Adenosine production: a common path for mesenchymal stem-cell and regulatory T-cell-mediated immunosuppression.

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Adenosine production: a common path for mesenchymal stem-cell and regulatory T-cell-mediated immunosuppression. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1035634828
P356DOI10.1007/S11302-016-9529-0
P932PMC publication ID5124006
P698PubMed publication ID27557887

P50authorJuliana Lott CarvalhoQ56860463
P2093author name stringFelipe Saldanha-Araujo
Martha de Oliveira Bravo
P2860cites workNatural killer cells acquire CD73 expression upon exposure to mesenchymal stem cellsQ87155796
Immune-related antigens, surface molecules and regulatory factors in human-derived mesenchymal stromal cells: the expression and impact of inflammatory primingQ95411196
The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epitheliaQ24311856
Identification and characterization of CD39/vascular ATP diphosphohydrolaseQ24336540
Adenosine receptors: therapeutic aspects for inflammatory and immune diseasesQ24651475
Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytesQ24673317
Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cellsQ24681395
Development of PD-1/PD-L1 Pathway in Tumor Immune Microenvironment and Treatment for Non-Small Cell Lung CancerQ26798047
CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppressionQ26801436
CD73-generated adenosine: orchestrating the tumor-stroma interplay to promote cancer growthQ26823709
Purinergic signaling: a common pathway for neural and mesenchymal stem cell maintenance and differentiationQ26865695
The A3 adenosine receptor: history and perspectivesQ27021898
The PI3K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritisQ28195442
Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4Q28204758
The inhibitory cytokine IL-35 contributes to regulatory T-cell functionQ28258462
Ecto-enzyme and signaling functions of lymphocyte CD73Q28268472
Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblastsQ28269878
Human mesenchymal stem cells modulate allogeneic immune cell responsesQ28288692
Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activationQ28294720
Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansionQ28507222
Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cellsQ28508311
Adenosine receptors as drug targets--what are the challenges?Q29346491
Multilineage cells from human adipose tissue: implications for cell-based therapiesQ29547688
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppressionQ29615344
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cellsQ29618766
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuliQ29618769
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 productionQ29619536
Mesenchymal stem cellsQ29619804
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Human mesenchymal stem cells modulate B-cell functionsQ29620705
Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialitiesQ30160229
Cell therapy for cardiac repair--lessons from clinical trials.Q30359782
Regulatory T cells in AKI.Q30409790
Autocrine adenosine signaling promotes regulatory T cell-mediated renal protectionQ30417431
Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humansQ30428503
Immunohistochemical localization of adenosine A2A receptors in the rat central nervous systemQ30472844
Adenosine: an old drug newly discoveredQ33555006
CD39-mediated effect of human bone marrow-derived mesenchymal stem cells on the human Th17 cell functionQ33692614
Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cellsQ33748026
Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acidQ33778359
Treating inborn errors of liver metabolism with stem cells: current clinical developmentQ33870631
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cellsQ33873201
Extracellular adenosine-mediated modulation of regulatory T cellsQ33878542
Adenosine signaling during acute and chronic disease statesQ34035228
Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cellsQ34107172
How does methotrexate suppress inflammation?Q34147592
Multipotent mesenchymal stromal cells express FoxP3: a marker for the immunosuppressive capacity?Q34149057
Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammationQ34184568
Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cellsQ34195216
Regulatory T cells enhance mesenchymal stem cell survival and proliferation following autologous cotransplantation in ischemic myocardiumQ34279141
Adenosine: an endogenous regulator of innate immunityQ34286701
Indoleamine 2,3 dioxygenase and metabolic control of immune responsesQ34308495
Regulatory T cell-derived exosomes: possible therapeutic and diagnostic tools in transplantationQ34454926
Immunomodulatory effects of caffeine: friend or foe?Q34502438
Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor betaQ34517421
Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.Q34529123
Human T regulatory cells can use the perforin pathway to cause autologous target cell deathQ34551876
Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cellsQ34552979
T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosineQ34578972
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.Q34621389
Graft-versus-host disease is enhanced by selective CD73 blockade in miceQ34631798
Inhibition of B-cell proliferation and antibody production by mesenchymal stromal cells is mediated by T cells.Q34751391
Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascadeQ34756092
A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in miceQ34826208
A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine productionQ35064373
IL-10-producing T cells suppress immune responses in anergic tuberculosis patientsQ35159232
CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejectionQ35202450
The role of the adenosinergic pathway in immunosuppression mediated by human regulatory T cells (Treg).Q37956691
New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptorsQ38005034
Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance?Q38059338
Cellular and molecular interactions of mesenchymal stem cells in innate immunityQ38059340
Application of MultiStem(®) Allogeneic Cells for Immunomodulatory Therapy: Clinical Progress and Pre-Clinical Challenges in Prophylaxis for Graft Versus Host DiseaseQ38064454
Paracrine mechanisms of proliferative, anti-apoptotic and anti-inflammatory effects of mesenchymal stromal cells in models of acute organ injuryQ38151419
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.Q38305613
Extracellular adenosine generation in the regulation of pro-inflammatory responses and pathogen colonizationQ38464138
Mesenchymal Stem Cell Therapy for Autoimmune Disease: Risks and RewardsQ38525790
Human CD4+ CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cellsQ39002543
Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cellsQ39299547
Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production.Q39523865
Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype.Q39698715
Placenta-derived multipotent cells exhibit immunosuppressive properties that are enhanced in the presence of interferon-gammaQ40274827
Interactions between human mesenchymal stem cells and natural killer cellsQ40385365
Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cellsQ40395279
Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiationQ40506554
High-level sustained transgene expression in human embryonic stem cells using lentiviral vectorsQ40610397
Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivoQ40662801
Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockadeQ40722338
CD39 and control of cellular immune responsesQ40730152
Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitoryQ41201229
Regulatory T cell-derived adenosine induces dendritic cell migration through the Epac-Rap1 pathway.Q41205971
Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected].Q41907086
Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human bloodQ41973912
A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytesQ41983445
Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype.Q41985015
Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsetsQ42066000
Mechanisms of T-cell immunosuppression by mesenchymal stromal cells: what do we know so far?Q42103653
Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responsesQ42575579
The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesiaQ42845569
Rolofylline, an adenosine A1-receptor antagonist, in acute heart failureQ42868532
Adenosine Receptor A1 Regulates Polymorphonuclear Cell Trafficking and Microvascular Permeability in Lipopolysaccharide-Induced Lung InjuryQ42930077
Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathwaysQ43227039
De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acidQ43283588
CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiationQ43406136
Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanismsQ43508044
Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activationQ43575878
Expression and function of adenosine receptors in human dendritic cellsQ43726407
Cardiac myocyte adenosine A2a receptor activation fails to alter cAMP or contractility: role of receptor localizationQ43880527
Differential expression of adenosine receptors in human endothelial cells: role of A2B receptors in angiogenic factor regulationQ43928343
Combined immunodeficiency disease associated with adenosine deaminase deficiency. Report on a workshop held in Albany, New York, October 1, 1973Q44456413
Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload modelQ44582352
A1 adenosine receptor activation inhibits inflammation, necrosis, and apoptosis after renal ischemia-reperfusion injury in miceQ44705269
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradationQ44786842
Infarct-sparing effect of A2A-adenosine receptor activation is due primarily to its action on lymphocytesQ44910151
Evidence for the involvement of nitric oxide in A2B receptor-mediated vasorelaxation of mouse aortaQ44922677
Antiinflammatory effect of A3 adenosine receptor agonists in murine autoimmune arthritis models.Q45293508
Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells.Q45834735
Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patientsQ45864185
The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes.Q46010474
MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2.Q46034364
Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivoQ35224328
The role of the combination of IL-2 and TGF-β or IL-10 in the generation and function of CD4+ CD25+ and CD8+regulatory T cell subsetsQ35547512
Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cellsQ35552588
Pharmacological and therapeutic effects of A3 adenosine receptor agonistsQ35788500
The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway.Q36075960
Expression of IL-37 contributes to the immunosuppressive property of human CD4+CD25+ regulatory T cellsQ36100192
MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTORQ36351026
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsivenessQ36370807
The A2b adenosine receptor protects against vascular injuryQ36393058
Distinct roles for the A2B adenosine receptor in acute and chronic stages of bleomycin-induced lung injury.Q36713583
Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?Q36821572
CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury.Q36860320
