Potential Therapeutic Applications of Adenosine A2A Receptor Ligands and Opportunities for A2A Receptor Imaging

scientific article published on 27 January 2017

Potential Therapeutic Applications of Adenosine A2A Receptor Ligands and Opportunities for A2A Receptor Imaging is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/MED.21432
P698PubMed publication ID28128443

P2093author name stringErik F J de Vries
Xiaoyun Zhou
Kiichi Ishiwata
Rudi A J O Dierckx
Hideo Tsukada
Aren van Waarde
Philip H Elsinga
Gert Luurtsema
Shivashankar Khanapur
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A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrierQ36867354
High homocysteine levels prevent via H2 S the CoCl2 -induced alteration of lymphocyte viabilityQ37117183
Adenosine A2A receptors in secondary progressive multiple sclerosis: a [(11)C]TMSX brain PET study.Q37150330
Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumorsQ37157425
Adenosine receptor agonists for promotion of dermal wound healingQ37165218
Systemic administration of the adenosine A(2A) agonist CGS 21680 induces sedation at doses that suppress lever pressing and food intakeQ37172329
Adenosine A2A receptor deficiency alleviates blast-induced cognitive dysfunctionQ37298281
Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytesQ37325379
The role of adenosine in Alzheimer's diseaseQ37402673
Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growthQ37540216
Adenosine receptors in wound healing, fibrosis and angiogenesis.Q37565195
Adenosine receptors and cancer.Q37565200
Adenosine receptor ligands and PET imaging of the CNS.Q37565222
High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumorsQ37636282
Chronic caffeine consumption prevents memory disturbance in different animal models of memory declineQ37698085
Adenosine, energy metabolism and sleep homeostasisQ37802539
Adenosine A(1) receptors in the central nervous system: their functions in health and disease, and possible elucidation by PET imagingQ37932582
CD73: a potent suppressor of antitumor immune responsesQ38001161
Adenosine: setting the stage for plasticityQ38075271
Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors.Q38098796
Cardiovascular adenosine receptors: expression, actions and interactionsQ38114251
Adenosine A(2A) receptor antagonists as Positron Emission Tomography (PET) tracersQ38140938
Adenosine A2A receptor antagonists in Parkinson's disease: progress in clinical trials from the newly approved istradefylline to drugs in early development and those already discontinuedQ38200930
Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancerQ38209586
Efficacy of adenosine A2A receptor antagonist istradefylline as augmentation for Parkinson's disease: a meta-analysis of randomized controlled trialsQ38237288
Adenosine receptor PET imaging in human brainQ38245133
An overview of adenosine A2A receptor antagonists in Parkinson's diseaseQ38245134
Adenosine receptor control of cognition in normal and diseaseQ38245141
Involvement of adenosine A2A receptors in depression and anxietyQ38245143
The effect of unpredictable chronic mild stress on depressive-like behavior and on hippocampal A1 and striatal A2A adenosine receptors.Q38319918
History and perspectives of A2A adenosine receptor antagonists as potential therapeutic agentsQ38395423
Preladenant as an Adjunctive Therapy With Levodopa in Parkinson Disease: Two Randomized Clinical Trials and Lessons LearnedQ38400990
Adenosine A2A and A2B receptor expression in neuroendocrine tumours: potential targets for therapyQ38406861
Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromersQ24304896
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptorQ24323906
Treating lung inflammation with agonists of the adenosine A2A receptor: promises, problems and potential solutionsQ24644038
A Metabolic Immune Checkpoint: Adenosine in Tumor MicroenvironmentQ26749571
Adenosine receptor signaling: a key to opening the blood-brain doorQ26795435
Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stressQ27324798
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptorsQ27343149
Graft versus host disease: New insights into A2A receptor agonist therapyQ28080809
A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapyQ28087576
Characterization and expression of the human A2a adenosine receptor geneQ28117604
Adenosine A2A receptors and depressionQ28190156
Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in ratsQ28195202
Medicinal chemistry of adenosine A2A receptor agonistsQ28207742
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damageQ28214799
Characterization of the Potent and Highly Selective A(2A) Receptor Antagonists Preladenant and SCH 412348 [7-[2-[4-2,4-Difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyraz olo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in Rodent Models ofQ28239772
Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironmentQ28250207
Adenosine receptor antagonists for cognitive dysfunction: a review of animal studiesQ28256117
Adenosine A2A and dopamine D2 heteromeric receptor complexes and their functionQ28261240
A2A adenosine receptor and its modulators: overview on a druggable GPCR and on structure-activity relationship analysis and binding requirements of agonists and antagonistsQ28283019
Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout miceQ28346715
Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell lineQ28363730
Adenosine A(2A) receptors measured with [C]TMSX PET in the striata of Parkinson's disease patientsQ28477288
Functional cooperation of metabotropic adenosine and glutamate receptors regulates postsynaptic plasticity in the cerebellumQ28507660
Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorderQ28575557
Adenosine 2A receptor availability in dyskinetic and nondyskinetic patients with Parkinson diseaseQ29346490
Functional architecture of basal ganglia circuits: neural substrates of parallel processingQ29618729
Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory DeathQ30278868
Selective adenosine-A2A activation reduces lung reperfusion injury following transplantation.Q30304456
Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatmentQ30423298
Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancerQ36620552
CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitisQ36756800
Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's diseaseQ43901692
Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat.Q43928004
A biomathematical modeling approach to central nervous system radioligand discovery and developmentQ44032522
Up-regulation of A(2A) adenosine receptors by proinflammatory cytokines in rat PC12 cellsQ44094196
Selective activation of adenosine A2A receptors on immune cells by a CD73-dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritisQ44114291
Localization of adenosine A2A-receptors in rat brain with [3H]ZM-241385.Q44181417
Antitumor imidazotetrazines. 40. Radiosyntheses of [4-11C-carbonyl]- and [3-N-11C-methyl]-8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (temozolomide) for positron emission tomography (PET) studiesQ44234294
The selective A2A receptor antagonist SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat.Q44257111
Adenosine A2A receptor imaging with [11C]KF18446 PET in the rat brain after quinolinic acid lesion: comparison with the dopamine receptor imagingQ44267331
Up-regulation of striatal adenosine A(2A) receptors in schizophreniaQ44360359
Istradefylline: first global approvalQ44360692
High expression of CD73 as a poor prognostic biomarker in human colorectal cancerQ44385757
The measurement of adenosine and estrogen receptor expression in rat brains following ovariectomy using quantitative PCR analysis.Q44404719
Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivativesQ44428843
Multiple sclerosis lymphocytes upregulate A2A adenosine receptors that are antiinflammatory when stimulatedQ44477698
Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeysQ44509618
Overexpression of CD73 in prostate cancer is associated with lymph node metastasisQ44531613
Potential of an adenosine A2A receptor antagonist [11C]TMSX for myocardial imaging by positron emission tomography: a first human studyQ44629601
Comparative pharmacological studies on the A2 adenosine receptor agonist 5'-n-ethyl-carboxamidoadenosine and its F19 isotope labelled derivativeQ44674613
Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorderQ44686783
Age-related changes in cardiac adenosine receptor expression.Q44795040
Upregulation of striatal adenosine A2A receptor mRNA in 6-hydroxydopamine-lesioned rats intermittently treated with L-DOPA.Q44830958
Adenosine A2A receptor deficient mice are partially resistant to limbic seizuresQ44873083
Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic miceQ44927020
Changes in purine levels and adenosine receptors in kindled seizures in the rat.Q44962342
Effect of free radicals on adenosine A(2A) and dopamine D2 receptors in the striatum of young adult and aged ratsQ44963688
Potential of [11C]TMSX for the evaluation of adenosine A2A receptors in the skeletal muscle by positron emission tomographyQ45089529
Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors.Q45271414
Adenosine A2A receptor dysfunction correlates with age at onset anticipation in blood platelets of subjects with Huntington's diseaseQ45298554
The platelet maximum number of A2A-receptor binding sites (Bmax) linearly correlates with age at onset and CAG repeat expansion in Huntington's disease patients with predominant chorea.Q45298788
