On the G protein-coupling selectivity of the native A2B adenosine receptor

scientific article published on 7 December 2017

On the G protein-coupling selectivity of the native A2B adenosine receptor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BCP.2017.12.003
P932PMC publication ID5899946
P698PubMed publication ID29225130

P2093author name stringKenneth A Jacobson
Zhan-Guo Gao
Asuka Inoue
P2860cites workEpac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMPQ22008544
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1BQ24317583
Attenuating myocardial ischemia by targeting A2B adenosine receptorsQ27006863
Adenosine signaling promotes hematopoietic stem and progenitor cell emergenceQ27308862
Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted systemQ28204412
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cellsQ28373204
Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cellsQ28581016
A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells. cross-talk between cyclic AMP and protein kinase c pathwaysQ30303596
Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptorQ30471184
The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.Q33178125
Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expressionQ33613207
Extracellular adenosine-mediated modulation of regulatory T cellsQ33878542
Probing biased/partial agonism at the G protein-coupled A(2B) adenosine receptorQ34027829
The ups and downs of Gs- to Gi-protein switchingQ43263435
The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38.Q44600959
Adenosine A₂B receptor agonism inhibits neointimal lesion development after arterial injury in apolipoprotein E-deficient miceQ45825539
Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins.Q46895130
Cancer drug addiction is relayed by an ERK2-dependent phenotype switchQ47700946
Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude HypoxiaQ48592063
A2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPK kinase pathwayQ51011427
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.Q51413360
BAY60-6583 acts as a partial agonist at adenosine A2B receptors.Q51749684
The ERK-dependent signalling is stage-specifically modulated by FSH, during primary Sertoli cell maturation.Q52131194
Corpus Cavernosum from Men with Vasculogenic Impotence Is Partially Resistant to Adenosine Relaxation due to Endothelial A2B Receptor DysfunctionQ57702982
On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cellsQ59673298
Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibitionQ71743487
Could dual G-protein coupling explain [D-Met2]FMRFamide's mixed action in vivo?Q71911872
Cell logic for dual coupling of a single class of receptors to G(s) and G(i) proteinsQ73071861
Cyclic AMP-dependent, protein kinase A-independent activation of extracellular signal-regulated kinase 1/2 following adenosine receptor stimulation in human umbilical vein endothelial cells: role of exchange protein activated by cAMP 1 (Epac1)Q80469682
Contribution of the extracellular cAMP-adenosine pathway to dual coupling of β2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscleQ83721269
Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein EpacQ34310769
Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C.Q34384615
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteinsQ34403963
Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to Gs and GiQ34442426
Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".Q34467944
Identification and characterization of small molecules as potent and specific EPAC2 antagonistsQ34535973
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.Q34536660
A2B adenosine receptor blockade inhibits growth of prostate cancer cells.Q34546999
Adenosine: trigger and mediator of cardioprotectionQ34713059
Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cellsQ34779773
An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scatteringQ34781560
Calcium signalling and secretory epitheliaQ35089327
A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxinQ35089870
Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activityQ35153229
Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancersQ35154034
2',3'-cAMP, 3'-AMP, and 2'-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptorsQ35159861
Gi-biased β2AR signaling links GRK2 upregulation to heart failureQ35766985
Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heartQ35898437
Differential Tissue-Specific Function of Adora2b in CardioprotectionQ36078415
Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor.Q36116925
Adenosine Attenuates Human Coronary Artery Smooth Muscle Cell Proliferation by Inhibiting Multiple Signaling Pathways That Converge on Cyclin D.Q36277823
The experimental power of FR900359 to study Gq-regulated biological processesQ36379426
A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.Q36778728
Detrimental effects of adenosine signaling in sickle cell diseaseQ36818005
On the selectivity of the Gαq inhibitor UBO-QIC: A comparison with the Gαi inhibitor pertussis toxin.Q36821853
Role of adenosine A(2B) receptors in inflammationQ37108355
Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblastsQ37190311
Adenosine A2B receptors play an important role in bone homeostasis.Q37256441
Distinct PKA and Epac compartmentalization in airway function and plasticityQ38054359
Adenosine signalling in diabetes mellitus--pathophysiology and therapeutic considerationsQ38358000
Adenosine regulation of the immune response initiated by ischemia reperfusion injuryQ38490402
Activation of adenosine A2B receptor impairs properties of trophoblast cells and involves mitogen-activated protein (MAP) kinase signalingQ38977306
Adenosine 2B Receptor Expression on Cancer Cells Promotes MetastasisQ40661065
The adenosine A2b receptor promotes tumor progression of bladder urothelial carcinoma by enhancing MAPK signaling pathwayQ41472094
Interaction of the delta-opioid receptor with GM1 ganglioside: conversion from inhibitory to excitatory modeQ42436030
P407language of work or nameEnglishQ1860
P577publication date2017-12-07
P1433published inBiochemical PharmacologyQ864229
P1476titleOn the G protein-coupling selectivity of the native A2B adenosine receptor