A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells

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A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.188.6.1191
P932PMC publication ID2212539
P698PubMed publication ID9743537
P5875ResearchGate publication ID13541411

P50authorMichael J GrusbyQ114438980
P2093author name stringA L Wurster
M H Kaplan
P2860cites workLigand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsetsQ41270009
P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skinQ42947599
Male development of chromosomally female mice transgenic for Sry.Q44051365
IL-4 directs the development of Th2-like helper effectorsQ46390956
Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.Q51123887
Disruption of the murine IL-4 gene blocks Th2 cytokine responses.Q52516840
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.Q55066450
Generation and analysis of interleukin-4 deficient miceQ57339987
P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissuesQ58808007
IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responsesQ71079171
Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cellsQ71902890
Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptorQ73588565
Selective expression of the eotaxin receptor CCR3 by human T helper 2 cellsQ24312942
Essential role of Stat6 in IL-4 signallingQ28276199
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 geneQ28276209
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophagesQ29618421
Functional diversity of helper T lymphocytesQ29619415
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cellsQ34388169
In differentiated CD4+ T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependentQ36082730
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducersQ36361001
Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cellsQ36376864
Interleukin 4 suppresses interleukin 2 and interferon gamma production by naive T cells stimulated by accessory cell-dependent receptor engagementQ36383339
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.Q36596732
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic systemQ37092217
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient miceQ41185362
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1191-1196
P577publication date1998-09-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleA signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells
P478volume188

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cites work (P2860)
Q34467924A call to arms: the cytokine selection service
Q37165356An insight into molecular mechanisms of human T helper cell differentiation
Q39865699CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis
Q60489257Cancer immunoediting and resistance to T cell-based immunotherapy
Q24797282Chitosan IFN-gamma-pDNA Nanoparticle (CIN) Therapy for Allergic Asthma
Q33653009Chromatin-based regulatory mechanisms governing cytokine gene transcription.
Q34700403Cytokine memory of T helper lymphocytes
Q33970977Cytokines and T cells in host defense
Q33704345Dealing from the evolutionary pawnshop: how lymphocytes make decisions
Q36368677Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells
Q34023428Dendritic cell regulation of TH1-TH2 development
Q52932975Early Th1/Th2 cell polarization in the absence of IL-4 and IL-12: T cell receptor signaling regulates the response to cytokines in CD4 and CD8 T cells.
Q46001789Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.
Q36167827Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
Q53618476Factors effecting the Th2-like immune response after gamma-irradiation: low production of IL-12 heterodimer in antigen-presenting cells and small expression of the IL-12 receptor in T cells.
Q37544473GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.
Q34282360Helper T cell differentiation, inside and out.
Q37502276How diverse--CD4 effector T cells and their functions
Q33664116Human CD4+ T cell differentiation and effector function: implications for autoimmunity
Q43710674IL-12, while beneficial, is not essential for the host response to VSV encephalitis
Q45069275In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting
Q34976848Infection-Triggered Regulatory Mechanisms Override the Role of STAT 4 in Control of the Immune Response to Influenza Virus Antigens
Q35783782Interleukin-12 drives the Th1 signaling pathway in Helicobacter pylori-infected human gastric mucosa.
Q34005268Interleukin-18 (IL-18) enhances innate IL-12-mediated resistance to Toxoplasma gondii
Q34987949Jaks, STATs, Cytokines, and Sepsis
Q24806655Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation
Q36368055Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells
Q26776185Luminal Conversion and Immunoregulation by Probiotics
Q34438456Maternal schistosomiasis: a growing concern in sub-Saharan Africa
Q52707883Mechanisms of Resistance to PD-1 and PD-L1 Blockade.
Q50502998Molecular characterization of the porcine STAT4 and STAT6 genes.
Q33607430Molecular regulation of cytokine gene expression during the immune response
Q35641142Opposing roles of NF-kappaB family members in the regulation of NK cell proliferation and production of IFN-gamma
Q48034535Oral tolerization with cardiac myosin peptide (614-629) ameliorates experimental autoimmune myocarditis: role of STAT 6 genes in BALB/CJ mice
Q39130451Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
Q34099106Review article: molecular signals and genetic reprogramming in peripheral T-cell differentiation
Q78162673STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis
Q36053053STAT3 and transactivation of steroid hormone receptors
Q35819291STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.
Q36257181STAT4 deficiency reduces the development of atherosclerosis in mice
Q34402250STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection.
Q28590165STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation
Q28250212STAT4: a critical regulator of inflammation in vivo
Q34185042SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells
Q35951819Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.
Q28201804Signaling through the JAK/STAT pathway, recent advances and future challenges
Q42130325Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation
Q34290627Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis
Q34537828T helper subset development: roles of instruction, selection, and transcription
Q74082060T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
Q36228437T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription
Q64377742TNF Enhances CD4+ T Cell Alloproliferation, IFN-γ Responses, and Intestinal Graft-Versus-Host Disease by IL-12-Independent Mechanisms
Q35158939Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets
Q74471802Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M
Q34319955Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways
Q28138102The biology of Stat4 and Stat6
Q37376021The different faces of Notch in T-helper-cell differentiation
Q35128263The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo
Q34207029The role of T helper cell differentiation in promoting nerve allograft survival with costimulation blockade
Q34619808Transcription: tantalizing times for T cells
Q37789145Transcriptional regulation of the mucosal immune system mediated by T-bet.
Q36015482Transcriptional regulatory networks for CD4 T cell differentiation
Q51993137Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation.
Q34593994Vaccinology for control of apicomplexan parasites: a simplified language of immune programming and its use in vaccine design
Q37700167Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factors

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