Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases

scientific article published in January 2005

Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1538-7836.2004.01063.X
P698PubMed publication ID15634270
P5875ResearchGate publication ID8097491

P2093author name stringCazenave JP
Gachet C
Ravanat C
Heitz A
Rochoux G
Aleil B
P2860cites workEffects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE studyQ28165115
Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistanceQ28166663
Combination therapy with aspirin plus clopidogrel versus aspirin plus ticlopidine for prevention of subacute thrombosis after successful native coronary stentingQ28175884
Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevationQ28188284
Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trialQ28194232
Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivityQ28196405
Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylationQ28196513
Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosisQ28199086
Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrelQ28370733
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering CommitteeQ29620666
Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting : the clopidogrel aspirin stent international cooperative studyQ33333456
Progress in the assessment of platelet functionQ34106873
Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interactionQ34168972
Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMPQ40195784
The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanismQ43744121
A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human plateletsQ43869554
Activation of Rap1B by G(i) family members in plateletsQ43968783
Individual variations of platelet inhibition after loading doses of clopidogrelQ44148275
Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in plateletsQ44189548
Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects.Q44545487
Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function — a flow cytometry studyQ44604925
Compliance with aspirin or placebo in the hypertension optimal treatment (HOT) studyQ57987943
P433issue1
P921main subjectpatientQ181600
phosphorylationQ242736
cardiovascular diseaseQ389735
clopidogrelQ410237
flow cytometryQ1141429
P304page(s)85-92
P577publication date2005-01-01
P1433published inJournal of Thrombosis and HaemostasisQ6296004
P1476titleFlow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases
P478volume3