The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's diseaseQ45300428
Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's diseaseQ45302947
Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease modelsQ45305389
Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.Q45946925
Selective adenosine A2a receptor antagonism reduces JNK activation in oligodendrocytes after cerebral ischaemia.Q46054884
Adenosine A(2A) receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving miceQ46124293
Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptorsQ46153879
Association study of A2a adenosine receptor genetic polymorphism in panic disorderQ46386938
Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men.Q46388832
Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats.Q46427356
Adenosine A2A receptor hyperexpression in patients with severe SIRS after cardiopulmonary bypassQ46454472
Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat.Q46460712
Sympathetic activity relates to adenosine A(2A) receptor gene variation in blood-injury phobiaQ46482339
Positron emission tomography analysis of [11C]KW-6002 binding to human and rat adenosine A2A receptors in the brainQ46529369
Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in miceQ46534022
Evaluation of brain and whole-body pharmacokinetics of 11C-labeled diphenylhydantoin in rats by means of planar positron imaging systemQ46554743
Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortexQ46574495
Role of adenosine A2A receptor in cerebral ischemia reperfusion injury: Signaling to phosphorylated extracellular signal-regulated protein kinase (pERK1/2).Q46681846
Greater adenosine A(2A) receptor densities in cardiac and skeletal muscle in endurance-trained men: a [11C]TMSX PET studyQ46777864
Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic ratsQ46779705
Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801.Q46810705
Regulation of fear responses by striatal and extrastriatal adenosine A2A receptors in forebrain.Q30423837
Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in ratsQ30427346
Effects of adenosine A₂A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in miceQ30427422
Reducing joint destruction due to septic arthrosis using an adenosine2A receptor agonistQ30433096
A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistenceQ30433250
Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel diseaseQ30437360
Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor inductionQ30437433
The role of adenosine A2A receptor signaling in bronchiolitis obliteransQ30437818
Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognitionQ30443210
Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injuryQ30444009
Adenosine A2A activation attenuates nontransplantation lung reperfusion injuryQ30444747
Upregulation of adenosine A2A receptors induced by atypical antipsychotics and its correlation with sensory gating in schizophrenia patientsQ30445339
Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritisQ30446178
Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophreniaQ30447546
Adenosine A(2A) agonist administration improves islet transplant outcome: Evidence for the role of innate immunity in islet graft rejectionQ30450509
Adenosine through the A2A adenosine receptor increases IL-1β in the brain contributing to anxietyQ30587153
Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomographyQ31588589
Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosineQ31853178
[(3)H]ZM241385--an antagonist radioligand for adenosine A(2A) receptors in rat brainQ31869332
Increased expression of adenosine A2A receptors in patients with spontaneous and head-up-tilt-induced syncopeQ33155294
Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonismQ33591276
Adenosine A2A receptor activation limits graft-versus-host disease after allogenic hematopoietic stem cell transplantationQ33615249
Extracellular adenosine-mediated modulation of regulatory T cellsQ33878542
Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmissionQ33912758
Adenosine in the central nervous system: release mechanisms and extracellular concentrationsQ33955930
The roles of CD73 in cancerQ34003164
Measuring receptor occupancy with PET.Q34023747
Roles of adenosine and its receptors in sleep-wake regulationQ34041863
Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomographyQ34067336
Adenosine receptor signaling modulates permeability of the blood-brain barrier.Q34216355
Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation.Q34462015
The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia.Q34489136
Adenosine and sleep-wake regulationQ34550187
Homeostatic control of brain function - new approaches to understand epileptogenesis.Q43090447
