Persistent cAMP-signals triggered by internalized G-protein-coupled receptors

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Persistent cAMP-signals triggered by internalized G-protein-coupled receptors is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PBIO.1000172
P3181OpenCitations bibliographic resource ID2901529
P932PMC publication ID2718703
P698PubMed publication ID19688034
P5875ResearchGate publication ID26749064

P50authorMartin J. LohseQ102058
Tiziana de FilippisQ117206761
Luca PersaniQ42816787
Carlo TacchettiQ56670600
Davide CalebiroQ57014481
Maria Cristina GaglianiQ57319998
Viacheslav O. NikolaevQ59832454
P2093author name stringChristian Dees
P2860cites workTheoretical analyses of the functioning of the high- and low-Km cyclic nucleotide phosphodiesterases in the regulation of the concentration of adenosine 3′,5′-cyclic monophosphate in animal cellsQ72863212
The localization and activity of cAMP-dependent protein kinase affect cell cycle progression in thyroid cellsQ73316766
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The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.Q24336212
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmiasQ24337832
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Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosomeQ27935159
Expression of multiple adenylyl cyclase isoforms in human and dog thyroidQ28143380
Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteinsQ28237045
G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitizationQ28276743
Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroidQ28512822
G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytesQ28566417
Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa proteinQ28584156
AKAP signalling complexes: focal points in space and timeQ29618533
Dynasore, a cell-permeable inhibitor of dynaminQ29619881
Seven-transmembrane receptorsQ29619896
The Thyrotropin Receptor and the Regulation of Thyrocyte Function and Growth*Q30009787
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterasesQ30480533
Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networksQ30489597
Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicatorQ30497812
Adenylyl cyclase co-distribution with the CaBPs, calbindin-D28 and calretinin, varies with cell type: assessment with the fluorescent dye, BODIPY forskolin, in enteric gangliaQ32060541
The human thyrotropin receptor is predominantly internalized by beta-arrestin 2.Q33235338
Imaging cyclic AMP changes in pancreatic islets of transgenic reporter miceQ33332135
cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonistsQ33617881
A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cellQ33949069
Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapsesQ33984279
The expression of the thyroid-stimulating hormone (TSH) receptor and the cAMP-dependent protein kinase RII beta regulatory subunit confers TSH-cAMP-dependent growth to mouse fibroblastsQ34220128
Fluorescence ratio imaging of cyclic AMP in single cellsQ41695021
Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascadesQ41884080
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Thyroid-stimulating hormone binding to beef thyroid membranes. Relation to adenylate cyclase activityQ43829708
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytesQ43901717
Measurement of the millisecond activation switch of G protein-coupled receptors in living cellsQ44479240
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.Q44831766
Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory NeuronsQ45964672
Differential involvement of the actin cytoskeleton in differentiation and mitogenesis of thyroid cells: inactivation of Rho proteins contributes to cyclic adenosine monophosphate-dependent gene expression but prevents mitogenesisQ46669908
Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathwayQ46853318
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Nycthemeral patterns of thyroid hormones and their relationships with thyrotropin variations and sleep structureQ48849564
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Highly inclined thin illumination enables clear single-molecule imaging in cells.Q53442959
Internalization and recycling pathways of the thyrotropin receptor.Q55033324
Signaling on the endocytic pathwayQ57359903
Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signallingQ57371068
Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β 1 -Adrenergic but Locally Confined β 2 -Adrenergic Receptor–Mediated SignalingQ57374826
Giving Space to Cell SignalingQ57711626
Local and global cytosolic Ca2+ oscillations in exocrine cells evoked by agonists and inositol trisphosphateQ63387803
Derivation of mouse embryonic stem cellsQ63407375
Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitizationQ72173227
Long-term synaptic facilitation in the absence of short-term facilitation in Aplysia neuronsQ72535972
Thyrocyte integration, and thyroid folliculogenesis and tissue regeneration: perspective for thyroid tissue engineeringQ34291761
Role of endocytosis in signalling and regulation of G-protein-coupled receptorsQ34332431
The Virtual Cell: a software environment for computational cell biologyQ34392313
'Green mice' as a source of ubiquitous green cells.Q34428099
Cell-signalling dynamics in time and spaceQ34495098
Computational cell biology: spatiotemporal simulation of cellular eventsQ34623629
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicatorQ34650064
Signal transduction and endocytosis: close encounters of many kindsQ34770359
Quantitative cell biology with the Virtual CellQ35565895
Intracellular chloride channels: determinants of function in the endosomal pathway.Q35776789
Not just a sink: endosomes in control of signal transductionQ35840127
The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesisQ36200459
Phagocytosis induced by thyrotropin in cultured thyroid cells is associated with myosin light chain dephosphorylation and stress fiber disruptionQ36232652
Compartmentalization of adenylate cyclase and cAMP signallingQ36295428
Accessory proteins for G proteins: partners in signaling.Q36364667
Phosphodiesterases and compartmentalized cAMP signalling in the heartQ36391237
Endocytosis conducts the cell signaling orchestraQ36418350
Monitoring of cAMP synthesis and degradation in living cellsQ36432214
Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusionQ36436363
Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP.Q36527160
Functional localization of cAMP signalling in cardiac myocytes.Q36542000
Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signallingQ36542008
Quantification of low density lipoprotein and transferrin endocytic sorting HEp2 cells using confocal microscopy.Q36729142
Monitoring receptor signaling by intramolecular FRET.Q36962644
One-step isolation of plasma membrane proteins using magnetic beads with immobilized concanavalin A.Q37011189
Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors.Q37080605
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartmentsQ37692357
Calcium ions, active zones and synaptic transmitter releaseQ38201298
Reduction of adenylate cyclase activity in lysates of human platelets by the alpha-adrenergic component of epinephrineQ39137213
Cyclic AMP diffusion coefficient in frog olfactory ciliaQ40143556
Selective modulation of protein kinase A I and II reveals distinct roles in thyroid cell gene expression and growth.Q40247954
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytesQ40370148
Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor.Q40443081
Role of heterotrimeric GTP binding proteins in vesicular protein transport: indications for both classical and alternative G protein cyclesQ40463775
Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.Q40478581
Novel single chain cAMP sensors for receptor-induced signal propagation.Q40539533
Fluorescent indicators for cyclic GMP based on cyclic GMP-dependent protein kinase Ialpha and green fluorescent proteinsQ40834397
The v-Ki-Ras oncogene alters cAMP nuclear signaling by regulating the location and the expression of cAMP-dependent protein kinase IIbetaQ41159170
Actin stress fiber disruption and tropomyosin isoform switching in normal thyroid epithelial cells stimulated by thyrotropin and phorbol estersQ41269449
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
P304page(s)e1000172
P577publication date2009-08-01
P1433published inPLOS BiologyQ1771695
P1476titlePersistent cAMP-signals triggered by internalized G-protein-coupled receptors
P478volume7

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