scholarly article | Q13442814 |
P50 | author | Kjetil Taskén | Q17111596 |
P2093 | author name string | Ana I Calejo | |
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Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms | Q22010992 | ||
Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin | Q24296241 | ||
Mutation of an A-kinase-anchoring protein causes long-QT syndrome | Q24304235 | ||
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain | Q24317008 | ||
A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events | Q24324609 | ||
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. | Q24336212 | ||
Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain | Q24336977 | ||
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module | Q24535019 | ||
Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5 | Q24561772 | ||
Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring | Q24681565 | ||
Structure, mechanism, and regulation of soluble adenylyl cyclases - similarities and differences to transmembrane adenylyl cyclases | Q27003358 | ||
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A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activation | Q28115053 | ||
Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding | Q28141713 | ||
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy | Q28219383 | ||
Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use | Q28263273 | ||
The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo | Q28281887 | ||
Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif | Q28286420 | ||
Association of protein kinase A and protein phosphatase 2B with a common anchoring protein | Q28287251 | ||
Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits | Q28305592 | ||
AKAP7gamma is a nuclear RI-binding AKAP | Q28507113 | ||
Selective activation of particulate cAMP-dependent protein kinase by isoproterenol and prostaglandin E1 | Q72608040 | ||
Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia | Q73071883 | ||
Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1 | Q79306359 | ||
Molecular basis of AKAP specificity for PKA regulatory subunits | Q79326012 | ||
Response to Schiattarella and Hill | Q95825142 | ||
Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides | Q38732399 | ||
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria | Q28509852 | ||
The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism | Q28547465 | ||
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells | Q28566309 | ||
Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline | Q28566350 | ||
AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling | Q28567111 | ||
Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area | Q28570735 | ||
A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy | Q28570967 | ||
The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling | Q28571079 | ||
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum | Q28571497 | ||
Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes | Q28578129 | ||
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy | Q28579323 | ||
The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin | Q28581667 | ||
Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes | Q28582029 | ||
Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope | Q28582179 | ||
Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes | Q28586669 | ||
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4 | Q28590119 | ||
Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy | Q28591518 | ||
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces | Q29547258 | ||
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling | Q29615163 | ||
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream | Q29617758 | ||
AKAP signalling complexes: focal points in space and time | Q29618533 | ||
Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function | Q30496446 | ||
Conformational biosensors reveal GPCR signalling from endosomes. | Q30557505 | ||
Antagonists of protein-protein interactions. | Q30861865 | ||
Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). | Q33242563 | ||
Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling. | Q33498108 | ||
The molecular biology of cyclic nucleotide phosphodiesterases. | Q33743815 | ||
A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screening | Q33792594 | ||
The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy | Q33818952 | ||
Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery | Q33890786 | ||
Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation | Q34110291 | ||
Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology. | Q34198623 | ||
Stapled peptides for intracellular drug targets | Q34245833 | ||
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules | Q34335785 | ||
Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. | Q34544553 | ||
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes | Q39589356 | ||
Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring | Q39906444 | ||
The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues | Q39937552 | ||
Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3‘:5‘-monophosphate-dependent protein kinase | Q40146034 | ||
Evidence that rabbit muscle protein kinase has two kinetically distinct binding sites for adenosine 3′; 5′-cyclic monophosphate | Q40176704 | ||
Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor | Q40275163 | ||
AKAP-Lbc nucleates a protein kinase D activation scaffold | Q40512904 | ||
Phospholamban: a prominent regulator of myocardial contractility | Q40919889 | ||
