Fluorinated pyrimidines, a new class of tumour-inhibitory compounds

scientific article (publication date: 30 March 1957)

Fluorinated pyrimidines, a new class of tumour-inhibitory compounds is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1024510095
P356DOI10.1038/179663A0
P3181OpenCitations bibliographic resource ID2213308
P698PubMed publication ID13418758

P2093author name stringC HEIDELBERGER
J SCHEINER
P DANNEBERG
R J SCHNITZER
N K CHAUDHURI
R DUSCHINSKY
D MOOREN
E PLEVEN
L GRIESBACH
P2860cites workChromatographic studies of nucleic acids; a technique for the identification and estimation of purine and pyrimidine bases, nucleosides and related substancesQ42626913
Studies of nucleic acid synthesis in ascites tumor cellsQ74007787
The fate of 6-mercaptopurine in miceQ78573325
The in vivo formation of citrate induced by fluoroacetate and its significanceQ80655039
The Separation of Purine and Pyrimidine Bases and of Nucleotides by Ion ExchangeQ80929979
P433issue4561
P407language of work or nameEnglishQ1860
P304page(s)663-6
P577publication date1957-03-30
P1433published inNatureQ180445
P1476titleFluorinated pyrimidines, a new class of tumour-inhibitory compounds
P478volume179

