Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade

scientific article (publication date: March 2003)

Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

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P6179Dimensions Publication ID1042293073
P356DOI10.1038/NCB942
P3181OpenCitations bibliographic resource ID3410927
P698PubMed publication ID12598905

P50authorYukiko GotohQ89556488
P2093author name stringKunihiro Matsumoto
Shigeaki Kato
Hiroshi Shibuya
Takashi Kadowaki
Yasuhiro Takeuchi
Toshimasa Yamauchi
Satoko Ogawa
Ichiro Takada
Fumiaki Ohtake
Junn Yanagisawa
Miyuki Suzawa
P2860cites workThe kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathwayQ22009096
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinaseQ24310066
TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transductionQ24312956
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIKQ24321797
Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNAQ27748829
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathwayQ28140039
Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivatorsQ28143758
Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylaseQ28144544
Bone resorption by osteoclastsQ28145169
The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulatorsQ28198125
An adipogenic cofactor bound by the differentiation domain of PPARgammaQ28586511
Combinatorial roles of the nuclear receptor corepressor in transcription and developmentQ28591431
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinaseQ29617567
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activationQ29620219
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistanceQ29622888
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cellsQ30476196
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinaseQ33886831
Roles of PPARs in health and disease.Q33934899
Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoformsQ34018199
The osteoblast: a sophisticated fibroblast under central surveillanceQ34021172
Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP).Q35596558
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgammaQ41144553
Bone morphogenetic proteins inhibit adipocyte differentiation by bone marrow stromal cellsQ41331286
Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor betaQ41568089
Cloning and characterization of a functional peroxisome proliferator activator receptor-gamma-responsive element in the promoter of the CAP geneQ42803987
Activation of peroxisome proliferator-activated receptor-gamma pathway inhibits osteoclast differentiationQ73754931
Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivatorsQ74485020
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectadipogenesisQ2824461
P304page(s)224-30
P577publication date2003-03-01
P1433published inNature Cell BiologyQ1574111
P1476titleCytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade
P478volume5

Reverse relations

cites work (P2860)
Q402101281Alpha,25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter
Q40457879A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes
Q50466779A comparison of the in vitro mineralisation and dentinogenic potential of mesenchymal stem cells derived from adipose tissue, bone marrow and dental pulp.
Q52682873A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor.
Q28572633A high-fat diet increases IL-1, IL-6, and TNF-α production by increasing NF-κB and attenuating PPAR-γ expression in bone marrow mesenchymal stem cells
Q56741581A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation
Q46418482AHSG gene variant is associated with leanness among Swedish men.
Q36324040Adipogenesis: cellular and molecular aspects.
Q42798017Adiponectin gene activation by thiazolidinediones requires PPAR gamma 2, but not C/EBP alpha-evidence for differential regulation of the aP2 and adiponectin genes
Q80794574Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha
Q34931211Adipose inflammation, insulin resistance, and cardiovascular disease
Q39302706Adipose tissue depots and inflammation: effects on plasticity and resident mesenchymal stem cell function
Q38286500Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality
Q36324053Adipose tissue: a regulator of inflammation
Q41953306Amelioration of mitochondrial dysfunction-induced insulin resistance in differentiated 3T3-L1 adipocytes via inhibition of NF-κB pathways
Q28208531Amyloid β peptide (Aβ42) activates PLC-δ1 promoter through the NF-κB binding site
Q35768672An essential role of NF-kappaB in the "tumor-like" phenotype of arthritic synoviocytes
Q42534662Analysis of the Pro- and Anti-Inflammatory Cytokines Secreted by Adult Stem Cells during Differentiation
Q33679156Antiobesity mechanisms of action of conjugated linoleic acid
Q38860543Apolipoprotein CIII Induces Monocyte Chemoattractant Protein-1 and Interleukin 6 Expression Via Toll-Like Receptor 2 Pathway in Mouse Adipocytes: Retracted
Q35559514Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys?
Q37096739Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells
Q84134073Beta-catenin protein utilized by Tumour necrosis factor-alpha in porcine preadipocytes to suppress differentiation
Q35606415Biology and clinical applications of mesenchymal stem cells
Q88631820Biology of GM3 Ganglioside
Q36291257Bone marrow-derived mesenchymal stem cells
Q37735741Bone marrow-derived mesenchymal stem cells and the tumor microenvironment
Q36161347Brain masculinization requires androgen receptor function
Q40449687C/EBPalpha activates the transcription of triacylglycerol hydrolase in 3T3-L1 adipocytes.
