Non-canonical signaling of the PTH receptor

scientific article

Non-canonical signaling of the PTH receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TIPS.2012.05.004
P932PMC publication ID3428041
P698PubMed publication ID22709554
P5875ResearchGate publication ID227341281

P50authorThomas J GardellaQ91142686
P2093author name stringJean-Pierre Vilardaga
Timothy N Feinstein
Vanessa L Wehbi
P2860cites workbeta-Arrestin: a protein that regulates beta-adrenergic receptor functionQ24305145
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Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosisQ29619487
A form of Jansen's metaphyseal chondrodysplasia with limited metabolic and skeletal abnormalities is caused by a novel activating parathyroid hormone (PTH)/PTH-related peptide receptor mutationQ30941843
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Molecular properties of the PTH/PTHrP receptorQ34276973
Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.Q34544553
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptorQ34708055
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Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformationsQ35622858
Parathyroid hormone and parathyroid hormone-related peptide, and their receptorsQ36032066
Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.Q36372640
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activationQ36411260
Trafficking of G protein-coupled receptorsQ36594595
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Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformationQ36946514
Regulation of GPCRs by endocytic membrane trafficking and its potential implicationsQ37053838
Elevations in serum and urinary calcium with parathyroid hormone (1-84) with and without alendronate for osteoporosisQ37101657
The arrestin fold: variations on a themeQ37236186
beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activationQ37350606
Role of phospholipase D in parathyroid hormone type 1 receptor signaling and traffickingQ37484589
Endocytosis and signalingQ37862859
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A docking site for G protein βγ subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathwaysQ40385537
G alpha12/G alpha13 subunits of heterotrimeric G proteins mediate parathyroid hormone activation of phospholipase D in UMR-106 osteoblastic cells.Q40459760
Novel parathyroid hormone (PTH) antagonists that bind to the juxtamembrane portion of the PTH/PTH-related protein receptorQ40490382
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A highly effective dominant negative alpha s construct containing mutations that affect distinct functions inhibits multiple Gs-coupled receptor signaling pathwaysQ40740952
Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor associationQ40765935
Analysis of parathyroid hormone (PTH)/secretin receptor chimeras differentiates the role of functional domains in the pth/ pth-related peptide (PTHrP) receptor on hormone binding and receptor activationQ40795070
Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopyQ40924347
Coupling of the PTH/PTHrP receptor to multiple G-proteins. Direct demonstration of receptor activation of Gs, Gq/11, and Gi(1) by [alpha-32P]GTP-gamma-azidoanilide photoaffinity labelingQ41016491
Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systemsQ41089415
Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalizationQ41238228
Parathyroid hormone (PTH)-PTH-related peptide hybrid peptides reveal functional interactions between the 1-14 and 15-34 domains of the ligandQ41358649
The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34).Q41489259
Evaluating the signal transduction mechanism of the parathyroid hormone 1 receptor. Effect of receptor-G-protein interaction on the ligand binding mechanism and receptor conformationQ43511313
Enhanced activity in parathyroid hormone-(1-14) and -(1-11): novel peptides for probing ligand-receptor interactionsQ43646678
Dual regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor signaling by protein kinase C and beta-arrestins.Q44142742
Occurrence of hypercalciuria in patients with osteoporosis treated with teriparatideQ44284969
Measurement of the millisecond activation switch of G protein-coupled receptors in living cellsQ44479240
Long-term treatment of hypoparathyroidism: a randomized controlled study comparing parathyroid hormone-(1-34) versus calcitriol and calcium.Q44582481
NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recyclingQ46989494
Teriparatide in postmenopausal women with osteoporosis and mild or moderate renal impairment.Q51932388
Measurement of agonist and antagonist ligand-binding parameters at the human parathyroid hormone type 1 receptor: evaluation of receptor states and modulation by guanine nucleotide.Q51984622
Recessive mutations in PTHR1 cause contrasting skeletal dysplasias in Eiken and Blomstrand syndromes.Q52085977
Minimization of parathyroid hormone. Novel amino-terminal parathyroid hormone fragments with enhanced potency in activating the type-1 parathyroid hormone receptorQ73703963
G protein signaling in yeast: new components, new connections, new compartmentsQ79397313
Parathyroid hormone-related protein: an essential physiological regulator of adult bone massQ80362942
P433issue8
P304page(s)423-431
P577publication date2012-06-16
P1433published inTrends in Pharmacological SciencesQ2451474
P1476titleNon-canonical signaling of the PTH receptor
P478volume33

Reverse relations

cites work (P2860)
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