Reverse relations

cites work (P2860)
Q47570792A Prospective, Randomized, Open-Label, Blinded, Endpoint Study Exploring Platelet Response to Half-Dose Prasugrel and Ticagrelor in Patients with the Acute Coronary Syndrome: HOPE-TAILOR Study
Q38672923A Safety Evaluation of Cangrelor in Patients Undergoing PCI.
Q39017052A novel mutation in the P2Y12 receptor and a function-reducing polymorphism in protease-activated receptor 1 in a patient with chronic bleeding
Q34761979A pharmacodynamic comparison of 5 anti-platelet protocols in patients with ST-elevation myocardial infarction undergoing primary PCI
Q40329955A point-of-care assay to measure platelet aggregation in patients taking clopidogrel
Q39645121A potential role for α-actinin in inside-out αIIbβ3 signaling
Q38037121Advances in the monitoring of anti-P2Y12 therapy.
Q42909234Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors.
Q45164756Altered platelet contents in survivors of early ischemic ventricular fibrillation: preliminary findings
Q28543952Another "string to the bow" of PJ34, a potent poly(ADP-Ribose)polymerase inhibitor: an antiplatelet effect through P2Y12 antagonism?
Q38543308Antiplatelet drugs: which targets for which treatments?
Q37049655Antiplatelet therapy for stroke prevention
Q46494893Antiplatelet therapy in acute coronary syndromes
Q28218702Antiplatelet therapy in populations at high risk of atherothrombosis
Q34771381Aspirin and platelet adenosine diphosphate receptor antagonists in acute coronary syndromes and percutaneous coronary intervention: role in therapy and strategies to overcome resistance
Q38132923Assessing post-treatment platelet reactivity: a focus on patient selection and setting.
Q28196714Biological effects of aspirin and clopidogrel in a randomized cross-over study in 96 healthy volunteers
Q83363907Can the PFA-100 be modified to detect P2Y12 inhibition?
Q38153779Cangrelor: a review on pharmacology and clinical trial development
Q37841560Clinical value of antiplatelet therapy in patients with acute coronary syndromes and in percutaneous coronary intervention
Q38154064Clopidogrel "resistance": pre- vs post-receptor determinants.
Q37786639Clopidogrel in acute coronary syndrome: implications of recent study findings
Q42003164Clopidogrel resistance "Live" - the risk of stent thrombosis should be evaluated before procedures
Q40347840Clopidogrel resistance: fact and fiction
Q28218055Clopidogrel resistance: myth or reality?
Q38274517Clopidogrel resistance: the way forward
Q46253334Comparative Long-Term Effect of Three Anti-P2Y12 Drugs after Percutaneous Angioplasty: An Observational Study Based on Electronic Drug Adherence Monitoring.
Q42055431Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy?
Q36976793Comparison of a new P2Y12 receptor specific platelet aggregation test with other laboratory methods in stroke patients on clopidogrel monotherapy
Q33636020Comparison of conventional aggregometry with VASP for monitoring P2Y12-specific platelet inhibition
Q48324589Comparison of cytotoxic and anti-platelet activities of polyphenolic extracts from Arnica montana flowers and Juglans regia husks.
Q37629641Comparison of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
Q37774825Considerations in patients receiving oral antiplatelet therapy after acute coronary syndrome and percutaneous coronary intervention
Q33760816Correlations between High Platelet Reactivity, Extent of Coronary Artery Disease, and Periprocedural Myonecrosis in Patients with Acute Coronary Syndrome
Q54236665Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome.
Q37752222Dosing strategies for antiplatelet therapy in percutaneous coronary intervention.
Q28198683Drug insight: Clopidogrel nonresponsiveness
Q34983154Drug-drug interaction between clopidogrel and the proton pump inhibitors.
Q46638114Effect of long-term adherence to clopidogrel on the VASP-PRI after elective coronary stent implantation: a randomized controlled study.
Q38694069Effects of P2Y12 receptor antagonists beyond platelet inhibition--comparison of ticagrelor with thienopyridines
Q46367587Effects of aspirin and clopidogrel in healthy men measured by platelet aggregation and PFA-100.
Q43744458Effects of cangrelor in coronary artery disease patients with and without diabetes mellitus: an in vitro pharmacodynamic investigation.
Q46477005Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients.
Q47792745Effects of statin therapy on platelet reactivity after percutaneous coronary revascularization in patients with acute coronary syndrome.
Q45872542Evaluation of the INNOVANCE PFA P2Y test cartridge: sensitivity to P2Y(12) blockade and influence of anticoagulant.
Q54546944Evaluation of the role of the new INNOVANCE PFA P2Y test cartridge in detection of clopidogrel resistance.
Q28200552Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance'
Q42245649Expression of miRNA-26a in platelets is associated with clopidogrel resistance following coronary stenting
Q30450312High platelet reactivity on clopidogrel therapy correlates with increased coronary atherosclerosis and calcification: a volumetric intravascular ultrasound study
Q53837582How to test the effect of aspirin and clopidogrel in patients on dual antiplatelet therapy?
Q37203987Impact of Cytochrome P450 2C19*2 and *3 on Clopidogrel Loading Dose in Saudi Patients with Acute Coronary Syndrome
Q47654408Impact of acute exacerbations on platelet reactivity in chronic obstructive pulmonary disease patients
Q28542407Impact of aspirin and clopidogrel interruption on platelet function in patients undergoing major vascular surgery