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Q67993427Phase II study of gemcitabine in advanced colorectal adenocarcinoma
Q47268080Phosphoribosyl pyrophosphate, pool size and tissue levels as a determinant of 5-fluorouracil response in murine colonic adenocarcinomas
Q30426511Plant-derived anticancer agents
Q36420719Positron emission tomography measurement of tumor metabolism and growth: its expanding role in oncology
Q59069547Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites Tumours
Q37406869Possible role of thymidine phosphorylase in gynecological tumors as an individualized treatment strategy
Q37311933Preclinical screening methods in cancer
Q44458788Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer
Q33320579Predictive value of Ki67 and p53 in locally advanced rectal cancer: correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy
Q68445322Preoperative irradiation and 5-fluorouracil suppository for carcinoma of the rectum
Q38232067Priming cancer cells for drug resistance: role of the fibroblast niche
Q34325743Programmed chemotherapy for patients with metastatic unresectable gastric cancer.
Q35039113Proteomic analysis of differentially expressed proteins in 5-fluorouracil-treated human breast cancer MCF-7 cells
Q34347434Protonation preferentially stabilizes minor tautomers of the halouracils: IRMPD action spectroscopy and theoretical studies.
Q26865050Pseudouridines in spliceosomal snRNAs
Q34019673Pyrimidine metabolism in man. V. The measurement in vivo of the biochemical effect of antineoplastic agents in animal and human subjects
Q76898304RADIOAUTOGRAPHIC STUDY OF THE EFFECTS OF 5-FLUORODEOXYURIDINE, ACTINOMYCIN AND PUROMYCIN IN ACETABULARIA MEDITERANEA
Q46446260Radiation dose estimates for [18F]5-fluorouracil derived from PET-based and tissue-based methods in rats
Q59081922Radiosensitization Of E. Coli by Purine and Pyrimidine Analogues Incorporated in Deoxyribonucleic Acid
Q35009893Raltitrexed: optimism and reality
Q38268619Recent studies of 5-fluorouracil resistance in pancreatic cancer
Q35556789Reexamining a proposal: thymidylate synthase 5'-untranslated region as a regulator of translation efficiency.
Q38211868Relationship between head and neck cancer therapy and some genetic endpoints
Q69934719Reminiscence and experience in experimental chemotherapy of cancer
Q40187481Repurposing of nucleoside- and nucleobase-derivative drugs as antibiotics and biofilm inhibitors.
Q26781245Research into cancer metabolomics: Towards a clinical metamorphosis
Q35567272Resistance to antifolates
Q41398588Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage
Q64997072Ribose-transfer Activity from Uridine to 5-Fluorouracil in Ehrlich Ascites Tumor Cells
Q47849564Routes to drug design via bioisosterism of carboxyl and sulfonamide groups.
Q37974935S-1 as a core anticancer fluoropyrimidine agent
Q27700205Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo
Q39312759Semisynthetic ursolic acid fluorolactone derivatives inhibit growth with induction of p21(waf1) and induce apoptosis with upregulation of NOXA and downregulation of c-FLIP in cancer cells
Q35969001Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway
Q40138085Solid Tumor Models for the Assessment of Different Treatment Modalities: VI: Perturbations in the Kinetics of Tumor and Host Organ Cellular Regulation Demonstrated by Single and Combined Experimental Therapy
Q39961474Specific targeting of prostate cancer cells in vitro by the suicide gene/prodrug system, uracil phosphoribosyltransferase/5-fluorouracil, under the control of prostate-specific membrane antigen promoter/enhancer
Q27006500Splice isoforms as therapeutic targets for colorectal cancer
Q38204673Standing the test of time: targeting thymidylate biosynthesis in cancer therapy
Q27675656Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs
Q42254777Structure-activity relationship of 1-propargyl-5-halopyrimidin-2-ones. Metaphase arresting properties and competitive inhibition of colchicine binding to tubulin
Q42697416Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues
Q46206827Studies on the mechanism of fluoropyrimidine cytotoxicity in l1210 cells: correlation with inhibition of thymidylate synthetase but not with incorporation into RNA.
Q44941786Study on the role of 5-fluorouracil in the polymerization of butylcyanoacrylate during the formation of nanoparticles.
Q33416158Survival benefit from S-1 as compared to Fluorouracil in Asian patients with advanced gastrointestinal cancer: a meta-analysis.
Q37901554Symptomatic 5-fluorouracil-induced sinus bradycardia
Q40264235Synergy between expression of fusogenic membrane proteins, chemotherapy and facultative virotherapy in colorectal cancer.
Q40038143Synthesis and bioevaluation of 5-fluorouracil derivatives.
Q52933943Synthesis and biological applications of fluoro-modified nucleic acids.
Q40050432Synthesis and biological evaluation of new 4beta-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives
Q39709630Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives.
Q39329841Synthesis of PEGylated fullerene-5-fluorouracil conjugates to enhance the antitumor effect of 5-fluorouracil
Q35111704Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents
Q42227659Synthesis of potential pyrimidine derivatives via Suzuki cross-coupling reaction as HIV and kinesin Eg5 inhibitors.
Q40258494Synthesis of virulence factors by Pasteurella pestis
Q37909031Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues.
Q38796140Systemic Antifungal Agents: Current Status and Projected Future Developments.
Q44249171Systemic chemotherapy for metastatic colorectal cancer: reasons to combine
Q37109507Systemic therapy for metastatic colorectal cancer: current questions
Q36529843Systemic therapy strategies for head-neck carcinomas: Current status
Q38597310TAS-102, a novel antitumor agent: a review of the mechanism of action
Q38652269TAS-102: a novel antimetabolite for the 21st century
Q77156773THE EFFECT OF 5-IODO-2'-DESOXYURIDINE ON THE PROPAGATION OF SV 40 VIRUS IN TISSUE CULTURE
Q33994714THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES
Q35973877Tailored chemotherapy for colorectal cancer: a new approach to therapy
