The downstream regulation of chemokine receptor signalling: implications for atherosclerosis

scientific article published on 14 April 2013

The downstream regulation of chemokine receptor signalling: implications for atherosclerosis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2013/459520
P932PMC publication ID3649756
P698PubMed publication ID23690662
P5875ResearchGate publication ID236924849

P50authorKeith ChannonQ56420294
Eileen McNeillQ41774481
P2093author name stringJyoti Patel
P2860cites workCcr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in MiceQ61386204
A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart AssociationQ72415283
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial treeQ72689998
Transfer of CD4(+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout miceQ73288555
Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4Q75411029
Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient miceQ77231603
Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient miceQ77340592
Mouse models of atherosclerosisQ77555168
Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor gamma-dependent pathwayQ80111777
Regulator of G protein signaling 5 marks peripheral arterial smooth muscle cells and is downregulated in atherosclerotic plaqueQ80509039
G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitisQ81546558
Novel candidate genes in unstable areas of human atherosclerotic plaques.Q51585538
Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers.Q51822453
The specific role of chemokines in atherosclerosis.Q53555491
Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles.Q54240315
Role of inflammation and metalloproteinases in plaque disruption and thrombosisQ57133777
Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general populationQ58363290
An oxidized lipid-peroxisome proliferator-activated receptor gamma-chemokine pathway in the regulation of macrophage-vascular smooth muscle cell adhesionQ24300694
Atherosclerosis — An Inflammatory DiseaseQ26776972
Regulation of atherogenesis by chemokines and chemokine receptorsQ27003124
GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteinsQ28145018
The regulator of G protein signaling familyQ28145604
Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applicationsQ28275259
Inflammation, atherosclerosis, and coronary artery diseaseQ29547232
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein EQ29615236
Chemokines: a new classification system and their role in immunityQ29615663
The many roles of chemokines and chemokine receptors in inflammationQ29618880
Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signalingQ30014843
Mammalian RGS proteins: multifunctional regulators of cellular signalling.Q30354302
Polarization of chemoattractant receptor signaling during neutrophil chemotaxisQ30493167
Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient miceQ33236495
Statins stimulate RGS-regulated ERK 1/2 activation in human calcified and stenotic aortic valvesQ33356824
Macrophage plasticity in experimental atherosclerosisQ33527405
Structure, function, and inhibition of chemokinesQ34110896
Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure.Q34144328
The germinal center reactionQ34148104
Eukaryotic chemotaxis: distinctions between directional sensing and polarizationQ34188022
Regulator of G protein signaling proteins: novel multifunctional drug targetsQ34253413
Current status of chemokine receptor inhibitors in developmentQ34304366
Chemokines in pathology and medicineQ34328278
G-protein-coupled receptor dimerization: modulation of receptor function.Q34578524
Agonist-selective mechanisms of GPCR desensitizationQ34722029
Signal transduction and endocytosis: close encounters of many kindsQ34770359
A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.Q40467498
Structure-activity relationships of chemokinesQ40531026
Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7.Q40571692
Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activationQ40699131
CC chemokine receptor-3 undergoes prolonged ligand-induced internalizationQ40959278
MIP-3alpha, MIP-3beta and fractalkine induce the locomotion and the mobilization of intracellular calcium, and activate the heterotrimeric G proteins in human natural killer cellsQ40979548
Differential regulation of G-protein-mediated signaling by chemokine receptorsQ41168752
Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activityQ41270179
Heterotrimeric G protein signaling: roles in immune function and fine-tuning by RGS proteinsQ41700415
G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.Q41982556
Regulators of G-protein signaling (RGS) 1 and 16 are induced in response to bacterial lipopolysaccharide and stimulate c-fos promoter expressionQ42473246
Chemokine receptor dimerization: two are better than one.Q43792050
Phosphorylation of the N-formyl peptide receptor is required for receptor internalization but not chemotaxisQ44072394
Transplantation of monocyte CC-chemokine receptor 2-deficient bone marrow into ApoE3-Leiden mice inhibits atherogenesisQ44342246
Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6.Q44666534
Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naïve and regulatory T cellsQ44823348
Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosisQ46897070
GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo.Q47286150
Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress.Q47334929
Identification of new genes differentially expressed in coronary artery disease by expression profilingQ47709919
Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune systemQ49071913
CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome.Q34774168
Leukocyte extravasation: chemokine transport and presentation by the endotheliumQ34998445
Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potentialQ35195555
Beta-arrestin-2 regulates the development of allergic asthmaQ35242857
Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transductionQ35523846
Matrix metalloproteinases A review of their structure and role in acute coronary syndromeQ35557333
Site specificity of atherosclerosis: site-selective responses to atherosclerotic modulatorsQ35578683
G protein-coupled receptor kinases: more than just kinases and not only for GPCRsQ35621624
Chemokines: multiple levels of leukocyte migration control.Q35753105
Regulation of chemokine-induced lymphocyte migration by RGS proteinsQ35864175
WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4.Q36079791
Dimerization of chemokine receptors and its functional consequencesQ36175293
R4 RGS proteins: regulation of G-protein signaling and beyondQ36301542
Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular diseaseQ36313343
Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout miceQ36482911
Moving toward understanding eukaryotic chemotaxisQ36492626
Chemoattractant receptor signaling and the control of lymphocyte migration.Q36557763
GRKs and arrestins: regulators of migration and inflammationQ36582023
T cells in atherogenesis: for better or for worse?Q36594608
Intertwining of thrombosis and inflammation in atherosclerosisQ36667645
Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- miceQ36732984
Clathrin-dependent mechanisms of G protein-coupled receptor endocytosisQ36765864
G-protein-coupled receptor expression, function, and signaling in macrophagesQ36800734
Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or GsQ36821880
Chemotaxis, chemokine receptors and human disease.Q37034783
Altered CXCR2 signaling in beta-arrestin-2-deficient mouse modelsQ37156680
The role of adaptive T cell immunity in atherosclerosisQ37339539
Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migrationQ37383096
Fine-tuning of GPCR activity by receptor-interacting proteinsQ37638132
Chemokine receptors intracellular trafficking.Q37745630
Heterophilic chemokine receptor interactions in chemokine signaling and biologyQ37819146
Turning off the signal: desensitization of beta-adrenergic receptor functionQ37887325
CC chemokine receptors and chronic inflammation--therapeutic opportunities and pharmacological challengesQ38072673
Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21.Q39938297
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmembrane proteinQ423042
signal transductionQ828130
cell surface receptorQ2476074
atherosclerosisQ12252367
chemokine receptor familyQ24720618
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)459520
P577publication date2013-04-14
P1433published inMediators of InflammationQ2144494
P1476titleThe downstream regulation of chemokine receptor signalling: implications for atherosclerosis
P478volume2013