The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

scientific article (publication date: 5 October 2000)

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1028457185
P356DOI10.1038/SJ.ONC.1203847
P8608Fatcat IDrelease_24dlemm6gjartgqm2vxhlr43v4
P3181OpenCitations bibliographic resource ID2277538
P698PubMed publication ID11039908
P5875ResearchGate publication ID12284368

P2093author name stringE Lees
W Seghezzi
W Korver
A O Walter
J Sheung
P2860cites workRegulation of the cyclin B degradation system by an inhibitor of mitotic proteolysisQ38612159
Cell cycle: checkpoint proteins and kinetochoresQ41642289
ayk1, a novel mammalian gene related to Drosophila aurora centrosome separation kinase, is specifically expressed during meiosisQ48048486
Requirement for cAMP-PKA pathway activation by M phase-promoting factor in the transition from mitosis to interphaseQ49016602
A checkpoint on the road to cancerQ58984637
Under arrest at atomic resolutionQ60081940
Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1Q24321907
Inhibitory effect of okadaic acid derivatives on protein phosphatases. A study on structure-affinity relationshipQ24527865
Cdc20 associates with the kinase aurora2/AikQ24648501
Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein KinaseQ27651185
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complexQ27729793
Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7pQ27931654
The spindle checkpoint.Q27931883
Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpointQ27933329
The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeastQ27937537
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell linesQ28239817
AIM-1: a mammalian midbody-associated protein required for cytokinesisQ28260554
cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2Q28265518
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancersQ28272347
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformationQ28285317
Polo-like kinases: a team that plays throughout mitosisQ28292469
Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulatorsQ28506448
A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulatorsQ28589729
Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exitQ28755173
Universal control mechanism regulating onset of M-phaseQ29616481
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindlesQ29617537
The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanismQ30175786
The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.Q30323011
Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-terQ31983674
Protein kinases in control of the centrosome cycleQ33665649
Regulation of the APC and the exit from mitosisQ33772649
The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathwayQ33889588
Polo-like kinases: positive regulators of cell division from start to finish.Q34663706
AIR-2: An Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryosQ36255964
Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregationQ36657172
P433issue42
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)4906-16
P577publication date2000-10-05
P1433published inOncogeneQ1568657
P1476titleThe mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation
P478volume19

