Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles

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Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1090707324
P356DOI10.1038/S41598-017-06178-Z
P932PMC publication ID5517616
P698PubMed publication ID28725005

P2093author name stringMichelle O'Brien
Dora Baczyk
John C Kingdom
P2860cites workRole of Extracellular Vesicles and microRNAs on Dysfunctional Angiogenesis during Preeclamptic PregnanciesQ26752382
Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsiaQ28073735
Exosomes in tumor microenvironment: novel transporters and biomarkersQ28079003
A gestational profile of placental exosomes in maternal plasma and their effects on endothelial cell migrationQ33721444
The effect of placental syncytiotrophoblast microvillous membranes from normal and pre-eclamptic women on the growth of endothelial cells in vitro.Q52515281
Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.Q52858097
Characterization of the soluble fms-like tyrosine kinase-1 to placental growth factor ratio in pregnancies complicated by fetal growth restriction.Q52875597
Effect of syncytiotrophoblast microvillous membrane treatment on gene expression in human umbilical vein endothelial cells.Q54574981
Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restrictionQ58623928
Pre-eclampsiaQ59546003
Trophoblast deportation in pre-eclamptic pregnancyQ67780828
Human placental syncytiotrophoblast microvillous membranes impair maternal vascular endothelial functionQ73154757
Plasma from women with pre-eclampsia induces an in vitro alteration in the endothelium-dependent behaviour of myometrial resistance arteriesQ73381908
Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnanciesQ74731060
Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticlesQ80178439
Angiogenic response of placental villi to heparinQ84180277
Trophoblast debris extruded from preeclamptic placentae activates endothelial cells: a mechanism by which the placenta communicates with the maternal endotheliumQ87511503
Placental expression of vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical preeclampsia and villous hypermaturityQ33824642
Standardization of sample collection, isolation and analysis methods in extracellular vesicle researchQ34369038
Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in PregnancyQ34379583
Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular VesiclesQ34455456
Extracellular vesicles and reproduction-promotion of successful pregnancyQ34455617
Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglinQ34599422
Biological properties of extracellular vesicles and their physiological functions.Q35611763
Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsiaQ35871466
Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell InteractionsQ36489261
Preeclampsia and Pregnancy-Related Hypertensive DisordersQ36584747
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a smaQ36984261
Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women.Q37024446
Trophoblast deportation: just a waste disposal system or antigen sharing?Q37844935
Extracellular vesicles: biology and emerging therapeutic opportunities.Q38098874
Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantagesQ38180964
Placenta-derived exosomes and syncytiotrophoblast microparticles and their role in human reproduction: immune modulation for pregnancy successQ38244018
Unsupervised Placental Gene Expression Profiling Identifies Clinically Relevant Subclasses of Human PreeclampsiaQ38447616
Classification of placental lesionsQ38597297
The Role of Exosomes in Breast CancerQ38607305
Proteomic analysis of exosomal cargo: the challenge of high purity vesicle isolation.Q38794211
Human trophoblast-derived exosomal fibronectin induces pro-inflammatory IL-1β production by macrophagesQ39575333
Cardiac output and related haemodynamics during pregnancy: a series of meta-analysesQ40078917
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.Q44044678
Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter studyQ45747422
Preeclampsia is associated with the presence of transcriptionally active placental fragments in the maternal lungQ46727905
Microvesicles of pregnant women receiving low molecular weight heparin improve trophoblast functionQ47342479
Sex-specific basis of severe placental dysfunction leading to extreme preterm deliveryQ47887570
Multicolor flow cytometry and nanoparticle tracking analysis of extracellular vesicles in the plasma of normal pregnant and pre-eclamptic women.Q48704434
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpre-eclampsiaQ61335
endotheliumQ111140
extracellular vesicleQ21097485
P304page(s)5887
P577publication date2017-07-19
P1433published inScientific ReportsQ2261792
P1476titleEndothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles
P478volume7

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cites work (P2860)
Q92110266Circulating endocan and preeclampsia: a meta-analysis
Q64253779Early onset preeclampsia in a model for human placental trophoblast
Q66678773Incidence and risk factors of transfusion reactions in postpartum blood transfusions
Q93156154Molecular Targets of Aspirin and Prevention of Preeclampsia and Their Potential Association with Circulating Extracellular Vesicles during Pregnancy
Q91774904Placental growth factor testing for suspected pre-eclampsia
Q59328860Reduced Uteroplacental Perfusion Pressure (RUPP) causes altered trophoblast differentiation and pericyte reduction in the mouse placenta labyrinth
Q89610277The Pathological Relevance of Increased Endothelial Glycocalyx Permeability
Q64090237The performance of pre-delivery serum concentrations of angiogenic factors in predicting postpartum antihypertensive drug therapy following abdominal delivery in severe preeclampsia and normotensive pregnancy

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