fetal Growth Restriction Is Associated With Prioritization of Umbilical Blood Flow to the Left Hepatic Lobe at the Expense of the Right LobeQ57273771
Ductus venosus shunting in growth-restricted fetuses and the effect of umbilical circulatory compromiseQ58495867
Fetal cardiac output, distribution to the placenta and impact of placental compromiseQ58495871
Stereological Investigation of Placental Morphology in Pregnancies Complicated by Pre-eclampsia with and without Intrauterine Growth RestrictionQ59366955
The role of carotid chemoreceptors in the effects of hypoxia on renal blood flow in the late gestation sheep fetusQ61052813
Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in uteroQ61052817
Action of adenosine and characterization of adenosine receptors in human placental vasculatureQ62059232
Blood flow to fetal organs as a function of arterial oxygen contentQ66970004
Role of plasma adenosine in breathing responses to hypoxia in fetal sheepQ67850055
Doppler investigation of the fetal circulationQ67941661
Quantitative studies of the vasculature of the carotid body in fetal and newborn sheepQ68042379
Cerebrovascular reactivity to adenosine analogues in 0.6-0.7 gestation and near-term fetal sheepQ68131903
Central effects of an alpha 2-adrenergic antagonist on fetal lambs: a possible mechanism for hypoxic apneaQ68170156
Long-term respiratory effects of neonatal hypoxia in the ratQ68348200
The response of the umbilical and femoral artery pulsatility indices in fetal sheep to progressively reduced uteroplacental blood flowQ68374979
Doppler examination of the middle cerebral artery in anemic fetusesQ68504166
Role of the carotid chemoreceptors in the respiratory response of newborn lambs to alternate pairs of breaths of air and a hypoxic gasQ68659947
Adenosine causes a biphasic response in the ovine fetal placental vasculatureQ68659958
Effects of chronic hypoxia from birth on the ventilatory response to acute hypoxia in the newborn ratQ68696922
Adenosine formation and energy metabolism: a 31P-NMR study in isolated rat heartQ68735197
Effect of adenosine on isolated and superfused cat carotid body activityQ68845945
Fetal breathing, sleep state, and cardiovascular responses to graded hypoxia in sheepQ68992695
Lesions in the upper lateral pons abolish the hypoxic depression of breathing in unanaesthetized fetal lambs in uteroQ69229406
Effects of regular and decaffeinated coffee on fetal breathing and heart rateQ69624029
Aminophylline effects on ventilatory response to hypoxia and hyperoxia in normal adultsQ69751945
Adenosine deaminase and adenosine uptake inhibitions facilitate ventilation in ratsQ69792703
Aminophylline reduces hypoxic ventilatory depression: possible role of adenosineQ69956585
Use of multiple radioligands to characterize adenosine receptors in human placentaQ70146915
Circulatory and humoral responses of sympathectomized fetal sheep to hypoxemiaQ70453845
Cardiovascular responses to hypoxemia in sinoaortic-denervated fetal sheepQ46497578
Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic respiratory chemoreflex in adult ratsQ46506174
The effects of caffeine on the preterm sheep ductus arteriosusQ46513243
Positron emission tomography analysis of [11C]KW-6002 binding to human and rat adenosine A2A receptors in the brainQ46529369
Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cellsQ46572514
Hypoxia reveals posterior thalamic, cerebellar, midbrain, and limbic deficits in congenital central hypoventilation syndromeQ46611270
Modest maternal caffeine exposure affects developing embryonic cardiovascular function and growthQ46687767
Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?Q46731926
The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep.Q46849283
Developmental plasticity of the carotid chemoafferent pathway in rats that are hypoxic during the prenatal period.Q46900864
The adenosine receptors present on the plasma membrane of chromaffin cells are of the A2b subtypeQ46956023
Development of ventilatory responsiveness to progressive hypoxia and hypercapnia in low-birth-weight lambsQ47324070
Evaluation of fetal intrapartum hypoxia by middle cerebral and umbilical artery Doppler velocimetry with simultaneous cardiotocography and pulse oximetryQ47402777
Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult ratsQ47644174
Changes in ventilatory adaptations associated with long-term intermittent hypoxia across the age spectrum in the rat.Q47793417
Level and duration of developmental hyperoxia influence impairment of hypoxic phrenic responses in ratsQ47814090
Relationship of the ventilatory response to hypoxia with neonatal apnea in preterm infantsQ48010668
Central origin of the hypoxic depression of breathing in the newbornQ48134163
Longitudinal brain perfusion changes in near-term small-for-gestational-age fetuses as measured by spectral Doppler indices or by fractional moving blood volumeQ48216414