Q36045746Impaired P2Y12 inhibition by clopidogrel in kidney transplant recipients: results from a cohort study
Q38154612Importance of measurement of platelet reactivity to ADP in patients with coronary artery disease: an historical account
Q37378896Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Wo
Q24629255International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy
Q37509443Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor
Q51572866Modifying clopidogrel maintenance doses according to vasodilator-stimulated phosphoprotein phosphorylation index improves clinical outcome in patients with clopidogrel resistance.
Q46789035Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stenting
Q36359617New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors
Q37799114Novel antiplatelet therapy
Q38780997Novel strategies for assessing platelet reactivity
Q37562606P2Y(12) inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use.
Q26861200P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells
Q89860277P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation
Q36536498P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease
Q38051192P2Y12 receptor: platelet thrombus formation and medical interventions.
Q37642822Personalized antiplatelet therapy for coronary artery disease patients: is this the future?
Q38154211Pharmacology of antiplatelet agents
Q58071120Phenotyping vs. genotyping for prediction of clopidogrel efficacy and safety: the PEGASUS-PCI study
Q91055048Phosphoflow cytometry and barcoding in blood platelets: Technical and analytical considerations
Q28200541Plasma levels of the growth arrest-specific gene 6 product (Gas6) and antiplatelet drug responsiveness in healthy subjects
Q41574497Platelet Aggregometry Testing: Molecular Mechanisms, Techniques and Clinical Implications.
Q92637510Platelet Function Test Use for Patients with Coronary Artery Disease in the Early 2020s
Q34325757Platelet aggregation and clot formation in comatose survivors of cardiac arrest treated with induced hypothermia and dual platelet inhibition with aspirin and ticagrelor; a prospective observational study
Q38068348Platelet function monitoring and clopidogrel
Q38094681Platelet function testing and tailored antiplatelet therapy
Q53281424Platelet function testing in hirudin and BAPA anticoagulated blood.
Q38089082Platelet function tests for the monitoring of P2Y12 inhibitors
Q35121464Platelet function tests: a comparative review
Q44426942Poor agreement between light transmission aggregometry, Verify Now P2Y₁₂ and vasodilatator-stimulated phosphoprotein for clopidogrel low-response assessment: a potential explanation of negative results of recent randomized trials.
Q37809122Poor responsiveness to antiplatelet drugs in acute coronary syndromes: clinical relevance and management.
Q41742863Post receptor determinants of acute platelet response to clopidogrel in patients with symptomatic myocardial ischemia.
Q46761762Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation
Q39908656Prostacyclin receptor stimulation facilitates detection of human platelet P2Y(12) receptor inhibition by the PFA-100 system
Q37540088Recent developments in clopidogrel pharmacology and their relation to clinical outcomes
Q28218401Relationships between optical aggregometry (type born) and flow cytometry in evaluating ADP-induced platelet activation
Q43405386Reproducibility and standardized reporting of the vasodilator-stimulated phosphoprotein phosphorylation assay
Q28192298Resistance to antiplatelet drugs: current status and future research
Q37807524Resistance to aspirin and clopidogrel therapy.
Q60018207Résistance au clopidogrel, tests génétiques et tests fonctionnels
Q30373414State-of-the-Art: Hypo-responsiveness to oral antiplatelet therapy in patients with type 2 diabetes mellitus.
Q26801874The Emerging Role of miR-223 in Platelet Reactivity: Implications in Antiplatelet Therapy
Q42929936The Influence of Proton Pump Inhibitors on the Antiplatelet Potency of Clopidogrel Evaluated by 5 Different Platelet Function Tests
Q38306767The P2Y(12) receptor as a target of antithrombotic drugs
Q46820390The Retention Index Test Homburg (RTH-II): Response to clopidogrel and comparison with aggregometry and CD62P-expression
Q42159559The influence of CYP 2C19*2 polymorphism on platelet function testing during single antiplatelet treatment with clopidogrel
Q53298721The new INNOVANCE® PFA P2Y cartridge is sensitive to the detection of the P2Y12receptor inhibition
Q89746429Ticagrelor and preconditioning in patients with stable coronary artery disease (TAPER-S): a randomized pilot clinical trial
Q41817424Towards personalized medicine based on platelet function testing for stent thrombosis patients
Q50940673Validation of a New ELISA-Based Vasodilator-Associated Stimulated Phosphoprotein Phosphorylation Assay to Assess Platelet Reactivity Index in a Chinese Population.
Q30498026Variable effect of P2Y12 inhibition on platelet thrombus volume in flowing blood
Q41620783Variations in Intraplatelet Phospho-VASP Expression Due to Pre-analytical Sample Preparations, Illustration of a Quality Control Issue in Platelet Pharmacology
Q53554561Vasodilator-stimulated phosphoprotein phosphorylation analysis prior to percutaneous coronary intervention for exclusion of postprocedural major adverse cardiovascular events.
Q43165529VerifyNow and VASP phosphorylation assays give similar results for patients receiving clopidogrel, but they do not always correlate with platelet aggregation

Search more.