Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia

scientific article published on 09 December 2008

Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.PLACENTA.2008.11.003
P932PMC publication ID2684656
P698PubMed publication ID19081132
P5875ResearchGate publication ID23661958

P2093author name stringG J Burton
T Cindrova-Davies
D S Charnock-Jones
H-W Yung
P2860cites workHyperuricemia and xanthine oxidase in preeclampsia, revisitedQ40951966
Morphological changes of the spiral arteries in the placental bed in relation to pre-eclampsia and fetal growth retardationQ41637367
The ultrastructure of the arterial supply of the human placenta in pregnancy complicated by fetal growth retardationQ42446824
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.Q44044678
Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restrictionQ44629064
Placental mitochondria as a source of oxidative stress in pre-eclampsiaQ45115339
Gabor Than Award Lecture 2008: pre-eclampsia - from placental oxidative stress to maternal endothelial dysfunctionQ46334762
Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions?Q46342132
Increased expression of N-myc downstream-regulated gene 1 (NDRG1) in placentas from pregnancies complicated by intrauterine growth restriction or preeclampsia.Q53575971
Urinary Placental Growth Factor and Risk of PreeclampsiaQ56619498
Soluble fms-Like Tyrosine Kinase 1 Is Increased in Preeclampsia But Not in Normotensive Pregnancies with Small-for-Gestational-Age Neonates: Relationship to Circulating Placental Growth FactorQ56619503
Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsiaQ57671364
Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restrictionQ58623928
The Placenta in Pre-eclampsia and Intrauterine Growth Restriction: Studies on Exchange Surface Areas, Diffusion Distances and Villous Membrane Diffusive ConductancesQ59366382
Increased placental apoptosis in pregnancies complicated by preeclampsiaQ59367145
Increased placental apoptosis in intrauterine growth restrictionQ59367671
The maternal plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated in SGA and the magnitude of the increase relates to Doppler abnormalities in the maternal and fetal circulationQ61845344
Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infantsQ69685000
Cell-free fetal DNA in the plasma of pregnant women with severe fetal growth restrictionQ73015033
Placental apoptosis in preeclampsiaQ74047219
Decreased expression of thioredoxin and glutaredoxin in placentae from pregnancies with pre-eclampsia and intrauterine growth restrictionQ74312079
Does endothelial cell activation occur with intrauterine growth restriction?Q74503868
A STUDY OF THE SPIRAL ARTERIES OF THE DECIDUA BASALIS IN NORMOTENSIVE AND HYPERTENSIVE PREGNANCIESQ76788299
Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardationQ77543305
Is oxidative stress the link in the two-stage model of pre-eclampsia?Q78258200
Endoplasmic reticulum stress: cell life and death decisions.Q24536108
Oxidative protein folding in eukaryotes: mechanisms and consequencesQ24676827
Hypoxia-activated genes from early placenta are elevated in preeclampsia, but not in Intra-Uterine Growth RetardationQ24816630
Fetal growth retardation and the arteries of the placental bedQ28235971
A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnanciesQ28239787
In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnanciesQ28350804
Protein kinase B alpha/Akt1 regulates placental development and fetal growthQ28588076
Oxidative stress in the pathogenesis of preeclampsiaQ33796834
Placental debris, oxidative stress and pre-eclampsiaQ34032003
A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsiaQ34404307
Latest advances in understanding preeclampsiaQ34425288
The human placental bed revisitedQ34934408
The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: a review of the literatureQ35002391
Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia.Q35096089
Trophoblastic oxidative stress and the release of cell-free feto-placental DNA.Q35221979
Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progressionQ35552863
Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidantQ35757165
Oxidative stress in the placentaQ35833479
Cerebral ischemia and the unfolded protein responseQ35893250
Oxidative stress, gene expression, and protein changes induced in the human placenta during laborQ36007397
Placental phenotypes of intrauterine growthQ36267751
Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathwayQ36313774
Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsiaQ36524450
ER stress and diseases.Q36731474
Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.Q36778250
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infantsQ37243746
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectpre-eclampsiaQ61335
endoplasmic reticulumQ79927
oxidative stressQ898814
pathophysiologyQ1135939
intrauterine growth restrictionQ1671598
placental insufficiencyQ2099138
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)S43-8
P577publication date2008-12-09
2009-03-01
P1433published inPlacentaQ7200288
P1476titlePlacental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia
P478volume30 Suppl A

Reverse relations

cites work (P2860)
Q337518903D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby.
