| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1111/APHA.12077 |
| P698 | PubMed publication ID | 23383621 |
| P2093 | author name string | V O Nikolaev | |
| R K Perera | |||
| P2860 | cites work | Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes | Q46616130 |
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| A family of cAMP-binding proteins that directly activate Rap1 | Q22008551 | ||
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| Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel | Q24292184 | ||
| Mutation of an A-kinase-anchoring protein causes long-QT syndrome | Q24304235 | ||
| Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current | Q24337525 | ||
| Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias | Q24337832 | ||
| mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module | Q24535019 | ||
| The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding | Q24538689 | ||
| Cyclic AMP underpins suppression by regulatory T cells | Q26824574 | ||
| Spatial control of cAMP signalling in health and disease | Q26866056 | ||
| Persistent cAMP-signals triggered by internalized G-protein-coupled receptors | Q27329609 | ||
| FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death | Q28183817 | ||
| Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins | Q28237045 | ||
| Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase | Q28368278 | ||
| Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice | Q28507989 | ||
| Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling | Q43131986 | ||
| Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. | Q43149051 | ||
| CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation | Q43199827 | ||
| Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes | Q43726354 | ||
| Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes | Q43901717 | ||
| Protecting the myocardium: a role for the beta2 adrenergic receptor in the heart | Q44835434 | ||
| Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels. | Q45091589 | ||
| Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor | Q45872754 | ||
| Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival | Q28568576 | ||
| The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling | Q28571079 | ||
| AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum | Q28571497 | ||
| AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway | Q28575625 | ||
| RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling | Q28580341 | ||
| Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy | Q28581098 | ||
| Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15 | Q28582314 | ||
| Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4 | Q28590119 | ||
| Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization | Q28740548 | ||
| cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes | Q29306674 | ||
| The molecular biology of memory storage: a dialogue between genes and synapses | Q29547845 | ||
| Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling | Q29615163 | ||
| Synergy between CaMKII Substrates and β-Adrenergic Signaling in Regulation of Cardiac Myocyte Ca2+ Handling | Q30430362 | ||
| Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice | Q30497498 | ||
| Differences in the structural characteristics of adult guinea pig and rat cardiomyocytes during their adaptation and maintenance in long-term cultures: confocal microscopy study | Q32160551 | ||
| Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy | Q33577131 | ||
| cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists | Q33617881 | ||
| beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation | Q33840022 | ||
| A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell | Q33949069 | ||
| Epac: defining a new mechanism for cAMP action | Q34091443 | ||
| Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation | Q34113265 | ||
| Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus | Q34113734 | ||
| In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves | Q34145105 | ||
| CREB and the CRTC co-activators: sensors for hormonal and metabolic signals | Q34166530 | ||
| Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications | Q34252901 | ||
| Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression | Q34270987 | ||
| Mitigation of beta 1- and/or beta 2-adrenoceptor function in human heart failure | Q34357125 | ||
| Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins | Q34403963 | ||
| Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1. | Q34436421 | ||
| Conserved expression and functions of PDE4 in rodent and human heart | Q34548139 | ||
| Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease. | Q34610395 | ||
| The arrhythmogenicity of theophylline. A multivariate analysis of clinical determinants | Q34618486 | ||
| Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator | Q34650064 | ||
| PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization | Q35005680 | ||
| A-kinase anchoring proteins: scaffolding proteins in the heart. | Q35543502 | ||
| What is the role of beta-adrenergic signaling in heart failure? | Q35582718 | ||
| cAMP detection methods in HTS: selecting the best from the rest | Q35709584 | ||
| Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes | Q35812341 | ||
| A-kinase anchoring proteins as potential drug targets | Q36159125 | ||
| The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart | Q36215999 | ||
