| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Isabelle Vernós | Q20100758 |
| P2093 | author name string | Georgina Garrido | |
| P2860 | cites work | A novel mechanism for activation of the protein kinase Aurora A | Q73280786 |
| Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast | Q77415542 | ||
| The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5 | Q77754825 | ||
| A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly | Q78954671 | ||
| Phospho-regulation of human protein kinase Aurora-A: analysis using anti-phospho-Thr288 monoclonal antibodies | Q79755823 | ||
| Identification of a TPX2-like microtubule-associated protein in Drosophila | Q21090968 | ||
| Structural basis of Aurora-A activation by TPX2 at the mitotic spindle | Q24298490 | ||
| Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A | Q24306319 | ||
| p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M | Q24314657 | ||
| Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells | Q24316034 | ||
| Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A | Q24318410 | ||
| A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2 | Q24321340 | ||
| Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2 | Q24321572 | ||
| TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle | Q24635228 | ||
| Spindle pole regulation by a discrete Eg5-interacting domain in TPX2 | Q24646873 | ||
| Human TPX2 is required for targeting Aurora-A kinase to the spindle | Q24671169 | ||
| The mechanism of spindle assembly: functions of Ran and its target TPX2 | Q24678114 | ||
| The RanGTP Pathway: From Nucleo-Cytoplasmic Transport to Spindle Assembly and Beyond | Q26770231 | ||
| Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins | Q26781574 | ||
| Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer | Q26784060 | ||
| Aurora kinase A in gastrointestinal cancers: time to target | Q26864277 | ||
| TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux | Q27310325 | ||
| TPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule | Q27314486 | ||
| Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes | Q27438173 | ||
| Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2 | Q27683971 | ||
| Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells | Q28118105 | ||
| The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation | Q28141731 | ||
| Mammalian RanBP1 regulates centrosome cohesion during mitosis | Q28184508 | ||
| Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human | Q28189663 | ||
| MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha | Q28201739 | ||
| Mitotic kinases as regulators of cell division and its checkpoints | Q28202545 | ||
| Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells | Q28208657 | ||
| HURP is part of a Ran-dependent complex involved in spindle formation | Q28235925 | ||
| A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers | Q28272347 | ||
| gamma-Tubulin in mammalian cells: the centrosomal and the cytosolic forms | Q28285228 | ||
| Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation | Q28285317 | ||
| Aurora-A kinase is essential for bipolar spindle formation and early development | Q28506140 | ||
| Aurora A is essential for early embryonic development and tumor suppression | Q28590685 | ||
| Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality | Q28594290 | ||
| Aurora kinases in head and neck cancer | Q28654389 | ||
| Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex | Q29615059 | ||
| Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles | Q29617537 | ||
| The cellular geography of aurora kinases | Q29617749 | ||
| Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein | Q30433665 | ||
| Molecular requirements for kinetochore-associated microtubule formation in mammalian cells | Q30477572 | ||
| Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer | Q33300353 | ||
| Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles | Q33392703 | ||
| The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function | Q34319953 | ||
| Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells | Q34361195 | ||
| Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A. | Q34386813 | ||
| The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. | Q34462480 | ||
| Analysis of a RanGTP-regulated gradient in mitotic somatic cells | Q34506840 | ||
| Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. | Q50719496 | ||
| A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. | Q51584233 | ||
| Tpx2 controls spindle integrity, genome stability, and tumor development. | Q53190557 | ||
| Aurora A: working from dawn to dusk in mitosis. | Q54384720 | ||
| The GTPase RAN regulates multiple steps of the centrosome life cycle. | Q55059510 | ||
| HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of Chromosomes | Q57985121 | ||
| Regulation ofXenopusAurora A Activation by TPX2 | Q60017623 | ||
| Segmental chromosome aberrations converge on overexpression of mitotic spindle regulatory genes in high-risk neuroblastoma | Q60819945 | ||
| Phosphorylation of targeting protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly | Q35580856 | ||
| Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic | Q35668733 | ||
| Nucleophosmin/B23 activates Aurora A at the centrosome through phosphorylation of serine 89. | Q35866192 | ||
| Aurora-kinase inhibitors as anticancer agents | Q35968406 | ||
| Aurora-A - a guardian of poles | Q35998764 | ||
| Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system | Q36055579 | ||
| Aurora kinases, aneuploidy and cancer, a coincidence or a real link? | Q36113247 | ||
| TPX or not TPX? | Q36234371 | ||
| Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain | Q36631161 | ||
| Aurora A kinase (AURKA) in normal and pathological cell division | Q36715681 | ||
| Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2. | Q36796428 | ||
| Mechanisms of mitotic spindle assembly and function | Q37085042 | ||
| Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes. | Q37104686 | ||
| Spatial and temporal coordination of mitosis by Ran GTPase | Q37163028 | ||
| The Aurora kinase family in cell division and cancer. | Q37228956 | ||
| The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme? | Q37779885 | ||
| Microtubule nucleation by γ-tubulin complexes | Q37945020 | ||
| The where, when and how of microtubule nucleation - one ring to rule them all. | Q38058295 | ||
| TPX2: of spindle assembly, DNA damage response, and cancer | Q38189984 | ||
| Aurora kinase A inhibitors: promising agents in antitumoral therapy | Q38247042 | ||
| Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress | Q38651701 | ||
| Control of Aurora-A stability through interaction with TPX2. | Q39621507 | ||
| Mitotic activation of the kinase Aurora-A requires its binding partner Bora | Q40247194 | ||
| Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells | Q40486207 | ||
| HURP wraps microtubule ends with an additional tubulin sheet that has a novel conformation of tubulin | Q41625292 | ||
| Microtubule nucleation in mitosis by a RanGTP-dependent protein complex | Q41658329 | ||
| Dissecting the role of Aurora A during spindle assembly | Q41860951 | ||
| The structure of C290A:C393A Aurora A provides structural insights into kinase regulation | Q42101067 | ||
| The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown | Q43453161 | ||
| Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts | Q43940269 | ||
| Determinants for Aurora-A activation and Aurora-B discrimination by TPX2. | Q44749022 | ||
| TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression. | Q45216328 | ||
| Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A. | Q45952223 | ||
| Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. | Q46002468 | ||
| Cell biology. A gradient signal orchestrates the mitotic spindle | Q46670021 | ||
| Spatial coordination of spindle assembly by chromosome-mediated signaling gradients | Q46670028 | ||
| Dissecting the role of Aurora A during spindle assembly | Q46853578 | ||
| An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles. | Q47069063 | ||
| Aurora kinases dawn as cancer drug targets | Q48022350 | ||
| K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly | Q48661634 | ||
| The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC. | Q50452810 | ||
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 88 | |
| P577 | publication date | 2016-01-01 | |
| P1433 | published in | Frontiers in Oncology | Q26839986 |
| P1476 | title | Non-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell Division | |
| P478 | volume | 6 |
| Q33750741 | AURKA mRNA expression is an independent predictor of poor prognosis in patients with non-small cell lung cancer |
| Q30252352 | Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP. |
| Q28395626 | Comparative Analysis of Toxic Responses of Organic Extracts from Diesel and Selected Alternative Fuels Engine Emissions in Human Lung BEAS-2B Cells |
| Q52719324 | P190RhoGAP prevents mitotic spindle fragmentation and is required to activate Aurora A kinase at acentriolar poles. |
| Q50225372 | Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2. |
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