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cites work (P2860)
Q37371599A G-quadruplex stabilizer induces M-phase cell cycle arrest
Q78954671A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly
Q30502070A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
Q50861755A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms.
Q24797580A method for analyzing the ubiquitination and degradation of aurora-A
Q35029166A non-mitotic role for Aurora kinase A as a direct activator of cell migration upon interaction with PLD, FAK and Src.
Q73280786A novel mechanism for activation of the protein kinase Aurora A
Q37296303A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma
Q31011135A translational regulator, PUM2, promotes both protein stability and kinase activity of Aurora-A
Q40070142ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis
Q30433665Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein
Q28585404An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics
Q93185770Antitumor profiles and cardiac electrophysiological effects of aurora kinase inhibitor ZM447439
Q51798018Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A.
Q34026716Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.
Q47598076Aurora A activation in mitosis promoted by BuGZ.
Q36352091Aurora A and B kinases as targets for cancer: will they be selective for tumors?
Q36715681Aurora A kinase (AURKA) in normal and pathological cell division
Q90788875Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration
Q24318115Aurora A, centrosome structure, and the centrosome cycle
Q34448311Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin
Q30309901Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation
Q27021024Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle
Q37072448Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells
Q35327725Aurora kinase A controls meiosis I progression in mouse oocytes
Q33830804Aurora kinase A is not involved in CPEB1 phosphorylation and cyclin B1 mRNA polyadenylation during meiotic maturation of porcine oocytes
Q41737123Aurora kinase a regulates m1 macrophage polarization and plays a role in experimental autoimmune encephalomyelitis
Q37666259Aurora kinase inhibitors: a new class of drugs targeting the regulatory mitotic system.
Q37030878Aurora kinase inhibitors: identification and preclinical validation of their biomarkers
Q40199075Aurora kinase targeted therapeutics in oncology: past, present and future
Q38472421Aurora kinases orchestrate mitosis; who are the players?
Q28118105Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
Q35022281Aurora-A in cell fate control
Q35927244Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma.
Q46658785Aurora-A kinase Ser349 phosphorylation is required during Xenopus laevis oocyte maturation
Q28506140Aurora-A kinase is essential for bipolar spindle formation and early development
Q34798251Aurora-A kinase-inactive mutants disrupt the interaction with Ajuba and cause defects in mitotic spindle formation and G2/M phase arrest in HeLa cells
Q37613047Aurora-A kinase: a novel target both for cellular immunotherapy and molecular target therapy against human leukemia
Q40388031Aurora-A site specificity: a study with synthetic peptide substrates
Q27310808Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly
Q28206898Aurora-B associated protein phosphatases as negative regulators of kinase activation
Q35968406Aurora-kinase inhibitors as anticancer agents
Q73320912Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non‐Hodgkin's lymphoma
Q40616838AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer
Q44727121Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis
Q28247388BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition
Q50881779Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one derivatives as Aurora A kinase inhibitors: LQTA-QSAR analysis and detailed systematic validation of the developed model.
Q35914001Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation
Q33531517Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases.
Q37736572Breast tumor subgroups reveal diverse clinical prognostic power
Q53075287CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors.
Q28190491CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function
Q44387441Cdc2-cyclin B triggers H3 kinase activation of Aurora-A in Xenopus oocytes
Q35885862Cell and molecular biology of spindle poles and NuMA.
Q40396015Characterization of plant Aurora kinases during mitosis
Q39466789Computational investigation of cancer-associated molecular mechanism in Aurora A (S155R) mutation
Q33836953Conditional transgenic system for mouse aurora a kinase: degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein
Q90221131Covalent Aurora A regulation by the metabolic integrator coenzyme A
Q26771374Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly
Q27639665Crystal structure of aurora-2, an oncogenic serine/threonine kinase
Q92315092Cyanidioschyzon merolae aurora kinase phosphorylates evolutionarily conserved sites on its target to regulate mitochondrial division
Q24300312Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases
Q30488012Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint
Q36324220Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.
Q47071031Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis
Q28279976EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A
Q84412773Evaluation of the cytotoxic activity of new jadomycin derivatives reveals the potential to improve its selectivity against tumor cells
Q41994033Evidence for reciliation of RPE1 cells in late G1 phase, and ciliary localisation of cyclin B1.
Q33792897Evidence toward a dual phosphatase mechanism that restricts Aurora A (Thr-295) phosphorylation during the early embryonic cell cycle.
Q24682520Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis
Q35123861Function and regulation of Aurora/Ipl1p kinase family in cell division
Q44692651Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner
Q34447855INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability
Q38630091Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A
Q48149761Identification and dynamics of two classes of aurora-like kinases in Arabidopsis and other plants
Q28215792Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins
Q77166197Identification of a functional destruction box in the Xenopus laevis aurora-A kinase pEg2
Q35787361Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit
Q40571912Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography
Q34386813Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A.
Q40374495Inhibition of Aurora A in response to DNA damage
Q38741827Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora.
Q60951707Inhibitory Effect of Synthetic Flavone Derivatives on Pan-Aurora Kinases: Induction of G2/M Cell-Cycle Arrest and Apoptosis in HCT116 Human Colon Cancer Cells
Q27679437Insights into Aurora-A Kinase Activation Using Unnatural Amino Acids Incorporated by Chemical Modification
Q90341131Insights into the non-mitotic functions of Aurora kinase A: more than just cell division
Q28215986Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle
Q35005238KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity.
Q24301118LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis
Q37458626MET inhibition overcomes radiation resistance of glioblastoma stem-like cells
Q39137312Mechanisms for nonmitotic activation of Aurora-A at cilia.
Q34282234Microtubule-targeted anticancer agents and apoptosis
Q27683971Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2
Q28587157NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment
Q26752389Non-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell Division
Q34083310Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation
Q54977862Novel localization of Aurora A kinase in mouse testis suggests multiple roles in spermatogenesis.
Q45717413Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases
Q48126977Nuclear envelope breakdown may deliver an inhibitor of protein phosphatase 1 which triggers cyclin B translation in starfish oocytes
Q37189439O-linked N-acetylglucosamine cycling regulates mitotic spindle organization
Q34818218On the role of aurora-A in centrosome function
Q38223676Pathways for genome integrity in G2 phase of the cell cycle
Q64245408Phosphatases in Mitosis: Roles and Regulation
Q79755823Phospho-regulation of human protein kinase Aurora-A: analysis using anti-phospho-Thr288 monoclonal antibodies
Q27931713Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p
Q41845102Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta.
Q30434079Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity
Q39956375Pituitary tumor transforming gene 1 regulates Aurora kinase A activity
Q40666306Preparation and characterization of a human aurora-A kinase monoclonal antibody
Q35125439Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3.
Q24321572Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Q24337213Protein phosphorylation profiling using an in situ proximity ligation assay: phosphorylation of AURKA-elicited EGFR-Thr654 and EGFR-Ser1046 in lung cancer cells
Q47564376RASSF1A interacts with and activates the mitotic kinase Aurora-A.
Q60017621Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation
Q28505990Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation
Q35591745Regulation of Aurora-A kinase on the mitotic spindle
Q60017623Regulation ofXenopusAurora A Activation by TPX2
Q35879819Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer
Q51036906Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells.
Q35133478SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition
Q54336316Simultaneous assessment of kinetic, site-specific, and structural aspects of enzymatic protein phosphorylation.
Q24298490Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
Q27640105Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
Q34831438Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion
Q38189984TPX2: of spindle assembly, DNA damage response, and cancer
Q52639097Targeting cell cycle kinases and kinesins in anticancer drug development.
Q38756932The Aurora kinase inhibitors in cancer research and therapy
Q42162215The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A.
Q27320051The Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic Complementation
Q24515254The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis
Q27851718The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells
Q34203062The aurora kinases in cell cycle and leukemia
Q29617749The cellular geography of aurora kinases
Q24540283The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.
Q35885867The centrosome in higher organisms: structure, composition, and duplication
Q24315132The decision to enter mitosis: feedback and redundancy in the mitotic entry network
Q34121234The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis.
Q34221736The tumor suppressive role of NUMB isoform 1 in esophageal squamous cell carcinoma.
Q39647543Tousled-mediated activation of Aurora B kinase does not require Tousled kinase activity in vivo.
Q36268536Transcriptomic characterization of fibrolamellar hepatocellular carcinoma
Q35925301Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells.
Q39219725Two newly identified sites in the N-terminal regulatory domain of Aurora-A are essential for auto-inhibition
Q28242189p21-activated kinases in cancer

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