| Compartmentalization of beta-adrenergic signals in cardiomyocytes | Q36384788 | ||
| Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. | Q36391033 | ||
| Anchoring proteins as regulators of signaling pathways. | Q36430063 | ||
| Monitoring of cAMP synthesis and degradation in living cells | Q36432214 | ||
| Creating order from chaos: cellular regulation by kinase anchoring | Q36518156 | ||
| Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases. | Q36622456 | ||
| cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling | Q36790455 | ||
| cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology | Q36843654 | ||
| Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway | Q36854286 | ||
| Live-cell imaging of cAMP dynamics | Q37047823 | ||
| Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice | Q37209626 | ||
| Nanoscale live-cell imaging using hopping probe ion conductance microscopy | Q37242814 | ||
| Oscillatory control of insulin secretion | Q37244825 | ||
| AKAP-scaffolding proteins and regulation of cardiac physiology. | Q37362251 | ||
| Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes | Q37431919 | ||
| cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies | Q37445957 | ||
| Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments | Q37692357 | ||
| A-kinase anchoring proteins: getting to the heart of the matter. | Q37709757 | ||
| cAMP: novel concepts in compartmentalised signalling. | Q37935260 | ||
| Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle. | Q37938771 | ||
| Modulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states | Q37964737 | ||
| Epac in cardiac calcium signaling. | Q38065643 | ||
| Ca2+ cycling and new therapeutic approaches for heart failure | Q39493909 | ||
| Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes | Q39589356 | ||
| Characterization of inhibitors of phosphodiesterase 1C on a human cellular system | Q40094557 | ||
| Novel single chain cAMP sensors for receptor-induced signal propagation. | Q40539533 | ||
| The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion | Q40938618 | ||
| Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes | Q41060678 | ||
| Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice | Q41447437 | ||
| Fluorescence ratio imaging of cyclic AMP in single cells | Q41695021 | ||
| Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels | Q41835572 | ||
| Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation | Q42507587 | ||
| PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes | Q42515385 | ||
| Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals | Q42953996 | ||
| P433 | issue | 4 | |
| P304 | page(s) | 650-662 | |
| P577 | publication date | 2013-02-26 | |
| P1433 | published in | Acta Physiologica | Q2662816 |
| P859 | sponsor | Collaborative Research Centre (CRC) 1002: "Modulatory Units in Heart Failure" | Q48693816 |
| P1476 | title | Compartmentation of cAMP signalling in cardiomyocytes in health and disease | |
| P478 | volume | 207 |
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| Q52689351 | Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes. |
| Q26781612 | Cardiac cAMP: production, hydrolysis, modulation and detection |
| Q87517725 | Carvedilol induces greater control of β2- than β 1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium |
| Q38546231 | Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytes |
| Q64969377 | Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats. |
| Q40601692 | Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. |
| Q26785322 | Imaging alterations of cardiomyocyte cAMP microdomains in disease |
| Q49787366 | Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes |
| Q48749621 | In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease |
| Q36270020 | Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway. |
| Q37486049 | Interactions of Calcium Fluctuations during Cardiomyocyte Contraction with Real-Time cAMP Dynamics Detected by FRET. |
| Q37226387 | Local cAMP signaling in disease at a glance |
| Q90595855 | Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis |
| Q38862807 | Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation |
| Q90308874 | Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy |
| Q41533475 | Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node Myocytes |
| Q96229897 | Rational Design of a Protein Kinase A Nuclear-cytosol Translocation Reporter |
| Q52809588 | Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System. |
| Q36609843 | Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network |
| Q26800056 | Studying GPCR/cAMP pharmacology from the perspective of cellular structure |
| Q28260629 | Targeting the sarcomere to correct muscle function |
| Q36402676 | The fractal-like complexity of heart rate variability beyond neurotransmitters and autonomic receptors: signaling intrinsic to sinoatrial node pacemaker cells |
| Q92070172 | Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis |
| Q89766315 | Will long-acting glucagon-like peptide-1 analogues recapitulate our agonizing experience with cyclic AMP-dependent positive inotropic agents in heart failure? |
| Q38202407 | cAMP signaling in subcellular compartments |
| Q87300783 | β₃-Adrenergic regulation of L-type Ca²⁺ current and force of contraction in human ventricle |
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