Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins

scientific article

Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FPHAR.2015.00192
P8608Fatcat IDrelease_pi4vfueqsvhm5fni7yu7maw4ti
P3181OpenCitations bibliographic resource ID635567
P932PMC publication ID4562273
P698PubMed publication ID26441649
P5875ResearchGate publication ID282760627

P50authorKjetil TaskénQ17111596
P2093author name stringAna I Calejo
P2860cites workEpac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMPQ22008544
A family of cAMP-binding proteins that directly activate Rap1Q22008551
Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220Q22009431
Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoformsQ22010992
Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrinQ24296241
Mutation of an A-kinase-anchoring protein causes long-QT syndromeQ24304235
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domainQ24317008
A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane eventsQ24324609
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.Q24336212
Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domainQ24336977
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling moduleQ24535019
Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5Q24561772
Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoringQ24681565
Structure, mechanism, and regulation of soluble adenylyl cyclases - similarities and differences to transmembrane adenylyl cyclasesQ27003358
Persistent cAMP-signals triggered by internalized G-protein-coupled receptorsQ27329609
A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activationQ28115053
Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP bindingQ28141713
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophyQ28219383
Cyclic nucleotide phosphodiesterases: molecular regulation to clinical useQ28263273
The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivoQ28281887
Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motifQ28286420
Association of protein kinase A and protein phosphatase 2B with a common anchoring proteinQ28287251
Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunitsQ28305592
AKAP7gamma is a nuclear RI-binding AKAPQ28507113
Selective activation of particulate cAMP-dependent protein kinase by isoproterenol and prostaglandin E1Q72608040
Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemiaQ73071883
Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1Q79306359
Molecular basis of AKAP specificity for PKA regulatory subunitsQ79326012
Response to Schiattarella and HillQ95825142
Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptidesQ38732399
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondriaQ28509852
The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent MechanismQ28547465
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cellsQ28566309
Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenalineQ28566350
AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signalingQ28567111
Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal areaQ28570735
A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophyQ28570967
The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signalingQ28571079
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulumQ28571497
Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytesQ28578129
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophyQ28579323
The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurinQ28581667
Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytesQ28582029
Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelopeQ28582179
Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexesQ28586669
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4Q28590119
Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophyQ28591518
Reaching for high-hanging fruit in drug discovery at protein-protein interfacesQ29547258
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signalingQ29615163
Small-molecule inhibitors of protein-protein interactions: progressing towards the dreamQ29617758
AKAP signalling complexes: focal points in space and timeQ29618533
Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac functionQ30496446
Conformational biosensors reveal GPCR signalling from endosomes.Q30557505
Antagonists of protein-protein interactions.Q30861865
Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).Q33242563
Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling.Q33498108
The molecular biology of cyclic nucleotide phosphodiesterases.Q33743815
A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screeningQ33792594
The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophyQ33818952
Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discoveryQ33890786
Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activationQ34110291
Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology.Q34198623
Stapled peptides for intracellular drug targetsQ34245833
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic moleculesQ34335785
Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.Q34544553
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytesQ39589356
Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoringQ39906444
The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissuesQ39937552
Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3‘:5‘-monophosphate-dependent protein kinaseQ40146034
Evidence that rabbit muscle protein kinase has two kinetically distinct binding sites for adenosine 3′; 5′-cyclic monophosphateQ40176704
Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptorQ40275163
AKAP-Lbc nucleates a protein kinase D activation scaffoldQ40512904
Phospholamban: a prominent regulator of myocardial contractilityQ40919889
Characterization of A-kinase-anchoring disruptors using a solution-based assayQ41079556
Tailoring cAMP-signalling responses through isoform multiplicityQ41516369
How does adrenaline accelerate the heart?Q41645115
Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I.Q41679326
Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channelsQ41835572
Targeted disruption of the heat shock protein 20-phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy.Q42094222