Q43248702CDP/cut is an osteoblastic coactivator of the vitamin D receptor (VDR).
Q30320094CLA isomers inhibit TNFalpha-induced eicosanoid release from human vascular smooth muscle cells via a PPARgamma ligand-like action
Q40526717Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.
Q39040821Caspase-1 promotes monocyte-macrophage differentiation by repressing PPARγ.
Q33828642Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration
Q39639461Challenges in Drug Discovery for Thiazolidinedione Substitute
Q40505444Classical and alternative NF-κB signaling cooperate in regulating adipocyte differentiation and function.
Q50101859ComPPARtmentalizing NF-kappaB in the gut.
Q50101913Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA.
Q34312856Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines
Q34147790Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production.
Q37086152Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol
Q53012519Control of homeostatic and pathogenic balance in adipose tissue by ganglioside GM3.
Q34625258Curcumin and obesity: evidence and mechanisms
Q37984124Curcumin molecular targets in obesity and obesity-related cancers
Q44735929Cytokines regulate fibroblast-like synovial cell differentiation to adipocyte-like cells
Q81526916Decreased fat mass in interleukin-1 receptor antagonist-deficient mice: impact on adipogenesis, food intake, and energy expenditure
Q30241888Dendritic cells and adipose tissue
Q43141500Development of a rapid culture method to induce adipocyte differentiation of human bone marrow-derived mesenchymal stem cells
Q36744091Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes
Q33393459Differential RelA- and RelB-dependent gene transcription in LTbetaR-stimulated mouse embryonic fibroblasts
Q40119020Differential ability of a thiazolidinedione PPARgamma agonist to attenuate cytokine secretion in primary microglia and macrophage-like cells
Q31135521Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: unique screening and Oncostatin M-like activity
Q40523512Distinct roles of BMP receptors Type IA and IB in osteo-/chondrogenic differentiation in mesenchymal progenitors (C3H10T1/2).
Q37981459Do microRNAs regulate bone marrow stem cell niche physiology?
Q33897689Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1
Q34092765Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate
Q28593674Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes
Q42804383Effect of Wnt-1 inducible signaling pathway protein-2 (WISP-2/CCN5), a downstream protein of Wnt signaling, on adipocyte differentiation
Q81160123Effects of chronic exercise on cytokine production in white adipose tissue and skeletal muscle of rats
Q42799080Effects of phorbol ester-sensitive PKC (c/nPKC) activation on the production of adiponectin in 3T3-L1 adipocytes
Q50470597Effects of substrate stiffness on adipogenic and osteogenic differentiation of human mesenchymal stem cells.
Q37116246Emerging role of adipose tissue hypoxia in obesity and insulin resistance
Q55517488Eosinophils support adipocyte maturation and promote glucose tolerance in obesity.
Q34679499Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts
Q36957982Flexible and dynamic organization of bone marrow stromal compartment
Q42597088Focal fat lesions at vertebral corners on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis.
Q46327329Gene expression profile of the bone microenvironment in human fragility fracture bone
Q36267948Genes involved in obesity: Adipocytes, brain and microflora
Q33493427Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program
Q38328121Genome-wide repression of NF-κB target genes by transcription factor MIBP1 and its modulation by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase
Q79976898HDAC activity is required for p65/RelA-dependent repression of PPARdelta-mediated transactivation in human keratinocytes
Q35640258HIV-associated lipodystrophy: pathogenesis, prognosis, treatment, and controversies
Q34346778Hemozoin (malarial pigment) inhibits differentiation and maturation of human monocyte-derived dendritic cells: a peroxisome proliferator-activated receptor-gamma-mediated effect
Q45770808High levels of β-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway
Q40538409IL-1 and LPS but not IL-6 inhibit differentiation and downregulate PPAR gamma in brown adipocytes.
Q50942222Identification and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency.
Q38317297Identification of novel PPARgamma target genes in primary human adipocytes
Q40168723Impaired peroxisome proliferator-activated receptor gamma function through mutation of a conserved salt bridge (R425C) in familial partial lipodystrophy.
