Signal transduction and endocytosis: close encounters of many kinds

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Signal transduction and endocytosis: close encounters of many kinds is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1033108369
P356DOI10.1038/NRM883
P698PubMed publication ID12154371

P2093author name stringAlexander Sorkin
Mark Von Zastrow
P2860cites workbeta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating proteinQ22008042
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexesQ22008730
Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypesQ22009161
beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2Q22253360
Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiationQ22254658
SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)PQ24291391
RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular traffickingQ24291954
Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugatesQ24292701
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptorsQ24534185
Hrs recruits clathrin to early endosomesQ24535764
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffoldsQ24605173
Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptorQ24619237
Human VPS34 is required for internal vesicle formation within multivesicular endosomesQ24652429
Neurotrophins: roles in neuronal development and functionQ24656166
A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartmentQ24671496
Cell signaling by receptor tyrosine kinasesQ27860474
Rab proteins as membrane organizersQ27860861
Notch signaling: cell fate control and signal integration in developmentQ27861061
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.Q27939053
Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosisQ28115833
Subtypes of the somatostatin receptor assemble as functional homo- and heterodimersQ28138304
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3Q28138462
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5Q28138959
Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and GolgiQ28140190
A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptorQ28145098
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestinQ28190513
Nerve growth factor activates persistent Rap1 signaling in endosomesQ28207982
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming proteinQ28210330
beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptinQ28214555
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosisQ28215045
A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activationQ28252768
Enhanced degradation of EGF receptors by a sorting nexin, SNX1Q28279650
Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptorQ28565816
Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domainQ28593533
Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptorQ28613695
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of deltaQ28646245
Membrane transport in the endocytic pathwayQ29616400
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1Q29617290
Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosisQ29617390
Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptorQ29618735
Induction of mutant dynamin specifically blocks endocytic coated vesicle formationQ29620182
A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptorsQ30175258
Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cellsQ30475853
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cellsQ30857023
Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3.Q31035895
The endocytosis of epidermal growth factor in A431 cells: a pH of microenvironment and the dynamics of receptor complex dissociationQ36415899
Pathways of internalization of the hCG/LH receptor: immunoelectron microscopic studies in Leydig cells and transfected L-cells.Q36531913
Association of p60c-src with endosomal membranes in mammalian fibroblastsQ36533201
Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeletonQ36823241
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular traffickingQ37074180
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.Q37105461
The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complexQ37273521
Distinct saturable pathways for the endocytosis of different tyrosine motifsQ38336105
Receptor-mediated endocytosis: concepts emerging from the LDL receptor systemQ39461911
Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431Q40718358
Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.Q40764200
Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sortingQ40773765
Phosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosisQ40777500
Epidermal growth factor receptor efficiently activates mitogen-activated protein kinase in HeLa cells and Hep2 cells conditionally defective in clathrin-dependent endocytosisQ40852171
Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitizationQ40920202
Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transductionQ40934310
Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathwayQ40966111
Regulated endocytosis of G-protein-coupled receptors by a biochemically and functionally distinct subpopulation of clathrin-coated pitsQ41009836
Nerve growth factor processing and trafficking events following TrkA-mediated endocytosisQ41030108
Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusionQ32024228
Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathwaysQ33774714
Fluorescence lifetime imaging of receptor tyrosine kinase activity in cellsQ33877832
G-protein-coupled receptors function as oligomers in vivoQ33896444
Downregulation of G protein-coupled receptorsQ33941580
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificityQ33970712
Hormone receptor topology and dynamics: Morphological analysis using ferritin-labeled epidermal growth factorQ33980063
Neurotrophins use the Erk5 pathway to mediate a retrograde survival response.Q34090264
Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.Q34101310
Imaging biochemistry inside cellsQ34228151
Heterotrimeric G proteins: organizers of transmembrane signalsQ34317073
Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular bodyQ34330127
A new ticket for entry into budding vesicles-ubiquitinQ34365247
