Extracellular adenosine-mediated modulation of regulatory T cells

scientific article

Extracellular adenosine-mediated modulation of regulatory T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2014.00304
P932PMC publication ID4091046
P698PubMed publication ID25071765
P5875ResearchGate publication ID264393953

P2093author name stringAkio Ohta
Michail Sitkovsky
P2860cites workRepression of Cyclic Adenosine Monophosphate Upregulation Disarms and Expands Human Regulatory T CellsQ60315852
Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-βQ61651632
The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sitesQ70988415
Adenosine in bronchoalveolar lavage fluid in asthmaQ72796936
High adenosine plasma concentration as a prognostic index for outcome in patients with septic shockQ73014129
Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier functionQ73112984
Renal interstitial concentration of adenosine during endotoxin shockQ73295599
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosineQ73470605
Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adQ73574475
Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injuryQ80428036
Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signalingQ80491718
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Adenosine receptors: therapeutic aspects for inflammatory and immune diseasesQ24651475
Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injuryQ24796780
Cyclic AMP underpins suppression by regulatory T cellsQ26824574
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Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damageQ28214799
Exploiting tumour hypoxia in cancer treatmentQ28264146
Hypoxia in cancer: significance and impact on clinical outcomeQ28298305
Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in miceQ28298659
Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansionQ28507222
Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient miceQ28512453
Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transportQ28571989
Adenosine receptors in regulation of dendritic cell differentiation and functionQ28586835
Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injuryQ28593969
Adenosine receptors as drug targets--what are the challenges?Q29346491
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppressionQ29615344
Immunosuppressive strategies that are mediated by tumor cellsQ29636247
Adenosine A2B receptor blockade slows growth of bladder and breast tumorsQ30416420
Autocrine adenosine signaling promotes regulatory T cell-mediated renal protectionQ30417431
Much Ado about Adenosine: Adenosine Synthesis and Function in Regulatory T Cell BiologyQ30433245
A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistenceQ30433250
A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.Q30440525
Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitisQ30441350
Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognitionQ30443210
CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppressionQ33533705
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasisQ33667612
Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cellsQ33748026
Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal.Q33940441
CD39/adenosine pathway is involved in AIDS progressionQ33959186
Inflammatory hypoxia: role of hypoxia-inducible factor.Q33984426
Advances in graft-versus-host disease biology and therapyQ34031916
Purinergic signaling during inflammationQ34034751
Cellular constituents of immune escape within the tumor microenvironmentQ38020632
Development and maintenance of regulatory T cellsQ38092234
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical applicationQ38163290
Regulatory T cells as immunotherapyQ38191610
A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironmentsQ39785317
Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotidesQ39797150
Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell linesQ40119910
Thyroid hormone stimulates 5'-ecto-nucleotidase of neonatal rat ventricular myocytes.Q40491983
IFN-alpha induced adenosine production on the endothelium: a mechanism mediated by CD73 (ecto-5'-nucleotidase) up-regulationQ40597263
Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptorQ41545207
Inhibition of adenosine deaminase attenuates endotoxin-induced release of cytokines in vivo in ratsQ42509429
Adenosine and prostaglandin e2 production by human inducible regulatory T cells in health and diseaseQ43075747
Simvastatin induces Foxp3+ T regulatory cells by modulation of transforming growth factor-beta signal transductionQ43090511
Methotrexate--how does it really work?Q43144564
Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signallingQ43279099
Regulatory T cells and transplantation tolerance.Q43563597
CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsivenessQ43943686
Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitorQ43946696
Adenosine slows migration of dendritic cells but does not affect other aspects of dendritic cell maturation.Q44525306
Blunted increase in plasma adenosine levels following dipyridamole stress in dilated cardiomyopathy patientsQ44671126
Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic miceQ44927020
Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alphaQ44948359
T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune responseQ45292627
Interferon-α suppresses cAMP to disarm human regulatory T cells.Q45955170
Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells.Q46013858
CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism.Q46019176
Rosuvastatin increases extracellular adenosine formation in humans in vivo: a new perspective on cardiovascular protectionQ46054691
Modulation of murine dendritic cell function by adenine nucleotides and adenosine: involvement of the A(2B) receptorQ46605600
Control of IFN-alphaA by CD73: implications for mucosal inflammationQ46717032
HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leakQ46726814
Induction of alloantigen-specific human T regulatory cells by vasoactive intestinal peptide.Q54722219
Beta2-adrenergic receptor signaling in CD4+ Foxp3+ regulatory T cells enhances their suppressive function in a PKA-dependent mannerQ56897543
Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cellsQ34107172
Regulatory T cells and Foxp3Q34177949
Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammationQ34184568
Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation.Q34462015
T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosineQ34578972
Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppressionQ34579516
CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction.Q34599954
Graft-versus-host disease is enhanced by selective CD73 blockade in miceQ34631798
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an updateQ34701303
Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritisQ34776189
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epitheliaQ34797847
A2A adenosine receptor protects tumors from antitumor T cells.Q35016529
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cellsQ35102340
Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cellsQ35566772
Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.Q35698535
Distinctive immunoregulatory effects of adenosine on T cells of older humansQ35787747
Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host diseaseQ35995245
The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway.Q36075960
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCIDQ36185196
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosaQ36339991
Neutrophil-derived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activationQ36404222
Host A(2B) adenosine receptors promote carcinoma growthQ36840284
CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury.Q36860320
Adenosine A₂A receptor agonist-mediated increase in donor-derived regulatory T cells suppresses development of graft-versus-host diseaseQ36907484
Creating immune privilege: active local suppression that benefits friends, but protects foes.Q37026641
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.Q37256978
Role for the cAMP-protein kinase A signaling pathway in suppression of antitumor immune responses by regulatory T cellsQ37357253
Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5'-nucleotidase (CD73).Q37363358
A(2B) adenosine receptors in immunity and inflammation.Q37373680
Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancerQ37390515
CD73: A Novel Target for Cancer ImmunotherapyQ37777541
Interplay of hypoxia and A2B adenosine receptors in tissue protectionQ37876539
Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunityQ37876541
CD73: a potent suppressor of antitumor immune responsesQ38001161
P304page(s)304
P577publication date2014-07-10
P1433published inFrontiers in ImmunologyQ27723748
P1476titleExtracellular adenosine-mediated modulation of regulatory T cells
P478volume5

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