The protein tyrosine kinase family of the human genome

scientific article (publication date: 20 November 2000)

The protein tyrosine kinase family of the human genome is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1051846624
P356DOI10.1038/SJ.ONC.1203957
P3181OpenCitations bibliographic resource ID1043558
P698PubMed publication ID11114734
P5875ResearchGate publication ID12212947

P50authorSu-Fang LinQ72169957
P2093author name stringWu YM
Robinson DR
P2860cites workESTablishing a human transcript mapQ72048152
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Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding geneQ24305125
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The Pfam protein families database.Q27861012
The protein kinases of budding yeast: six score and moreQ27930077
Tec family of protein-tyrosine kinases: an overview of their structure and functionQ28143299
Tec kinases: a family with multiple roles in immunityQ28143522
Protein tyrosine kinase structure and functionQ28145008
Tyrosine kinase SYK: essential functions for immunoreceptor signallingQ28145413
Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemiasQ28236745
Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family membersQ28250257
The ephrins and Eph receptors in neural developmentQ28266706
The c-Fes family of protein-tyrosine kinasesQ28283854
Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinaseQ28286701
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous systemQ28304840
AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cellsQ28590932
Ryk is expressed in a differentiation-specific manner in epithelial tissues and is strongly induced in decidualizing uterine stromaQ28594165
EGF receptorQ28646107
The Syk family of protein tyrosine kinases in T-cell activation and developmentQ28647330
Vascular endothelial growth factor (VEGF) and its receptorsQ29615390
Cellular functions regulated by Src family kinasesQ29616038
Active and inactive protein kinases: structural basis for regulationQ29616320
Signaling--2000 and beyondQ29617413
Growth factor signaling by receptor tyrosine kinasesQ29618315
Jaks and STATs: biological implicationsQ29619657
Domain interactions in protein tyrosine kinase Csk.Q30175369
A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruptionQ30194028
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Protein kinases and phosphatases in the Drosophila genomeQ30887459
Signal perception and transduction: the role of protein kinasesQ33540927
Epidermal growth factor receptors: critical mediators of multiple receptor pathwaysQ33597368
Discoidin domain receptors: structural relations and functional implicationsQ33648751
FAK and PYK2/CAKbeta in the nervous system: a link between neuronal activity, plasticity and survival?Q33650545
Janus kinases and their role in growth and diseaseQ33664276
Chemical approaches to the study of protein tyrosine kinases and their implications for mechanism and inhibitor designQ33716117
RET proto-oncogene in the development of human cancerQ33718087
Cell signaling by protein tyrosine phosphorylationQ33724532
Ephrins and their Eph receptors: multitalented directors of embryonic developmentQ33744607
Evolution of the vertebrate neurotrophin and Trk receptor gene familiesQ33745309
The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organismsQ33777991
The IGF-I receptor in cancer researchQ33783474
The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasisQ33783517
Src family tyrosine kinases and growth factor signalingQ33810017
Growth factor signaling pathways in vascular developmentQ33814336
New roles for Src kinases in control of cell survival and angiogenesisQ33838903
From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motilityQ33840680
RAFTK/Pyk2-mediated cellular signallingQ33855347
Early events in M-CSF receptor signalingQ33855769
Signalling through the insulin receptorQ33860499
Tec family kinases in lymphocyte signaling and functionQ33898915
The Jak-STAT pathwayQ33899139
The RET receptor tyrosine kinase: activation, signalling and significance in neural development and diseaseQ33919864
The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation.Q33922881
EGF receptor signalling: the importance of presentationQ33932869
Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesisQ33933866
JAK-STAT signaling activated by Abl oncogenesQ33941370
Control of cell behaviour by signalling through Eph receptors and ephrins.Q33941577
The insulin receptor: from protein sequence to structure.Q33985665
Growth factor receptor tyrosine kinases: cell adhesion kinase family suggests a novel signaling mechanism in cancerQ33989023
Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.Q34403860
Vertebrate non-receptor protein-tyrosine kinase familiesQ34425007
Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme familyQ35124455
A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiationQ36821163
The Mouse Genome Database (MGD): expanding genetic and genomic resources for the laboratory mouse. The Mouse Genome Database GroupQ39541591
Structural and functional properties of the TRK family of neurotrophin receptorsQ40374660
The Trk family of neurotrophin receptorsQ40590908
Tyrosine kinase receptors in the control of epithelial growth and morphogenesis during developmentQ40853801
The Src and Csk families of tyrosine protein kinases in hemopoietic cells.Q40921703
The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and functionQ40921713
Abl tyrosine protein kinaseQ40921721
Nuclear tyrosine kinases: from Abl to WEE1.Q41099672
Oncoprotein networksQ41352439
Signal transduction by the neurotrophin receptorsQ41382912
The HGF receptor family: unconventional signal transducers for invasive cell growthQ41458148
New insights into the control of cell growth; the role of the AxI familyQ41523439
Sequential roles of agrin, MuSK and rapsyn during neuromuscular junction formationQ41541455
Eph-related receptors and their ligands: mediators of contact dependent cell interactionsQ41594083
Direct binding and activation of receptor tyrosine kinases by collagenQ41681111
A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell divisionQ41688982
The Src/Csk regulatory circuit arose early in metazoan evolution.Q41756921
Autoregulatory mechanisms in protein-tyrosine kinasesQ41758716
Paralogy and orthology of tyrosine kinases that can extend the life span of Caenorhabditis elegansQ42624801
MetaBlasts: tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes.Q42631613
Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanismsQ42857007
Gene structure and function of tyrosine kinases in the marine sponge Geodia cydonium: autapomorphic characters in MetazoaQ47695455
Integrin signalling and tyrosine phosphorylation: just the FAKs?Q47721433
Signaling by Eph receptors and their ephrin ligandsQ47754321
The family of Caenorhabditis elegans tyrosine kinase receptors: similarities and differences with mammalian receptorsQ47909945
Extensive gene duplication in the early evolution of animals before the parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydraQ47967462
Role of focal adhesion proteins in signal transduction and oncogenesisQ47988371
The protein tyrosine kinases of the sea urchin Anthocidaris crassispinaQ48039297
Sperm-egg binding protein or proto-oncogene?Q48065655
Guidelines for human gene nomenclature (1997). HUGO Nomenclature CommitteeQ48772399
Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.Q52183100
Mutations of theRET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and Hirschsprung diseaseQ57591326
Neuronal and non-neuronal Trk neurotrophin receptor-like proteins in Eisenia foetida (Annelida Oligochaeta)Q63283467
P433issue49
P407language of work or nameEnglishQ1860
P304page(s)5548-5557
P577publication date2000-11-01
P1433published inOncogeneQ1568657
P1476titleThe protein tyrosine kinase family of the human genome
P478volume19

Reverse relations

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Q37481329RNA interference as an anticancer therapy: a patent perspective
Q64941091RON and RONΔ160 promote gastric cancer cell proliferation, migration, and adaption to hypoxia via interaction with β-catenin.
Q37777990ROS receptor tyrosine kinase: a new potential target for anticancer drugs
Q38002468ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway
Q38852070ROS1 fusions in cancer: a review
Q39102554ROS1 gene rearrangement and copy number gain in non-small cell lung cancer
Q37317847ROS1 immunohistochemistry for detection of ROS1-rearranged lung adenocarcinomas
Q89967335Rational Drug Design of Axl Tyrosine Kinase Type I Inhibitors as Promising Candidates Against Cancer
Q38640765Recent Advances in Targeting ROS1 in Lung Cancer
Q52654047Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking.
Q58607138Receptor Tyrosine Kinase-Targeted Cancer Therapy
Q30315828Receptor tyrosine kinase gene expression profiles of Ewing sarcomas reveal ROR1 as a potential therapeutic target in metastatic disease
Q38033672Receptor tyrosine kinase inhibitors: molecularly targeted drugs for veterinary cancer therapy
Q36065321Receptor tyrosine kinase mutations in developmental syndromes and cancer: two sides of the same coin
Q37841746Receptor tyrosine kinases and their activation in melanoma.