Q92747984Targeted therapy for colorectal cancer metastases: A review of current methods of molecularly targeted therapy and the use of tumor biomarkers in the treatment of metastatic colorectal cancer
Q47646742Targeting Metabolism for Cancer Therapy.
Q35599748Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies
Q33815796The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies
Q39233316The Role of Fluoropirimidines in Gastrointestinal Tumours: from the Bench to the Bed.
Q37795648The Unique Potential for Noninvasive Imaging in Modernizing Drug Development and in Transforming Therapeutics: PET/MRI/MRS
Q78907567The biosynthesis of poliovirus in cell cultures
Q34054268The clinical impact of screening and other experimental tumor studies
Q34980526The dual role of thymidine phosphorylase in cancer development and chemotherapy
Q34761260The effect of dihydropyrimidine dehydrogenase deficiency on outcomes with fluorouracil
Q39638939The effect of leucovorin on the therapeutic index of fluorouracil in cancer patients
Q42198572The effect of structural modifications of 5-fluorouracil derivatives on their transport and biodegradation by isolated rat jejunum
Q39927801The emergence of drug resistance in tumours: a characteristic which may be exploited therapeutically
Q52507634The essential role of folic acid and the effect of antimetabolites on growth and metamorphosis of housefly larvae Musca domestica L
Q51776805The high-affinity maltose switch MBP317-347 has low affinity for glucose: implications for targeting tumors with metabolically directed enzyme prodrug therapy.
Q52334121The mechanistic basis of pH-dependent 5-flucytosine resistance in Aspergillus fumigatus.
Q40003629The metabolism and pharmacology of 5-fluorouracil
Q72893958The metabolism of 5-fluorocytosine-214C and of cytosine-14C in the rat and the disposition of 5-fluorocytosine-214C in man
Q34211250The oral fluorinated pyrimidines
Q78983322The polymerization of 8-Azaguanosine 5′-diphosphate by polynucleotide phosphorylase
Q33352896The potentiation of radiation effects with 5-fluoro-uracil
Q53692873The response to neoadjuvant chemoradiotherapy with 5-fluorouracil in locally advanced rectal cancer patients: a predictive proteomic signature.
Q35602147The role of funding and policies on innovation in cancer drug development
Q72720011The synthesis, characterization and biological properties of a new substance, 5-fluoropyrimidin-2-one
Q36038314The value of fluorinated pyrimidines in advanced malignancy
Q44929190Therapeutic evaluation of intralesional 5% 5-fluorouracil in condyloma acuminata
Q33884698Therapeutic strategies with oral fluoropyrimidine anticancer agent, S-1 against oral cancer
Q24633384Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur-Uracil (UFT) in patients with breast cancer: focus on the results of clinical studies in Japan
Q71832497Thermodynamic and Kinetic Aspects of the Reaction of γ-Fluoroglutamate with d-Glutamate Cyclase
Q34216779Thymidine analogues for tracking DNA synthesis.
Q39940923Thymidylate Synthetase
Q35183525Thymidylate synthase as a prognostic biomarker for locally advanced rectal cancer after multimodal treatment
Q81481891Thymidylate synthase gene polymorphism as a prognostic factor for colon cancer
Q43932425Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
Q40960400Thymidylate synthase in advanced gastrointestinal and breast cancers
Q37379373Thymidylate synthase in situ protein expression and survival in stage I nonsmall-cell lung cancer
Q35549719Thymidylate synthetase - a target enzyme in cancer chemotherapy
Q40442939Topical and systemic antifungals in dermatology practice.
Q40307900Topical chemotherapy with 5-fluorouracil. A review
Q71299502Topical cytotoxic therapy of solar keratoses with 5-fluorouracil
Q70576748Topical therapy with 5‐fluorouracil
Q37207935Topoisomerase I and IIalpha protein expression in primary colorectal cancer and recurrences following 5-fluorouracil-based adjuvant chemotherapy
Q80554169Topoisomerase I protein expression in primary colorectal cancer and recurrences after 5-FU-based adjuvant chemotherapy
Q34438530Tramadol--a true natural product?
Q33233929Treatment of Genital Condylomata with Topical 5-Fluorouracil
Q33468659Treatment of cancer with weekly intravenous 5-fluorouracil.Study by the Western Cooperative Cancer Chemotherapy Group (WCCCG)
Q37255172Treatment of invasive candidiasis in immunocompromised pediatric patients
Q70580395Treatment of metastatic colorectal carcinoma with 5-fluorouracil by mouth
Q26774713Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer
Q71843761Tumor retention of 5-fluorouracil following irradiation observed using 19F nuclear magnetic resonance spectroscopy
Q35553869UFT and Oral Leucovorin as Radiation Sensitizers in Rectal and Other Gastrointestinal Malignancies
Q47129907Uncovering Large-Scale Conformational Change in Molecular Dynamics without Prior Knowledge
Q39789627Update in cancer chemotherapy: gastrointestinal cancer--colorectal cancer, Part 1.
Q79064008Use of 5-Fluorouracil in Disseminated Solid Neoplasms
Q35212953Use of capecitabine in management of early colon cancer
Q38997864Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: a shorter drug-free interval leads to more efficient antitumor effects.
Q42916637Variants in the Dihydropyrimidine Dehydrogenase, Methylenetetrahydrofolate Reductase and Thymidylate Synthase Genes Predict Early Toxicity of 5-Fluorouracil in Colorectal Cancer Patients
Q39406815What's new in treatment of pancreatic cancer: a patent review (2010-2017).
Q46906887Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells
Q37425429XIII International Charles Heidelberger Symposium and 50 Years of Fluoropyrimidines in Cancer Therapy Held on september 6 to 8, 2007 at New York University Cancer Institute, Smilow Conference Center
Q78560478[Chemotherapy & bacterial resistance]
Q33532192[Human papillomavirus-associated warts in organ transplant recipients. Incidence, risk factors, management].
Q33727842dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial
Q41767730dUTPase inhibition augments replication defects of 5-Fluorouracil.
Q33754032microRNA-200a-3p increases 5-fluorouracil resistance by regulating dual specificity phosphatase 6 expression

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