Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase

scientific article (publication date: 28 May 1999)

Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.22.15947
P3181OpenCitations bibliographic resource ID4357808
P698PubMed publication ID10336501
P5875ResearchGate publication ID12961339

P2093author name stringX Wu
F Wang
W L McKeehan
M Kan
P2860cites workA homeo-interaction sequence in the ectodomain of the fibroblast growth factor receptorQ41091047
Identification of glypican as a dual modulator of the biological activity of fibroblast growth factorsQ41110684
Nuclear localization of a complex of fibroblast growth factor(FGF)-1 and an NH2-terminal fragment of FGF receptor isoforms R4 and R1alpha in human liver cellsQ41134771
Identification and assay of fibroblast growth factor receptorsQ41706529
Heparan sulfate is required for interaction and activation of the epithelial cell fibroblast growth factor receptor-2IIIb with stromal-derived fibroblast growth factor-7.Q42061209
Molecular modeling and deletion mutagenesis implicate the nuclear translocation sequence in structural integrity of fibroblast growth factor-1.Q42807941
Developmental Regulation of Neural Response to FGF-1 and FGF-2 by Heparan Sulfate ProteoglycanQ52225676
High salt inhibits both heparin-dependent and heparin-independent complexes of fibroblast growth factor and the receptor kinase.Q52561654
Receptor specificity of the fibroblast growth factor familyQ24320178
Structure of a heparin-linked biologically active dimer of fibroblast growth factorQ27760195
Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2Q28273441
Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regenerationQ34307150
Endothelial and fibroblast cell-derived heparan sulphate bind with differing affinity to basic fibroblast growth factorQ38334436
Interaction of heparan sulfate from mammary cells with acidic fibroblast growth factor (FGF) and basic FGF. Regulation of the activity of basic FGF by high and low affinity binding sites in heparan sulfateQ38338357
Structural modification of fibroblast growth factor-binding heparan sulfate at a determinative stage of neural developmentQ38339362
Properly oriented heparin-decasaccharide-induced dimers are the biologically active form of basic fibroblast growth factor.Q38346690
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)15947-52
P577publication date1999-05-28
P1433published inJournal of Biological ChemistryQ867727
P1476titleSpecificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase
P478volume274