Q35417015Implication of low level inflammation in the insulin resistance of adipose tissue at late pregnancy
Q112292512In situ transplantation of adipose-derived stem cells via photoactivation improves glucose metabolism in obese mice
Q50622058In vivo gene transfer of PPAR gamma is insufficient to induce adipogenesis in skeletal muscle.
Q44522392Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels
Q38333467Inflammation inhibits GPR81 expression in adipose tissue
Q37906726Inflammation-mediated obesity and insulin resistance as targets for nutraceuticals
Q44228560Inflammatory environment induces gingival tissue-specific mesenchymal stem cells to differentiate towards a pro-fibrotic phenotype
Q36447976Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP
Q36838847Insulin signalling mechanisms for triacylglycerol storage
Q46703969Interaction between NF-κB signaling and Notch signaling in gliogenesis of mouse mesencephalic neural crest cells.
Q33768617Interactive changes between macrophages and adipocytes
Q34318738Interleukin-1 beta: a potential link between stress and the development of visceral obesity
Q46872864Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents.
Q34558529Interleukin-1β regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability
Q36375063Interplay between mesenchymal stem cells and lymphocytes: implications for immunotherapy and tissue regeneration
Q38341516Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression
Q35631488Involvement of neuronal TGF-β activated kinase 1 in the development of tolerance to morphine-induced antinociception in rat spinal cord
Q23912824Is NF-kappaB a culprit in type 2 diabetes?
Q35196534JNK inhibition by SP600125 attenuates trans-10, cis-12 conjugated linoleic acid-mediated regulation of inflammatory and lipogenic gene expression
Q36747280Lessons from musculoskeletal stem cell research: the key to successful regenerative medicine development
Q42819277Lipopolysaccharides reduce adipogenesis in 3T3-L1 adipocytes through activation of NF-κB pathway and downregulation of AMPK expression
Q36782381Local adipose tissue depots as cardiovascular risk factors
Q37257195Lymphotoxin-β receptor signaling through NF-κB2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells
Q51109464Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes.
Q42491649Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.
Q34331776Mechanisms of insulin resistance in obesity
Q36848096Mechanisms of transcriptional repression by 1,25(OH)2 vitamin D.
Q40053820Membrane proteomic analysis of human mesenchymal stromal cells during adipogenesis
Q39324809Mesenchimal stem cells: a possible role in the pathogenesis and treatment of spondyloarthritis
Q55314890Mesenchymal Stem Cell Transplantation for Tissue Repair.
Q80226827Mesenchymal stem cells
Q37592909Mesenchymal stem cells for craniofacial tissue regeneration: designing hydrogel delivery vehicles
Q37156192Mesenchymal stem cells for tissue engineering and regenerative medicine
Q36933699Mesenchymal stem cells in rheumatology: a regenerative approach to joint repair
Q35686355Mesenchymal stem cells: clinical applications and biological characterization.
Q37370552Mesenchymal stromal cells in rheumatoid arthritis: biological properties and clinical applications.
Q39224695MiR-143 is not essential for adipose development as revealed by in vivo antisense targeting
Q35008901MiRNA-181a regulates adipogenesis by targeting tumor necrosis factor-α (TNF-α) in the porcine model
Q38337327Modulation of peroxisome proliferator-activated receptor gamma (PPAR γ) by conjugated fatty acid in obesity and inflammatory bowel disease.
Q38509245Molecular Mechanisms of PPAR-γ Governing MSC Osteogenic and Adipogenic Differentiation.
Q48312086Molecular characterisation of tumour necrosis factor alpha and its potential connection with lipoprotein lipase and peroxisome proliferator-activated receptors in blunt snout bream (Megalobrama amblycephala).
Q83737442Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies
Q36294297Molecular targets related to inflammation and insulin resistance and potential interventions
Q34695969Myocyte enhancer factor-2 interacting transcriptional repressor (MITR) is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stem cells by inactivating peroxisome proliferator-activated receptor gamma-2.
Q40296221NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity
Q34744211NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK.
Q37777775NF-κB inducing kinase: A key regulator in the immune system and in cancer
Q57420154NF-κB is important for TNF-α-induced lipolysis in human adipocytes
Q59607686Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice
Q35786209New insights into inhibitors of adipogenesis
Q37858464New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases
Q38272011Nicotinic acid regulates glucose and lipid metabolism through lipid independent pathways
Q37073554Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments.
