The biology of Stat4 and Stat6

scientific article (publication date: 15 May 2000)

The biology of Stat4 and Stat6 is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1019341913
P356DOI10.1038/SJ.ONC.1203485
P3181OpenCitations bibliographic resource ID3934214
P698PubMed publication ID10851056
P5875ResearchGate publication ID12467612

P2093author name stringT Tanaka
A L Wurster
M J Grusby
P2860cites workRequirements for interleukin-4-induced gene expression and functional characterization of Stat6Q24308078
Mutational analysis of the STAT6 SH2 domainQ24311539
A family of cytokine-inducible inhibitors of signallingQ24313168
A new protein containing an SH2 domain that inhibits JAK kinasesQ24313242
Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor geneQ24324698
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcriptionQ24522496
Structure of the amino-terminal protein interaction domain of STAT-4Q27748849
Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cellsQ28142061
The IL-4 receptor: signaling mechanisms and biologic functionsQ28198739
Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cellsQ28237381
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiationQ28243701
An interleukin-4-induced transcription factor: IL-4 StatQ28248059
Essential role of Stat6 in IL-4 signallingQ28276199
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 geneQ28276209
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylationQ28288257
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytesQ28295404
cDNA cloning and characterization of the human interleukin 13 receptor alpha chainQ28296335
The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokinesQ28509281
Structure and function of a new STAT-induced STAT inhibitorQ28584775
Control of inflammation, cytokine expression, and germinal center formation by BCL-6Q28585541
Stat3 and Stat4: members of the family of signal transducers and activators of transcriptionQ28610081
Functional diversity of helper T lymphocytesQ29619415
Jaks and STATs: biological implicationsQ29619657
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient miceQ31949951
Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptorQ33633115
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteinsQ33734222
Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector functionQ33776116
Stat proteins control lymphocyte proliferation by regulating p27Kip1 expressionQ33994618
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cellsQ34388169
Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6.Q35671051
Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: a cellular signal for hypertrophy in cardiac muscleQ36092619
Cytokine-induced immune deviation as a therapy for inflammatory autoimmune diseaseQ36364080
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.Q36364256
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4Q36364774
Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cellsQ36368055
Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cellsQ36376864
Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus productionQ36400465
Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient miceQ36400723
A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cellsQ36401785
The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.Q36454430
Functional subsets of allergen-reactive human CD4+ T cellsQ36544291
Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesisQ36551756
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.Q36596732
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.Q36735213
T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6.Q36799306
The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.Q36804149
Defective STAT signaling by the leptin receptor in diabetic miceQ37509613
Checkpoints in the progression of autoimmune disease: lessons from diabetes modelsQ37689425
Human interleukin-13 activates the interleukin-4-dependent transcription factor NF-IL4 sharing a DNA binding motif with an interferon-gamma-induced nuclear binding factorQ38307929
Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domainQ38354217
Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cellsQ40022554
Products from mast cells influence T lymphocyte proliferation and cytokine production--relevant to allergic asthma?Q41106448
P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family membersQ41145752
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient miceQ41185362
Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?Q41558461
Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cellsQ41712990
Cytokines induce the development of functionally heterogeneous T helper cell subsetsQ41732572
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapyQ42675165
Stat6 and Jak1 are common elements in platelet-derived growth factor and interleukin-4 signal transduction pathways in NIH 3T3 fibroblastsQ42809070
Components of a Stat recognition code: evidence for two layers of molecular selectivityQ44747920
The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptorQ46855643
The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.Q50335906
Disruption of the murine IL-4 gene blocks Th2 cytokine responses.Q52516840
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.Q55066450
STATs as Mediators of Cytokine-Induced ResponsesQ56555369
Generation and analysis of interleukin-4 deficient miceQ57339987
Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent MechanismQ61357092
Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptorQ71066464
IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responsesQ71079171
Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4Q72105063
An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growthQ72284713
Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptorQ72411348
Allergy-associated I epsilon and Ec epsilon receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive elementQ72650413
Multistage regulation of Th1-type immune responses by the transcription factor IRF-1Q73479951
Interferon regulatory factor-1 is required for a T helper 1 immune response in vivoQ73479956
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiationQ77769108
Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17Q78128202
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)2577-84
P577publication date2000-05-15
P1433published inOncogeneQ1568657
P1476titleThe biology of Stat4 and Stat6
P478volume19

Reverse relations

cites work (P2860)
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