Beta-Arrestins: new roles in regulating heptahelical receptors' functionsQ34401868
Ras effectors and their role in mitogenesis and oncogenesisQ34439160
On Trk for retrograde signalingQ34459758
Location, location, location: a spatial view of neurotrophin signal transductionQ34536363
Arresting developments in heptahelical receptor signaling and regulationQ34540902
A serine cluster prevents recycling of the V2 vasopressin receptorQ35908261
Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblastsQ35995783
Selective membrane protein trafficking: vectorial flow and filterQ36107994
Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblastsQ36206988
Comparison of rapid changes in surface morphology and coated pit formation of PC12 cells in response to nerve growth factor, epidermal growth factor, and dibutyryl cyclic AMPQ36209904
Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblastsQ36210313
Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic systemQ36219234
Dual pathways of internalization of the cholecystokinin receptorQ36235452
Insulation of a G protein-coupled receptor on the plasmalemmal surface of the pancreatic acinar cellQ36235856
Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomesQ36257284
Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.Q36257343
Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranesQ36288145
G protein-coupled receptor/arrestin3 modulation of the endocytic machineryQ36325794
Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosisQ36328720
Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5aQ36342565
Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.Q41066099
Receptor-induced internalization of selective peptidic mu and delta opioid ligandsQ41132393
Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalizationQ41176691
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptorsQ41229236
Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cellsQ41497903
Pool of ligand‐bound platelet‐derived growth factor β‐receptors remain activated and tyrosine phosphorylated after internalizationQ41540271
The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascadesQ41688659
Type-specific sorting of G protein-coupled receptors after endocytosisQ41728938
Ligand-induced transformation by a noninternalizing epidermal growth factor receptorQ41743656
Regulated endocytic routing modulates wingless signaling in Drosophila embryos.Q41919592
Re-localization of activated EGF receptor and its signal transducers to multivesicular compartments downstream of early endosomes in response to EGF.Q41919651
Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide bindingQ42667054
Epidermal growth factor induces ubiquitination of Eps15.Q42800482
Lysosomal targeting of epidermal growth factor receptors via a kinase-dependent pathway is mediated by the receptor carboxyl-terminal residues 1022-1123.Q42806787
A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo.Q42828083
Rap1 mediates sustained MAP kinase activation induced by nerve growth factorQ42830846
Recycling of epidermal growth factor-receptor complexes in A431 cells: identification of dual pathwaysQ43107632
Receptor-mediated activation of heterotrimeric G-proteins in living cellsQ43551201
Agonist-dependent traffic of raft-associated Ras and Raf-1 is required for activation of the mitogen-activated protein kinase cascadeQ43683633
Rab5-dependent trafficking of the m4 muscarinic acetylcholine receptor to the plasma membrane, early endosomes, and multivesicular bodiesQ43759024
Retrograde support of neuronal survival without retrograde transport of nerve growth factorQ43859330
Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in DrosophilaQ43879100
Control of EGF receptor signaling by clathrin-mediated endocytosis.Q45345953
NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking.Q45987073
Creation of a Sog morphogen gradient in the Drosophila embryoQ46099920
Gradient formation of the TGF-beta homolog Dpp.Q47071783
G-protein-coupled receptors: turn-ons and turn-offsQ47754228
Lipid modifications and membrane targeting of G alphaQ47966148
Spatio-temporal images of growth-factor-induced activation of Ras and Rap1.Q48356131
The retrograde axonal transport of nerve growth factorQ48571703
Mechanisms of beta-adrenergic receptor desensitization and resensitizationQ48609403
The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.Q52539180
EGF-dependent translocation of green fluorescent protein-tagged PLC-gamma1 to the plasma membrane and endosomes.Q52543260
Signal transduction by target-derived neurotrophinsQ58415321
Binding and processing of epidermal growth factor in Panc-I human pancreatic carcinoma cellsQ70083513
Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomesQ71955066
Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interactionQ72591875
Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranesQ72592191
Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopyQ73205125
Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinaseQ73236641
An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neuronsQ73599484
Wingless gradient formation in the Drosophila wingQ73616453
Recruitment of activated G protein-coupled receptors to pre-existing clathrin-coated pits in living cellsQ74623203
Compartmentalized signal transduction by receptor tyrosine kinasesQ75294267
NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathwayQ77334867
Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartmentQ77758352
P433issue8
P304page(s)600-614
P577publication date2002-08-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleSignal transduction and endocytosis: close encounters of many kinds
P478volume3

Reverse relations

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Q28581715High-resolution fractionation of signaling endosomes containing different receptors
Q35741040Histamine-functionalized copolymer micelles as a drug delivery system in 2D and 3D models of breast cancer
Q36270087Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury
Q24313594Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
Q42801018Hrs regulates the endocytic sorting of the fibroblast growth factor receptor 2b.