Effect of insulin on the distribution of cardiac output in the fetal lambQ48226408
Fetal breathing movement, sleep state and cardiovascular responses to an inhibitor of mitochondrial ATPase in sheep.Q48383466
Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxiaQ48420875
Fetal brain sparing is strongly related to the degree of increased placental vascular impedanceQ48466973
Recurrent hypoxia in rats during development increases subsequent respiratory sensitivity to fentanylQ48489389
Characterization of [125I]ZM 241385 binding to adenosine A2A receptors in the pineal of sheep brainQ48503276
Source of extracellular brain adenosine during hypoxia in fetal sheepQ48540123
Day-night pattern of sudden death in obstructive sleep apneaQ48558148
Respiratory effects of gestational intermittent hypoxia in the developing rat.Q48634061
Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort studyQ48715089
Prognostic significance of the interaction between abnormal umbilical and middle cerebral artery Doppler velocimetry in pregnancies complicated by fetal growth restriction.Q48787774
Identification of brainstem neurons responding to hypoxia in fetal and newborn sheepQ48799894
Calcitonin gene-related peptide contributes to the umbilical haemodynamic defence response to acute hypoxaemiaQ48818730
Unilateral cooling in the region of locus coeruleus blocks the fall in respiratory output during hypoxia in anaesthetized neonatal sheepQ48871141
Adenosine infusion and periodic breathing during sleepQ48887800
Red nucleus lesions abolish the biphasic respiratory response to isocapnic hypoxia in decerebrate young rabbitsQ48942358
The effect of chronic hypoxia upon the development of respiratory chemoreflexes in the newborn kittenQ48944265
Potential cell signalling mechanisms involved in differential placental angiogenesis in mild and severe pre-eclampsiaQ50334572
Effect of adenosine on pulmonary circulation of rabbits.Q50519232
Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus.Q50720857
Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction.Q50734891
An in vivo nitric oxide clamp to investigate the influence of nitric oxide on continuous umbilical blood flow during acute hypoxaemia in the sheep fetus.Q51341516
Aminophylline partially blocks ventilatory depression with hypoxia in the awake cat.Q51633299
Cardiovascular responses to adenosine in fetal sheep: autonomic blockade.Q51673117
Neonatal exposure to 65% oxygen durably impairs lung architecture and breathing pattern in adult mice.Q51687212
Site-dependent effects of increases in placental vascular resistance on the umbilical arterial velocity waveform in fetal sheep.Q51743161
Ventilatory effects of adenosine mediated by carotid body chemoreceptors in the rat.Q51795375
Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability.Q51890344
New Doppler index for prediction of perinatal brain damage in growth-restricted and hypoxic fetuses.Q51907214
Clinical correlation between adenosine deaminase activity and pre-eclampsia severity.Q51936747
Hypoxia and mitochondrial oxidative metabolismQ37691909
Tuning and fine-tuning of synapses with adenosine.Q37700201
The role of ion channels in hypoxic pulmonary vasoconstrictionQ37702931
Fetal growth restriction - from observation to interventionQ37703260
Nitric oxide and oxidative stress in vascular diseaseQ37715827
The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysisQ37731210
Maturation of the antioxidant system and the effects on preterm birthQ37746371
Mitochondrial complex III: an essential component of universal oxygen sensing machinery?Q37779842
Mechanisms for acute oxygen sensing in the carotid bodyQ37782164
A revisit to O2 sensing and transduction in the carotid body chemoreceptors in the context of reactive oxygen species biology.Q37787556
Regulation of hypoxia inducible factors (HIF) in hypoxia and normoxia during placental development.Q37792446
Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in MetazoansQ37799688
Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentaeQ38336049
Factors affecting gas transfer across the placenta and the oxygen supply to the fetusQ38787342
The importance of baro- and chemoreflexes in the control of the fetal cardiovascular systemQ39573698
Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survivalQ39634161
Ion channel regulation by AMPK: the route of hypoxia-response coupling in thecarotid body and pulmonary artery.Q39785093
AMP-activated protein kinase inhibits TREK channelsQ39785772
Distribution and regulation of blood flow in the fetal and neonatal lambQ39834351
Auto-inhibition of rat parallel fibre-Purkinje cell synapses by activity-dependent adenosine releaseQ40009462