Q36051617Nuclear receptors as targets for drug development: crosstalk between peroxisome proliferator-activated receptor gamma and cytokines in bone marrow-derived mesenchymal stem cells
Q42834658Oncostatin M inhibits adipogenesis through the RAS/ERK and STAT5 signaling pathways
Q38441017Oral anti-diabetic drugs and fracture risk, cut to the bone: safe or dangerous? A narrative review
Q53310070Overexpressed human heme Oxygenase-1 decreases adipogenesis in pigs and porcine adipose-derived stem cells.
Q112722648Oxidant therapy improves adipogenic differentiation of adipose-derived stem cells in human wound healing
Q36076299PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation
Q34007810PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance
Q42612084PPAR-gamma Signaling Crosstalk in Mesenchymal Stem Cells
Q45965487PPARgamma Pro12Ala polymorphism in HIV-1-infected patients with HAART-related lipodystrophy.
Q24633440PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
Q41828567PPARs and Adipose Cell Plasticity
Q35235680Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner
Q83204970Peroxisome proliferator-activated receptor alpha, delta, gamma1 and gamma2 expressions are present in human monocyte-derived dendritic cells and modulate dendritic cell maturation by addition of subtype-specific ligands
Q46662311Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway
Q44710999Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells
Q47684295Peroxisome proliferator-activated receptor gamma polymorphism is related to peak bone mass: the JPOS study
Q40499667Peroxisome proliferator-activated receptor gamma-dependent and -independent growth inhibition of gastrointestinal tumour cells
Q37959656Peroxisome proliferator-activated receptor-γ cross-regulation of signaling events implicated in liver fibrogenesis
Q38192745Physiologic versus diabetogenic effects of interleukin-1: a question of weight
Q80010792Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes
Q47667700Prenatal Exposure to Endocrine Disruptors and Reprogramming of Adipogenesis: An Early-Life Risk Factor for Childhood Obesity
Q53602578Preservation of high-fat diet-induced femoral trabecular bone loss through genetic target of TNF-α.
Q39068615Pro-Inflammation Cytokines: New Potential Therapeutic Targets for Obesity-Related Bone Disorders
Q57815847Pro-inflammatory cytokines: The link between obesity and osteoarthritis
Q35865862Progeroid syndrome as a model for impaired bone formation in senile osteoporosis
Q54499514Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation.
Q42987178Prostaglandin F(2alpha) suppresses early phase of adipogenesis, but is not associated with osteoblastogenesis in mouse mesenchymal stem cells
Q53294010Proteomics and transcriptomics investigation on longissimus muscles in Large White and Casertana pig breeds.
Q82399353Radiation hybrid mapping of seven bovine genes encoding transcription factors involved in adipogenesis
Q38131118Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation
Q37226915Regulation of PPARgamma function by TNF-alpha
Q37770377Regulation of energy metabolism by inflammation: a feedback response in obesity and calorie restriction
Q35786203Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines
Q27028193Regulation of stem cell differentiation in adipose tissue by chronic inflammation
Q47386774Regulatory effects of interleukin (IL)-1, interferon-beta, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue
Q39270866Retinoic acid regulates commitment of undifferentiated mesenchymal stem cells into osteoblasts and adipocytes
Q85892558Retraction: Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade
Q37611364Role of NF-kappa B in the pathogenesis of diabetes and its associated complications
Q42467739Role of transforming growth factor-activated kinase-1 on tumor necrosis factor-α actions in human adipose tissue-derived stromal cells
Q79901709Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium
Q39622012Rosiglitazone attenuates the metalloprotease/anti-metalloprotease imbalance in emphysema induced by cigarette smoke: involvement of extracellular signal-regulated kinase and NFκB signaling
Q48262575Scaffold-free generation of uniform adipose spheroids for metabolism research and drug discovery.
Q47793450Sequestration of thermogenic transcription factors in the cytoplasm during development of brown adipose tissue
Q37159360Signal transduction and transcriptional regulation during mesenchymal cell differentiation.