Q24528171Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting
Q36189855IGFBP2 potentiates nuclear EGFR-STAT3 signaling.
Q24305385Identification and characterization of two splice variants of human diacylglycerol kinase eta
Q24336955Identification of a novel family of G protein-coupled receptor associated sorting proteins
Q35806672Identification of an AAA ATPase VPS4B-dependent pathway that modulates epidermal growth factor receptor abundance and signaling during hypoxia.
Q41303100In Vivo Analysis of the Neurovascular Niche in the Developing Xenopus Brain.
Q27349439In vivo delta opioid receptor internalization controls behavioral effects of agonists
Q36847020Independent of ErbB1 gene copy number, EGF stimulates migration but is not associated with cell proliferation in non-small cell lung cancer
Q42113223Induced Endocytosis of the Receptor Kinase FLS2
Q35195881Inhibiting EGFR dimerization using triazolyl-bridged dimerization arm mimics
Q27684953Inhibition of the Human Respiratory Syncytial Virus Small Hydrophobic Protein and Structural Variations in a Bicelle Environment
Q36717104Inhibitors of PI(4,5)P2 synthesis reveal dynamic regulation of IgE receptor signaling by phosphoinositides in RBL mast cells.
Q40946309Initial fungal effector production is mediated by early endosome motility
Q50989299Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt.
Q34627656Integrating signals from RTKs to ERK/MAPK.
Q40463360Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signaling.
Q24681060Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells
Q40485996Internalization and trafficking of guanylyl (guanylate) cyclase/natriuretic peptide receptor A is regulated by an acidic tyrosine-based cytoplasmic motif GDAY.
Q44700235Internalization at glutamatergic synapses during development
Q53800846Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic.
Q24321346Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation
Q24299976Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling
Q34449541Intersecting pathways in cell biology
Q47612221Intracellular Trafficking of Gonadotropin Receptors in Health and Disease
Q35216845Intracellular angiotensin II activates rat myometrium.
Q40890723Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells
Q36189964It's HIP to be a hub: new trends for old-fashioned proteins
Q27332234Itch is required for lateral line development in zebrafish
Q48011865Kinetics of ligand equilibration between tubular and vesicular parts of the endosome
Q37154050Knockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis
Q39093813Label-free luminescent mesoporous silica nanoparticles for imaging and drug delivery.
Q47117332Lamp1 Increases the Efficiency of Lassa Virus Infection by Promoting Fusion in Less Acidic Endosomal Compartments
Q41828407Landscape of finite-temperature equilibrium behaviour of curvature-inducing proteins on a bilayer membrane explored using a linearized elastic free energy model
Q59044303Life on Mars, cellularly speaking
Q42834842Ligand-induced clathrin-mediated endocytosis of the keratinocyte growth factor receptor occurs independently of either phosphorylation or recruitment of eps15.
Q34471127Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis
Q35048177Ligand-mediated endocytosis and intracellular sequestration of guanylyl cyclase/natriuretic peptide receptors: role of GDAY motif
Q30564103Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis
Q46602647Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.
Q36779673Loss of vacuolar H+-ATPase (V-ATPase) activity in yeast generates an iron deprivation signal that is moderated by induction of the peroxiredoxin TSA2.
Q40669337Lysophosphatidic acid stimulates brush border Na+/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism
Q24298248Lysosomal targeting of phafin1 mediated by Rab7 induces autophagosome formation
Q30834535MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation
Q40589753Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization.
Q38385016Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes
Q36794886Mechanisms of axon guidance: membrane dynamics and axonal transport in semaphorin signalling.
Q35995003Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling.
Q37401247Membrane protein targeting to the MVB/lysosome
Q38556953Membrane turnover and receptor trafficking in regenerating axons
Q40112771Membranous structures transfer cell surface proteins across NK cell immune synapses
Q38665073Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer
Q36260739Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity
Q28586483Mind bomb-2 is an E3 ligase for Notch ligand
Q24676764Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes
Q47859413MnAl Layered Double Hydroxide Nanoparticles as a Dual-Functional Platform for Magnetic Resonance Imaging and siRNA Delivery
Q21093228Modeling the signaling endosome hypothesis: why a drive to the nucleus is better than a (random) walk
Q38896046Modulation of Host Immunity by the Human Metapneumovirus.
