| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S1359-6446(03)02738-7 |
| P698 | PubMed publication ID | 12850333 |
| P50 | author | Graeme Milligan | Q28468987 |
| P2860 | cites work | Initial sequencing and analysis of the human genome | Q21045365 |
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| The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor | Q22253381 | ||
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| Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer | Q28208425 | ||
| Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer | Q28213709 | ||
| A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation | Q28252768 | ||
| Detection of receptor ligands by monitoring selective stabilization of a Renilla luciferase-tagged, constitutively active mutant, G-protein-coupled receptor | Q28364896 | ||
| ??? | Q28207849 | ||
| Exploring the dynamics of regulation of G protein-coupled receptors using green fluorescent protein | Q33749457 | ||
| Using green fluorescent proteins to study G-protein-coupled receptor localization and trafficking | Q33901020 | ||
| Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome. | Q33923309 | ||
| How accurately can we image inositol lipids in living cells? | Q33953238 | ||
| Determinants of metabotropic glutamate receptor-5-mediated Ca2+ and inositol 1,4,5-trisphosphate oscillation frequency. Receptor density versus agonist concentration | Q34139041 | ||
| Diversity and specificity in the regulated endocytic membrane trafficking of G-protein-coupled receptors | Q34228099 | ||
| Reporter-gene systems for the study of G-protein-coupled receptors. | Q34476206 | ||
| Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function | Q34504071 | ||
| Target validation of G-protein coupled receptors | Q34525952 | ||
| Ligand rescue of constitutively active mutant receptors | Q34594472 | ||
| Signal transduction and endocytosis: close encounters of many kinds | Q34770359 | ||
| Strategies to identify ligands for orphan G-protein-coupled receptors | Q34797778 | ||
| G-protein-coupled receptor oligomerization and its potential for drug discovery | Q34932201 | ||
| The use of constitutively active GPCRs in drug discovery and functional genomics | Q34981350 | ||
| Applications of novel resonance energy transfer techniques to study dynamic hormone receptor interactions in living cells. | Q34997121 | ||
| Creating new fluorescent probes for cell biology. | Q35014035 | ||
| Functional Assays for Identifying Ligands at Orphan G Protein-Coupled Receptors | Q35105373 | ||
| Aequorin-Based Functional Assays for G-Protein-Coupled Receptors, Ion Channels, and Tyrosine Kinase Receptors | Q35105382 | ||
| The Use of Biosensors to Study GPCR Function: Applications for High-Content Screening | Q35105386 | ||
| Agonist-dependent dissociation of oligomeric complexes of G protein-coupled cholecystokinin receptors demonstrated in living cells using bioluminescence resonance energy transfer | Q38295489 | ||
| CypHer 5: a generic approach for measuring the activation and trafficking of G protein-coupled receptors in live cells | Q40565846 | ||
| The cellular distribution of fluorescently labeled arrestins provides a robust, sensitive, and universal assay for screening G protein-coupled receptors | Q40565884 | ||
| Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors | Q40665282 | ||
| The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS). | Q40680819 | ||
| A pH-sensitive fluor, CypHer 5, used to monitor agonist-induced G protein-coupled receptor internalization in live cells | Q40687781 | ||
| Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor | Q40689812 | ||
| A novel strategy to engineer functional fluorescent inhibitory G-protein alpha subunits | Q40727552 | ||
| Quantitative analysis of agonist-dependent parathyroid hormone receptor trafficking in whole cells using a functional green fluorescent protein conjugate | Q40762537 | ||
| Studies of signal transduction events using chimeras to green fluorescent protein | Q40846784 | ||
| Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors | Q40889383 | ||
| Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility | Q41132503 | ||
| Inverse agonism and the regulation of receptor number | Q41698383 | ||
| Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat mu-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation | Q41918661 | ||
| Signal characteristics of G protein-transactivated EGF receptor | Q41960343 | ||
| Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster alpha1B-adrenoceptor by ligands that act as inverse agonists | Q42443312 | ||
| Visualization of a functional Galpha q-green fluorescent protein fusion in living cells. Association with the plasma membrane is disrupted by mutational activation and by elimination of palmitoylation sites, but not be activation mediated by recepto | Q42495882 | ||
| Receptor-mediated activation of heterotrimeric G-proteins in living cells | Q43551201 | ||
| Real-time visualization of a fluorescent G(alpha)(s): dissociation of the activated G protein from plasma membrane | Q43865607 | ||
| Generation and analysis of constitutively active and physically destabilized mutants of the human beta(1)-adrenoceptor | Q44104311 | ||
| Ligand-dependent inhibition of oligomerization at the human thyrotropin receptor | Q44132523 | ||
| Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate | Q73467321 | ||
| Resolution of inverse agonist-induced up-regulation from constitutive activity of mutants of the alpha(1b)-adrenoceptor | Q74045645 | ||
| Monitoring receptor-mediated activation of heterotrimeric G-proteins by fluorescence resonance energy transfer | Q74752806 | ||
| P433 | issue | 13 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | G protein-coupled receptor | Q38173 |
| P304 | page(s) | 579-85 | |
| P577 | publication date | 2003-07-01 | |
| P1433 | published in | Drug Discovery Today | Q3040085 |
| P1476 | title | High-content assays for ligand regulation of G-protein-coupled receptors | |
| P478 | volume | 8 |
| Q35051254 | A systems approach for analysis of high content screening assay data with topic modeling |
| Q40181625 | An encoded viral micropatch for multiplex cell-based assays through localized gene delivery |
| Q37668411 | Carbon nanotubes towards medicinal biochips |
| Q37553926 | Cellular assays as portals to seven-transmembrane receptor-based drug discovery |
| Q33386660 | Duplexed label-free G protein--coupled receptor assays for high-throughput screening |
| Q51103454 | G protein-coupled receptor internalization assays in the high-content screening format. |
| Q36290216 | G-protein-coupled receptors in drug discovery: nanosizing using cell-free technologies and molecular biology approaches. |
| Q40017822 | Label-free optical biosensor for ligand-directed functional selectivity acting on beta(2) adrenoceptor in living cells. |
| Q44695513 | Ligand-selective signaling and high-content screening for GPCR drugs |
| Q37610141 | Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery. |
| Q36460541 | New directions in kinetic high information content assays |
| Q40185924 | Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells. |
| Q51392727 | Probing cytoskeleton modulation by optical biosensors. |
| Q40269125 | Resonant waveguide grating biosensor for living cell sensing. |
| Q52691334 | Reverting iodine avidity of radioactive-iodine refractory thyroid cancer with a new tyrosine kinase inhibitor (K905-0266) excavated by high-throughput NIS (sodium iodide symporter) enhancer screening platform using dual reporter gene system. |
| Q33890786 | Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery |
| Q36601823 | Stably transformed insect cell lines: tools for expression of secreted and membrane-anchored proteins and high-throughput screening platforms for drug and insecticide discovery |
| Q33253601 | The 7 TM G-protein-coupled receptor target family |
| Q73826172 | The secret lives of GPCRs |
| Q40463546 | The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation. |
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