Q42802584Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation
Q24633409Smad3 deficiency in mice protects against insulin resistance and obesity induced by a high-fat diet
Q37070707Stem cells: an overview
Q38324142Stimulation of resorption in cultured mouse calvarial bones by thiazolidinediones
Q46866093Stress-induced cytokine responses and central adiposity in young women
Q24301453Structure of the SCAN domain from the tumor suppressor protein MZF1
Q34656434Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts
Q40624072Suppression of apolipoprotein AI gene expression in HepG2 cells by TNF alpha and IL-1beta
Q24297399TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation
Q35006572TNF-alpha and adipocyte biology
Q54389261TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-κB and PPAR-γ.
Q85014609TNF-α stimulates alkaline phosphatase and mineralization through PPARγ inhibition in human osteoblasts
Q81268702TRRAP as a hepatic coactivator of LXR and FXR function
Q35129349Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals
Q42814401Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes
Q83165111Tensile strain as a regulator of mesenchymal stem cell osteogenesis
Q28078585The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis
Q47267239The Effects of Hyperacute Serum on Adipogenesis and Cell Proliferation of Mesenchymal Stromal Cells
Q92012185The Influence of Light on Reactive Oxygen Species and NF-кB in Disease Progression
Q28288503The NF-kappaB regulatory network
Q40032475The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma
Q39661936The anti-adipogenic effect of macrophage-conditioned medium requires the IKKβ/NF-κB pathway.
Q37641459The autocrine and paracrine roles of adipokines.
Q37430626The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response
Q42818803The effects of NOD activation on adipocyte differentiation
Q42806255The effects of hydroxycinnamic acid derivatives on adiponectin secretion
Q35571994The function of nuclear receptors in bone tissues
Q33994438The many facets of PPARgamma: novel insights for the skeleton
Q34208083The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation
Q35948133The pituitary function of androgen receptor constitutes a glucocorticoid production circuit
Q36268038The role of recipient T cells in mesenchymal stem cell-based tissue regeneration
Q24628865The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-β (TGFβ) signaling
Q51230354The use of small interfering RNAs to inhibit adipocyte differentiation in human preadipocytes and fetal-femur-derived mesenchymal cells.
Q46265499Thiazolidinediones enhance skeletal muscle triacylglycerol synthesis while protecting against fatty acid-induced inflammation and insulin resistance
Q42827019Tissue inhibitor of metalloproteases-4 (TIMP-4) modulates adipocyte differentiation in vitro
Q39990710Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages
Q36193738Towards a Systematic Screening Tool for Quality Assurance and Semiautomatic Fraud Detection for Images in the Life Sciences
Q36544924Toxic metabolic syndrome associated with HAART.
Q42141293Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes
Q42826754Transcription suppression of peroxisome proliferator-activated receptor gamma2 gene expression by tumor necrosis factor alpha via an inhibition of CCAAT/ enhancer-binding protein delta during the early stage of adipocyte differentiation.
Q37650762Transcriptional and post-translational regulation of adiponectin
Q35141043Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol
Q28219857Tumor necrosis factor alpha and adalimumab differentially regulate CD36 expression in human monocytes
Q40610380Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells
Q81480642Tumor necrosis factor-alpha stimulates HIV-1 production in primary culture of human adipocytes
Q39247138Tumour necrosis factor alpha down-regulates the expression of peroxisome proliferator activated receptor alpha (PPARα) in human hepatocarcinoma HepG2 cells by activation of NF-κB pathway.
Q42027895Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway.
Q42798829Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response
Q33717545Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure
Q34336984Use of small interfering ribonucleic acids to inhibit the adipogenic effect of alcohol on human bone marrow-derived mesenchymal cells
Q42805768Valsartan ameliorates the constitutive adipokine expression pattern in mature adipocytes: a role for inverse agonism of the angiotensin II type 1 receptor in obesity
Q40079327Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene
Q29540785Winning a Won Game: Caffeine Panacea for Obesity Syndemic
Q37542905Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis
Q28568441Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis
Q44046208Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes
Q34575607Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment.
Q80259243[Diabetes and the metabolic syndrome]
Q42505862dlk1/FA1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related factors
Q94667781β-arrestin 2 quenches TLR signaling to facilitate the immune evasion of EPEC
Q83395250γ-Oryzanol recovers mouse hypoadiponectinemia induced by animal fat ingestion

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