Q34444375A transcriptional profile of the decidua in preeclampsia
Q47886362ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells
Q46491999Abnormal Placentation Associated with Infertility as a Marker of Overall Health
Q53639289Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome.
Q36328239Alpha-1-antitrypsin suppresses oxidative stress in preeclampsia by inhibiting the p38MAPK signaling pathway: An in vivo and in vitro study
Q99551832Altered gestational outcomes and delayed pubertal onset in prenatally and early postnatally food restricted male and female rats: mitigation by quercetin and kaempferol
Q41839328Angiogenesis in the placenta: the role of reactive oxygen species signaling
Q38370968Angiogenic biomarkers in pregnancy: defining maternal and fetal health
Q57316846Association of Doppler parameters with placental signs of underperfusion in late-onset small-for-gestational-age pregnancies
Q38104276Association of microparticles and preeclampsia
Q45230594Can maternal serum placental growth factor estimation in early second trimester predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction? A prospective cohort study
Q35980425Changes in Copper, Zinc, and Malondialdehyde Levels and Superoxide Dismutase Activities in Pre-Eclamptic Pregnancies
Q37612423Changes of placental syndecan-1 expression in preeclampsia and HELLP syndrome
Q57316839Correlation between histological signs of placental underperfusion and perinatal morbidity in late-onset small-for-gestational-age fetuses
Q44745098Correlation of paraoxonase1 activities with birth weight
Q37149069Decidual cell regulation of natural killer cell-recruiting chemokines: implications for the pathogenesis and prediction of preeclampsia
Q47159835Deciphering transcriptional regulation in human embryonic stem cells specified towards a trophoblast fate
Q34182374Differences and similarities in the transcriptional profile of peripheral whole blood in early and late-onset preeclampsia: insights into the molecular basis of the phenotype of preeclampsiaa
Q54342986Distinct roles for S100a8 in early embryo development and in the maternal deciduum.
Q33976312Dysregulated complement activation as a common pathway of injury in preeclampsia and other pregnancy complications
Q92590467Early onset of renal oxidative stress in small for gestational age newborn pigs
Q64253779Early onset preeclampsia in a model for human placental trophoblast
Q90700304Early pregnancy bisphenol and phthalate metabolite levels, maternal hemodynamics and gestational hypertensive disorders
Q64226471Effect of Oxidative Stress on the Estrogen-NOS-NO-K Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications
Q33744933Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial.
Q92702860Effects of Maternal Fructose Intake on Perinatal ER-Stress: A Defective XBP1s Nuclear Translocation Affects the ER-stress Resolution
Q28084110Endoplasmic reticulum stress in periimplantation embryos
Q50643277Endoplasmic reticulum stress is increased after spontaneous labor in human fetal membranes and myometrium where it regulates the expression of prolabor mediators.
Q35902115Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats
Q42367742Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor
Q47929679Environmental chemicals and preterm birth: Biological mechanisms and the state of the science.
Q40491658Erythropoietin and Soluble Erythropoietin Receptor: A Role for Maternal Vascular Adaptation to High-Altitude Pregnancy
Q34372600Evolutionary origins of the placental expression of chromosome 19 cluster galectins and their complex dysregulation in preeclampsia
Q35007417FOXO1 expression in villous trophoblast of preeclampsia and fetal growth restriction placentas
Q46329620Favorable Maternal and Fetal Effects of Danshensu in an Experimental Mice Model of Preeclampsia
Q94522049Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia
Q34041888Fetal programming and metabolic syndrome
Q41582146Fetal sex dependency of maternal vascular adaptation to pregnancy: a prospective population-based cohort study
Q34445181Feto-placental adaptations to maternal obesity in the baboon
Q35362708Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice
Q28081459Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia
Q39172256Gestational food restriction decreases placental interleukin-10 expression and markers of autophagy and endoplasmic reticulum stress in murine intrauterine growth restriction
Q24298359Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
Q102053975Identifying potential biomarkers related to pre-term delivery by proteomic analysis of amniotic fluid
Q47550799Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father
Q37854853Impact of dietary soy isoflavones in pregnancy on fetal programming of endothelial function in offspring
Q36111159Impact of oxidative stress in fetal programming
Q34505704In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy
Q41103787Incident Coronary Heart Disease After Preeclampsia: Role of Reduced Fetal Growth, Preterm Delivery, and Parity
Q34345453Increased autophagy in placentas of intrauterine growth-restricted pregnancies
Q35534279Increased endoplasmic reticulum stress in decidual tissue from pregnancies complicated by fetal growth restriction with and without pre-eclampsia
Q38816011Innate Immune System at the Maternal-Fetal Interface: Mechanisms of Disease and Targets of Therapy in Pregnancy Syndromes
Q58795465Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia
Q35243821Interleukin-10: a pleiotropic regulator in pregnancy
Q36435256Interleukin-11 alters placentation and causes preeclampsia features in mice
Q37487239Intrauterine growth restriction, human placental development and trophoblast cell death
Q36857971Intrauterine trophoblast migration: A comparative view of humans and rodents
Q37686924Involvement of miRNAs in placental alterations mediated by oxidative stress.