Reverse relations

cites work (P2860)
Q24685118A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice
Q40832433A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells
Q35103291Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease
Q38922385Activation of FGF receptor signaling promotes invasion of non-small-cell lung cancer
Q88936926Basement Membranes in Development and Disease
Q38302571Binding of heparin/heparan sulfate to fibroblast growth factor receptor 4.
Q44591813Biospecific Extraction and Neutralization of Anticoagulant Heparin with Fibroblast Growth Factors (FGF)
Q38977291Cardiac actions of fibroblast growth factor 23.
Q40730239Cell- and receptor isotype-specific phosphorylation of SNT1 by fibroblast growth factor receptor tyrosine kinases
Q33767961Cellular cofactors for amyloid beta-peptide-induced cell stress. Moving from cell culture to in vivo
Q31036531Chlamydia trachomatis co-opts the FGF2 signaling pathway to enhance infection
Q35010389Co-administration of cyclosporine an alleviates thioacetamide-induced liver injury
Q42801360Control of fibroblast growth factor (FGF) 7- and FGF1-induced mitogenesis and downstream signaling by distinct heparin octasaccharide motifs
Q34258918Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations
Q58418712Depot-Specific Expression of Fibroblast Growth Factors in Human Adipose Tissue
Q39374896Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.
Q37256534Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation.
Q77178108Directional specificity of prostate stromal to epithelial cell communication via FGF7/FGFR2 is set by cell- and FGFR2 isoform-specific heparan sulfate
Q28590891Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
Q36332838Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor.
Q35043172Endovascular laser–tissue interactions and biological responses in relation to endovenous laser therapy
Q30443021Evidence for digenic inheritance in some cases of Antley-Bixler syndrome?
Q74456882Expression and biological effect of urodele fibroblast growth factor 1: relationship to limb regeneration
Q52052484Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse.
Q40593865Expression of fibroblast growth factor receptor genes in human hepatoma-derived cell lines
Q37376265FGFR4 and TGF-β1 expression in hepatocellular carcinoma: correlation with clinicopathological features and prognosis
Q58377532Fibroblast Growth Factor Receptors 1 and 2 Interact Differently with Heparin/Heparan Sulfate
Q45143894Fibroblast growth factor (Fgf) signaling pathway regulates liver homeostasis in zebrafish
Q42704110Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease
Q38923517Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma
Q35364559Fibroblast growth factor receptor 4 polymorphism is associated with liver cirrhosis in hepatocarcinoma
Q35231830Fibroblast growth factor receptor isotype expression and its association with overall survival in patients with hepatocellular carcinoma.
Q44508747Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration
Q33179207Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides
Q24534355Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts
Q43597363Fibroblast growth factors 1 and 2 differently activate MAP kinase in Xenopus oocytes expressing fibroblast growth factor receptors 1 and 4.
Q36923642Fibroblast growth factors, old kids on the new block
Q38784876Function of Membrane-Associated Proteoglycans in the Regulation of Satellite Cell Growth
Q43096150HIP/RPL29 antagonizes VEGF and FGF2 stimulated angiogenesis by interfering with HS-dependent responses.
Q41504553Heparanase Inhibitors Facilitate the Assembly of the Basement Membrane in Artificial Skin
Q34222480Heparin and liver heparan sulfate can rescue hepatoma cells from topotecan action.
Q36625238Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancer
Q22253352Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins
Q24684986Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice
Q45305228Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids
Q54195848Inhibition of fibroblast growth factor receptor signaling impairs metastasis of hepatocellular carcinoma.
Q40337083Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans
Q28740388Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo
Q33751398Is fibroblast growth factor receptor 4 a suitable target of cancer therapy?
Q35991812Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma
Q35764259Mechanistic diversity of cytokine receptor signaling across cell membranes
Q39676210Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation
Q34114308Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors
Q26738860Personalized Clinical Trials in Hepatocellular Carcinoma Based on Biomarker Selection
Q43568416Probing fibroblast growth factor dimerization and role of heparin-like glycosaminoglycans in modulating dimerization and signaling
Q38990794Regulation of metastasis of pediatric multiple myeloma by MMP13.
Q41839560Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis
Q35792203Role of Fibroblast Growth Factor Type 1 and 2 in Carbon Tetrachloride-Induced Hepatic Injury and Fibrogenesis
Q33369576Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome
Q28646255Seeing the light: preassembly and ligand-induced changes of the interferon gamma receptor complex in cells
Q37512367Signals and cells involved in regulating liver regeneration
Q36324847Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly
Q27673616Structural basis of heparan sulfate-specific degradation by heparinase III
Q40630770Sulfated Derivatives of Escherichia coli K5 Polysaccharides as Modulators of Fibroblast Growth Factor Signaling
Q24306135Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho
Q35219630Syndecan-4: dispensable or indispensable?
Q38176101Targeted inhibition of the FGF19-FGFR4 pathway in hepatocellular carcinoma; translational safety considerations
Q42343453Targeting FGF19/FGFR4 Pathway: A Novel Therapeutic Strategy for Hepatocellular Carcinoma.
Q28729944Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models
Q38303270Targeting fibroblast growth factor 19 in liver disease: a potential biomarker and therapeutic target.
Q54649699The Fibroblast Growth Factor Receptor-4 Arg388 Allele is Associated with Gastric Cancer Progression
Q92959917The Role of Fibroblast Growth Factor 23 in Inflammation and Anemia
Q30432483The extracellular matrix in development and morphogenesis: a dynamic view
Q35006524Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway
Q44235710Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling
Q34576805βKlotho suppresses tumor growth in hepatocellular carcinoma by regulating Akt/GSK-3β/cyclin D1 signaling pathway

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