Concise review: the clinical application of mesenchymal stem cells for musculoskeletal regeneration: current status and perspectivesQ36862085
Priming mesenchymal stem cells boosts stem cell therapy to treat myocardial infarctionQ36881332
Myeloid-derived suppressor cellsQ36916250
Adenosine production by human B cells and B cell-mediated suppression of activated T cellsQ36983750
Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cellsQ36998218
The rise of cell therapy trials for stroke: review of published and registered studiesQ37025630
Concise review: mesenchymal stem cells for diabetesQ37056264
Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulationsQ37060678
Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review).Q37091784
Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.Q37208648
Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each otherQ37233905
Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expressionQ37245083
Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-κB signallingQ37295170
Extracellular adenosine regulates naive T cell development and peripheral maintenanceQ37322177
Diminished adenosine A1 receptor expression in pancreatic α-cells may contribute to the pathology of type 1 diabetesQ37333575
A(2B) adenosine receptors in immunity and inflammation.Q37373680
Regulatory T cells: how do they suppress immune responses?Q37593768
tTregs, pTregs, and iTregs: similarities and differencesQ37695519
IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cellsQ46040716
A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral bloodQ46284741
Modulation of murine dendritic cell function by adenine nucleotides and adenosine: involvement of the A(2B) receptorQ46605600
Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells.Q46670167
Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in miceQ46715465
Generation of highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) regulatory T cells by continuous antigen stimulationQ46760280
Adenosine, through the A1 receptor, inhibits vesicular MHC class I cross-presentation by resting DC.Q46820722
Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cellsQ47372947
Involvement of adenosine A2A receptor in sleep promotionQ47755458
Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cellsQ47777710
Adenosinergic Immunosuppression by Human Mesenchymal Stromal Cells Requires Co-Operation with T cells.Q50273159
Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis.Q50640546
Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages.Q50956366
CD39+ regulatory T cells attenuate allergic airway inflammation.Q51050332
CD73 Pathway Contributes to the Immunosuppressive Ability of Mesenchymal Stem Cells in Intraocular Autoimmune Responses.Q53250000
IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.Q53347772
Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction.Q53547964
Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo.Q54011232
Caspase inhibition via A3 adenosine receptors: a new cardioprotective mechanism against myocardial infarction.Q54397580
Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg.Q54473058
TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.Q54641474
Anti-inflammatory and immunosuppressive effects of the A2A adenosine receptor.Q55230640
Mesenchymal stromal cells up-regulate CD39 and increase adenosine production to suppress activated T-lymphocytesQ56787014
Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotypeQ56902900
Isolation of multipotent adult stem cells from the dermis of mammalian skinQ57042245
Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptorsQ57731080
Phenotypic and functional characterization of human CD25+ B cellsQ59526654
Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulationQ60313622
Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cellsQ61645531
Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier functionQ73112984
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosineQ73470605
Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: role of A2B receptorsQ73841698
Multipotent mesenchymal stem cells from adult human synovial membraneQ74384605
A2A-adenosine receptor reserve for coronary vasodilationQ77142330
Adenosine A(2A) and A(2B) receptors mediated nitric oxide production in coronary artery endothelial cellsQ77354771
Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cordQ78799982
Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complexQ78833880
Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cellsQ80057941
Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signalingQ80491718
In search of the in vivo identity of mesenchymal stem cellsQ81485769
T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppressionQ81704121
Inhibition of T-cell proliferation by murine multipotent mesenchymal stromal cells is mediated by CD39 expression and adenosine generationQ82986187
High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturationQ84014638
CD39 expression in mesenchymal stromal cellsQ84576422
CD56brightCD16- NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+ T Cell ProliferationQ85410539
Combination cell therapy using mesenchymal stem cells and regulatory T-cells provides a synergistic immunomodulatory effect associated with reciprocal regulation of TH1/TH2 and th17/treg cells in a murine acute graft-versus-host disease modelQ86245224
IDO-independent suppression of T cell effector function by IFN-γ-licensed human mesenchymal stromal cellsQ87057765
P433issue4
P921main subjectimmunosuppressionQ1455316
mesenchymal stem cellQ1922379
P304page(s)595-609
P577publication date2016-08-25
P1433published inPurinergic SignallingQ15716545
P1476titleAdenosine production: a common path for mesenchymal stem-cell and regulatory T-cell-mediated immunosuppression
P478volume12