Characterization of A-kinase-anchoring disruptors using a solution-based assay | Q41079556 | ||
Tailoring cAMP-signalling responses through isoform multiplicity | Q41516369 | ||
How does adrenaline accelerate the heart? | Q41645115 | ||
Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I. | Q41679326 | ||
Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels | Q41835572 | ||
Targeted disruption of the heat shock protein 20-phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy. | Q42094222 | ||
A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion | Q42204987 | ||
Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein | Q42219462 | ||
The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice | Q42238979 | ||
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases | Q42462628 | ||
A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility | Q42550135 | ||
A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function | Q43815794 | ||
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes | Q43901717 | ||
Identifying the molecular switches that determine whether (Rp)-cAMPS functions as an antagonist or an agonist in the activation of cAMP-dependent protein kinase I. | Q44068463 | ||
Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels. | Q45091589 | ||
Cyclic adenosine 3'-5'-monophosphate (cAMP) exerts proliferative and anti-proliferative effects in pituitary cells of different types by activating both cAMP-dependent protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac). | Q45387297 | ||
Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis | Q46707380 | ||
Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins | Q47754146 | ||
Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotides | Q48859017 | ||
Inhibition of hypertrophy, per se, may not be a good therapeutic strategy in ventricular pressure overload: other approaches could be more beneficial. | Q50985800 | ||
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. | Q52928840 | ||
The potential use of AKAP18δ as a drug target in heart failure patients | Q58123133 | ||
An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle | Q68579160 | ||
Purification and properties of rabbit skeletal muscle adenosine 3',5'-monophosphate-dependent protein kinases | Q68623815 | ||
Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure | Q34550912 | ||
Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease | Q34621208 | ||
The scaffold protein muscle A-kinase anchoring protein β orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. | Q34778695 | ||
Epac and PKA: a tale of two intracellular cAMP receptors | Q34792821 | ||
Designing isoform-specific peptide disruptors of protein kinase A localization | Q34921315 | ||
The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology | Q35047674 | ||
Opposing roles of PKA and EPAC in the cAMP-dependent regulation of schwann cell proliferation and differentiation [corrected] | Q35070200 | ||
Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2. | Q35172592 | ||
Screening for small molecule disruptors of AKAP-PKA interactions. | Q35580075 | ||
Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis | Q35591725 | ||
Localized effects of cAMP mediated by distinct routes of protein kinase A. | Q35625604 | ||
PKA-type I selective constrained peptide disruptors of AKAP complexes | Q35762738 | ||
A-kinase anchoring proteins as potential drug targets | Q36159125 | ||
CNG and HCN channels: two peas, one pod. | Q36387907 | ||
The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16). | Q36401530 | ||
The where's and when's of kinase anchoring | Q36475672 | ||
A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. | Q36481868 | ||
Creating order from chaos: cellular regulation by kinase anchoring | Q36518156 | ||
Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling | Q36542008 | ||
A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes | Q36542016 | ||
Protein-protein interactions as targets for small molecule drug discovery | Q36607010 | ||
Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases. | Q36622456 | ||
Signalosomes as Therapeutic Targets | Q36666473 | ||
Interfering with disease: a progress report on siRNA-based therapeutics | Q36836598 | ||
Remodelling of gap junctions and connexin expression in diseased myocardium. | Q36870641 | ||
Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection | Q36928929 | ||
G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains. | Q37168203 | ||
The cAMP binding protein Epac regulates cardiac myofilament function | Q37310787 | ||
AKAP signaling complexes: pointing towards the next generation of therapeutic targets? | Q37427846 | ||
Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins | Q37691091 | ||
A-kinase anchoring proteins: getting to the heart of the matter. | Q37709757 | ||
The emerging role of HSP20 as a multifunctional protective agent | Q37880357 | ||
PDEs create local domains of cAMP signaling. | Q37925887 | ||
A-kinase anchoring proteins that regulate cardiac remodeling | Q37954942 | ||
A-kinase anchoring proteins: molecular regulators of the cardiac stress response | Q38034313 | ||
Anchored protein kinase A signalling in cardiac cellular electrophysiology | Q38248672 | ||
P407 | language of work or name | English | Q1860 |
P921 | main subject | protein-protein interaction | Q896177 |
P304 | page(s) | 192 | |
P577 | publication date | 2015-01-01 | |
P1433 | published in | Frontiers in Pharmacology | Q2681208 |
P1476 | title | Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins | |
P478 | volume | 6 |
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