Adenosine A2a receptor-mediated, normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages.Q40132540
The central control of fetal breathing and skeletal muscle movementsQ40210822
Regulation of blood flow through the ductus venosus.Q40303617
Oxygen-sensing pathway for SK channels in the ovine adrenal medulla.Q40371017
NOX4 as an oxygen sensor to regulate TASK-1 activityQ40397773
Control of vascular resistance in the maternal and feto-placental arterial bedsQ40551065
Adenosine modulates hypoxia-induced responses in rat PC12 cells via the A2A receptorQ41037134
Adenosine A2 receptor-mediated excitatory actions on the nervous systemQ41059796
Hypoxia and brain developmentQ41119056
Changes in plasma adenosine during simulated birth of fetal sheepQ41188355
Effects on carotid chemoreceptor resetting of pulmonary ventilation in the fetal lamb in utero.Q41389594
Hormonal role of adenosine in maintaining patency of the ductus arteriosus in fetal lambsQ41500789
Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal gangliaQ41624006
Adenosine modulates corticotropin and cortisol release during hypoxia in fetal sheepQ41665388
Red nucleus inhibits breathing during hypoxia in neonatesQ41667732
Developmental plasticity of the hypoxic ventilatory responseQ41667738
Fetal arterial Doppler-IUGR and hypoxiaQ41692062
Thalamic lesions dissociate breathing inhibition by hypoxia and adenosine in fetal sheepQ41728400
Acute oxygen sensing in heme oxygenase-2 null miceQ41839871
DNA synthesis is reduced in selected fetal tissues during prolonged hypoxemiaQ41901618
The relationship between the umbilical artery systolic/diastolic ratio and umbilical blood gas measurements in specimens obtained by cordocentesisQ42124108
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascadeQ42160057
Regulation of rat heart cytosol 5'-nucleotidase by adenylate energy chargeQ42165473
Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constrictionQ42165626
Adenosine A2A receptors are expressed by GABAergic neurons of medulla oblongata in developing rat.Q42168761
Pharmacological characterization of the receptor involved in chemoexcitation induced by adenosineQ42265890
Activation of A2-purinoceptors by adenosine stimulates L-arginine transport (system y+) and nitric oxide synthesis in human fetal endothelial cellsQ42435604
Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A2A and GABA A receptor mRNA transcriptionQ42440368
Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine releaseQ42442065
Effects of acute acidemia on the fetal cardiovascular defense to acute hypoxemia.Q42443257
AMP-activated protein kinase and the regulation of Ca2+ signalling in O2-sensing cellsQ36482354
Fetal cerebrovascular response to chronic hypoxia--implications for the prevention of brain damageQ36573075
Reactive oxygen species cerebral autoregulation in health and diseaseQ36617246
The role of NADPH oxidase in carotid body arterial chemoreceptorsQ36708232
Is ATP a suitable co-transmitter in carotid body arterial chemoreceptors?Q36727340
Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneasQ36743171
Mechanisms of acute oxygen sensing by the carotid body: lessons from genetically modified animalsQ36759765
Purines, the carotid body and respiration.Q36769620
TASK-like potassium channels and oxygen sensing in the carotid bodyQ36784629
The relationship between uterine artery Doppler velocimetry and umbilical venous adenosine levels in pregnancies complicated by preeclampsiaQ36792139
Peripheral arterial chemoreceptors and sudden infant death syndromeQ36796518
Brain structural changes in obstructive sleep apneaQ36800544
P433issue3
P304page(s)R601-22
P577publication date2011-06-15
P1433published inAmerican Journal of Physiology - Regulatory, Integrative and Comparative PhysiologyQ2201819
P1476titleAdenosine A₂a receptors and O₂ sensing in development
P478volume301

Reverse relations

cites work (P2860)
Q38043832Carotid chemoreceptor "resetting" revisited
Q38223735Developmental programming of cardiovascular disease by prenatal hypoxia.
Q36706940Laryngeal reflex apnea in neonates: effects of CO2 and the complex influence of hypoxia
Q56811510Loss of from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice
Q91619653Mitochondrial Dysfunction and Changes in High-Energy Compounds in Different Cellular Models Associated to Hypoxia: Implication to Schizophrenia
Q38110513Neuromodulation: purinergic signaling in respiratory control
Q35836829Regulation of cardiovascular development by adenosine and adenosine-mediated embryo protection
Q34633405Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes
Q36902549Thalamic mediation of hypoxic respiratory depression in lambs
Q37721517The Role of Adenosine Signaling in Headache: A Review
Q38614901The fetal brain sparing response to hypoxia: physiological mechanisms.

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