Q35558528Receptor tyrosine kinases in normal and malignant haematopoiesis
Q28082793Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers
Q36738608Receptor tyrosine kinases: mechanisms of activation and signaling
Q41819306Receptor tyrosine kinases: molecular switches regulating CNS axon regeneration
Q30157090Reengineering the signaling properties of a Src family kinase
Q33944599Regorafenib: an evidence-based review of its potential in patients with advanced liver cancer
Q47371096Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases.
Q35006333Regulation of ack-family nonreceptor tyrosine kinases
Q34271347Regulation of phagocytosis by TAM receptors and their ligands
Q24301621Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition
Q41693807Relationship between expression of IGFBP7 and clinicopathological variables in gastric cancer.
Q39802930Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer
Q34674715Retracted: Inhibition of the Receptor Tyrosine Kinase ROR1 by Anti-ROR1 Monoclonal Antibodies and siRNA Induced Apoptosis of Melanoma Cells
Q38261470Reversal of Cisplatin resistance by epigallocatechin gallate is mediated by downregulation of axl and tyro 3 expression in human lung cancer cells
Q37183670Reversing multidrug resistance by tyrosine kinase inhibitors
Q42637698Role of ABC transporters in cancer chemotherapy.
Q90284727Role of CD135/CD117 on Prognosis and Overall Survival of Acute Myeloid Leukemia
Q38328408Role of epidermal growth factor receptor signaling in the interaction of Neisseria meningitidis with endothelial cells
Q33883849Role of receptor tyrosine kinases and their ligands in glioblastoma
Q28242840Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapy
Q46132798Role of tyrosine kinases in tumor progression of the head and neck
Q37520844Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases
Q38841650Screening of multi-targeted natural compounds for receptor tyrosine kinases inhibitors and biological evaluation on cancer cell lines, in silico and in vitro.
Q35622986Selective targeting of antibody conjugated multifunctional nanoclusters (nanoroses) to epidermal growth factor receptors in cancer cells
Q33334075Sequence similarity network reveals common ancestry of multidomain proteins
Q45732972Serum lemur tyrosine kinase 3 expression in colorectal cancer patients predicts cancer progression and prognosis
Q33598601Serum-dependent selective expression of EhTMKB1-9, a member of Entamoeba histolytica B1 family of transmembrane kinases
Q37401172Sex-specific aspects of tumor therapy
Q28211506Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry
Q34797452Soluble AXL: a possible circulating biomarker for neurofibromatosis type 1 related tumor burden.
Q37790248Sorafenib in hepatocellular carcinoma
Q60326103Spinal 5-HT7 receptor activation induces long-lasting phrenic motor facilitation
Q42665233Sponge homologs of vertebrate protein tyrosine kinases and frequent domain shufflings in the early evolution of animals before the parazoan-eumetazoan split
Q42066556Stretch-induced mitogen-activated protein kinase activation in lung fibroblasts is independent of receptor tyrosine kinases
Q34012560Structural and evolutionary relationships among protein tyrosine phosphatase domains
Q53659660Surrogate endpoints in cancer drug development.
Q54344110Synthesis and biological evaluation of new pyrimidine-4-yl-ethanol derivatives as ROS1 kinase inhibitors.
Q36121958Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains
Q35163573Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains
Q33770643Systematic deletion analysis of fission yeast protein kinases.
Q34794927TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer
Q93078108TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling
Q50999469TRPC Channels and Programmed Cell Death.
Q37725990Targeted immunotherapy for colorectal cancer: monoclonal antibodies and immunotoxins
Q90706409Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment
Q104289124Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer
Q92128519Targeting Tyrosine Kinases in Acute Myeloid Leukemia: Why, Who and How?
Q26767351Targeting hypoxic response for cancer therapy
Q42769520Targeting key signalling pathways in oesophageal adenocarcinoma: a reality for personalised medicine?
Q36280842Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N'-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily.
