The stem cell factor (SCF)/c-KIT signalling in testis and prostate cancer

scientific article published on 27 June 2017

The stem cell factor (SCF)/c-KIT signalling in testis and prostate cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12079-017-0399-1
P932PMC publication ID5704042
P698PubMed publication ID28656507

P50authorHenrique J CardosoQ59675157
Marília I FigueiraQ59675160
Sílvia SocorroQ38589960
P2093author name stringHenrique J Cardoso
Marília I Figueira
P2860cites workSignaling through extracellular signal-regulated kinase is required for spermatogonial proliferative response to stem cell factorQ61191165
Stem cell factor-induced signal transduction in rat mast cells. Activation of phospholipase D but not phosphoinositide-specific phospholipase C in c-kit receptor stimulationQ72086709
Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potentialQ73219883
Expression of proto-oncogene c-kit in high risk prostate cancerQ80894250
KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumorsQ81270275
Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptorQ22010151
Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cellsQ24291395
Stat1 associates with c-kit and is activated in response to stem cell factorQ24530497
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligandQ24555963
Cell signaling by receptor tyrosine kinasesQ24598357
Testicular cancer: a prototypic tumor of young adultsQ24655649
Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activationQ27625275
Structure of a c-kit product complex reveals the basis for kinase transactivationQ27641501
New Progress of Epigenetic Biomarkers in Urological CancerQ28073982
Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancersQ28082793
The protein tyrosine kinase family of the human genomeQ28140214
Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cellsQ28183216
Oncogenic kinase signallingQ28189493
Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signalingQ28213000
Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cellsQ28252234
The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136Q28275577
Stem cell factor receptor/c-Kit: from basic science to clinical implicationsQ28277237
Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cellsQ28285759
Signal transduction via the stem cell factor receptor/c-KitQ28291675
Generation of a prostate from a single adult stem cellQ28298344
Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytesQ28303950
Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPKQ28569847
Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transferQ28593279
JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factorQ28637652
Kit receptor dimerization is driven by bivalent binding of stem cell factorQ28637863
MAP kinase signalling pathways in cancerQ29615542
Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012Q29615661
Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68.Q30164372
Requirement of Gab2 for mast cell development and KitL/c-Kit signalingQ30167578
Involvement of phospholipase Cgamma1 in mouse egg activation induced by a truncated form of the C-kit tyrosine kinase present in spermatozoa.Q30176067
Epidemiology of Prostate and Testicular CancerQ30248216
Activating c-kit gene mutations in human germ cell tumorsQ30304054
Mechanisms of activation of receptor tyrosine kinases: monomers or dimersQ33883884
Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinaseQ34150271
Epigenetic susceptibility factors for prostate cancer with aging.Q34541756
KIT mutations are common in testicular seminomasQ35083255
Of JAKs, STATs, blind watchmakers, jeeps and trainsQ35163904
Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells.Q35804427
Human Stromal Cells in the Peripheral Zone of the Prostate Promote Tumorigenesis of Prostatic Cancer Stem Cells through Up-regulation of C-Kit ExpressionQ35856865
STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death.Q35946035
Phase I study investigating the safety and feasibility of combining imatinib mesylate (Gleevec) with sorafenib in patients with refractory castration-resistant prostate cancerQ36166836
Somatic mutations of KIT in familial testicular germ cell tumoursQ36697196
Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions.Q36739411
The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activityQ36745695
Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST).Q36894901
Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literatureQ36974533
Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.Q37693932
Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance.Q37977174
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinasesQ38053052
Therapeutic targeting of c-KIT in cancerQ38057806
miRNA and TMPRSS2-ERG do not mind their own business in prostate cancer cellsQ38096240
Recent advances in molecular and cell biology of testicular germ-cell tumors.Q38254896
The SCF/c-KIT system in the male: Survival strategies in fertility and cancerQ38264052
Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?Q38275897
Stem cell factor activates STAT-5 DNA binding in IL-3-derived bone marrow mast cellsQ38347182
Overview on the complexity of androgen receptor-targeted therapy for prostate cancerQ38364166
Signaling lansdscape of prostate cancerQ38717542
Prostate Cancer Stem Cells: Viewing Signaling Cascades at a Finer ResolutionQ38723375
Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic cancerQ38730400
Paradoxical and contradictory effects of imatinib in two cell line models of hormone-refractory prostate cancerQ38897955
Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length.Q39121231
Secondary c-Kit mutations confer acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells.Q39167351
Regulation of cell proliferation through a KIT-mediated mechanism in benign prostatic hyperplasia.Q39400004
Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy.Q39716863
Expression of c-Kit isoforms in multiple myeloma: differences in signaling and drug sensitivity.Q39987410
Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell linesQ40583274
Src family kinases are involved in the differential signaling from two splice forms of c-KitQ40679645
Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect.Q40714444
Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor.Q40714451
Gastric GISTs: Analysis of c-Kit, PDGFRA and BRAF mutations in relation to prognosis and clinical pathological characteristics of patients - A GIRCG study.Q40717804
Soluble Kit receptor blocks stem cell factor bioactivity in vitroQ40812961
Lyn is activated during late G1 of stem-cell-factor-induced cell cycle progression in haemopoietic cellsQ40938029
A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cells.Q41206096
Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form.Q41378313
Stem cell factor, the JAK-STAT pathway and signal transductionQ41708996
Identification of a ligand for the c-kit proto-oncogeneQ41718674
Label retention and stem cell marker expression in the developing and adult prostate identifies basal and luminal epithelial stem cell subpopulationsQ42112184
Differential expression of the c-kit proto-oncogene in germ cell tumours.Q42513650
A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids.Q42602776
Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblastsQ42809755
Phase I trial of zoledronic acid + imatinib mesylate (Gleevec) in patients with bone metastasesQ43299092
Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogoniaQ43503981
Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domainQ43840377
Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient miceQ43933405
Alterations of the c-kit gene in testicular germ cell tumorsQ44490297
Imatinib mesylate and zoledronic acid in androgen-independent prostate cancerQ44889720
Platelet-derived growth factor receptor inhibitor imatinib mesylate and docetaxel: a modular phase I trial in androgen-independent prostate cancerQ45018087
Ectopic expression of KitD814Y in spermatids of transgenic mice, interferes with sperm morphogenesisQ45286586
Expression of stem cell factor and its receptor c-Kit during the development of intrahepatic cholangiocarcinoma.Q45874538
Properties of variant forms of human stem cell factor recombinantly expressed in Escherichia coliQ46308495
Combined low-dose imatinib mesylate and paclitaxel lack synergy in an experimental model of extra-osseous hormone-refractory prostate cancerQ46654052
Complete response after treatment with imatinib in pretreated disseminated testicular seminoma with overexpression of c-KIT.Q46919489
The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challenges.Q50889968
A variant c-KIT mutation, D816H, fundamental to the sequential development of an ovarian mixed germ cell tumor and systemic mastocytosis with chronic myelomonocytic leukemia.Q51363110
Chemoattractant action and molecular signaling pathways of Kit ligand on mouse primordial germ cells.Q51987573
Detection of c-kit exons 11- and 17-activating mutations in testicular seminomas by high-resolution melting amplicon analysis.Q54598705
c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminomaQ58194329
P433issue4
P304page(s)297-307
P577publication date2017-06-27
P1433published inJournal of Cell Communication and SignalingQ26841964
P1476titleThe stem cell factor (SCF)/c-KIT signalling in testis and prostate cancer
P478volume11

Reverse relations

cites work (P2860)
Q92447986Association between Circulation Indole-3-Acetic Acid Levels and Stem Cell Factor in Maintenance Hemodialysis Patients: A Cross-Sectional Study
Q53703721CD117/c-kit in Cancer Stem Cell-Mediated Progression and Therapeutic Resistance.
Q49610684Exploring the molecular aspects associated with testicular germ cell tumors: a review
Q58608388Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions
Q64092289and evaluation of possible pro-survival activities of PGE2, EGF, TPO and FLT3L on human hematopoiesis

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