Q38393275Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.
Q35189428Modulation of developmental signals by endocytosis: different means and many ends.
Q34213559Molecular Mechanisms that Regulate Epidermal Growth Factor Receptor Inactivation
Q33609045Molecular systems biology of ErbB1 signaling: bridging the gap through multiscale modeling and high-performance computing
Q36904780Monitoring endosomal trafficking of the g protein-coupled receptor somatostatin receptor 3.
Q45300336Multifunctional Liposomes
Q93007098Multifunctional Polymer Nanoparticles for Dual Drug Release and Cancer Cell Targeting
Q54115773Multiple Transceptors for Macro- and Micro-Nutrients Control Diverse Cellular Properties Through the PKA Pathway in Yeast: A Paradigm for the Rapidly Expanding World of Eukaryotic Nutrient Transceptors Up to Those in Human Cells.
Q47754729Multiple mechanisms of CB1 cannabinoid receptors regulation
Q34663489Multivesicular bodies in neurons: distribution, protein content, and trafficking functions
Q48142730Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling.
Q39843842Multivesicular endosome biogenesis in the absence of ESCRTs
Q38625908Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway
Q64930044NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice.
Q41510497NEU3 Sialidase Protein Interactors in the Plasma Membrane and in the Endosomes
Q26782566Nanoparticle Drug Delivery Systems Designed to Improve Cancer Vaccines and Immunotherapy
Q40486921Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity
Q41052566New image colocalization coefficient for fluorescence microscopy to quantify (bio-)molecular interactions.
Q36950646New roles for endosomes: from vesicular carriers to multi-purpose platforms
Q37004113Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization
Q30489162Nonlinear pharmacokinetics of therapeutic proteins resulting from receptor mediated endocytosis
Q34233390Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes
Q35089368Nuclear localization and possible functions of receptor tyrosine kinases
Q24323268Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1
Q36155980Oncogenic breakdowns in endocytic adaptor proteins.
Q35809213Organelles and trafficking machinery for postsynaptic plasticity
Q40637745Oxytocin receptor elicits different EGFR/MAPK activation patterns depending on its localization in caveolin-1 enriched domains
Q38692217PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity
Q42113983PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2.
Q27329609Persistent cAMP-signals triggered by internalized G-protein-coupled receptors
Q36420521Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion
Q46017179Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.
Q64267972PhotonSABER: new tool shedding light on endocytosis and learning mechanisms
Q45122612Photoswitchable cyan fluorescent protein for protein tracking
Q36020685Poly(lactic-co-glycolic) Acid-Chitosan Dual Loaded Nanoparticles for Antiretroviral Nanoformulations
Q38584191Polyphosphate as a metabolic fuel in Metazoa: A foundational breakthrough invention for biomedical applications
Q38521179Postendocytic Sorting of Adrenergic and Opioid Receptors: New Mechanisms and Functions.
Q37907064Potential cross-talk between (pro)renin receptors and Wnt/frizzled receptors in cardiovascular and renal disorders
Q39825669PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site.
Q33751225Production and characterization of a recombinant single-chain antibody against Hantaan virus envelop glycoprotein
Q35990940Proteasomes mediate prolactin-induced receptor down-regulation and fragment generation in breast cancer cells
Q35573989Protein Targeting to Endosomes and Phagosomes via FYVE and PX Domains
Q44446240Protein kinase C-mediated phosphorylation of a single serine residue on the rat glial glutamine transporter SN1 governs its membrane trafficking
Q24304888Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells
Q28292379Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling
Q41925259Protoparvovirus Knocking at the Nuclear Door.
Q40190596Purification method directly influences effectiveness of an epidermal growth factor-coupled targeting agent for noninvasive tumor detection in mice
Q33351305Quantification of the brassinosteroid insensitive1 receptor in planta
Q49121415Quantitative Microscopic Analysis of Plasma Membrane Receptor Dynamics in Living Plant Cells
Q39201415Quantum Dot Surface Engineering: Toward Inert Fluorophores with Compact Size and Bright, Stable Emission
Q50482466RABA members act in distinct steps of subcellular trafficking of the FLAGELLIN SENSING2 receptor.
