Regulation of G proteins by covalent modification

scientific article (publication date: 26 March 2001)

Regulation of G proteins by covalent modification is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1019923619
P356DOI10.1038/SJ.ONC.1204185
P3181OpenCitations bibliographic resource ID4301020
P698PubMed publication ID11313912
P5875ResearchGate publication ID12020725

P2093author name stringC A Chen
D R Manning
P2860cites workGalpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane bindingQ22253446
Lipid modifications of trimeric G proteinsQ24309425
RGSZ1, a Gz-selective Regulator of G Protein Signaling Whose Action Is Sensitive to the Phosphorylation State of GzαQ24316172
Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane associationQ24336696
Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytesQ24527360
G-protein alpha-subunit expression, myristoylation, and membrane association in COS cellsQ24559862
A Cytoplasmic Acyl-Protein Thioesterase That Removes Palmitate from G Protein α Subunits and p21RASQ28273568
RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamilyQ28283407
Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase CQ28284741
Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complexQ28289381
Inhibition of adenylyl cyclase by Gi alphaQ28646204
The caveolae membrane systemQ29614726
Functions of lipid rafts in biological membranesQ29616845
Transformation of Rat-1 fibroblasts with the v-src oncogene increases the tyrosine phosphorylation state and activity of the alpha subunit of Gq/G11.Q30453900
Tyrosine phosphorylation of G protein alpha subunits by pp60c-srcQ30454096
Identification of the in vitro phosphorylation sites on Gs alpha mediated by pp60c-srcQ30463936
Phosphorylation of the G Protein γ12 Subunit Regulates Effector SpecificityQ30472460
Caveolins, liquid-ordered domains, and signal transductionQ33752828
A detergent-free method for purifying caveolae membrane from tissue culture cellsQ33818572
Galpha12 and galpha13 are phosphorylated during platelet activationQ34398937
Inhibition of Brain G z GAP and Other RGS Proteins by Palmitoylation of G Protein α SubunitsQ34444567
Persistent membrane association of activated and depalmitoylated G protein alpha subunitsQ34810345
Localization of a peripheral membrane protein: Gbetagamma targets Galpha(Z).Q35004171
Receptor regulation of G-protein palmitoylationQ35135424
Gsalpha contains an unidentified covalent modification that increases its affinity for adenylyl cyclaseQ36179486
Purification and characterization of smooth muscle cell caveolaeQ36234345
Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human diseaseQ36234407
Plasma Membrane Localization of GαzRequires Two SignalsQ36847578
Organization of G Proteins and Adenylyl Cyclase at the Plasma MembraneQ36945617
Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunitQ37045553
Myristoylation of the G alpha i2 polypeptide, a G protein alpha subunit, is required for its signaling and transformation functionsQ37249953
Activation-induced subcellular redistribution of Gs alphaQ37381937
Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C.Q37410606
Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachmentQ37671954
N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localizationQ38306703
G-protein palmitoyltransferase activity is enriched in plasma membranesQ38360176
Functional importance of the amino terminus of Gq alphaQ38362899
The dynamic role of palmitoylation in signal transductionQ40443876
Protein modification. Palmitoylation in G-protein signaling pathwaysQ40521352
Genetic and biochemical studies of protein N-myristoylationQ40643081
Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q).Q40907600
Activation of the beta(2)-adrenergic receptor-Galpha(s) complex leads to rapid depalmitoylation and inhibition of repalmitoylation of both the receptor and Galpha(s).Q40923011
Gonadotropin-Releasing Hormone Receptor Couples to Multiple G Proteins in Rat Gonadotrophs and in GGH3 Cells: Evidence from Palmitoylation and Overexpression of G proteins1Q41013759
Activation of the G protein Gq/11 through tyrosine phosphorylation of the alpha subunitQ41104196
Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptorQ41108350
Lipid-modified, cysteinyl-containing peptides of diverse structures are efficiently S-acylated at the plasma membrane of mammalian cellsQ41182094
Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gammaQ41197816
Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteinsQ41260833
Reversible palmitoylation of signaling proteinsQ41382874
N-terminal fatty acylation of the alpha-subunit of the G-protein Gi1: only the myristoylated protein is a substrate for palmitoylationQ41430135
Activation and depalmitoylation of Gs alphaQ41459257
The G protein alpha s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modificationQ41533556
Gbetagamma and palmitate target newly synthesized Galphaz to the plasma membraneQ41673440
Pseudo-enzymatic S-acylation of a myristoylated Yes protein tyrosine kinase peptide in vitro may reflect non-enzymatic S-acylation in vivoQ41850479
Phosphorylation of F-actin-associating G protein gamma12 subunit enhances fibroblast motilityQ42816896
Gα12 Requires Acylation for Its Transforming ActivityQ42831318
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclaseQ46680546
Understanding covalent modifications of proteins by lipids: where cell biology and biophysics mingleQ47896008
Lipid modifications and membrane targeting of G alphaQ47966148
The Dually Acylated NH2-terminal Domain of Gi1αIs Sufficient to Target a Green Fluorescent Protein Reporter to Caveolin-enriched Plasma Membrane DomainsQ57371805
Lipid-dependent Targeting of G Proteins into RaftsQ57371836
Reciprocal Signaling between Heterotrimeric G Proteins and the p21-stimulated Protein KinaseQ61640755
Activation of signal-transducing guanine-nucleotide-binding regulatory proteins by guanosine 5'-[gamma-thio]triphosphate. Information transfer by intermediately thiophosphorylated beta gamma subunitsQ67985898
Binding of acylated peptides and fatty acids to phospholipid vesicles: pertinence to myristoylated proteinsQ70480633
Autoacylation of G protein alpha subunitsQ71514812
Biochemical Characterization of a Palmitoyl Acyltransferase Activity That Palmitoylates Myristoylated ProteinsQ72055049
Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPasesQ72315760
Doubly-lipid-modified protein sequence motifs exhibit long-lived anchorage to lipid bilayer membranesQ72638453
Purification and biochemical characterization of a protein-palmitoyl acyltransferase from human erythrocytesQ73248202
N-Myristoylation and betagamma play roles beyond anchorage in the palmitoylation of the G protein alpha(o) subunitQ73280050
Regulation of galpha i palmitoylation by activation of the 5-hydroxytryptamine-1A receptorQ73807687
Role of G alpha q or G alpha o proteins in alpha 1-adrenoceptor subtype-mediated responses in Fischer 344 rat aortaQ73988115
Nucleoside diphosphate kinase activity in soluble transducin preparations biochemical properties and possible role of transducin-beta as phosphorylated enzyme intermediateQ74672779
Signalling functions of protein palmitoylationQ77631481
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)1643-52
P577publication date2001-03-26
P13046publication type of scholarly workreview articleQ7318358
P1433published inOncogeneQ1568657
P1476titleRegulation of G proteins by covalent modification
P478volume20

Reverse relations

cites work (P2860)
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Q52549569Heterotrimer formation, together with isoprenylation, is required for plasma membrane targeting of Gbetagamma
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