Q34064856Is fetal growth restriction associated with a more severe maternal phenotype in the setting of early onset pre-eclampsia? A retrospective study
Q35178408Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism
Q90191966Maternal Exposure to Ambient Air Pollution and Risk of Preeclampsia: A Population-Based Cohort Study in Scania, Sweden
Q92636314Maternal Serum Placental Growth Factor, Soluble Fms-Like Tyrosine Kinase-1, and Soluble Endoglin in Twin Gestations and the Risk of Preeclampsia-A Systematic Review
Q64112691Maternal Supplementation with Antioxidant Vitamins in Sheep Results in Increased Transfer to the Fetus and Improvement of Fetal Antioxidant Status and Development
Q34245469Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2.
Q41657065Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis.
Q34619975Maternal plasma concentrations of sST2 and angiogenic/anti-angiogenic factors in preeclampsia.
Q55004295Maternal plasma fetuin-A concentration is lower in patients who subsequently developed preterm preeclampsia than in uncomplicated pregnancy: a longitudinal study.
Q34078658Maternal vitamin D status in preeclampsia: seasonal changes are not influenced by placental gene expression of vitamin D metabolizing enzymes
Q56879162Measurement of spiral artery jets: general principles and differences observed in small-for-gestational-age pregnancies
Q39376655Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity
Q37567589Microarray profiling reveals that placental transcriptomes of early-onset HELLP syndrome and preeclampsia are similar
Q43375827Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders
Q92689931Molecular pathways of senescence regulate placental structure and function
Q64092899More Maternal Vascular Malperfusion and Chorioamnionitis in Placentas After Expectant Management vs. Immediate Delivery in Fetal Growth Restriction at (Near) Term: A Further Analysis of the DIGITAT Trial
Q90394758N-Acetylcysteine protects against intrauterine growth retardation-induced intestinal injury via restoring redox status and mitochondrial function in neonatal piglets
Q90340201NADPH oxidase is the major source of placental superoxide in early pregnancy: association with MAPK pathway activation
Q35013259Natural killer cells and regulatory T cells in early pregnancy loss
Q36214135Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates
Q39380099Overexpression of calreticulin in pre-eclamptic placentas: effect on apoptosis, cell invasion and severity of pre-eclampsia
Q60949465Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment
Q38641180Oxidative Stress: Placenta Function and Dysfunction
Q59633631Oxidative stress
Q26830141Oxidative stress in preeclampsia and the role of free fetal hemoglobin
Q38954940Oxidative stress in pregnancy and reproduction.
Q38752852Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes
Q28742192PP13, maternal ABO blood groups and the risk assessment of pregnancy complications
Q35607465Pathogenesis of preeclampsia: the genetic component
Q33693037Pathophysiology of ischemic placental disease
Q59796448Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model
Q30245567Placental Origins of Chronic Disease
Q26861380Placental Protein 13 (PP13) - A Placental Immunoregulatory Galectin Protecting Pregnancy
Q54256280Placental Regulation of Inflammation and Hypoxia after TNF-α Infusion in Mice.
Q37337545Placental disease and the maternal syndrome of preeclampsia: missing links?
Q36667589Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6β: implications for the pathophysiology of human pregnancy complications
Q59135607Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery
Q36480074Placental protein 13 (PP13/galectin-13) undergoes lipid raft-associated subcellular redistribution in the syncytiotrophoblast in preterm preeclampsia and HELLP syndrome.