Test-retest variability of adenosine A2A binding in the human brain with (11)C-TMSX and PET.Q43104979
Adenosine A(2A) receptor gene: evidence for association of risk variants with panic disorder and anxious personalityQ43119816
Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slicesQ43192912
Lipopolysaccharide and TNF-alpha modify adenosine A(2A) receptor expression and function in equine monocytes.Q43200122
Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexateQ43269361
Preferential enhancement of working memory in mice lacking adenosine A(2A) receptorsQ43270185
A2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's diseaseQ43272318
Altered distribution and function of A2A adenosine receptors in the brain of WAG/Rij rats with genetic absence epilepsy, before and after appearance of the diseaseQ43282432
How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivoQ43557989
Adenosine enhances glial glutamate efflux via A2a adenosine receptorsQ43627485
Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorderQ43714688
In vivo labelling of the adenosine A2A receptor in mouse brain using the selective antagonist [3H]SCH 58261.Q43808697
Evaluation of [4-O-methyl-(11)C]KW-6002 as a potential PET ligand for mapping central adenosine A(2A) receptors in ratsQ43825588
Blockade of A(2A) adenosine receptors leads to c-fos inhibition in a rat model of brain ischemiaQ43887494
CD73-adenosine: a next-generation target in immuno-oncologyQ38711094
Adenosine receptors in brain: neuromodulation and role in epilepsyQ38747116
CD73 is associated with poor prognosis in high-grade serous ovarian cancerQ38835904
Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptorQ38841915
Effect of hyperoxic and hyperbaric conditions on the adenosinergic pathway and CD26 expression in rat.Q38872376
Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell ResponsesQ38910729
Antimetastatic effects of blocking PD-1 and the adenosine A2A receptorQ38978881
Increased striatal adenosine A2A receptor levels is an early event in Parkinson's disease-related pathology and it is potentially regulated by miR-34b.Q38988738
Overcoming the blood-brain barrier for delivering drugs into the brain by using adenosine receptor nanoagonistQ39011210
CD73-deficient mice are resistant to carcinogenesisQ39384112
Fall in oxygen tension of culture medium stimulates the adenosinergic signalling of a human T cell line.Q39396959
Development of Polar Adenosine A2A Receptor Agonists for Inflammatory Bowel Disease: Synergism with A2B AntagonistsQ39514425
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.Q39531156
Monoclonal antibody-assisted stimulation of adenosine A2A receptors induces simultaneous downregulation of CXCR4 and CCR5 on CD4+ T-cells.Q39664323
DNA methylation regulates adenosine A(2A) receptor cell surface expression levels.Q39764820
A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironmentsQ39785317
Modulation of adenosine A1 and A2A receptors in C6 glioma cells during hypoxia: involvement of endogenous adenosine.Q40006549
Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fieldsQ40183574
Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma.Q40276687
Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation.Q40314032
Adenosine A2A receptors promote adenosine-stimulated wound healing in bronchial epithelial cellsQ40339055
CD73 Expression Is an Independent Prognostic Factor in Prostate CancerQ40646654
Evidence for Coordinated Induction and Repression of Ecto-5'-Nucleotidase (CD73) and the A2a Adenosine Receptor in a Human B Cell LineQ40652135
From "Hellstrom Paradox" to anti-adenosinergic cancer immunotherapyQ40729839
Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells.Q40779392
Adenosine receptor subtypesQ40808680
Chronic sleep restriction induces long-lasting changes in adenosine and noradrenaline receptor density in the rat brainQ41032052
The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intakeQ41075372
A2 adenosine receptors: their presence and neuromodulatory role in the central nervous systemQ41204066
Characterization in humans of 18F-MNI-444, a PET radiotracer for brain adenosine 2A receptorsQ41385155
The expression and clinical significance of CD73 molecule in human rectal adenocarcinomaQ41441746
Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptorQ41545207
Inhibition of small HA fragment activity and stimulation of A2A adenosine receptor pathway limit apoptosis and reduce cartilage damage in experimental arthritis.Q41685843
Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptorsQ41700452
A2A adenosine receptor deletion is protective in a mouse model of TauopathyQ41755392
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep lossQ41776277
Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophilsQ42046896
Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironmentQ42094877
[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in ratsQ42354388
Autoradiographic comparison of in vitro binding characteristics of various tritiated adenosine A2A receptor ligands in rat, mouse and pig brain and first ex vivo results.Q42455807
Distribution of adenosine A2 receptor mRNA in the human brainQ42469615
Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington diseaseQ42494225
Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptorsQ42536513
Treadmill running frequency on anxiety and hippocampal adenosine receptors density in adult and middle-aged ratsQ42624014
Regulation of leukocyte migration across endothelial barriers by ECTO-5'-nucleotidase-generated adenosineQ42634450
Pharmacokinetic modelling of N-(4-[(18)F]fluorobenzoyl)interleukin-2 binding to activated lymphocytes in an xenograft model of inflammationQ42646895
An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteersQ42655771
Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory.Q42701014
Positive allosteric modulation of the adenosine A2a receptor attenuates inflammationQ43052140
The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slicesQ43078271
Adenosine A2A receptor expression in peripheral blood mononuclear cells of patients with mild cognitive impairmentQ43088167
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an updateQ34701303
Effect of Caffeine Chronically Consumed During Pregnancy on Adenosine A1 and A2A Receptors Signaling in Both Maternal and Fetal Heart from Wistar RatsQ34709509
Brain adenosine A2A receptor occupancy by a novel A1/A2A receptor antagonist, ASP5854, in rhesus monkeys: relationship to anticataleptic effectQ34786391
Adenosine A2A receptor contributes to ischemic brain damage in newborn pigletQ34824112
Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxiaQ34842221
Applications of adenosine receptor ligands in medical imaging by positron emission tomographyQ34947203
Automated reference region extraction and population-based input function for brain [(11)C]TMSX PET image analysesQ34957647
Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathwayQ35014590
A2A adenosine receptor protects tumors from antitumor T cells.Q35016529
Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice.Q35046240
Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologistsQ35090797
Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis.Q35098311
Human brain endothelial cells are responsive to adenosine receptor activationQ35136806
Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425.Q35167540
Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2.Q35410561
Involvement of NADPH oxidase in A2A adenosine receptor-mediated increase in coronary flow in isolated mouse heartsQ35587846
A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier PermeabilityQ35630252
Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine.Q35739759
Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population.Q35759035
Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's diseaseQ35799088
The discovery of a selective and potent A2a agonist with extended lung retentionQ35822325
Tissue distribution of adenosine receptor mRNAs in the rat.Q35873795
A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase releaseQ35907768
Adenosine dysfunction in epilepsyQ36036212
Adenosine A2A receptor activation prevents wear particle-induced osteolysisQ36067491
The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway.Q36075960
Growth regulation of the vascular system: an emerging role for adenosineQ36193019
Pharmacological blockade of adenosine A2A receptors diminishes scarringQ36252358
Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptorsQ36380776
Adenosine A2A receptor plays an important role in radiation-induced dermal injuryQ36385392
Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists.Q36466181
Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cellsQ36496998
The effect of regadenoson-induced transient disruption of the blood-brain barrier on temozolomide delivery to normal rat brainQ36522674
Neurotransmitters and neuromodulators in the basal gangliaQ36586002
Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in ratsQ46842748
Effect of adenosine A2A receptor activation in murine models of respiratory disordersQ46844203
N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptorsQ46876692
Upregulation of A2A adenosine receptors in platelets from patients affected by bipolar disorders under treatment with typical antipsychoticsQ46907529
The effect of A2A adenosine receptor agonist on composite tissue allotransplant survival: an in vivo preliminary studyQ46927153