Q37127313RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis
Q42134556Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells
Q24338474Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth
Q33471497Rapid insulin-dependent endocytosis of the insulin receptor by caveolae in primary adipocytes
Q35120159Ras proteins: different signals from different locations
Q36880352Ras proteins: paradigms for compartmentalised and isoform-specific signalling.
Q34413566Ras/MAPK signaling from endomembranes
Q42159264Real-time imaging of Rab5 activity using a prequenched biosensor.
Q40460839Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.
Q52608532Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10.
Q47706872Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs
Q51814356Recycling of cell surface pro-transforming growth factor-{alpha} regulates epidermal growth factor receptor activation.
Q34166288Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection
Q38595745Region-specific alterations of adenosine receptors expression level in kidney of diabetic rat.
Q38193549Regulated intramembrane proteolysis of the TGFβ type I receptor conveys oncogenic signals
Q33292189Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8.
Q37188507Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
Q46852260Regulation of apical NHE3 trafficking by ouabain-induced activation of the basolateral Na+-K+-ATPase receptor complex
Q39998896Regulation of clathrin-mediated endocytosis by p53.
Q28308073Regulation of endocytic sorting by ESCRT-DUB-mediated deubiquitination
Q37657338Regulation of epidermal growth factor receptor degradation by heterotrimeric Galphas protein
Q36731459Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8
Q41905591Regulation of membrane cholecystokinin-2 receptor by agonists enables classification of partial agonists as biased agonists.
Q42858237Regulation of sodium pump endocytosis by cardiotonic steroids: Molecular mechanisms and physiological implications
Q30496565Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src.
Q21285001Releasing the brake: targeting Cbl-b to enhance lymphocyte effector functions
Q33571642Retrograde neurotrophic signaling requires a protein interacting with receptor tyrosine kinases via C2H2 zinc fingers
Q39321282RhoA-GTPase facilitates entry of Kaposi's sarcoma-associated herpesvirus into adherent target cells in a Src-dependent manner
Q24317093Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes
Q45146972Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons.
Q40264478Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3.
Q24292840Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression
Q39429925SNX3-dependent regulation of epidermal growth factor receptor (EGFR) trafficking and degradation by aspirin in epidermoid carcinoma (A-431) cells
Q28205230STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes
Q33677340Salt-induced subcellular kinase relocation and seedling susceptibility caused by overexpression of Medicago SIMKK in Arabidopsis
Q30930491Sedimentation equilibrium of a small oligomer-forming membrane protein: effect of histidine protonation on pentameric stability
Q36803842Separate endocytic pathways regulate IL-5 receptor internalization and signaling
Q49403566Shear stress induces noncanonical autophagy in intestinal epithelial monolayers.
Q34407232Shiga toxin regulates its entry in a Syk-dependent manner
Q27303629Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells
Q57359903Signaling on the endocytic pathway
Q34381865Small peptide recognition sequence for intracellular sorting
Q36638101Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia
Q35575284Sorting motifs in receptor trafficking
Q39295020Sorting of the FGF receptor 1 in a human glioma cell line
Q36713646Stable isotopic labeling by amino acids in cultured primary neurons: application to brain-derived neurotrophic factor-dependent phosphotyrosine-associated signaling
Q41668344Stat-mediated signaling induced by type I and type II interferons (IFNs) is differentially controlled through lipid microdomain association and clathrin-dependent endocytosis of IFN receptors
Q50154286Statistical mechanics of viral entry
Q24681194Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2
Q40607521Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11.
Q37665298Subcellular targeting strategies for drug design and delivery
Q37332439Subcellular trafficking of the TRH receptor: effect of phosphorylation
Q34652403Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation
Q39716000Sul1 and Sul2 sulfate transceptors signal to protein kinase A upon exit of sulfur starvation.
Q40469010Synaptic targeting of retrogradely transported trophic factors in motoneurons: comparison of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor, and cardiotrophin-1 with tetanus toxin.
Q35695057Synthesis and Characterization of 8-O-Carboxymethylpyranine (CM-Pyranine) as a Bright, Violet-Emitting, Fluid-Phase Fluorescent Marker in Cell Biology
Q34194358Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP.
