Prolonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expression

scientific article (publication date: March 2006)

Prolonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expression is …
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scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2005.09.065
P932PMC publication ID2600890
P698PubMed publication ID16303162
P5875ResearchGate publication ID7465968

P2093author name stringAndrew D Yurochko
Ian B DeMeritt
Jagat P Podduturi
Maciej T Nogalski
A Michael Tilley
P2860cites workMapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradationQ24650561
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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathwayQ28615706
Shaping the nuclear action of NF-kappaBQ29614600
Inhibition of NF-kappa B by sodium salicylate and aspirinQ29614708
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-betaQ29617188
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa BQ29618194
Infection and atherosclerosis: emerging mechanistic paradigmsQ33696699
Cytomegalovirus is involved in vascular pathologyQ33762118
Potential role of cytomegalovirus in the pathogenesis of restenosis and atherosclerosisQ33762124
Cytomegalovirus and atherogenesisQ33768702
Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutantQ33782001
Replication of wild-type and mutant human cytomegalovirus in life-extended human diploid fibroblastsQ33787378
The human cytomegalovirus major immediate-early distal enhancer region is required for efficient viral replication and immediate-early gene expressionQ33797024
Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signalingQ33842473
Construction of a rationally designed human cytomegalovirus variant encoding a temperature-sensitive immediate-early 2 proteinQ34016717
The Rel/NF-kappa B family: friend and foe.Q34023268
Series introduction: the transcription factor NF-kappaB and human diseaseQ34116362
NF-kappaB signaling and human diseaseQ34264609
Do pathogens accelerate atherosclerosis?Q34389205
The human cytomegalovirus major immediate-early enhancer determines the efficiency of immediate-early gene transcription and viral replication in permissive cells at low multiplicity of infectionQ34743775
Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promotersQ39879958
Posttranscriptional suppression of interleukin-6 production by human cytomegalovirus.Q40481090
Human cytomegalovirus stimulates cellular IKK2 activity and requires the enzyme for productive replication.Q40584504
Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virusQ40595020
Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression.Q40677826
Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production.Q40707169
Bromodeoxyuridine-labeled viral particles as a tool for visualization of the immediate-early events of human cytomegalovirus infectionQ40967781
Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acidQ41107899
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.Q41565250
Productive infection of human endometrial stromal cells by human cytomegalovirusQ43608447
Has cytomegalovirus infection any role in the development of atherosclerosis?Q43792385
A prospective study of cytomegalovirus, herpes simplex virus 1, and coronary heart disease: the atherosclerosis risk in communities (ARIC) studyQ45741610
Immunoprecipitation of virus-specific immediate-early and early polypeptides from cells lytically infected with human cytomegalovirus strain AD 169.Q45801980
A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirusQ48378635
Interleukin-1 (IL-1) inhibits growth of cytomegalovirus in human marrow stromal cells: inhibition is reversed upon removal of IL-1.Q51604924
Cytomegalovirus in the pathogenesis of atherosclerosis: the role of inflammation as reflected by elevated C-reactive protein levels.Q54071052
Cytomegalovirus as a possible cause of a disease resembling infectious mononucleosis.Q54641160
NF- B activation can mediate inhibition of human cytomegalovirus replicationQ56787221
Human cytomegalovirus infection of the major leukocyte subpopulations and evidence for initial viral replication in polymorphonuclear leukocytes from viremic patientsQ67506305
Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigrationQ71059480
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivoQ73596145
High anti-cytomegalovirus (CMV) IgG antibody titer is associated with coronary artery disease and may predict post-coronary balloon angioplasty restenosisQ74471681
Human cytomegalovirus binding to human monocytes induces immunoregulatory gene expressionQ77320669
Absence of IE1 p72 protein function during low-multiplicity infection by human cytomegalovirus results in a broad block to viral delayed-early gene expressionQ34998851
Human cytomegalovirus UL69 protein is required for efficient accumulation of infected cells in the G1 phase of the cell cycleQ35079311
High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosisQ35811381
Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promotersQ35845633
UL82 virion protein activates expression of immediate early viral genes in human cytomegalovirus-infected cellsQ35847129
Integrin alphavbeta3 is a coreceptor for human cytomegalovirusQ35865693
The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter.Q35872328
The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infectionQ35887796
Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infectionQ36090467
Promoter-regulatory region of the major immediate early gene of human cytomegalovirusQ36252923
Identification of sequence elements in the human cytomegalovirus DNA polymerase gene promoter required for activation by viral gene products.Q36621424
Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start siteQ36680389
A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2Q36680417
Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element.Q36781988
The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap siteQ36796246
Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domainsQ36803353
Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoterQ36811230
Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene regionQ36828401
Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1.Q36853873
trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirusQ36865895
Organization and expression of the immediate early genes of human cytomegalovirusQ36905093
Structural analysis of the major immediate early gene of human cytomegalovirusQ36911017
Neutrality of the canonical NF-kappaB-dependent pathway for human and murine cytomegalovirus transcription and replication in vitroQ36944091
Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cellsQ37093324
A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulationQ37248409
Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoterQ37422869
Role of the proximal enhancer of the major immediate-early promoter in human cytomegalovirus replicationQ37596556
Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathwayQ37683123
Possible role of cytomegalovirus in atherogenesisQ37875443
NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulationQ38342724
Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivityQ38359214
A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiencyQ39594664
Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genesQ39602194
Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replicationQ39682884
ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequencesQ39791161
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectCytomegalovirusQ6946
NF-κBQ411114
P304page(s)15-31
P577publication date2006-03-01
P1433published inVirologyQ7934867
P1476titleProlonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expression
P478volume346