Drug insight: Clopidogrel nonresponsiveness

scientific article (publication date: July 2006)

Drug insight: Clopidogrel nonresponsiveness is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1038/NCPCARDIO0602
P698PubMed publication ID16810174

P50authorPaul A GurbelQ89230591
P2093author name stringUdaya S Tantry
P2860cites workCentral role of the P2Y12 receptor in platelet activationQ24618777
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Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndromeQ28168804
Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarctionQ28168881
Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stentingQ28171392
A patient with stent thrombosis, clopidogrel-resistance and failure to metabolize clopidogrel to its active metaboliteQ28174186
Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: a case-control studyQ28176594
Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trialQ28181168
Platelet CD40 ligand (CD40L)--subcellular localization, regulation of expression, and inhibition by clopidogrelQ28181620
Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatmentQ28185431
Matching the evaluation of the clinical efficacy of clopidogrel to platelet function tests relevant to the biological properties of the drugQ28187017
Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevationQ28188284
Resistance to antiplatelet drugs: current status and future researchQ28192298
Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING StudyQ28193340
Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trialQ28194232
Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirinQ28195019
Initial experience with an intravenous P2Y12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trialQ28195423
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic eventsQ28195656
Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivityQ28196405
Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylationQ28196513
Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trialQ28199508
Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapyQ28209140
Platelet activation in type 2 diabetes mellitusQ28210554
The difference between clopidogrel responsiveness and posttreatment platelet reactivityQ28210845
P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading doseQ28211480
Clopidogrel did not inhibit platelet function early after coronary bypass surgery: A prospective randomized trialQ28212518
Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic TherapyQ28213372
Aspirin and clopidogrel: efficacy, safety, and the issue of drug resistanceQ28213734
Role of protease-activated and ADP receptor subtypes in thrombin generation on human plateletsQ28257658
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering CommitteeQ29620666
Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interactionQ34168972
Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270.Q34530924
Platelet activation in myocardial ischemic syndromesQ35821899
Variability in platelet responsiveness to clopidogrel among 544 individuals.Q40454244
Individual variations of platelet inhibition after loading doses of clopidogrelQ44148275
Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapiesQ44530596
P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study.Q44684860
Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterizationQ44768151
Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy.Q45121029
Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting.Q45165021
Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseasesQ45213002
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) studyQ45287859
The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stentingQ46464355
Platelet microparticles and soluble P selectin in peripheral artery disease: relationship to extent of disease and platelet activation markersQ46498134
What is the best measure of thrombotic risks--pretreatment platelet aggregation, clopidogrel responsiveness, or posttreatment platelet aggregation?Q46738731
Effects of clopidogrel on the rebound hypercoagulable state after heparin discontinuation in patients with acute coronary syndromesQ46754050
Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel EfQ46783983
Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST StudyQ46802481
Effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: results from the CLEAR PLATELETS 1b study.Q51095063
Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular InjuryQ56944225
ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention—Summary ArticleQ56986819
Pharmacokinetics of clopidogrel after administration of a high loading doseQ80371510
Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic riskQ81873159
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectclopidogrelQ410237
P304page(s)387-95
P577publication date2006-07-01
P1433published inNature Clinical Practice Cardiovascular MedicineQ15727036
P1476titleDrug insight: Clopidogrel nonresponsiveness
P478volume3

Reverse relations

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