Q36220170Synthesis, Characterization, and Biological Evaluation of Anti-HER2 Indocyanine Green-Encapsulated PEG-Coated PLGA Nanoparticles for Targeted Phototherapy of Breast Cancer Cells
Q24310480Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation
Q35156394Systems biology and physical biology of clathrin-mediated endocytosis.
Q33481328TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells.
Q36013089TRKing signals through the Golgi
Q24304479TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation
Q28594301Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization
Q39030620Targeted extracellular signal-regulated kinase activation mediated by Leishmania amazonensis requires MP1 scaffold
Q37155730Targeting CBLB as a potential therapeutic approach for disseminated candidiasis
Q37564511Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis
Q24308624The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting
Q37635355The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner.
Q51076920The EGFR demonstrates linear signal transmission.
Q24547253The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.
Q34282400The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28.
Q36860490The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner
Q36058465The Myopic-Ubpy-Hrs nexus enables endosomal recycling of Frizzled
Q37657288The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface
Q35897293The Role of Hydroxyl Channel in Defining Selected Physicochemical Peculiarities Exhibited by Hydroxyapatite.
Q34623704The carboxyl terminus controls ligand-dependent activation of VEGFR-2 and its signaling
Q37333190The coming of age of axonal neurotrophin signaling endosomes
Q36654494The dark side of the NGF family: neurotrophins in neoplasias
Q36831073The downstream regulation of chemokine receptor signalling: implications for atherosclerosis
Q51599527The dynamics of Turing patterns for morphogen-regulated growing domains with cellular response delays.
Q24295295The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion
Q36747760The hepatitis E virus ORF3 protein modulates epidermal growth factor receptor trafficking, STAT3 translocation, and the acute-phase response
Q39648363The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking
Q39848000The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane
Q38208062The ins and outs of fibroblast growth factor receptor signalling.
Q37732998The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release
Q35674439The peroxisome: orchestrating important developmental decisions from inside the cell
Q36501163The physiology of membrane transport and endomembrane-based signalling
Q32884425The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless.
Q36540733The role of protein turnover in ethylene biosynthesis and response
Q43258170The secreted Salmonella dublin phosphoinositide phosphatase, SopB, localizes to PtdIns(3)P-containing endosomes and perturbs normal endosome to lysosome trafficking
Q50747092The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA.
Q34305323The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling
Q24306610The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.
Q37400805The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFR degradation
Q24293671The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling
Q34302331Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide
Q24297958Tom1, a VHS Domain-containing Protein, Interacts with Tollip, Ubiquitin, and Clathrin
Q36961129Tracking TrkA's trafficking: NGF receptor trafficking controls NGF receptor signaling
Q36161695Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks
Q37308472Trafficking of receptor tyrosine kinases to the nucleus
Q34286964Trafficking the NGF signal: implications for normal and degenerating neurons
Q42316604Transceptors as a functional link of transporters and receptors
Q35650838Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway
Q46024455Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma.
Q40631955Two Distinct Transport Motifs in the Adenovirus E3/10.4-14.5 Proteins Act in Concert to Down-modulate Apoptosis Receptors and the Epidermal Growth Factor Receptor
Q44969005Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases.
Q34283427Tyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/β-catenin pathway signaling
Q24653688Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation
Q36251951Ubiquitylation and cell signaling
Q38910202Ultrastructural Morphometry Points to a New Role for LAMTOR2 in Regulating the Endo/Lysosomal System.
Q24301314V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway
Q24299236Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
Q36642826Vesicle trafficking in plant immune responses
Q44644024Visualization of Rab5 activity in living cells by FRET microscopy and influence of plasma-membrane-targeted Rab5 on clathrin-dependent endocytosis
Q42911386Yeast nutrient transceptors provide novel insight in the functionality of membrane transporters
Q54324866[Involvement of the endosomal compartment in cellular insulin signaling].
Q40090625c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling
Q35887991hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation
Q58605707mRNA as novel technology for passive immunotherapy
Q52879772pERK1/2 Peripheral Recruitment and Filopodia Protrusion Augment Oligodendrocyte Progenitor Cell Migration: Combined Effects of PDGF-A and Fibronectin.
Q36282567pH-dependent binding of the Epsin ENTH domain and the AP180 ANTH domain to PI(4,5)P2-containing bilayers.
Q35214338β-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons

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