Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA

scientific article (publication date: 9 June 2000)

Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M909794199
P698PubMed publication ID10748159

P2093author name stringK Williams
J Simonetti
N Matton
P2860cites workIdentification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2Q24314329
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6Q24323176
Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repairQ27617873
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesisQ27766073
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairsQ27930815
Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.Q27934985
Eukaryotic DNA mismatch repairQ27939116
The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switchQ28258968
Identification of mismatch repair genes and their role in the development of cancerQ28288647
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor CellsQ28292781
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cellsQ28292790
MutS homologs in mammalian cellsQ28303186
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switchQ28610649
hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNAQ28610839
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairQ28610858
Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanismQ28610864
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD.Q32108861
MutS mediates heteroduplex loop formation by a translocation mechanismQ33887145
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA.Q34657088
ATP hydrolysis-dependent formation of a dynamic ternary nucleoprotein complex with MutS and MutL.Q34712687
Genetic instability in human ovarian cancer cell lines.Q35791709
Mechanisms and biological effects of mismatch repairQ37041860
hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalphaQ38336441
MutS and MutL activate DNA helicase II in a mismatch-dependent mannerQ38337755
The significance of DNA and protein adducts in human biomonitoring studiesQ39640488
Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical PerspectivesQ40482404
Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.Q40920177
DNA-replication fidelity, mismatch repair and genome instability in cancer cellsQ41016785
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Inefficient in vivo repair of mismatches at an oncogenic hotspot correlated with lack of binding by mismatch repair proteins and with phase of the cell cycleQ42812756
A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.Q53963518
Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal CancerQ61946741
The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activityQ77765360
The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexesQ77863139
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectDNA mismatch repairQ2984243
P304page(s)17808-13
P577publication date2000-06-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleIdentification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA
P478volume275

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cites work (P2860)
Q35910908Detection of activity centers in cellular pathways using transcript profiling
Q73794909Human DNA repair genes
Q28209230Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX
Q34293069Molecular mechanisms of DNA mismatch repair
Q33643516Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage
Q39600696Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSalpha mismatch-binding activity
Q24805338Recognition and binding of mismatch repair proteins at an oncogenic hot spot
Q28285134Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities
Q44100502Visualization of mosaicism in tissues of normal and mismatch-repair-deficient mice carrying a microsatellite-containing transgene
Q24292227hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.

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