Improved spatial recognition memory in mice lacking adenosine A2A receptorsQ46977578
Protective effect of adenosine A2A receptor activation in small-for-size liver transplantationQ47308949
Activation of adenosine receptor potentiates the anticonvulsant effect of phenytoin against amygdala kindled seizuresQ48026821
Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A2A receptors in the limbic cortex, but not striatum, of aged ratsQ48103969
Striatum adenosine A2 receptors are modified during seizure: effect of cyclopentyladenosine administrationQ48109713
Changes in adenosine receptors in the neonatal rat brain following hypoxic ischemiaQ48110047
Behavioural characteristics and gene expression in the hyperactive wiggling (Wig) rat.Q48116633
The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in ratsQ48147257
Influence of age on BDNF modulation of hippocampal synaptic transmission: interplay with adenosine A2A receptors.Q48209802
Expression of adenosine A2a receptors gene in the olfactory bulb and spinal cord of rat and mouseQ48260829
Time-course of protection by the selective A2A receptor antagonist SCH58261 after transient focal cerebral ischemiaQ48264449
Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomographyQ48336994
Adenosine A2A receptors are up-regulated in Pick's disease frontal cortex.Q48369377
Antidepressant-like activity of the adenosine A(2A) receptor antagonist, istradefylline (KW-6002), in the forced swim test and the tail suspension test in rodentsQ48403772
Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in miceQ48410779
Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brainQ48440230
Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stressQ48488684
Genetic inactivation of the adenosine A(2A) receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitisQ48491942
Differential effects of age on human striatal adenosine A₁ and A(2A) receptors.Q48496249
Synthesis and preclinical evaluation of 2-(2-furanyl)-7-[2-[4-[4-(2-[11C]methoxyethoxy)phenyl]-1-piperazinyl]ethyl]7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine-5-amine ([11C]Preladenant) as a PET tracer for the imaging of cerebral adenosine A2Q48498628
Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorderQ48530599
Effect of pulsed electromagnetic field exposure on adenosine receptors in rat brainQ48829546
Maternal glutamate intake during gestation and lactation regulates adenosine A₁ and A(2A) receptors in rat brain from mothers and neonatesQ48854281
The selective adenosine A2A receptor antagonist SCH 58261 discriminates between two different binding sites for [3H]-CGS 21680 in the rat brainQ48905814
Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus.Q48943968
Detection of subclinical synovitis with macrophage targeting and positron emission tomography in patients with rheumatoid arthritis without clinical arthritisQ49173312
The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockadeQ50262179
Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia.Q50480825
Quantification of Dynamic 11C-Phenytoin PET Studies.Q50889203
A2A adenosine receptors are up-regulated in lymphocytes from amyotrophic lateral sclerosis patients.Q50989087
Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats.Q51028680
A2A adenosine receptor agonists reduce both high-palatability and low-palatability food intake in female rats.Q51329119
Activation of the adenosine A2A receptor attenuates experimental autoimmune encephalomyelitis and is associated with increased intracellular calcium levels.Q53093570
A long-term study of istradefylline safety and efficacy in patients with Parkinson disease.Q53579832
Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxia.Q54046112
Brain regional pharmacokinetics of 11C-labeled diphenylhydantoin: positron emission tomography in humans.Q54498084
Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.Q54532556
Influence of haemodialysis and left ventricular failure on peripheral A(2A) adenosine receptor expression.Q54569706
Adenosine receptors and wound healing.Q55008833
Adenosine receptors and wound healing, revised.Q55339762
Synthesis of [3-N-(11) C-methyl]temozolomide via in situ activation of 3-N-hydroxymethyl temozolomide and alkylation with [(11) C]methyl iodide.Q55460168
Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of diseaseQ57655621
Extracellular Adenosine, Inosine, Hypoxanthine, and Xanthine in Relation to Tissue Nucleotides and Purines in Rat Striatum During Transient IschemiaQ57982925
P577publication date2017-01-27
P1433published inMedicinal Research ReviewsQ2436033
P1476titlePotential Therapeutic Applications of Adenosine A2A Receptor Ligands and Opportunities for A2A Receptor Imaging

Reverse relations

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