Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population

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Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/HR.2011.25
P698PubMed publication ID21451528

P50authorYoshihiro KokuboQ64858497
Hiromi RakugiQ35703947
Tomonori OkamuraQ37390501
Tetsutarō MatayoshiQ46118316
P2093author name stringSatoko Nakamura
Kei Kamide
Toshiyuki Miyata
Yuhei Kawano
Jin Yang
Takeshi Horio
Mitsuru Ohishi
Yoshikazu Miwa
Fumiki Yoshihara
Sachiko Matsumoto
Yoshio Iwashima
Hajime Nakahama
Ryousuke Oguro
Shin Takiuchi
Hisayo Yasuda
Mariko Banno
P2860cites workRGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling.Q53878865
An Alternative Fast and Convenient Genotyping Method for the Screening of Angiotensin Converting Enzyme Gene PolymorphismsQ54774814
Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertensionQ56901991
Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: Evidence for susceptibility loci on 1qQ57073109
Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cellsQ73487478
Verification of 525 coding SNPs in 179 hypertension candidate genes in the Japanese population: identification of 159 SNPs in 93 genesQ74616572
Renin-angiotensin system and atherosclerosisQ79798837
Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin IIQ83311058
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common diseaseQ22337234
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressureQ24299443
The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signallingQ24529925
Atherosclerosis — An Inflammatory DiseaseQ26776972
N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cellsQ28283150
G protein selectivity is a determinant of RGS2 function.Q30323308
Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general populationQ34432231
Pleiotropic actions of sphingosine-1-phosphateQ35146936
Nitric oxide and atherosclerosis: an updateQ36473426
Prevalence of asymptomatic carotid atherosclerotic lesions detected by high-resolution ultrasonography and its relation to cardiovascular risk factors in the general population of a Japanese city: the Suita studyQ39441228
Potential of carotid enlargement as a useful indicator affected by high blood pressure in a large general population of a Japanese city: the Suita studyQ39553719
Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study.Q39927614
Endothelin and endothelin antagonism: Roles in cardiovascular health and diseaseQ40474649
Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese populationQ44829932
Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors.Q45246026
Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives.Q45984379
Rationale, study design and implementation of the COLM study: the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patients.Q46099840
Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophyQ46870087
P433issue6
P304page(s)740-746
P577publication date2011-03-31
P1433published inHypertension ResearchQ15762136
P1476titleAssociation of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population
P478volume34

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cites work (P2860)
Q37190345Genetic associations with hypertension: meta-analyses of six candidate genetic variants
Q30769610Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: data from the Norwegian HUNT2 study
Q34023105Non-dipping and arterial hypertension depend on clinical factors rather than on genetic variability of ACE and RGS2 genes in patients with type 1 diabetes
Q36831073The downstream regulation of chemokine receptor signalling: implications for atherosclerosis

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