Phase I study investigating the safety and feasibility of combining imatinib mesylate (Gleevec) with sorafenib in patients with refractory castration-resistant prostate cancer

scientific article

Phase I study investigating the safety and feasibility of combining imatinib mesylate (Gleevec) with sorafenib in patients with refractory castration-resistant prostate cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1032750595
P356DOI10.1038/BJC.2012.312
P932PMC publication ID3419960
P698PubMed publication ID22805325
P5875ResearchGate publication ID229159483

P2093author name stringM J Egorin
C Nabhan
T M Lestingi
J D Bitran
D Villines
J H Beumer
K Tolzien
S M Christner
T V Valdez
P2860cites workSipuleucel-T immunotherapy for castration-resistant prostate cancerQ27860648
Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancerQ29616123
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancerQ29616218
Abiraterone and increased survival in metastatic prostate cancerQ29617512
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trialQ29620155
Receptor tyrosine kinases as rational targets for prostate cancer treatment: platelet-derived growth factor receptor and imatinib mesylateQ33184380
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptorsQ33918083
NCCN clinical practice guidelines in oncology: prostate cancerQ34616548
Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptorQ35788293
Combination docetaxel and platelet-derived growth factor receptor inhibition with imatinib mesylate in prostate cancerQ35791273
A clinical phase II study with sorafenib in patients with progressive hormone-refractory prostate cancer: a study of the CESAR Central European Society for Anticancer Drug Research-EWIV.Q36610713
Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome P450 3A4 substrate, in patients with chronic myeloid leukaemiaQ36671633
Sorafenib for the treatment of advanced renal cell carcinomaQ36692604
A multi-institutional phase ii study of SU101, a platelet-derived growth factor receptor inhibitor, for patients with hormone-refractory prostate cancerQ38461620
Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculatureQ40270911
In vitro cytotoxic effects of imatinib in combination with anticancer drugs in human prostate cancer cell lines.Q40477521
Liquid chromatographic-mass spectrometric assay for quantitation of imatinib and its main metabolite (CGP 74588) in plasmaQ40582408
A phase I trial of docetaxel/estramustine/imatinib in patients with hormone-refractory prostate cancerQ43583678
Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patientsQ44780594
Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjectsQ44892834
Platelet-derived growth factor receptor inhibitor imatinib mesylate and docetaxel: a modular phase I trial in androgen-independent prostate cancerQ45018087
A phase II trial of imatinib mesylate in patients with prostate specific antigen progression after local therapy for prostate cancerQ45076471
Mechanisms of androgen-refractory prostate cancerQ45094999
A phase II trial of imatinib mesylate in patients with biochemical relapse of prostate cancer after definitive local therapyQ46041319
Safety and efficacy of sorafenib in patients with castrate resistant prostate cancer: a Phase II studyQ46369839
Metabolism and disposition of imatinib mesylate in healthy volunteersQ46592261
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: updated survival in the TAX 327 studyQ46817220
A phase II clinical trial of sorafenib in androgen-independent prostate cancerQ46825505
A phase II study of sorafenib in patients with chemo-naive castration-resistant prostate cancerQ46868463
Platelet-derived growth factor receptor inhibition and chemotherapy for castration-resistant prostate cancer with bone metastasesQ46972241
Sorafenib and sunitinib, two anticancer drugs, inhibit CYP3A4-mediated and activate CY3A5-mediated midazolam 1'-hydroxylationQ48292912
Her wedding.Q53378194
Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer.Q54598136
Gene expression correlates of clinical prostate cancer behaviorQ60156349
Immunohistochemistry analysis of platelet-derived growth factor A and B chains and platelet-derived growth factor alpha and beta receptor expression in benign prostatic hyperplasias and Gleason-graded human prostate adenocarcinomasQ71652817
Response evaluation criteria in solid tumors (RECIST): new guidelinesQ74245275
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectimatinibQ177094
prostate cancerQ181257
P304page(s)592-597
P577publication date2012-07-17
P1433published inBritish Journal of CancerQ326309
P1476titlePhase I study investigating the safety and feasibility of combining imatinib mesylate (Gleevec) with sorafenib in patients with refractory castration-resistant prostate cancer
P478volume107

Reverse relations

cites work (P2860)
Q34548719Ageing is a risk factor in imatinib mesylate cardiotoxicity
Q34353130Bone-induced c-kit expression in prostate cancer: a driver of intraosseous tumor growth
Q38094296Imatinib and prostate cancer: lessons learned from targeting the platelet-derived growth factor receptor.
Q36270115Inefficiencies and Patient Burdens in the Development of the Targeted Cancer Drug Sorafenib: A Systematic Review
Q38116358Novel therapeutic approaches for the treatment of castration-resistant prostate cancer
Q38897955Paradoxical and contradictory effects of imatinib in two cell line models of hormone-refractory prostate cancer
Q27022567Recent progress in pharmaceutical therapies for castration-resistant prostate cancer
Q42530532Retrospective study testing next generation sequencing of selected cancer-associated genes in resected prostate cancer.
Q39401758The stem cell factor (SCF)/c-KIT signalling in testis and prostate cancer

Search more.