Q64115565Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Placental Gene Expression and Fetal Antioxidant Status, DNA-Methylation and Phenotype
Q33699038Polyphenols and IUGR pregnancies: Maternal hydroxytyrosol supplementation improves prenatal and early-postnatal growth and metabolism of the offspring.
Q56019568Pre-eclampsia
Q33416340Pre-eclampsia part 1: current understanding of its pathophysiology
Q38828159Preeclampsia and the Risk of Future Vascular Disease and Mortality: A Review
Q60913447Preeclampsia in 2018: Revisiting Concepts, Physiopathology, and Prediction
Q37534671Preeclampsia is associated with alterations in the p53-pathway in villous trophoblast
Q89861390Preeclampsia: The Interplay Between Oxygen-Sensitive miRNAs and Erythropoietin
Q96230008Pregnancy and cardiovascular disease
Q29248701Prenatal Lead Exposure and Fetal Growth: Smaller Infants Have Heightened Susceptibility
Q50430668Prenatal hypoxia and placental oxidative stress: linkages to developmental origins of cardiovascular disease
Q34635145Pro-inflammatory profile of preeclamptic placental mesenchymal stromal cells: new insights into the etiopathogenesis of preeclampsia
Q47295190Progesterone inhibited endoplasmic reticulum stress associated apoptosis induced by interleukin-1β via the GRP78/PERK/CHOP pathway in BeWo cells.
Q64945574Proteomic identification of membrane-associated placental protein 4 (MP4) as perlecan and characterization of its placental expression in normal and pathologic pregnancies.
Q30235366Provocative ideas on human placental biology: A prerequisite for prevention and treatment of neonatal health challenges
Q36018182Reactive oxygen species-triggered trophoblast apoptosis is initiated by endoplasmic reticulum stress via activation of caspase-12, CHOP, and the JNK pathway in Toxoplasma gondii infection in mice
Q33441799Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy
Q39043919Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies.
Q35033616Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth
Q39227831Roles of Grp78 in Female Mammalian Reproduction
Q52958837Roles of oxidative stress and endoplasmic reticulum stress in selenium deficiency-induced apoptosis in chicken liver.
Q34997391Selenium status in U.K. pregnant women and its relationship with hypertensive conditions of pregnancy
Q64980896Sex-Specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia.
Q36862632Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model.
Q56330679Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness
Q90090385Status of VEGF in preeclampsia and its effect on endoplasmic reticulum stress in placental trophoblast cells
Q33870546Syncytiotrophoblast derived extracellular vesicles transfer functional placental miRNAs to primary human endothelial cells
Q30356149Syncytiotrophoblast extracellular vesicles - Circulating biopsies reflecting placental health.
Q58188912The Free Radical Diseases of Prematurity: From Cellular Mechanisms to Bedside
Q41651141The Paraoxonase 1 Arylesterase Activity, Total Oxidative Stress, Nitric Oxide and Vitamin C Levels in Maternal Serum, and Their Relation to Birth Weight of Newborn
Q34150192The anti-aging factor α-klotho during human pregnancy and its expression in pregnancies complicated by small-for-gestational-age neonates and/or preeclampsia
Q36004213The double life of MULE in preeclamptic and IUGR placentae
Q28392215The effects of oxidative stress on female reproduction: a review
Q52631138The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia.
Q84413068The expression of pentraxin 3 and tumor necrosis factor-alpha is increased in preeclamptic placental tissue and maternal serum
Q36053252The placenta in preeclampsia
Q27687553The placenta: a multifaceted, transient organ
Q50102668The profiles of soluble adhesion molecules in the "great obstetrical syndromes".
Q98770895The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis
Q38506665The roles of endoplasmic reticulum stress response in female mammalian reproduction
Q50663287Thinking Outside the Box.
Q36309225Timing of ischemic insult alters fetal growth trajectory, maternal angiogenic balance, and markers of renal oxidative stress in the pregnant rat.
Q60510168Translocon-associated protein subunit Trap-γ/Ssr3 is required for vascular network formation in the mouse placenta
Q38638997Understanding Pre-Eclampsia Using Alzheimer's Etiology: An Intriguing Viewpoint
Q91587411Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction
Q36300246Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent.
Q47997086VEGF and VEGFR1 levels in different regions of the normal and preeclampsia placentae
Q47548778Vitamin E as an Antioxidant in Female Reproductive Health.
Q37484037eNOS/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia

Search more.