Q34078275Targeting lymphatic vessel functions through tyrosine kinases
Q27013050Targeting receptor tyrosine kinases in gastric cancer
Q33620537Targeting the tyrosine kinase signalling pathways for treatment of immune-mediated glomerulonephritis: from bench to bedside and beyond
Q49887906Targeting tumour microenvironment by tyrosine kinase inhibitor.
Q89910913The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways
Q41591726The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation
Q53541067The Fps/Fes kinase regulates leucocyte recruitment and extravasation during inflammation.
Q94059147The Journey of Protein S from an Anticoagulant to a Signaling Molecule
Q36032222The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors.
Q42477783The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway
Q37602303The epidermal growth factor system of ligands and receptors in cancer
Q30157512The evolutionarily conserved arrangement of domains in SRC family kinases is important for substrate recognition
Q37098747The immunopharmacologic potential of Semaxanib and new generation directed therapeutic drugs: Receptor tyrosine kinase regulation with anti-tumorigenensis/angiogenesis properties
Q28264717The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation
Q41206091The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids
Q54616415The prognostic impact of EphB2/B4 expression on patients with advanced ovarian carcinoma.
Q38104686The receptor tyrosine kinase Axl in cancer: biological functions and therapeutic implications.
Q24802089The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules
Q24803062The repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinations
Q38940140The role of Axl in drug resistance and epithelial-to-mesenchymal transition of non-small cell lung carcinoma
Q27007359The role of Eph receptors in lens function and disease
Q89634997The role of RICTOR amplification in targeted therapy and drug resistance
Q52669235The role of TAM family receptors and ligands in the nervous system: From development to pathobiology.
Q42777814The role of Tec kinase signaling pathways in the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis
Q39077751The secret life of kinases: functions beyond catalysis
Q39401758The stem cell factor (SCF)/c-KIT signalling in testis and prostate cancer
Q24297359The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1
Q30636360The venus kinase receptor (VKR) family: structure and evolution
Q64265577Therapeutic potential of nimotuzumab PEGylated-maytansine antibody drug conjugates against EGFR positive xenograft
Q51818965Therapeutic targeting of leukemic stem cells in acute myeloid leukemia - the biological background for possible strategies.
Q34661707Tissue repair: The hidden drama
Q33874421Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer
Q37944145Transglutaminases and receptor tyrosine kinases.
Q37704902Transmembrane helix-helix interactions involved in ErbB receptor signaling.
Q38208280Trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy
Q47329331Tunicamycin-Induced ER Stress in Breast Cancer Cells Neither Expresses GRP78 on the Surface Nor Secretes it into the Media.
Q37565593Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells
Q85037235Tyrosine kinase expression profile in clear cell renal cell carcinoma
Q28674280Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis
Q36977823Tyrosine kinase inhibitors in pediatric malignancies
Q34983846Tyrosine kinase inhibitors: Multi-targeted or single-targeted?
Q27692524Tyrosine kinase signaling and the emergence of multicellularity
Q34166503Tyrosine kinases in inflammatory dermatologic disease
Q33755097Tyrosine phosphorylation enrichment and subsequent analysis by MALDI-TOF/TOF MS/MS and LC-ESI-IT-MS/MS.
Q36646778Tyrosine-kinase expression profiles in human gastric cancer cell lines and their modulations with retinoic acids
Q35309992Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycin
Q79903719Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma
Q36230812Use of protein array technology to investigate receptor tyrosine kinases activated in hepatocellular carcinoma
Q45261205Using Illumina next generation sequencing technologies to sequence multigene families in de novo species
Q26823601Venus kinase receptors: prospects in signaling and biological functions of these invertebrate kinases
Q42575520Whole Genome Duplications Shaped the Receptor Tyrosine Kinase Repertoire of Jawed Vertebrates
Q81890266[Cellular mechanisms of tumor response: clinical demands]
Q37403951c-Abl and insulin receptor signalling
Q50985108c-Met and Other Cell Surface Molecules: Interaction, Activation and Functional Consequences.
Q39722178erbB receptor expression patterns in human bladder cancer
Q34353437β-catenin contributes to lung tumor development induced by EGFR mutations

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