Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

scientific article (publication date: 23 August 2002)

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M202753200
P698PubMed publication ID12063255

P50authorRobert LefkowitzQ80910
Louis M. LuttrellQ56056855
P2093author name stringA Musa Zamah
Martha Delahunty
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Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanismsQ28181949
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Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytesQ33181618
Recent advances in cardiac beta(2)-adrenergic signal transductionQ33778780
Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.Q34083299
Mammalian .beta.2-adrenergic receptor: purification and characterizationQ34707003
Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclaseQ34708451
Cardiac hypertrophy. Mechanical, neural, and endocrine dependenceQ37075902
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.Q37105461
Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.Q38302685
Beta-adrenergic receptors: biochemical mechanisms of physiological regulationQ40093639
beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-RafQ40875727
Functional and structural complexity of signal transduction via G-protein-coupled receptorsQ40914327
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.Q41080173
The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascadesQ41688659
Selectivity of the .beta.-adrenergic receptor among Gs, Gi's, and Go: assay using recombinant .alpha. subunits in reconstituted phospholipid vesiclesQ42463391
The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase systemQ46158674
Expression of G-protein alpha subunits in Escherichia coli.Q54645309
Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitroQ63208133
Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylationQ68260026
A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptorQ68473070
G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alphaQ69193410
Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibitionQ71743487
Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipidQ72223349
Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophyQ74638195
Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cellsQ77863391
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytesQ77896707
P433issue34
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)31249-31256
P577publication date2002-06-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleProtein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system
P478volume277

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