Adenosine A₂A receptor agonist-mediated increase in donor-derived regulatory T cells suppresses development of graft-versus-host disease

scientific article published on 7 December 2012

Adenosine A₂A receptor agonist-mediated increase in donor-derived regulatory T cells suppresses development of graft-versus-host disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1201325
P932PMC publication ID3674549
P698PubMed publication ID23225892
P5875ResearchGate publication ID233888498

P50authorHarry MalechQ42654598
P2093author name stringElizabeth M Kang
Kyu Lee Han
Seung-Kwon Ha
Cattlena M Changpriroa
Sherry M Koontz
Stephenie V M Thomas
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A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.Q30440525
Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitisQ30441350
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Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kineticsQ34144161
A Crucial Role for Host APCs in the Induction of Donor CD4+CD25+ Regulatory T Cell-Mediated Suppression of Experimental Graft-versus-Host DiseaseQ34312261
CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host diseaseQ34525987
Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantationQ34561047
Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis.Q34896844
Cytokines, viruses, and graft-versus-host diseaseQ34977543
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Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host diseaseQ35848458
Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host diseaseQ35995245
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCIDQ36185196
Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantationQ36370863
Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cellsQ36496998
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.Q36693820
Novel mechanism of rapamycin in GVHD: increase in interstitial regulatory T cellsQ36831117
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Impact of immunosuppressive drugs on CD4+CD25+FOXP3+ regulatory T cells: does in vitro evidence translate to the clinical setting?Q37116728
Donor reactive regulatory T cellsQ37485835
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Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotidesQ39797150
Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 productionQ41908710
Efficient and selective prevention of GVHD by antigen-specific induced Tregs via linked-suppression in miceQ42109680
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantationQ44408941
Immune reconstitution is preserved in hematopoietic stem cell transplantation coadministered with regulatory T cells for GVHD preventionQ44641693
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Regulatory T-cells in the graft and the risk of acute graft-versus-host disease after allogeneic stem cell transplantation.Q53557826
Elevation of intracellular cyclic AMP in alloreactive CD4(+) T Cells induces alloantigen-specific tolerance that can prevent GVHD lethality in vivo.Q53558142
Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissueQ61762159
The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosineQ72028809
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The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethalityQ78033315
Gastrointestinal involvement in chronic graft-versus-host disease: a clinicopathologic studyQ78812754
Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+ CD25+ FoxP3+ T cellsQ79919091
Cutaneous gene expression by DNA microarray in murine sclerodermatous graft-versus-host disease, a model for human sclerodermaQ80135176
The use of laparoscopic liver biopsies in pediatric patients with hepatic dysfunction following allogeneic hematopoietic stem cell transplantationQ81261229
Can Treg therapy prevent GVHD?Q83253234
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)458-468
P577publication date2012-12-07
P1433published inJournal of ImmunologyQ3521441
P1476titleAdenosine A₂A receptor agonist-mediated increase in donor-derived regulatory T cells suppresses development of graft-versus-host disease
P478volume190

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Q90400275Special Issue: G Protein-Coupled Adenosine Receptors: Molecular Aspects and Beyond
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