A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusionQ42204987
Neurochondrin is an atypical RIIα-specific A-kinase anchoring proteinQ42219462
The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG miceQ42238979
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterasesQ42462628
A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractilityQ42550135
A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its functionQ43815794
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytesQ43901717
Identifying the molecular switches that determine whether (Rp)-cAMPS functions as an antagonist or an agonist in the activation of cAMP-dependent protein kinase I.Q44068463
Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.Q45091589
Cyclic adenosine 3'-5'-monophosphate (cAMP) exerts proliferative and anti-proliferative effects in pituitary cells of different types by activating both cAMP-dependent protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac).Q45387297
Association of a common AKAP9 variant with breast cancer risk: a collaborative analysisQ46707380
Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteinsQ47754146
Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotidesQ48859017
Inhibition of hypertrophy, per se, may not be a good therapeutic strategy in ventricular pressure overload: other approaches could be more beneficial.Q50985800
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.Q52928840
The potential use of AKAP18δ as a drug target in heart failure patientsQ58123133
An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscleQ68579160
Purification and properties of rabbit skeletal muscle adenosine 3',5'-monophosphate-dependent protein kinasesQ68623815
Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failureQ34550912
Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular diseaseQ34621208
The scaffold protein muscle A-kinase anchoring protein β orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure.Q34778695
Epac and PKA: a tale of two intracellular cAMP receptorsQ34792821
Designing isoform-specific peptide disruptors of protein kinase A localizationQ34921315
The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacologyQ35047674
Opposing roles of PKA and EPAC in the cAMP-dependent regulation of schwann cell proliferation and differentiation [corrected]Q35070200
Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.Q35172592
Screening for small molecule disruptors of AKAP-PKA interactions.Q35580075
Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysisQ35591725
Localized effects of cAMP mediated by distinct routes of protein kinase A.Q35625604
PKA-type I selective constrained peptide disruptors of AKAP complexesQ35762738
A-kinase anchoring proteins as potential drug targetsQ36159125
CNG and HCN channels: two peas, one pod.Q36387907
The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).Q36401530
The where's and when's of kinase anchoringQ36475672
A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.Q36481868
Creating order from chaos: cellular regulation by kinase anchoringQ36518156
Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signallingQ36542008
A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytesQ36542016
Protein-protein interactions as targets for small molecule drug discoveryQ36607010
Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases.Q36622456
Signalosomes as Therapeutic TargetsQ36666473
Interfering with disease: a progress report on siRNA-based therapeuticsQ36836598
Remodelling of gap junctions and connexin expression in diseased myocardium.Q36870641
Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selectionQ36928929
G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains.Q37168203
The cAMP binding protein Epac regulates cardiac myofilament functionQ37310787
AKAP signaling complexes: pointing towards the next generation of therapeutic targets?Q37427846
Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteinsQ37691091
A-kinase anchoring proteins: getting to the heart of the matter.Q37709757
The emerging role of HSP20 as a multifunctional protective agentQ37880357
PDEs create local domains of cAMP signaling.Q37925887
A-kinase anchoring proteins that regulate cardiac remodelingQ37954942
A-kinase anchoring proteins: molecular regulators of the cardiac stress responseQ38034313
Anchored protein kinase A signalling in cardiac cellular electrophysiologyQ38248672
P407language of work or nameEnglishQ1860
P921main subjectprotein-protein interactionQ896177
P304page(s)192
P577publication date2015-01-01
P1433published inFrontiers in PharmacologyQ2681208
P1476titleTargeting protein-protein interactions in complexes organized by A kinase anchoring proteins
P478volume6

Reverse relations

cites work (P2860)
Q58122701A Cell-Based High-Throughput Assay for Gap Junction Communication Suitable for Assessing Connexin 43–Ezrin Interaction Disruptors Using IncuCyte ZOOM
Q92515041AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting
Q93023553Allosteric modulation of a human protein kinase with monobodies
Q90072012Cardiac function modulation depends on the A-kinase anchoring protein complex
Q92703368Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium
Q55026707Immunological identification of a cAMP-dependent protein kinase regulatory subunit-like protein from the Trypanosoma equiperdum TeAp-N/D1 isolate.
Q90124520Integrin α9 depletion promotes β-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis
Q26752389Non-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell Division
Q38991921Outside the mainstream: novel collecting duct proteins regulating water balance.
Q52609114PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination.
Q47270899Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders
Q37024139Protein Kinase A: A Master Kinase of Granulosa Cell Differentiation
Q92809424Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation
Q91650580Synemin Redefined: Multiple Binding Partners Results in Multifunctionality
Q58746531The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit
Q48172039The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation

Search more.